Triglyceride Glucose Index and Prognosis of Patients With Subarachnoid hemorrhage.

OBJECTIVE: The triglyceride glucose index (TyG) is regarded as a reliable alternative indicator for measuring insulin resistance. We investigated the association between the prognosis of SAH patients and the TyG, explored the potential of the TyG as a new biomarker for forecasting the outcomes of SAH patients, explored independent risk factors for predicting the condition of SAH patients.

METHOD: A retrospective analysis was carried out to look into the patients who were admitted to the first Linping District People's Hospital because of subarachnoid hemorrhage from January 1, 2021 to December 1, 2023. According to the GOS score, 134 patients with SAH were divided into Grades 3-5 and Grades 1-2. The differences in clinical data and the correlation between laboratory indexes, disease severity score on admission, and prognosis score were compared between the two groups. The study employed multivariate logistic regression analysis to examine the independent influencing aspects of GOS score. Draw the receiver operating characteristic (ROC) curve and calculate the area under the curve (AUC), which can be applicable to predict the best cut-off value of the degree of neurological impairment in patients with SAH and to assess the correlation with the severity of neurological damage in patients with SAH.

RESULTS: Univariate analysis showed that GCS score (86.3% versus 12.0% versus p<0.001), Hunt-Hess score(88.2% versus 15.7% x p<0.001), WBC (11.20(7.9-15.2) versus 9.1 (7.0-12.2); p =0.027) and TyG index(1.49(1.40,1.59) versus 1.16(1.06,1.27);p<0.001) between the two groups were statistically significantly different. Nevertheless, there was no statistically significant difference in age, gender, BMI and Personal history. Multivariate analysis showed that TyG index,Hunt-Hess score and GCS grade were independent risk factors for poor prognosis.

CONCLUSION: Our findings show that patients with SAH may benefit from using the TyG as a predictive method. In our clinical practice, considering the TyG index is beneficial for managing diseases and making decisions. More research is required to find out if improved TyG index control would lead to better clinical results in the future.