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European Journal of Medical Research

https://read.qxmd.com/read/38773551/antitumour-effects-of-artesunate-via-cell-cycle-checkpoint-controls-in-human-oesophageal-squamous-carcinoma-cells
#1
JOURNAL ARTICLE
Linlin Mao, Guodong Deng, Mengfan Li, Shih-Hsin Lu, Wei Jiang, Xiying Yu
Artesunate (ART), an effective antimalarial semisynthetic derivative of artemisinin, exhibits antitumour properties, but the mechanism(s) involved remain elusive. In this study, we investigated the antitumour effects of ART on human oesophageal squamous cell carcinoma (ESCC) cell lines. Treatment of ESCC cell lines with ART resulted in the production of excessive reactive oxygen species (ROS) that induced DNA damage, reduced cell proliferation and inhibited clonogenicity via G1-S cell cycle arrest and/or apoptosis in vitro...
May 22, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38773560/molecular-subtypes-of-clear-cell-renal-carcinoma-based-on-pcd-related-long-non-coding-rnas-expression-insights-into-the-underlying-mechanisms-and-therapeutic-strategies
#2
JOURNAL ARTICLE
Han Wang, Yang Liu, Aifa Tang, Xiansheng Zhang
BACKGROUND: PCD-related long non-coding RNAs (PRLs) are rarely investigated in relation to clear cell renal carcinoma (ccRCC). As part of this study, we evaluated the immunological potential of PRL signatures as a biomarker for ccRCC prognosis and immunological function. MATERIALS AND METHODS: Data were downloaded from the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) databases. A Pearson correlation analysis was conducted on the 27 PCD-associated genes to determine whether lncRNAs were significantly associated with PCD...
May 21, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38764061/the-incidence-and-factors-associated-with-anemia-in-elective-surgical-patients-admitted-to-a-surgical-intensive-care-unit-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
Habtie Bantider Wubet, Lidya Haddis Mengistu, Negesse Zurbachew Gobezie, Begizew Yimenu Mekuriaw, Alemie Fentie Mebratie, Wosenyeleh Admasu Sahile
BACKGROUND: Anemia is a frequently reported and commonly documented issue in intensive care units. In surgical intensive care units, more than 90% of patients are found to be anemic. It is a hematologic factor that contributes to extended mechanical ventilation, sepsis, organ failure, longer hospitalizations in critical care units, and higher mortality. Thus, this study aimed to determine the incidence and identify factors associated with anemia in elective surgical patients admitted to the surgical intensive care unit...
May 19, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38764054/radix-actinidiae-chinensis-induces-the-autophagy-and-apoptosis-in-renal-cell-carcinoma-cells
#4
JOURNAL ARTICLE
Biao Liu, Yuanliang Yan, Liang Zhang
BACKGROUND: Renal cell carcinoma (RCC) is a malignant tumor. Radix Actinidiae chinensis (RAC) is the root of Actinidia arguta (Sieb. et Zucc) Planch. ex Miq. In clinical research, RAC was confirmed to have a certain anti-tumor effect, including liver cancer and cholangiocarcinoma. This study investigated the anticancer effect and mechanism of RAC in RCC cells. METHODS: The 786-O and A498 cells were intervened with varying concentrations of RAC (0-100 mg/mL) to detect the half maximal inhibitory concentration (IC50 ) of RAC...
May 19, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38760844/imaging-and-blood-flow-characteristics-of-cerebrovascular-fenestration-malformation-and-its-relationship-with-the-occurrence-of-ischemic-cerebrovascular-disease
#5
JOURNAL ARTICLE
Weifang Xing, Wensheng Zhang, Minzhen Zhu, Yangchun Wen, Yunqiang Huang, JinZhao He
OBJECTIVE: To explore the imaging and transcranial Doppler cerebral blood flow characteristics of cerebrovascular fenestration malformation and its relationship with the occurrence of ischemic cerebrovascular disease. METHODS: A retrospective analysis was conducted on the imaging data of 194 patients with cerebrovascular fenestration malformation who visited the Heyuan People's Hospital from July 2021 to July 2023. The location and morphology of the fenestration malformation blood vessels as well as the presence of other cerebrovascular diseases were analyzed...
May 17, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38750607/factors-and-management-techniques-in-odontogenic-keratocysts-a-systematic-review
#6
REVIEW
Mario Dioguardi, Cristian Quarta, Diego Sovereto, Giorgia Apollonia Caloro, Andrea Ballini, Riccardo Aiuto, Angelo Martella, Lorenzo Lo Muzio, Michele Di Cosola
OBJECTIVES: Odontogenic keratocysts exhibit frequent recurrence, distinctive histopathological traits, a tendency towards aggressive clinical behavior, and a potential linkage to the nevoid basal cell carcinoma syndrome. The aim of this systematic review is to compile insights concerning the control of this condition and assess the effectiveness of various treatment approaches in reducing the likelihood of recurrence. MATERIALS AND METHODS: The following systematic review adhered to the PRISMA guidelines...
May 15, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38750605/the-value-of-dynamic-changes-in-ft3-level-for-predicting-90-day-prognosis-of-hbv-aclf-patients
#7
JOURNAL ARTICLE
Jian Zhang, Luxue Zhang, Xiaokang Fu, Yu Chen, Zhongping Duan, Geng Tian
OBJECTIVE: To explore the effect of dynamic changes in free triiodothyronine (FT3) level for predicting the 90 day prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). METHODS: The clinical data of 122 hospitalised patients with HBV-ACLF between September 2018 and January 2020 were collected and divided into a survival group (77 cases) and a death group (45 cases) according to the 90 day prognosis. We statistically analysed the characteristics of FT3 changes in the two groups of patients...
May 15, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38745338/correlating-reiff-scores-with-clinical-functional-and-prognostic-factors-characterizing-noncystic-fibrosis-bronchiectasis-severity-validation-from-a-nationwide-multicenter-study-in-taiwan
#8
MULTICENTER STUDY
Wen-Chien Cheng, Chia-Ling Chang, Chau-Chyun Sheu, Ping-Huai Wang, Meng-Heng Hsieh, Ming-Tsung Chen, Wei-Fan Ou, Yu-Feng Wei, Tsung-Ming Yang, Chou-Chin Lan, Cheng-Yi Wang, Chih-Bin Lin, Ming-Shian Lin, Yao-Tung Wang, Ching-Hsiung Lin, Shih-Feng Liu, Meng-Hsuan Cheng, Yen-Fu Chen, Chung-Kan Peng, Ming-Cheng Chan, Ching-Yi Chen, Lun-Yu Jao, Ya-Hui Wang, Chi-Jui Chen, Shih-Pin Chen, Yi-Hsuan Tsai, Shih-Lung Cheng, Horng-Chyuan Lin, Jung-Yien Chien, Hao-Chien Wang, Wu-Huei Hsu
BACKGROUND: Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB). METHODS: This extensive multicenter retrospective study, performed in Taiwan, concentrated on patients diagnosed with NCFB verified through high-resolution computed tomography (HRCT) scans. We not only compared the clinical features of various types of bronchiectasis (cylindrical, varicose, and cystic)...
May 14, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38745325/hydrogen-gas-inhalation-ameliorates-lps-induced-bpd-by-inhibiting-inflammation-via-regulating-the-tlr4-nf%C3%AE%C2%BAb-il6-nlrp3-signaling-pathway-in-the-placenta
#9
JOURNAL ARTICLE
Yafang Zhang, Xianhui Ren, Linli Zhang, Xinliu Sun, Wenjing Li, Yunxi Chen, Yan Tian, Zhongxia Chu, Youzhen Wei, Guo Yao, Yan Wang
INTRODUCTION: Hydrogen (H2 ) is regarded as a novel therapeutic agent against several diseases owing to its inherent biosafety. Bronchopulmonary dysplasia (BPD) has been widely considered among adverse pregnancy outcomes, without effective treatment. Placenta plays a role in defense, synthesis, and immunity, which provides a new perspective for the treatment of BPD. This study aimed to investigate if H2 reduced the placental inflammation to protect the neonatal rat against BPD damage and potential mechanisms...
May 14, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38745261/endotyping-in-ards-one-step-forward-in-precision-medicine
#10
JOURNAL ARTICLE
Andréanne Côté, Chel Hee Lee, Sayed M Metwaly, Christopher J Doig, Graciela Andonegui, Bryan G Yipp, Ken Kuljit S Parhar, Brent W Winston
BACKGROUND: The Berlin definition of acute respiratory distress syndrome (ARDS) includes only clinical characteristics. Understanding unique patient pathobiology may allow personalized treatment. We aimed to define and describe ARDS phenotypes/endotypes combining clinical and pathophysiologic parameters from a Canadian ARDS cohort. METHODS: A cohort of adult ARDS patients from multiple sites in Calgary, Canada, had plasma cytokine levels and clinical parameters measured in the first 24 h of ICU admission...
May 14, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38735989/the-impact-of-inhalation-injury-on-fluid-resuscitation-in-major-burn-patients-a-10-year-multicenter-retrospective-study
#11
MULTICENTER STUDY
Shuao Xiao, Zeping Pan, Hang Li, Yuheng Zhang, Tian Li, Hao Zhang, Jinbin Ning
BACKGROUND: It remains unclear whether additional fluid supplementation is necessary during the acute resuscitation period for patients with combined inhalational injury (INHI) under the guidance of the Third Military Medical University (TMMU) protocol. METHODS: A 10-year multicenter, retrospective cohort study, involved patients with burns ≥ 50% total burn surface area (TBSA) was conducted. The effect of INHI, INHI severity, and tracheotomy on the fluid management in burn patients was assessed...
May 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38735983/base-excess-be-reloaded
#12
REVIEW
Rolf Zander
The base excess value (BE, mmol/L), not standard base excess (SBE), correctly calculated including pH, pCO2 (mmHg), sO2 (%) and cHb (g/dl) is a diagnostic tool for several in vivo events, e.g., mortality after multiple trauma or shock, acidosis, bleeding, clotting, artificial ventilation. In everyday clinical practice a few microlitres of blood (arterial, mixed venous or venous) are sufficient for optimal diagnostics of any metabolic acidosis or alkalosis.The same applies to a therapeutic tool-then referred to as potential base excess (BEpot)-for several in vitro assessments, e...
May 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38735974/a-dosiomics-model-for-prediction-of-radiation-induced-acute-skin-toxicity-in-breast-cancer-patients-machine-learning-based-study-for-a-closed-bore-linac
#13
JOURNAL ARTICLE
Pegah Saadatmand, Seied Rabi Mahdavi, Alireza Nikoofar, Seyede Zohreh Jazaeri, Fahime Lamei Ramandi, Golbarg Esmaili, Soheil Vejdani
BACKGROUND: Radiation induced acute skin toxicity (AST) is considered as a common side effect of breast radiation therapy. The goal of this study was to design dosiomics-based machine learning (ML) models for prediction of AST, to enable creating optimized treatment plans for high-risk individuals. METHODS: Dosiomics features extracted using Pyradiomics tool (v3.0.1), along with treatment plan-derived dose volume histograms (DVHs), and patient-specific treatment-related (PTR) data of breast cancer patients were used for modeling...
May 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38735968/comparison-of-angiographic-change-in-side-branch-ostium-after-drug-coated-balloon-vs-drug-eluting-stent-vs-medication-for-the-treatment-of-de-novo-coronary-bifurcation-lesions
#14
COMPARATIVE STUDY
Ae-Young Her, Bitna Kim, Sunwon Kim, Yong Hoon Kim, Bruno Scheller, Eun-Seok Shin
OBJECTIVES: Data on side-branch (SB) ostial effect after drug-coated balloon (DCB) treatment in the context of de novo coronary bifurcation lesions are limited. We aimed to investigate the angiographic outcomes of SB ostium after DCB treatment compared with drug-eluting stents (DESs) implantation in the main vessel (MV) or optimal medical therapy (OMT) for the treatment of de novo coronary bifurcation lesions. METHODS: Serial angiographic changes in the SB ostium were compared between DCB, DES, and medication alone for MV treatment...
May 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38725073/twenty-four-month-follow-up-after-bullectomy-unilateral-and-bilateral-lung-volume-reduction-surgery-a-single-center-retrospective-analysis-of-consecutive-cases
#15
JOURNAL ARTICLE
Slavisa Bascarevic, Maja Ercegovac, Mir Alireza Hoda, Milan Savic, Radomir Vesovic, Vladimir Milenkovic, Marina Moromila, Marko Popovic, Daniela Gompelmann, Petar Madzarevic
PURPOSE: While pharmacologic therapy remains the cornerstone of lung emphysema treatment, surgery is an additional therapeutic option in selected patient groups with advanced emphysema. The aim of lung volume reduction surgery (LVRS) is to improve lung function, exercise capacity, quality of life and survival. We sought to determine the therapeutic value of surgical resection in specific patients with lung emphysema. PATIENTS AND METHODS: A retrospective study was performed consisting of 58 patients with lung emphysema who underwent surgical intervention over a 10-year period and were followed for 2 years postoperatively...
May 10, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38730507/low-ankle-brachial-index-is-associated-with-higher-cardiovascular-mortality-in-individuals-with-nonalcoholic-fatty-liver-disease
#16
JOURNAL ARTICLE
Guang Xiong, Liuqing Guo, Liwei Li, Min Liang
BACKGROUND AND AIMS: Ankle brachial index (ABI) is a risk factor for cardiovascular mortality, but it is unclear whether ABI is associated with cardiovascular mortality in patients with nonalcoholic fatty liver disease (NAFLD). The current study aimed to evaluate the association between ABI with cardiovascular and all-cause mortality in patients with NAFLD. METHODS: We performed a cohort study using the data of the1999-2004 National Health and Nutrition Examination Survey data of adults...
May 9, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38725045/the-potential-association-between-metabolic-disorders-and-pulmonary-tuberculosis-a-mendelian-randomization-study
#17
JOURNAL ARTICLE
Zhi-Xiang Du, Yun-Yao Ren, Jia-Luo Wang, Shun-Xin Li, Yi-Fan Hu, Li Wang, Miao-Yang Chen, Yang Li, Chun-Mei Hu, Yong-Feng Yang
BACKGROUND: Metabolic disorders (MetDs) have been demonstrated to be closely linked to numerous diseases. However, the precise association between MetDs and pulmonary tuberculosis (PTB) remains poorly understood. METHOD: Summary statistics for exposure and outcomes from genome-wide association studies (GWASs) for exposures and outcomes were obtained from the BioBank Japan Project (BBJ) Gene-exposure dataset. The 14 clinical factors were categorized into three groups: metabolic laboratory markers, blood pressure, and the MetS diagnostic factors...
May 9, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38725036/development-and-validation-of-a-predictive-model-for-the-risk-of-sarcopenia-in-the-older-adults-in-china
#18
JOURNAL ARTICLE
Qiugui Li, Hongtao Cheng, Wenjiao Cen, Tao Yang, Shengru Tao
BACKGROUND: Sarcopenia is a progressive age-related disease that can cause a range of adverse health outcomes in older adults, and older adults with severe sarcopenia are also at increased short-term mortality risk. The aim of this study was to construct and validate a risk prediction model for sarcopenia in Chinese older adults. METHODS: This study used data from the 2015 China Health and Retirement Longitudinal Study (CHARLS), a high-quality micro-level data representative of households and individuals aged 45 years and older adults in China...
May 9, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38720374/repair-of-a-long-and-narrow-skin-defect-of-the-upper-extremity-with-a-modified-design-of-a-compound-scip-flap-a-series-of-12-cases
#19
JOURNAL ARTICLE
Haiwen Wang, Zetian Shi, Deqing Zeng, Haibo Wang, Pengcheng Lv, Pei Li
BACKGROUND: Large skin lesions of the upper extremity tend to be ''long and narrow'' in shape, and the currently used repair and reconstruction protocols still have some drawbacks, including difficulty in closure of the donor area, poor cosmetic appearance of the donor and recipient areas, and low flap survival rates. The ilioinguinal flap has been more widely used for repair and reconstruction of various complex conditions. In order to improve the versatility of the flap design and to achieve better aesthetic results, we report a study on the improved design of Compound SCIP flap for repairing "long and narrow" large skin defects of the upper extremity by using a modified design of the ilioinguinal flap for the procurement of perforating blood vessels and flap excision...
May 9, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38720365/human-pan-cancer-analysis-of-the-predictive-biomarker-for-the-cdkn3
#20
JOURNAL ARTICLE
Yingjun Chen, Dai Li, Kaihui Sha, Xuezhong Zhang, Tonggang Liu
BACKGROUND: Cell cycle protein-dependent kinase inhibitor protein 3 (CDKN3), as a member of the protein kinase family, has been demonstrated to exhibit oncogenic properties in several tumors. However, there are no pan-carcinogenic analyses for CDKN3. METHODS: Using bioinformatics tools such as The Cancer Genome Atlas (TCGA) and the UCSC Xena database, a comprehensive pan-cancer analysis of CDKN3 was conducted. The inverstigation encompassed the examination of CDKN3 function actoss 33 different kinds of tumors, as well as the exploration of gene expressions, survival prognosis status, clinical significance, DNA methylation, immune infiltration, and associated signal pathways...
May 8, 2024: European Journal of Medical Research
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