Ophthalmology Retina

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PURPOSE: To evaluate the incidence, pathogenesis, risk factors, and treatment outcomes of postoperative macular hole (MH) after pars plana vitrectomy (PPV) for myopic traction maculopathy (MTM). DESIGN: Multicenter, interventional, retrospective case series. SUBJECTS: Consecutive eyes that underwent PPV for MTM with a minimum six-month follow-up. METHODS: We investigated the characteristics and treatment outcomes of postoperative MH after MTM surgery...

PURPOSE: To use electronic health record (EHR) time logs and Time-Driven Activity Based Costing (TDABC) to calculate the complete cost profile of office-based fluorescein angiography (FA). DESIGN: Economic analysis. SUBJECTS: Patients undergoing routine FA (CPT 92235) at Vanderbilt Eye Institute in Fiscal year 2022 METHODS: Process flow mapping for routine FA was used to define the care episode after manual observation. De-identified time logs were sourced from the EHR and all manually validated to calculate durations for each stage...

OBJECTIVE: To identify individual and systems-focused risk factors for pars plana vitrectomy among patients with proliferative diabetic retinopathy in the diverse, urban, safety-net hospital setting. DESIGN: Single-center, retrospective, observational, case-control study at Zuckerberg San Francisco General Hospital and Trauma Center between 2017 and 2022. SUBJECTS, PARTICIPANTS, AND CONTROLS: 222 patients with proliferative diabetic retinopathy over a 5-year span (2017-2022), consisting of 111 cases who underwent vitrectomy for vision-threatening complications (tractional retinal detachment, non-clearing vitreous hemorrhage, and neovascular glaucoma) and 111 controls with proliferative diabetic retinopathy with no history of vitrectomy or vision-threatening complications...

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No abstract text is available yet for this article.

PURPOSE: To assess the risk of retinal displacement following scleral buckle (SB) versus pars plana vitrectomy with scleral buckle (PPV-SB). DESIGN: Multi-center prospective non-randomized clinical trial. METHODS: The study took place at VitreoRetinal Surgery in Minneapolis, USA; Sankara Nethralaya in Chennai, India and St. Michael's Hospital in Toronto, Canada from July 2019 to February 2022. Patients who underwent successful SB or PPV-SB for fovea-involving rhegmatogenous retinal detachment (RRD) with gradable post-operative fundus autofluorescence (FAF) imaging were included in the final analysis...

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No abstract text is available yet for this article.

PURPOSE: To evaluate the outer retinal bands using optical coherence tomography (OCT) in ABCA4- and PRPH2-associated retinopathy and develop a novel imaging biomarker to differentiate between these two genotypes. DESIGN: Multicenter case-control study. PARTICIPANTS: Patients with a clinical and genetic diagnosis of ABCA4- or PRPH2-associated retinopathy and an age-matched control group. METHODS: Macular OCT was used to measure the thickness of the outer retinal Bands 2 and 4 by two independent examiners at 4 retinal loci...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

TOPIC: To compare outcomes of scleral buckle (SB), pars plana vitrectomy (PPV), and combined PPV-SB to treat rhegmatogenous retinal detachments with inferior retinal breaks (IRB-RRD). CLINICAL RELEVANCE: IRB-RRD are not uncommon; their management is challenging with higher risk of failure. There is no consensus about their treatment, specifically whether SB, PPV or PPV-SB should be performed. METHODS: Systematic review and meta-analysis. Randomised controlled trials (RCT), case-control, and prospective/retrospective series (if n >50) in English were eligible...

OBJECTIVE: To evaluate the efficacy, safety, and immunogenicity of a ranibizumab biosimilar candidate (XSB-001) versus reference product (Lucentis®) for neovascular age-related macular degeneration (nAMD). DESIGN: Phase 3, multicenter, randomized, double-masked, parallel-group study. PARTICIPANTS: Patients with nAMD. METHODS: Eligible patients were randomized (1:1) to receive intravitreal injections of XSB-001 or reference ranibizumab (0...

PURPOSE: To investigate the progression of geographic atrophy (GA) secondary to non-neovascular age-related macular degeneration (AMD) in early and later stage lesions using AI-based precision tools. DESIGN: Retrospective analysis of an observational cohort study. SUBJECTS: Seventy-four eyes of forty-nine patients with at least one complete retinal pigment epithelial and outer retinal atrophy (cRORA) lesion secondary to AMD were included. Patients were divided between recently developed cRORA and lesions with advanced disease status...

PURPOSE: To assess the impact of a 3-hour polysomnography (PSG)-recorded night of sleep deprivation on next-morning simulated microsurgical skills among vitreoretinal surgeons with different levels of surgical experience, and to associate the sleep parameters obtained by PSG with the Eyesi-generated performance. DESIGN: Self-controlled cohort study. PARTICIPANTS AND CONTROLS: Eleven junior vitreoretinal surgery fellows with less than 2 years' surgical experience and 11 senior surgeons with more than 10 years' surgical practice...

TOPIC: Systematic literature review of treatment efficacy of previously used protocols in treating patients with proven cancer-associated retinopathy (CAR). CLINICAL RELEVANCE: There is no universally accepted treatment algorithm for CAR and visual prognosis in very poor. We describe a patient with CAR with dramatic improvement in vision after treatment with high doses of corticosteroids followed by plasma exchange (PLEX) and present results of systematic literature review of treatment efficacy of previously used protocols in treating patients with proven CAR...

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