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Ophthalmology Retina

Atsuro Uchida, Deepa Manjunath, Rishi P Singh, Aleksandra V Rachitskaya, Peter K Kaiser, Sunil K Srivastava, Jamie L Reese, Justis P Ehlers
Objective: To evaluate the use of optical coherence tomography angiography (OCTA) to detect choroidal neovascularization (CNV) in eyes with indeterminate CNV features on conventional imaging. Design: The AVATAR study is a prospective observational study of OCTA in patients undergoing routine spectral-domain optical coherence tomography (SD-OCT) for macular disease. Participants: Subjects enrolled in the AVATAR study for which CNV was considered as part of a differential diagnosis based on clinical exam and/or prior imaging, but in whom the presence of CNV was not definitive on SD-OCT and fluorescein angiography (FA) imaging...
November 2018: Ophthalmology Retina
Duncan Berry, Akshay S Thomas, Sharon Fekrat, Dilraj S Grewal
Purpose: To determine whether disorganization of retinal inner layers (DRIL) on optical coherence tomography (OCT) is associated with ischemia on ultra-widefield fluorescein angiography (UWFFA) and with visual outcomes in eyes with acute, treatment-naïve central retinal vein occlusion (CRVO). Design: Retrospective, single-institution, longitudinal cohort study. Participants: Twenty-five consecutive patients with treatment-naïve CRVO and ≥ 1 year follow-up...
November 2018: Ophthalmology Retina
Maxwell W Dixon, George J Harocopos, Albert S Li, James C Liu, Rithwick Rajagopal
No abstract text is available yet for this article.
October 2018: Ophthalmology Retina
A Domalpally, R P Danis, R Trane, B A Blodi, T E Clemons, E Y Chew
Purpose: To identify the development and progression of macular retinal pigment epithelial atrophy in eyes with neovascular (CNV) age-related macular degeneration (AMD) and to correlate with visual acuity (VA). Design: Cohort study. Participants: Age-Related Eye Disease Study 2 (AREDS2) participants with intermediate AMD enrolled in a randomized controlled clinical trial of oral supplements. Analyses were conducted in the subset of AREDS2 participants who were also enrolled in the fundus autofluorescence ancillary (FAF) ancillary study...
October 2018: Ophthalmology Retina
Xi Chen, Shwetha Mangalesh, Alexandria Dandridge, Du Tran-Viet, David K Wallace, Sharon F Freedman, Cynthia A Toth
PURPOSE: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic en face viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascular junction, a critical location for pathogenesis of ROP, to date this has not been possible in vivo . Here we present bedside, non-sedated in vivo cross-sectional imaging and analysis of retinal microstructures at the vascular-avascular junction in infants with ROP using handheld spectral-domain optical coherence tomography (SDOCT)...
September 2018: Ophthalmology Retina
Ryan Swan, Sang Jin Kim, J Peter Campbell, R V Paul Chan, Kemal Sonmez, Kent D Taylor, Xiaohui Li, Yii-Der Ida Chen, Jerome I Rotter, Charles Simmons, Michael F Chiang
TOPIC: Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease in premature infants, and is a major cause of childhood blindness worldwide. In addition to known clinical risk factors such as low birth weight and gestational age, there is a growing body of evidence supporting a genetic basis for ROP. CLINICAL RELEVANCE: While comorbidities and environmental factors have been identified as contributing to ROP outcomes in premature infants, most notably gestational age and oxygen, some infants progress to severe disease despite absence of these clinical risk factors...
September 2018: Ophthalmology retina
Scott M McClintic, Simon Gao, Jie Wang, Ahmed Hagag, Andreas K Lauer, Christina J Flaxel, Kavita Bhavsar, Thomas S Hwang, David Huang, Yali Jia, Steven T Bailey
Purpose: To use optical coherence tomography angiography (OCTA) derived quantitative metrics to assess the response of choroidal neovascularization to pro-re-nata (PRN) anti-endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (AMD). Design: Prospective longitudinal cohort study. Participants: Fourteen eyes from 14 study participants with treatment-naïve neovascular AMD were enrolled. Methods: Subjects were evaluated monthly and treated with intravitreal anti-VEGF agents under a PRN protocol for one year...
September 2018: Ophthalmology Retina
Touka Banaee, Rishi P Singh, Kathryn Champ, Felipe F Conti, Karen Wai, Jim Bena, Lucas Beven, Justis P Ehlers
Purpose: To evaluate the association of baseline ellipsoid zone (EZ) parameters on optical coherence tomography (OCT) as calculated by a semi-automated computer algorithm with baseline visual acuity in eyes with retinal vein occlusion (RVO). Design: Retrospective consecutive case series. Subjects: Patients affected by RVO presenting from January 2011 to December 2014. Methods: Baseline demographics, clinical characteristics, and SD-OCT data at presentation were collected...
August 2018: Ophthalmology Retina
S Grace Prakalapakorn, Sharon F Freedman, Amy K Hutchinson, David K Wallace, Sandra S Stinnett, J Wayne Riggins, Keith J Gallaher
PURPOSE: To evaluate (1) the feasibility of non-ophthalmologist healthcare workers (HCWs) to obtain images of sufficient quality for retinopathy of prematurity (ROP) screening using a FDA-approved portable, non-contact, narrow-field fundus camera (i.e., Pictor™), and (2) the accuracy of grading these images to identify infants who developed treatment-warranted (type 1) ROP. DESIGN: Prospective cohort study. SUBJECTS: Infants undergoing routine ROP screening examinations (i...
August 2018: Ophthalmology retina
Rachel C Patel, Jie Wang, Thomas S Hwang, Miao Zhang, Simon S Gao, Mark E Pennesi, Steven T Bailey, Brandon J Lujan, Xiaogang Wang, David J Wilson, David Huang, Yali Jia
Objective: To evaluate the projection-resolved (PR) optical coherence tomography angiography (OCTA) algorithm in detecting plexus-specific vascular abnormalities in retinal pathologies. Design: Cross-sectional observational clinical study. Participants: Patients diagnosed with retinal vascular diseases and healthy volunteers. Methods: Eyes were imaged using an OCT system operating at 840 nm and employing the split-spectrum amplitude decorrelation algorithm...
August 2018: Ophthalmology Retina
Stacy M Scofield-Kaplan, Royce W S Chen, Harry W Flynn, James Lin, Jason D Horowitz
No abstract text is available yet for this article.
July 2018: Ophthalmology Retina
Amir H Kashani, Kyle M Green, Julie Kwon, Zhongdi Chu, Qinqin Zhang, Ruikang K Wang, Sean Garrity, David Sarraf, Carl B Rebhun, Nadia K Waheed, Karen B Schaal, Marion R Munk, Sarra Gattoussi, K Bailey Freund, Fang Zheng, Guanghui Liu, Philip J Rosenfeld
Objective: To characterize features of extra-vascular optical coherence tomography angiography (OCTA) signals corresponding to hyperreflective intraretinal fluid across various exudative maculopathies. Design: Multicenter, retrospective, observational study. Participants: Eyes with various forms of exudative maculopathy including diabetic retinopathy (DR), retinal vein occlusion (RVO), and neovascular-age related macular degeneration (nvAMD)...
July 2018: Ophthalmology Retina
Kaivon Pakzad-Vaezi, Kosar Khaksari, Zhongdi Chu, Russell N Van Gelder, Ruikang K Wang, Kathryn L Pepple
Purpose: To examine and quantify choriocapillaris lesions in active and quiescent serpiginous choroiditis (SC) using swept-source optical coherence tomography angiography (SS-OCTA) and en-face image analysis. Design: Prospective observational case series. Participants: Patients with a clinical diagnosis of SC. Methods: A SS-OCTA prototype was used to image active and quiescent serpiginous lesions longitudinally before and after anti-inflammatory treatment...
July 2018: Ophthalmology Retina
Jennifer Enright, Richard Schroeder, James R Waymack, Gregg Lueder, Rithwick Rajagopal
No abstract text is available yet for this article.
June 2018: Ophthalmology Retina
Lydia Sauer, Rebekah H Gensure, Martin Hammer, Paul S Bernstein
Purpose: Macular Telangiectasia Type 2 (MacTel) is an uncommon, late-onset complex retinal disease that leads to central vision loss. No causative gene(s) have been identified so far, resulting in a challenging clinical diagnostic dilemma because retinal changes of early stages are often subtle. The objective of this study was to investigate the benefit of fluorescence lifetime imaging ophthalmoscopy (FLIO) for retinal imaging in patients with MacTel. Design: Cross-sectional study from a tertiary-care retinal referral practice...
June 2018: Ophthalmology Retina
Amy S Babiuch, Mehnaz Khan, Ming Hu, Peter K Kaiser, Sunil K Srivastava, Rishi P Singh, Allison Watts, Jamie L Reese, Justis P Ehlers
Purpose: To compare review strategies for optical coherence tomography angiography (OCT-A) for multiple disease features found in common diseases of the choroid and retina. Design: Prospective, observational study. Participants: Patients with macular disease undergoing routine spectral-domain optical coherence tomography (SDOCT). Methods: Eyes were imaged with the Avanti RTVue XR HD (Optovue, Fremont, CA), and the split-spectrum amplitude decorrelation angiography (SSADA) algorithm software was utilized for OCT-A performance...
June 2018: Ophthalmology Retina
Gui-Shuang Ying, Maureen G Maguire, Wei Pan, Juan E Grunwald, Ebenezer Daniel, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Daniel F Martin
Purpose: To determine baseline predictors of visual acuity (VA) outcomes at 5 years after initiating treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). Design: Secondary analysis of data from a cohort study. Participants: Patients enrolled in the Comparison of AMD Treatments Trials (CATT) who completed a 5-year follow-up visit. Methods: Participants were randomly assigned to ranibizumab or bevacizumab and to 1 of 3 dosing regimens...
June 2018: Ophthalmology Retina
Mehnaz Khan, Sunil K Srivastava, Jamie L Reese, Zryan Shwani, Justis P Ehlers
Purpose: To delineate the feasibility and role of intraoperative optical coherence tomography (iOCT) in surgical decision-making during vitreoretinal surgical interventions for proliferative diabetic retinopathy (PDR). Design: Prospective, single-site, multi-surgeon consecutive case series. Participants: Patients enrolled in the DISCOVER study who underwent vitreoretinal surgery for sequelae of PDR. Methods: Subjects were identified from the first 2 years of the DISCOVER study that underwent vitreoretinal surgery for complications of PDR...
May 2018: Ophthalmology Retina
William G Christen, Daniel I Chasman, Nancy R Cook, Stephanie E Chiuve, Paul M Ridker, Julie E Buring
No abstract text is available yet for this article.
May 2018: Ophthalmology Retina
Gary Gensler, Traci E Clemons, Amitha Domalpally, Ronald P Danis, Barbara Blodi, Jack Wells, Michael Rauser, John Hoskins, G Baker Hubbard, Michael J Elman, Gary E Fish, Alexander Brucker, Alan Margherio, Emily Y Chew
Objective/Purpose: To evaluate efficacy and safety of monthly intravitreal injections of sirolimus, an immunosuppressive drug, for the treatment of age-related macular degeneration associated geographic atrophy (GA). Design: Randomized, controlled, single-masked multi-center phase 2 clinical trial of intravitreal sirolimus vs. sham therapy in AREDS2 clinical centers. Subjects: Participants with GA. Methods: Participants eligible in one eye were randomly assigned to a monthly intravitreal injection of sirolimus (20 µL [440 µg]) or sham treatment while participants with two study eyes were assigned to a monthly intravitreal injection in a randomly-selected eye...
May 2018: Ophthalmology Retina
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