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European Journal of Medical Research

https://read.qxmd.com/read/37268989/the-direct-prognosis-comparison-of-125-i-low-dose-rate-brachytherapy-versus-laparoscopic-radical-prostatectomy-for-patients-with-intermediate-risk-prostate-cancer
#1
REVIEW
Zhen Liang, Chen Yuliang, Ming Zhu, Yi Zhou, Xingcheng Wu, Hanzhong Li, Bu Fan, Zhien Zhou, Weigang Yan
BACKGROUND: This study aims to compare the clinical outcomes after performing radical prostatectomy (RP) or low-dose-rate brachytherapy (LDR) for patients with intermediate-risk prostate cancer (IRPC). METHODS: We performed a retrospective analysis on 361 IRPC patients who underwent treatment in Peking Union Medical College Hospital from January 2014 to August 2021, of which 160 underwent RP and 201 underwent Iodine-125 LDR. Patients were followed in clinic monthly during the first three months and at three-month intervals thereafter...
June 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37254221/exercise-and-epigenetic-ages-in-older-adults-with-myeloid-malignancies
#2
JOURNAL ARTICLE
Kah Poh Loh, Chandrika Sanapala, Marielle Jensen-Battaglia, Anish Rana, Michael B Sohn, Erin Watson, Nikesha Gilmore, Heidi D Klepin, Jason H Mendler, Jane Liesveld, Eric Huselton, Marissa LoCastro, Martha Susiarjo, Colleen Netherby-Winslow, AnnaLynn M Williams, Karen Mustian, Paula Vertino, Michelle C Janelsins
BACKGROUND: Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age. Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies, yet there is little evidence of the effects of exercise on DNAm age...
May 30, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37248529/association-between-thyroid-function-and-obesity-phenotypes-in-healthy-euthyroid-individuals-an-investigation-based-on-tehran-thyroid-study
#3
JOURNAL ARTICLE
Behnaz Abiri, Amirhossein Ramezani Ahmadi, Maryam Mahdavi, Atieh Amouzegar, Majid Valizadeh
AIMS: We investigated whether thyroid function could be associated with obesity phenotypes amongst euthyroid individuals. MATERIALS AND METHODS: A cross-sectional analysis was conducted among healthy, euthyroid subjects. The study participants were chosen from the Tehran Thyroid Study (TTS). We analyzed 2988 euthyroid adults and classified them into four obesity phenotype groups: metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obese (MUO)...
May 30, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37221574/the-impact-of-the-duration-of-the-integrated-disease-management-program-on-copd-related-outcomes
#4
JOURNAL ARTICLE
Ching-Hsiung Lin, Yi-Rong Li, Bing-Yen Wang, Sheng-Hao Lin, Kuo-Yang Huang, Cheng-Hsiung Chen, Chew-Teng Kor
BACKGROUND: The aim of this study is to assess the impact of the duration of the integrated disease management (IDM) program on COPD-related outcomes in real-world setting. METHODS: A retrospective cohort study among 3771 patients with COPD who had regularly completed 4 visits of IDM program within 1 year between April 1, 2017 and December 31, 2018. CAT score as the primary outcome used to investigate the association between IDM intervention duration and improvement in CAT score...
May 23, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37208700/bacterial-pathogens-and-in-hospital-mortality-in-revision-surgery-for-periprosthetic-joint-infection-of-the-hip-and-knee-analysis-of-346-patients
#5
JOURNAL ARTICLE
Filippo Migliorini, Christian David Weber, Andreas Bell, Marcel Betsch, Nicola Maffulli, Vanessa Poth, Ulf Krister Hofmann, Frank Hildebrand, Arne Driessen
INTRODUCTION: The management of periprosthetic joint infections (PJI) of the lower limb is challenging, and evidence-based recommendations are lacking. The present clinical investigation characterized the pathogens diagnosed in patients who underwent revision surgery for  PJI of total hip arthroplasty (THA) and total knee arthroplasty (TKA). METHODS: The present study follows the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)...
May 19, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37189176/cuproptosis-related-ferroptosis-genes-for-predicting-prognosis-in-kidney-renal-clear-cell-carcinoma
#6
JOURNAL ARTICLE
Gang Luo, Lini Wang, Ziyu Zheng, Baobao Gao, Chong Lei
Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and prognosis in tumors. However, the role of Cuproptosis-related Ferroptosis genes (CRFGs) in KIRC has rarely been fully understood. Therefore, we constructed a prognostic signature based on different expression of CRFGs in KIRC. All raw data of this study were extracted from public TCGA datasets. Cuproptosis and Ferroptosis genes were collected from the previous research...
May 15, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37189132/expression-of-micrornas-in-leukocytes-and-serum-of-asbestosis-patients
#7
JOURNAL ARTICLE
Vivien Kauschke, Monika Philipp-Gehlhaar, Joachim Schneider
BACKGROUND: Although asbestos use is banned in many countries, long latency of asbestos-related diseases like pleural plaques or asbestosis mean it is still a public health issue. People suffering from these diseases have a higher risk of developing mesothelioma or lung cancer, which can progress quickly and aggressively. MicroRNAs were suggested as potential biomarkers in several diseases. However, in asbestosis, blood microRNAs are less explored. Since miR-32-5p, miR-143-3p, miR-145-5p, miR-146b-5p, miR-204-5p and miR-451a are involved in fibrotic processes and in cancer, expression of these microRNAs was analyzed in leukocytes and serum of asbestosis patients...
May 15, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37183248/association-between-corrected-serum-calcium-levels-after-dialysis-and-post-dialysis-fatigue-risk-a-hospital-based-case-control-study
#8
JOURNAL ARTICLE
Ping Xiao, Zhi-Hong Wang, Yan Lu, Shuang Zhang, Yu-Xin Jin, Xin Liu, Zhen-Li Jiang, Shu-Xin Liu
OBJECTIVE: Post-dialysis fatigue (PDF) is an important problem in patients undergoing maintenance hemodialysis (MHD); however, evidence of the association between serum calcium after dialysis and the risk of PDF is limited and controversial. We explored this association among patients receiving MHD. METHODS: We carried out a case-control study of patients in the dialysis unit of Dalian Municipal Central Hospital between December 2019 and January 2020, including 340 patients with PDF and 270 patients without PDF...
May 15, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37183240/fvc-d-lco-identifies-pulmonary-hypertension-and-predicts-5-year-all-cause-mortality-in-patients-with-copd
#9
JOURNAL ARTICLE
Yuer Li, Rui Zhang, Hu Shan, Wenhua Shi, Xiaoli Feng, Haijuan Chen, Xia Yang, Yali Li, Jie Zhang, Ming Zhang
BACKGROUND: Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD). However, it is unknown whether the ratio of forced vital capacity (FVC) to diffusing lung capacity for carbon monoxide (DLCO ) can identify PH in the patients with COPD and predict its prognosis. METHODS: The study population I included 937 COPD patients who were admitted to inpatient treatments from 2010 to 2017, and finally 750 patients were available to follow-up the 5-year all-cause mortality (study population II)...
May 15, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37179366/membrane-tension-mediated-stiff-and-soft-tumor-subtypes-closely-associated-with-prognosis-for-prostate-cancer-patients
#10
JOURNAL ARTICLE
Dechao Feng, Jie Wang, Xu Shi, Dengxiong Li, Wuran Wei, Ping Han
BACKGROUND: Prostate cancer (PCa) is usually considered as cold tumor. Malignancy is associated with cell mechanic changes that contribute to extensive cell deformation required for metastatic dissemination. Thus, we established stiff and soft tumor subtypes for PCa patients from perspective of membrane tension. METHODS: Nonnegative matrix factorization algorithm was used to identify molecular subtypes. We completed analyses using software R 3.6.3 and its suitable packages...
May 13, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37179365/tumor-immune-microenvironment-time-to-enhance-antitumor-immunity
#11
REVIEW
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha
The tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells. The short review highlights important immune infiltrates within the tumor microenvironment that shape cytotoxic t lymphocyte (CTL)-rich immune hot and CTL-deficient immune cold tumors and novel strategies that have potential role in enhancing our immune responses in both immune hot and immune cold tumors...
May 13, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37179360/the-influence-of-vitamin-d-on-handgrip-strength-in-elderly-trauma-patients
#12
JOURNAL ARTICLE
Tamara Ostermeier, Leon Faust, Adrian Cavalcanti-Kußmaul, Christian Kammerlander, Matthias Knobe, Wolfgang Böcker, Maximilian M Saller, Carl Neuerburg, Alexander M Keppler
BACKGROUND AND OBJECTIVES: The treatment of elderly patients is an increasing challenge and the long-term sequelae often affect activities of daily living and quality of life in those patients. Handgrip strength (HGS) appears as a promising value to predict the outcome after trauma in elderly patients and to assess the overall muscle strength. Besides the possible role of psychological and hormonal factors, vitamin D may have a positive influence. Furthermore, some data suggest that Vitamin D is beneficial regarding muscle strength and possibly prevents further falls and injuries in orthogeriatric patients...
May 13, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37179346/the-significance-of-transrectal-ultrasound-and-urologist_dually-guided-pelvic-floor-muscle-exercise-in-improving-urinary-continence-after-radical-prostatectomy
#13
JOURNAL ARTICLE
Yin Huaqi, Du Zheng, Ma Yongkang, Zhao Shiming, Sun Zhenghui, Wang Zhiwei, Li Congyu, Li Qian, Dong Bingqi, Zhu Mingkai, Zhu Chaoshuai, Peng Jiangshan, Yang Tiejun
BACKGROUND: To determine whether transrectal ultrasound and urologist_dually guided pelvic floor muscle exercise is associated with immediate, early and long-term urinary continence after radical prostatectomy. MATERIALS AND METHODS: Data from 114 patients with localized prostate cancer (PC) who underwent RP at Henan Cancer Hospital from November 2018 to April 2021 were included in the retrospective study. Of the 114 patients, 50 patients in the observation group underwent transrectal ultrasound and urologist_dually guided PFME, and 64 patients in the control group underwent verbally_guided PFME...
May 13, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37173785/inflammatory-bowel-disease-increases-the-levels-of-albuminuria-and-the-risk-of-urolithiasis-a-two-sample-mendelian-randomization-study
#14
JOURNAL ARTICLE
Hao Wu, Peng Liu, Siming Gong, Xiaoming Liu, Michael A Hill, Zhenguo Liu, Meihua Xu, Canxia Xu
BACKGROUND: Alterations in kidney function and increased risk of kidney diseases in patients with inflammatory bowel disease (IBD) have been reported, but the causal relationship remains unclear. Herein, Mendelian randomization was employed to identify the causal effect of inflammatory bowel disease on kidney function and the risk of chronic kidney disease (CKD), urolithiasis, and IgA nephropathy. METHODS: The International Inflammatory Bowel Disease Genetics Consortium provided the summary-level genome-wide association study (GWAS) data that correlates with Crohn's disease (CD) and ulcerative colitis (UC)...
May 12, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37173752/a-risk-score-to-predict-30-day-hospital-readmission-rate-in-cirrhotic-patients-with-spontaneous-bacterial-peritonitis
#15
JOURNAL ARTICLE
Nasser Mousa, Ahmed Abdel-Razik, Sherif Elbaz, Mohamed Salah, Mohammed Abdelaziz, Alaa Habib, Ahmed Deib, Abdel-Naser Gadallah, Niveen El-Wakeel, Waleed Eldars, Narmin Effat, Ola El-Emam, Khaled Taha, Alaa Elmetwalli, Eman Mousa, Dina Elhammady
BACKGROUND AND AIM: There is lack of 30-day hospital readmission prediction score in patients with liver cirrhosis and SBP. The aim of this study is to recognize factors capable of predicting 30-day readmission and to develop a readmission risk score in patients with SBP. METHODS: This study prospectively examined the 30-day hospital readmission for patients previously discharged with a diagnosis of SBP. Based on index hospitalization variables, a multivariable logistic regression model was implemented to recognize predictors of patient hospital readmission within 30 days...
May 12, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37161594/a-new-alternative-risk-score-for-sarcopenia-in-chinese-patients-with-type-2-diabetes-mellitus
#16
RANDOMIZED CONTROLLED TRIAL
Qinghua He, Xiuzhi Wang, Caizhe Yang, Xiaoming Zhuang, Yanfen Yue, Hongjiang Jing, Jing Hu, Mingxiao Sun, Lixin Guo
OBJECTIVE: To develop a new, alternative sarcopenia risk score to screen for sarcopenia in type 2 diabetes patients in China and to demonstrate its validity. RESEARCH DESIGN AND METHODS: The data for this study came from a multicenter, cross-sectional study that had been designed to estimate the prevalence of sarcopenia among adults with type 2 diabetes and had been conducted in several hospitals in Beijing, China. A total of 1125 participants were randomly divided into two groups: an exploratory population and a validation population...
May 10, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37161502/comparison-of-insulin-resistance-indices-in-predicting-albuminuria-among-patients-with-type-2-diabetes
#17
JOURNAL ARTICLE
Seyed Ali Nabipoorashrafi, Azam Adeli, Seyed Arsalan Seyedi, Soghra Rabizadeh, Razman Arabzadeh Bahri, Fatemeh Mohammadi, Amirhossein Yadegar, Manouchehr Nakhjavani, Alireza Esteghamati
PURPOSE: Diabetes is the leading cause of kidney disease. Up to 40% of the population with diabetes experience diabetic kidney disease (DKD). The correlation of DKD with insulin resistance (IR) indices has been shown in previous studies. In this study, the objective was to evaluate surrogate IR indices, including the Triglyceride-Glucose (TyG) index, Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to find the most valuable index for the correlation between albuminuria and IR in the type 2 diabetes (T2D) population...
May 10, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37161548/role-of-regulatory-t-cells-in-spinal-cord-injury
#18
REVIEW
Hao Chen, Hao Peng, Ping-Chuan Wang, Tao Zou, Xin-Min Feng, Bo-Wen Wan
Spinal cord injury is an intricate process involving a series of multi-temporal and multi-component pathological events, among which inflammatory response is the core. Thus, it is crucial to find a way to prevent the damaging effects of the inflammatory response. The research has found that Treg cells can suppress the activation, proliferation, and effector functions of many parenchymal cells by multiple mechanisms. This review discusses how Treg cells regulate the inflammatory cells to promote spinal cord recovery...
May 9, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37161465/evaluation-of-three-scoring-systems-for-predicting-renal-prognosis-in-antineutrophil-cytoplasmic-antibody-associated-glomerulonephritis
#19
JOURNAL ARTICLE
Ruiqiang Wang, Xiaofeng Zhang, Xinfang Wang, Lin Chen, Qiuling Ma, Yajing Su, Jingwen Liu, Huihui Shi
BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is characterized by rapidly progressive glomerulonephritis, and timely initiation of treatment and evaluation is critical to prevent the progression of renal disease to end-stage renal disease (ESRD). The aim of this study was to evaluate predictive value of the renal risk score (RRS), Birmingham vasculitis activity score (BVAS), and renal vascular lesions (RVLs) score for renal prognosis in AAGN...
May 9, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37143170/excellent-clinical-outcomes-of-renal-transplant-from-pediatric-deceased-donors-with-acute-kidney-injury
#20
JOURNAL ARTICLE
Qiuhao Liu, Hedong Zhang, Mingda Zhong, Liang Tan, Shanbiao Hu, Longkai Peng, Xubiao Xie, Gongbin Lan
BACKGROUND: The use of kidneys from deceased donors with acute kidney injury (AKI) to expand the donor pool is an ongoing trend. Prior research on the utilization of AKI donor kidneys, especially from pediatric AKI donors, was limited and has been subject to small sample sizes. In this study, we aimed to evaluate the safety and effectiveness of early post-transplantation outcomes in pediatric deceased donors with AKI. METHODS: This retrospective study compared the clinical results (including delayed graft function [DGF], acute rejection, patient and death-censored graft survival rates and renal function post-transplant) of kidney transplantation from deceased donors who were categorized as pediatric donors and adult donors with or without AKI, as defined by the Kidney Disease: Improving Global Outcomes (KIDGO) criteria, at our center between January 2018 and December 2020...
May 4, 2023: European Journal of Medical Research
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