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European Journal of Medical Research

https://read.qxmd.com/read/36717930/analysis-of-clinical-features-and-risk-factors-of-peripheral-neuropathy-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#1
JOURNAL ARTICLE
Zhihong Wu, Dong Wang, Lirong Chen, Kaipu Xianyu, Huiqing Yang
OBJECTIVE: To observe the clinical features and efficacy of immunosuppressive therapy in patients with primary Sjögren's syndrome (PSS) combined with peripheral neuropathy (PN) syndrome and to explore the risk factors for PN in patients with PSS. METHODS: Sixty consecutive patients with PSS admitted to the Department of Rheumatology and Immunology, Wuhan No. 1 Hospital, from January 2014 to June 2020 were analysed retrospectively. Patients were divided into a PN group (N = 15) and a non-PN group (N = 45)...
January 30, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707911/integrated-investigation-of-the-clinical-implications-and-targeted-landscape-for-rna-methylation-modifications-in-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
Jianping Zhang, Jie Gao, Mingchao Hu, Shiyu Xu, Chun Cheng, Wenjie Zheng, Jie Zhang
BACKGROUND: RNA methylation (RM) is a crucial post-translational modification (PTM) that directs epigenetic regulation. It mostly consists of N1 -methyladenosine (m1 A), 5-methylcytosine (m5 C), N3 -methylcytidine (m3 C), N6 -methyladenosine (m6 A), and 2'-O-methylation (Nm). The "writers" mainly act as intermediaries between these modifications and associated biological processes. However, little is known about the interactions and potential functions of these RM writers in hepatocellular carcinoma (HCC)...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707905/trmt6-promotes-hepatocellular-carcinoma-progression-through-the-pi3k-akt-signaling-pathway
#3
JOURNAL ARTICLE
Yanqing Ye, Maosheng Liu, Fengfei Wu, Shiyu Ou, Weidong Wang, Jieying Fei, Fang Xie, Lan Bai
BACKGROUND: Hepatocellular carcinoma is one of the most common and deadly cancers. The aim of this study was to elucidate the role of tRNA methyltransferase 6 (TRMT6) during HCC progression. METHODS: The role of TRMT6 in the progression and prognosis of HCC was confirmed by analysis of online databases and clinical human samples. The effects of up-regulation or down-regulation of TRMT6 on HCC cell proliferation and PI3K/AKT pathway-related protein expressions were verified...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707899/therapeutic-potential-of-mesenchymal-stem-stromal-cells-mscs-based-cell-therapy-for-inflammatory-bowel-diseases-ibd-therapy
#4
REVIEW
Mohamed J Saadh, Maria V Mikhailova, Soheil Rasoolzadegan, Mojgan Falaki, Roozbeh Akhavanfar, José Luis Arias Gonzáles, Amir Rigi, Bahman Abedi Kiasari
Recently, mesenchymal stem/stromal cells (MSCs) therapy has become an emerging therapeutic modality for the treatment of inflammatory bowel disease (IBD), given their immunoregulatory and pro-survival attributes. MSCs alleviate dysregulated inflammatory responses through the secretion of a myriad of anti-inflammatory mediators, such as interleukin 10 (IL-10), transforming growth factor-β (TGFβ), prostaglandin E2 (PGE2), tumor necrosis factor-stimulated gene-6 (TSG-6), etc. Indeed, MSC treatment of IBD is largely carried out through local microcirculation construction, colonization and repair, and immunomodulation, thus alleviating diseases severity...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707895/primary-headache-types-in-adult-epilepsy-patients
#5
JOURNAL ARTICLE
Katharina Schiller, Markus Rauchenzauner, Tamir Avidgor, Sana Hannan, Carlo Lorenzen, Manuela Kaml, Gerald Walser, Iris Unterberger, Vera Filippi, Gregor Broessner, Gerhard Luef
BACKGROUND: Headache is among the most common comorbidities in epilepsy. This study examined the distribution of different primary headache disorders in a large cohort of patients with diagnosed epilepsy. Headache types were analysed with regard to gender, type of epilepsy and antiepileptic drugs (AEDs). METHODS: In this prospective single-centre study, 500 patients with epilepsy (250 female, mean age: 45.52 ± 17.26 years) were evaluated with regards to primary headache types using a validated German headache questionnaire categorizing for migraine (MIG), tension-type headache (TTH) or trigeminal autonomic cephalalgias (TAC), their combinations and unclassifiable headache...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707888/effects-of-low-level-laser-therapy-on-orthodontic-miniscrew-stability-a-systematic-review
#6
REVIEW
De-Hua Zheng, Feng-Chun Hou, Yan-Jun Zang, Bing Li
BACKGROUND: Miniscrews as auxiliary anchorage devices in orthodontic treatment have definite advantages and efficacy. The aim of the present study was to investigate the scientific evidence including randomized controlled trials (RCTs) or controlled clinical trials (CCTs) to support the application of low-level laser therapy to improve miniscrews stability in orthodontic treatment. METHODS: An extensive literature research was conducted with the Cochrane Library, PubMed, EMBASE, Web of Science and ScienceDirect without language limitations...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707858/comparison-of-the-effect-of-oral-and-vaginal-misoprostol-on-labor-induction-updating-a-systematic-review-and-meta-analysis-of-interventional-studies
#7
JOURNAL ARTICLE
Maryam Rahimi, Ladan Haghighi, Hamid Reza Baradaran, Mobin Azami, Samaneh Saghafian Larijani, Paniz Kazemzadeh, Yousef Moradi
OBJECTIVES: This study is aimed to compare the effect of oral misoprostol with vaginal misoprostol to induce labor as a systematic review and meta-analysis. METHODS: Electronic databases including PubMed [Medline], Scopus, Web of science, Embase, Ovid, Cochrane library, and ClinicalTrials.gov were searched using the relevant keywords. All RCTs comparing the effect of oral vs vaginal misoprostol on labor induction were considered. The Cochrane Risk of Bias checklist was used for assessing quality of included RCTs...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707848/icariin-synergizes-therapeutic-effect-of-dexamethasone-on-adriamycin-induced-nephrotic-syndrome
#8
JOURNAL ARTICLE
Juan Lv, Guozhong Xue, Yunxia Zhang, Xinbin Wang, Enlai Dai
BACKGROUND: Glomerular damage is a common clinical indicator of nephrotic syndrome. High-dose hormone treatment often leads to hormone resistance in patients. How to avoid resistance and improve the efficiency of hormone therapy draws much attention to clinicians. METHODS: Adriamycin (ADR) was used to induce nephropathy model in SD rats. The rats were treated with dexamethasone (DEX), icariin (ICA), and DEX + ICA combination therapy. The changes in urinary protein (UP), urea nitrogen (BUN), and serum creatinine (SCR) contents in rats were detected by enzyme-linked immunosorbent assay (ELISA), and the degree of pathological injury and the expression level of podocin were detected by HE staining and immunohistochemistry, to test the success of the model and the therapeutic effects of three different ways...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36707844/current-advances-in-noninvasive-methods-for-the-diagnosis-of-oral-squamous-cell-carcinoma-a-review
#9
REVIEW
Shan Wang, Mao Yang, Ruiying Li, Jie Bai
Oral squamous cell carcinoma (OSCC), one of the most common types of cancers worldwide, is diagnosed mainly through tissue biopsy. However, owing to the tumor heterogeneity and other drawbacks, such as the invasiveness of the biopsy procedure and high cost and limited usefulness of longitudinal surveillance, there has been a focus on adopting more rapid, economical, and noninvasive screening methods. Examples of these include liquid biopsy, optical detection systems, oral brush cytology, microfluidic detection, and artificial intelligence auxiliary diagnosis, which have their own strengths and weaknesses...
January 27, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36694233/diagnosis-pathophysiology-and-preventive-strategies-for-cardiac-surgery-associated-acute-kidney-injury-a-narrative-review
#10
REVIEW
Ying Yu, Chenning Li, Shuainan Zhu, Lin Jin, Yan Hu, Xiaomin Ling, Changhong Miao, Kefang Guo
Acute kidney injury (AKI) is a common and serious complication of cardiac surgery and is associated with increased mortality and morbidity, accompanied by a substantial economic burden. The pathogenesis of cardiac surgery-associated acute kidney injury (CSA-AKI) is multifactorial and complex, with a variety of pathophysiological theories. In addition to the existing diagnostic criteria, the exploration and validation of biomarkers is the focus of research in the field of CSA-AKI diagnosis. Prevention remains the key to the management of CSA-AKI, and common strategies include maintenance of renal perfusion, individualized blood pressure targets, balanced fluid management, goal-directed oxygen delivery, and avoidance of nephrotoxins...
January 24, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36694211/obesity-difference-on-association-blood-malondialdehyde-level-and-diastolic-hypertension-in-the-elderly-population-a-cross-sectional-analysis
#11
JOURNAL ARTICLE
Ying Huang, Hong Chen, Qifan Liu, Jinzhu Hu, Dongxi Hu, Zixi Huang, Zhenyan Xu, Rong Wan
AIMS: Although increased production of malondialdehyde (MDA), an end product of lipid oxidation caused by reactive oxygen species (ROS), has been found be elevated in hypertensive population, whether MDA contributed to a changed risk of hypertension is uncertain. We aimed to investigate whether elevated blood levels of MDA contribute to increased risk of hypertension and obesity has a modified effect on the association in an older Chinese population. METHODS: Data were obtained from 2011 to 2012 of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a national cohort of older adults in China...
January 24, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36681855/a-novel-machine-learning-model-based-on-ubiquitin-related-gene-pairs-and-clinical-features-to-predict-prognosis-and-treatment-effect-in-colon-adenocarcinoma
#12
JOURNAL ARTICLE
Liping Liang, Le Liu, Shijie Mai, Ye Chen
BACKGROUND: Ubiquitin and ubiquitin-like (UB/UBL) conjugations are essential post-translational modifications that contribute to cancer onset and advancement. In colon adenocarcinoma (COAD), nonetheless, the biological role, as well as the clinical value of ubiquitin-related genes (URGs), is unclear. The current study sought to design and verify a ubiquitin-related gene pairs (URGPs)-related prognostic signature for predicting COAD prognoses. METHODS: Using univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression, URGP's predictive signature was discovered...
January 21, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36681850/sirna-e6-sensitizes-hpv-16-related-cervical-cancer-through-oxaliplatin-an-in-vitro-study-on-anti-cancer-combination-therapy
#13
JOURNAL ARTICLE
Parisa Shiri Aghbash, Nima Hemmat, Behzad Baradaran, Hossein Bannazadeh Baghi
BACKGROUND: Persistent infection with high-risk Human papillomaviruses (HPV), such as hr-HPV-16 and hr-HPV-18, lead to cervical cancer, the fourth most common cancer in the world. In the present study, we investigated the alteration of E6 oncogene expression by E6-specific short interfering RNA (siRNA) combined with Oxaliplatin. METHODS: The cervical cancer cell line, CaSki, was transfected with E6-siRNA, then treated with Oxaliplatin. The cellular genes, such as p53, MMP9, Nanog, and caspases expression, were assessed by quantitative real-time PCR...
January 21, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36681833/are-bacterial-coinfections-really-rare-in-covid-19-intensive-care-units
#14
JOURNAL ARTICLE
Banu Karaca, Murat Aksun, Nagihan Altıncı Karahan, Senem Girgin, Bahar Ormen, Ahmet Salih Tuzen, Tuna Demirdal, Atilla Sencan
OBJECTIVES: There are limited data about nosocomial coinfections of COVID-19 cases monitored in the intensive care unit. This study aims to investigate coinfections in COVID-19 patients followed in an intensive care unit of a university hospital. METHODS: This study analyzed retrospectively the data of coinfections of 351 COVID-19 patients in the period 28.02.2020-15.01.2021 in a tertiary care intensive care unit in a university hospital. RESULTS: Bacterial coinfections were present in 216 of the 351 cases...
January 21, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36670509/impact-of-peritumoral-brain-edema-on-pre-and-postoperative-clinical-conditions-and-on-long-term-outcomes-in-patients-with-intracranial-meningiomas
#15
JOURNAL ARTICLE
Hajrullah Ahmeti, Amke Caliebe, Christoph Röcken, Olav Jansen, Maximilian H Mehdorn, Michael Synowitz
BACKGROUND: Peritumoral brain edema (PTBE) is a common complication related to intracranial meningiomas. In several studies, researchers have investigated the pathogenesis of PTBE, and the factors involved in its development in patients with intracranial meningiomas have been reported. However, very little is known about the clinical effect of PTBE on patients with intracranial meningiomas; therefore, a systematic examination of this matter is necessary. METHODS: In this study, we performed a systematic examination of 696 patients with primary intracranial meningiomas to assess the effect of preoperative PTBE on preoperative symptoms, neurological deficits and postoperative complications, and long-term outcomes with a follow-up period of 16...
January 21, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36670466/the-global-prevalence-of-primary-central-nervous-system-tumors-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Nader Salari, Hooman Ghasemi, Reza Fatahian, Kamran Mansouri, Sadat Dokaneheifard, Mohammad Hossain Shiri, Mahvan Hemmati, Masoud Mohammadi
BACKGROUND: Primary central nervous system (CNS) tumors are a heterogeneous group of neoplasms, including benign and malignant tumors. Since there are many heterogeneities in the prevalence reported in previous studies on this type of tumor, this study was performed to determine the overall prevalence of different primary CNS tumors. METHOD: The study was conducted as a systematic review and meta-analysis by searching international databases, including PubMed, Scopus, Science Direct, Web of science, and the Google Scholar search engine until August 2020...
January 20, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36670454/respiratory-viruses-and-postoperative-hemodynamics-in-patients-with-unrestrictive-congenital-cardiac-communications-a-prospective-cohort-study
#17
JOURNAL ARTICLE
Kelly C O Abud, Clarisse M Machado, Lucy S Vilas Boas, Nair Y Maeda, Eloisa S Carvalho, Maria Francilene S Souza, Paula V Gaiolla, Claudia R P Castro, Juliana Pereira, Marlene Rabinovitch, Antonio Augusto Lopes
BACKGROUND: Pulmonary vascular abnormalities pose a risk for severe life-threatening hemodynamic disturbances following surgical repair of congenital cardiac communications (CCCs ). In the distal lung, small airways and vessels share a common microenvironment, where biological crosstalks take place. Because respiratory cells infected by viruses express a number of molecules with potential impact on airway and vascular remodeling, we decided to test the hypothesis that CCC patients carrying viral genomes in the airways might be at a higher risk for pulmonary (and systemic) hemodynamic disturbances postoperatively...
January 20, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36658625/significant-increase-of-serum-extracellular-vesicle-packaged-growth-differentiation-factor-15-in-type-2-diabetes-mellitus-a-cross-sectional-study
#18
JOURNAL ARTICLE
Wen Zhao, Xinwei Li, Xinxin Li, Lu Peng, Yu Li, Yunhui Du, Jianxun He, Yanwen Qin, Huina Zhang
BACKGROUND: Growth differentiation factor 15 (GDF15) is a stress-inducible factor involved in the inflammatory progression of many complications, including type 2 diabetes mellitus (T2DM). Growing evidence suggests that molecules in extracellular vesicles (EVs) are associated with diabetes or diabetes-related complications. However, the correlation between serum extracellular vesicle-derived growth differentiation factor15 (EV-GDF15) and T2DM is unknown. The aim of this cross-sectional study is to investigate whether serum EV-GDF15 is associated with T2DM incidence...
January 19, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36658623/the-predictive-value-of-deep-learning-based-cardiac-ultrasound-flow-imaging-for-hypertrophic-cardiomyopathy-complicating-arrhythmias
#19
JOURNAL ARTICLE
Haotang Wu, Zhiyong Huang, Juanjuan Liu, Jiancheng Dai, Yong Zhao, Weiquan Luo
OBJECTIVE: To investigate the predictive value of deep learning-based cardiac ultrasound flow imaging for hypertrophic cardiomyopathy (HCM) complicated by arrhythmias. METHODS: The clinical data of 158 patients with hypertrophic cardiomyopathy were retrospectively collected from July 2019 to December 2021, and additionally divided into training group 106 cases, validation group 26 cases and test group 26 cases according to the ratio of 4:1:1, and divided into concurrent and non-concurrent groups according to whether they were complicated by arrhythmia or not, respectively...
January 19, 2023: European Journal of Medical Research
https://read.qxmd.com/read/36653881/association-between-central-venous-pressure-measurement-and-outcomes-in-critically-ill-patients-with-severe-coma
#20
JOURNAL ARTICLE
Xin Tong, Xin Feng, Chuanzhi Duan, Aihua Liu
BACKGROUND: The use of central venous pressure (CVP) measurements among (intensive care unit) ICU patients with severe coma has been questioned. This study aimed to investigate the application value of CVP in this population. METHODS: Data stored in the ICU Collaborative Research Database (eICU-CRD) and Medical Information Mart for Intensive Care III (MIMIC-III) database were reviewed. Critically ill patients with a Glasgow Coma Scale (GCS) score of 3-8 were included...
January 18, 2023: European Journal of Medical Research
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