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JOURNAL ARTICLE
Thibaud Garcin, Alain Gaudric, Anne Sikorav, Ramin Tadayoni, Aude Couturier
PURPOSE: To evaluate the very long-term functional and structural outcomes of internal limiting membrane (ILM) peeling for full-thickness macular holes (FTMH). DESIGN: Observational case series nested within a multicenter, randomized, controlled clinical trial (RCT) (ClinicalTrials.gov: NCT00190190). SUBJECTS: Patients who underwent vitrectomy with or without ILM peeling for an idiopathic large FTMH in a tertiary ophthalmology center, with a minimum follow-up of 10 years after surgery...
September 12, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Tarannum Mansoori, Satish Gooty Agraharam, Swetha Nasani
No abstract text is available yet for this article.
September 11, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Savithiri Palanivel, Anand Rajendran
No abstract text is available yet for this article.
September 11, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Chandrakumar Balaratnasingam, Elon H C van Dijk
No abstract text is available yet for this article.
September 11, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Connor Ross, Sophia Ghauri, Joshua B Gilbert, Daniel Hu, Varun Ullanat, Dan Gong, Paul B Greenberg, Dean Eliott, Tobias Elze, Alice Lorch, Joan W Miller, Magdalena G Krzystolik
PURPOSE: To determine if intravitreal injection of antibiotics alone versus early pars plana vitrectomy (PPV) plus injection of intravitreal antibiotics predicted better or worse visual outcomes for patients with endophthalmitis after anti-vascular endothelial growth factor (anti-VEGF) injections. DESIGN: Retrospective cohort study PARTICIPANTS: Patients developing endophthalmitis after receiving an intravitreal anti-VEGF injection from the American Academy of Ophthalmology IRIS® Registry between 2016 and 2020...
September 9, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Rita Serra, Laurent Kodjikian, Thibaud Mathis
No abstract text is available yet for this article.
September 9, 2024: Ophthalmology Retina
#7
JOURNAL ARTICLE
Hasenin Al-Khersan, Elioenai Garcia, Kenneth C Fan, Patrick C Staropoli, Edward H Wood, Philip Storey, Murtaza K Adam, David W Parke, Lawrence S Halperin, Kevin Quinn, Charles Wykoff
No abstract text is available yet for this article.
September 2, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Shaima Awadh Hashem, Michalis Georgiou, Genevieve Wright, Yu Fujinami-Yokokawa, Yannik Laich, Malena Daich Varela, Thales A C de Guimaraes, Omar A Mahroo, Andrew R Webster, Kaoru Fujinami, Michel Michaelides
PURPOSE: To analyze the genetics, clinical characteristics, and natural history of PDE6A-associated retinitis pigmentosa. DESIGN: Retrospective, longitudinal, observational cohort study. PARTICIPANTS: Patients with molecularly confirmed PDE6A-associated retinal dystrophy in a single tertiary referral center. METHODS: Review of medical records and retinal imaging, including fundus autofluorescence (FAF) imaging and spectral-domain optical coherence tomography (SD-OCT)...
August 30, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Enrico Borrelli, Chiara Olivieri, Sonia Serafino, Andrea Coletto, Federico Ricardi, Giovanni Neri, Paola Marolo, Michele Reibaldi
PURPOSE: Macular atrophy is a common complication in neovascular age-related macular degeneration (AMD) and is associated with poorer visual outcomes. This study evaluated inter-reader and inter-modality variability in measuring macular atrophy in previously-treated neovascular AMD eyes without exudation, using six imaging modalities. DESIGN: Prospective, cohort study. PARTICIPANTS: Thirty participants with previously-treated neovascular AMD, showing no signs of exudation at the time of enrollment, and exhibiting macular atrophy...
August 29, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Justis P Ehlers, Kristin Josic, Sari Yordi, Alison Martin, Sunil K Srivastava, Jenifer K Sun
PURPOSE: Evaluate quantitative leakage parameters on ultra-widefield fluorescein angiography (UWF-FA) images and explore their association with Diabetic Retinopathy Severity Scale (DRSS), predominantly peripheral lesions (PPLs), visual acuity, and clinical characteristics. DESIGN: A post-hoc analysis of baseline UWF-FA images in the DRCR Retina Network observational study Protocol AA. PARTICIPANTS: N = 575 eyes from 384 adults across 38 sites in the US and Canada with gradable UWF-FA...
August 29, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Junran Sun, Yanping Song, Yuanyuan Gong, Liming Tao, Hong Wang, Xiangwen Shu, Ying Wen, Ling Cui, Jian Ye, Shujie Lu, Junjie Deng, Haoyu Li, Yihua Xu, Lei Qian, Zhifeng Wu, Yanlong Bi, Qinghuai Liu, Xiangzhong Xu, Miaoqin Wu, Jinglin Zhang, Jilong Hao, Jianping Tong, Hong Dai, Feng Wang, MingWei Zhao, Junfeng Mao, Chaopeng Li, Tao He, Cheng Pei, Xiaoling Liu, Xian Wang, Mingxin Li, Wei Wang, Qinxiang Zheng, Huaijin Guan, Hui Peng, Ke Fan, Wenfang Zhang, Dan Zhu, Songping Yu, Wenbin Wei, Lin Ding, Jinying Li, Peirong Lu, Ming Yan, Wei Liu, Huixun Jia, Xiaodong Sun
PURPOSE: To evaluate efficacy and safety of efdamrofusp alfa compared with aflibercept in neovascular age-related macular degeneration (nAMD). DESIGN: Randomized, double-masked, multicenter, active-controlled, non-inferiority phase 2 study PARTICIPANTS: A total of 231 treatment-naïve and previously treated participants with active choroidal neovascularization secondary to nAMD were enrolled. METHODS: Eligible participants were randomized (1:1:1) to 2 mg efdamrofusp alfa, 4 mg efdamrofusp alfa or 2 mg aflibercept groups...
August 28, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Peter A Campochiaro, David Eichenbaum, Margaret A Chang, W Lloyd Clark, Jordan M Graff, Sophie Le Pogam, Melina Cavichini Cordeiro, Shamika Gune, Mel Rabena, Natasha Singh, Stephanie Lin, Natalia Callaway
OBJECTIVE: The Port Delivery System with ranibizumab (PDS) is approved in the United States for neovascular age-related macular degeneration (nAMD). Portal (NCT03683251) is evaluating long-term safety and tolerability of the PDS in patients with nAMD who completed the phase II Ladder (NCT02510794) or phase III Archway (NCT03677934) trials. DESIGN: Multicenter, nonrandomized, open-label, extension clinical trial. PARTICIPANTS: All-PDS safety population (N = 555) comprises patients enrolled in Portal who completed Ladder or Archway...
August 27, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Misato Okamoto, Itsuka Matsushita, Tatsuo Nagata, Yoshihisa Fujino, Hiroyuki Kondo
PURPOSE: To determine the ultra-widefield fluorescein angiographic (UWFA) characteristics of patients with mild familial exudative vitreoretinopathy (FEVR) who had been confirmed to have pathogenic variants of the autosomal dominant (AD) genes of FEVR. DESIGN: Single center, observational case series. SUBJECTS AND CONTROLS: Thirty-seven patients with mild FEVR from 27 families who had pathogenic variants of the Norrin/β-catenin genes were studied...
August 26, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Subhav Pershad, Vijay Anand P Reddy, Santosh G Honavar
No abstract text is available yet for this article.
August 26, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Shiyi Yin, Jinyuan Wang, Wenbin Wei
No abstract text is available yet for this article.
August 24, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Marina Ger, Srikanta Kumar Padhy
No abstract text is available yet for this article.
August 24, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Tugche S Chen, Yasmin Motekalem, Isabela Martins Melo, Roxane J Hillier, Alan R Berger, Louis R Giavedoni, David T Wong, Filiberto Altomare, Rajeev H Muni
PURPOSE: To assess long-term re-detachment rates of the Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT). DESIGN: Randomized controlled trial. SUBJECTS: PIVOT trial participants METHODS: This study was performed at St. Michael's Hospital, Unity Health Toronto, Toronto, Canada. PIVOT trial participants, with a minimum follow-up of two years, who had undergone either pneumatic retinopexy or ppv for rrd repair were assessed for long-term re-detachment by chart review or telephone interview...
August 23, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Prithviraj Udaya, Toshit Varshney, Naresh Babu Kannan
No abstract text is available yet for this article.
August 18, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Lumin Liang, Nan Zhou, Wenbin Wei
No abstract text is available yet for this article.
August 18, 2024: Ophthalmology Retina
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JOURNAL ARTICLE
Grace S Yin, Zhuo Shao, Hanna Faghfoury, Brian G Ballios
OBJECTIVE: To investigate the ability of a new clinical model to improve accessibility and expedite the pathway to molecular diagnosis for patients with suspected inherited retinal diseases (IRD). DESIGN: Retrospective cohort study of electronic patient records. PARTICIPANTS: All patients referred to general medical genetic clinic between September 2017 to September 2019 and an ophthalmologist-led IRD clinic between October 2021 to July 2023 for suspected IRD were included...
August 16, 2024: Ophthalmology Retina
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