We have located links that may give you full text access.
Severity of Disorganization of Retinal Layers and Visual Function Impairment in Diabetic Retinopathy.
Ophthalmology Retina 2024 April 10
PURPOSE: To evaluate best corrected visual acuity (BCVA), retina sensitivity (RS) and fixation impairment by microperimetry (MP) due to the presence and severity of disorganization of inner and outer retinal layers (DRIL/DROL) and ischemia in OCT/OCT-Angiography(OCT-A) in diabetic retinopathy (DR).
DESIGN: Retrospective case-control study.
SUBJECTS: Seventy-six eyes (65 patients) with DR were analyzed. Major exclusion criteria were: center-involving diabetic macular edema (DME), significant media opacity, nondiabetic macular pathology, active proliferative DR. Patients with DRIL and DROL within central 3 mm were enrolled as cases. Patients with DR and no retina disorganization were considered as controls.
METHODS: A detailed grading of microperimetry and OCT/OCT-A images using Image J software, and specific Image Manipulation Program was applied to co-localize the presence of retina disorganization and RS. BCVA and RS were correlated with the disorganization of retina layers' characteristics and grading (Grade 1-DRIL; Grade 2-DROL; Grade 3-DROL plus, with involvement of the ellipsoid zone). The same procedure of co-localization was applied to the vascular layers on OCT-A using Matlab.
MAIN OUTCOME: Correlation between BCVA and microperimetry parameters with disorganization of retina layers grading and OCT-A parameters.
RESULTS: BCVA, mean RS within 1mm and central 3mm (overall RS-oRS), perfusion density, vessel density and geometric perfusion deficit in intermediate and deep capillary plexuses were lower in cases versus controls (p<.001). Mean RS within 1mm (21.4dB±2.4 vs 13.8dB±5.4, p=.002), oRS (22.0dB±2.1 vs 14.4dB ±4.6, p<.001), and BCVA (76.1±7.4 vs 61.2±20.4 ETDRS letters; p=.02), had a significant decrease from grade 1 to grade 3 retina disorganization.Choriocapillaris flow-voids (CC-FV) increased from grade 1 to grade 3 (DROL plus) (p=.004). oRS and CC-FV were identified as significant predictors of retina disorganization grade with an adjusted coefficient of determination, R2 =0.45. Cases had more dense scotomas(p=.03) than controls with a positive correlation between the worsening of fixation stability and the severity of DRIL/DROL(p=.04).
CONCLUSION: MP and BCVA documented a reduction in visual function in patients with DR and disorganization of retina layers at different grades, with greater functional impairment when outer retina layers and photoreceptors are involved. The severity of retina disorganization and the presence of ischemia could serve as a potential biomarker of functional impairment.
DESIGN: Retrospective case-control study.
SUBJECTS: Seventy-six eyes (65 patients) with DR were analyzed. Major exclusion criteria were: center-involving diabetic macular edema (DME), significant media opacity, nondiabetic macular pathology, active proliferative DR. Patients with DRIL and DROL within central 3 mm were enrolled as cases. Patients with DR and no retina disorganization were considered as controls.
METHODS: A detailed grading of microperimetry and OCT/OCT-A images using Image J software, and specific Image Manipulation Program was applied to co-localize the presence of retina disorganization and RS. BCVA and RS were correlated with the disorganization of retina layers' characteristics and grading (Grade 1-DRIL; Grade 2-DROL; Grade 3-DROL plus, with involvement of the ellipsoid zone). The same procedure of co-localization was applied to the vascular layers on OCT-A using Matlab.
MAIN OUTCOME: Correlation between BCVA and microperimetry parameters with disorganization of retina layers grading and OCT-A parameters.
RESULTS: BCVA, mean RS within 1mm and central 3mm (overall RS-oRS), perfusion density, vessel density and geometric perfusion deficit in intermediate and deep capillary plexuses were lower in cases versus controls (p<.001). Mean RS within 1mm (21.4dB±2.4 vs 13.8dB±5.4, p=.002), oRS (22.0dB±2.1 vs 14.4dB ±4.6, p<.001), and BCVA (76.1±7.4 vs 61.2±20.4 ETDRS letters; p=.02), had a significant decrease from grade 1 to grade 3 retina disorganization.Choriocapillaris flow-voids (CC-FV) increased from grade 1 to grade 3 (DROL plus) (p=.004). oRS and CC-FV were identified as significant predictors of retina disorganization grade with an adjusted coefficient of determination, R2 =0.45. Cases had more dense scotomas(p=.03) than controls with a positive correlation between the worsening of fixation stability and the severity of DRIL/DROL(p=.04).
CONCLUSION: MP and BCVA documented a reduction in visual function in patients with DR and disorganization of retina layers at different grades, with greater functional impairment when outer retina layers and photoreceptors are involved. The severity of retina disorganization and the presence of ischemia could serve as a potential biomarker of functional impairment.
Full text links
Related Resources
Trending Papers
Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.International Journal of Molecular Sciences 2024 April 5
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Revascularization Strategy in Myocardial Infarction with Multivessel Disease.Journal of Clinical Medicine 2024 March 27
Clinical practice guidelines on the management of status epilepticus in adults: A systematic review.Epilepsia 2024 April 13
Interstitial Lung Disease: A Review.JAMA 2024 April 23
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app