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Journals European Journal of Medical Re...

European Journal of Medical Research

https://read.qxmd.com/read/38049883/association-between-body-mass-index-and-myopia-in-the-united-states-population-in-the-national-health-and-nutrition-examination-surveys-1999-to-2008-a-cross-sectional-study
#1
JOURNAL ARTICLE
Yaohui Qu, Huamin Huang, Hongxing Zhang
BACKGROUND: This study investigated the association between body mass index (BMI) and myopia in the United States. METHODS: This cross-sectional study included 8,000 participants from the 1999 to 2008 National Health and Nutrition Examination Survey (NHANES). BMI was classified into four groups: < 18.5, 18.5 - 24.9, 25-29.9, and > 29.9. Three diagnostic thresholds were used for myopia A\B\C: spherical equivalent ≤ -0...
December 5, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38049903/performance-of-severity-indices-for-admission-and-mortality-of-trauma-patients-in-the-intensive-care-unit-a-retrospective-cohort-study
#2
JOURNAL ARTICLE
Tatiane Gonçalves Gomes de Novais do Rio, Lilia de Souza Nogueira, Fernanda Rodrigues Lima, Carolina Cassiano, Diogo de Freitas Valeiro Garcia
BACKGROUND: Little is known about the performance of severity indices for indicating intensive care and predicting mortality in the Intensive Care Unit (ICU) of trauma patients. This study aimed to compare the performance of severity indices to predict trauma patients' ICU admission and mortality. METHODS: A retrospective cohort study which analyzed the electronic medical records of trauma patients aged ≥ 18 years, treated at a hospital in Brazil, between 2014 and 2017...
December 4, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38049897/adhatoda-vasica-and-tinospora-cordifolia-extracts-ameliorate-clinical-and-molecular-markers-in-mild-covid-19-patients-a-randomized-open-label-three-armed-study
#3
JOURNAL ARTICLE
Mukta Verma, Neha Rawat, Ritu Rani, Manju Singh, Aditi Choudhary, Sarfaraz Abbasi, Manish Kumar, Sachin Kumar, Ankur Tanwar, Bishnu Raman Misir, Sangeeta Khanna, Anurag Agrawal, Mohammed Faruq, Shalini Rai, Richa Tripathi, Anil Kumar, Mukta Pujani, Meera Bhojani, Anil Kumar Pandey, Tanuja Nesari, Bhavana Prasher
BACKGROUND: SARS-CoV-2 infections caused mild-to-moderate illness. However, a sizable portion of infected people experience a rapid progression of hyper-inflammatory and hypoxic respiratory illness that necessitates an effective and safer remedy to combat COVID-19. METHODS: A total of 150 COVID-19-positive patients with no to mild symptoms, between the age groups 19-65 years were enrolled in this randomized, open-labeled three-armed clinical trial. Among them, 136 patients completed the study with RT-PCR negative reports...
December 4, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38049896/a-j-shaped-relationship-between-body-mass-index-and-the-risk-of-elevated-liver-stiffness-a-cross-sectional-study
#4
JOURNAL ARTICLE
Yuwei Liu, Sheng Yuan, Jing Zuo, Sha Liu, Xiaoyan Tang, Xia Li, Dongai Yao, Yalei Jin
BACKGROUND: Liver stiffness (LS) is regarded as an indicator of the stages of liver fibrosis and liver cirrhosis. Numerous studies have investigated the relationship between body mass index (BMI) and LS; however, the conclusions remain controversial. In the current study, we utilized transient elastography (TE) technique, which could measure LS in a non-painful and noninvasive way, to explore the relationship between BMI and the risk of elevated LS in common community residents. METHODS: 5791 participants were included in the present study...
December 4, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38049886/severity-of-oxidative-stress-as-a-hallmark-in-covid-19-patients
#5
JOURNAL ARTICLE
Alireza Bastin, Fatemeh Abbasi, Narges Roustaei, Jahangir Abdesheikhi, Hossein Karami, Mohammad Gholamnezhad, Mahdieh Eftekhari, Amirhossein Doustimotlagh
INTRODUCTION: Understanding the mechanisms and identifying effective treatments for the COVID-19 outbreak are imperative. Therefore, this study aimed to assess the antioxidant status and oxidative stress parameters as potential pivotal mechanisms in asymptomatic, non-severe, and severe COVID-19 patients. METHODS: This study is a case-control study that was performed on patients referred to the Persian Gulf Martyrs Hospital of Bushehr University of Medical Sciences, Bushehr, Iran, from May 2021 to September 2021...
December 4, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38049839/functional-independence-frailty-and-perceived-quality-of-life-in-patients-who-developed-delirium-during-icu-stay-a-prospective-cohort-study
#6
JOURNAL ARTICLE
Beatriz Lobo-Valbuena, Rosario Molina, Raúl Castañeda-Vozmediano, Leire Lopez de la Oliva Calvo, Ana Abella, María-Mercedes Garcia-Arias, Irene Salinas Gabiña, Federico Gordo
BACKGROUND: Survivors of critical illness are frequently left with a long-lasting disability. We hypothesised that patients who developed delirium during ICU stay, compared with patients who did not, would have worse health-related quality of life following a critical illness. METHODS: Prospective longitudinal observational and analytical study assessing functional independence, frailty and perceived quality of life measured with the Barthel Index, the Clinical Frailty Scale, and the SF-36, comparing patients who developed delirium during ICU stay and patients who did not...
December 4, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38042909/role-of-advanced-glycation-end-products-in-diabetic-vascular-injury-molecular-mechanisms-and-therapeutic-perspectives
#7
REVIEW
Jing Liu, Shuo Pan, Xiqiang Wang, Zhongwei Liu, Yong Zhang
BACKGROUND: In diabetic metabolic disorders, advanced glycation end products (AGEs) contribute significantly to the development of cardiovascular diseases (CVD). AIMS: This comprehensive review aims to elucidate the molecular mechanisms underlying AGE-mediated vascular injury. CONCLUSIONS: We discuss the formation and accumulation of AGEs, their interactions with cellular receptors, and the subsequent activation of signaling pathways leading to oxidative stress, inflammation, endothelial dysfunction, smooth muscle cell proliferation, extracellular matrix remodeling, and impaired angiogenesis...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38042838/top-100-cited-articles-in-the-thromboangiitis-obliterans-a-bibliometric-analysis-and-visualized-study
#8
JOURNAL ARTICLE
Zhenxing Liu, Weiwei Ning, Jinlong Liang, Tao Zhang, Qingxu Yang, Jie Zhang, Ming Xie
OBJECTIVE: Thromboangiitis obliterans (TAO) is one of the most common types of peripheral arterial disease (PAD). This study aimed to explore the characteristics of the top 100 most cited articles in the TAO. METHODS: A bibliometric analysis based on the Web of Science (WOS) database was performed. Literature was retrieved and ranked by the citations. Listed below are the top 100 citations, including original articles, reviews, full-length proceeding papers, and case reports that were included for analysis...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38042817/non-alcoholic-fatty-liver-disease-associated-with-greater-herpes-zoster-risk-than-alcoholic-fatty-liver-disease
#9
JOURNAL ARTICLE
Cheng-Wei Yu, Chia-Hung Chen, Yung-Chi Cheng, Wen-Che Hsieh, Tzu-Ju Hsu, Fuu-Jen Tsai, Chao-Yu Hsu
BACKGROUND: Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FLD is associated with an elevated risk of HZ. METHODS: For this study, we utilized data from the National Health Insurance Research Database, patients with FLD from 2000 to 2017 were observed (follow-up until 2018). Patients were considered to have FLD if they had at least two outpatient visits or at least one admission record with a diagnostic code of FLD...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38042816/validation-of-non-invasive-indicators-in-the-screening-of-metabolic-dysfunction-associated-fatty-liver-disease-a-cross-sectional-study-among-uighurs-in-rural-xinjiang
#10
JOURNAL ARTICLE
Yanbo Guo, Yunhua Hu, Jing Yang, Rulin Ma, Xianghui Zhang, Heng Guo, Xinping Wang, Yu Li, Xinyu Peng, Shijie Zhang, Jia He, Shuxia Guo
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease in China. Our study aimed to evaluate the screening value of the fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation product (LAP), visceral adiposity index (VAI), and Zhejiang University index (ZJU), as well as other single indicators for MAFLD. We aimed to find the optimal screening tool and its appropriate cut-off values for rural Uyghur adults. METHODS: We completed a survey of 14,321 Uyghur adults in 51 groups in Kashgar, Xinjiang, in 2016 using a typical sampling method, with 12,794 patients ultimately included in statistical analyses...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38042812/clinico-biological-radiomics-cbr-based-machine-learning-for-improving-the-diagnostic-accuracy-of-fdg-pet-false-positive-lymph-nodes-in-lung-cancer
#11
JOURNAL ARTICLE
Caiyue Ren, Fuquan Zhang, Jiangang Zhang, Shaoli Song, Yun Sun, Jingyi Cheng
BACKGROUND: The main problem of positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging is the high false positive rate (FPR). Thus, we aimed to explore a clinico-biological-radiomics (CBR) model via machine learning (ML) to reduce FPR and improve the accuracy for predicting the hypermetabolic mediastinal-hilar LNs status in lung cancer than conventional PET/CT. METHODS: A total of 260 lung cancer patients with hypermetabolic mediastinal-hilar LNs (SUVmax ≥ 2...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38042806/rna-n6-methyladenosine-modified-binding-protein-ythdf1-promotes-prostate-cancer-progression-by-regulating-androgen-function-related-gene-trim68
#12
JOURNAL ARTICLE
Qihong Nie, Xiaoyuan Wu, Yongming Huang, Tao Guo, Jin Kuang, Chuance Du
PURPOSE: There is no report about the direct relationship between m6A modification and androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the mechanisms of m6A methylation in regulating the pathogenesis of PC from the perspective of AR-related genes. METHODS: qRT-PCR was applied to detect the expression of m6A-related genes in PC cell with or without AR inhibitor. The effects of YTHDF1 knockdown on PC cell viability, apoptosis, migration and invasion were investigated using flow cytometry, wound healing and transwell assays, respectively...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38031121/global-cluster-analysis-and-network-visualization-in-cancer-associated-fibroblast-insights-from-web-of-science-database-from-1999-to-2021
#13
JOURNAL ARTICLE
Dun Yuan, Bo-Wen Zheng, Bo-Yv Zheng, Hua-Qing Niu, Ming-Xiang Zou, Song-Lin Liu, Fu-Sheng Liu
BACKGROUND: A scientific and comprehensive analysis of the current status and trends in the field of cancer-associated fibroblast (CAF) research is worth investigating. This study aims to investigate and visualize the development, research frontiers, and future trends in CAFs both quantitatively and qualitatively based on a bibliometric approach. METHODS: A total of 5518 publications were downloaded from the Science Citation Index Expanded of Web of Science Core Collection from 1999 to 2021 and identified for bibliometric analysis...
November 29, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38017592/clinicopathological-characteristics-and-prognosis-of-medullary-thyroid-microcarcinoma-a-tumor-with-a-similar-prognosis-to-macrocarcinoma
#14
JOURNAL ARTICLE
Xin Wu, Binglu Li, Chaoji Zheng
BACKGROUND: Tumor size plays an important role in the staging and treatment of thyroid carcinoma. A tumor with a maximum diameter of 1 cm or less is referred to as microcarcinoma. It is unclear if the clinicopathological characteristics and prognosis of medullary thyroid microcarcinoma (≤ 1 cm; MTMC) and macrocarcinoma (> 1 cm) differ. The present study aims to clarify the clinical features and prognosis of patients with MTMC. METHODS: The patients with medullary thyroid carcinoma underwent radical operation at our hospital between December 2000 and January 2022 were retrospectively studied...
November 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38017579/predicting-the-prognosis-immune-response-and-immunotherapy-in-head-and-neck-squamous-cell-carcinoma-using-a-novel-risk-model-based-on-anoikis-related-lncrnas
#15
JOURNAL ARTICLE
Hongxia Deng, Zhengyu Wei, Juan Du, Zhisen Shen, Chongchang Zhou
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an extremely heterogeneous and metastatic disease. Anoikis, which is a specific type of programmed apoptosis, is involved in tumor metastasis, tissue homeostasis, and development. Herein, we constructed an anoikis-related long non-coding RNA (lncRNA) signature to predict the prognosis, immune responses, and therapeutic effects in HNSCC patients. METHODS: A total of 501 HNSCC samples were acquired from the TCGA database and randomly classified into the training and validation groups (1:1 ratio)...
November 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38017568/the-fda-approved-anti-amyloid-%C3%AE-monoclonal-antibodies-for-the-treatment-of-alzheimer-s-disease-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Wenxue Wu, Yi Ji, Zilan Wang, Xiaoxiao Wu, Jiaxuan Li, Feng Gu, Zhouqing Chen, Zhong Wang
BACKGROUND: Alzheimer's disease (AD) is a worldwide public health problem and is difficult to cure. Drugs aimed at slowing the progression of the disease have been developed, with the Food and Drug Administration (FDA) granting accelerated approval for aducanumab on June 21, 2021 and a new accelerated approval for lecanemab on January 22, 2023. We performed this systematic review and meta-analysis to assess the efficacy and safety of FDA-approved anti-amyloid-β (anti-Aβ) monoclonal antibodies (mabs) for the treatment of AD...
November 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38017548/a-novel-tumor-purity-and-immune-infiltration-related-model-for-predicting-distant-metastasis-free-survival-in-prostate-cancer
#17
JOURNAL ARTICLE
Qiang Su, Yongbei Zhu, Bingxi He, Bin Dai, Wei Mu, Jie Tian
BACKGROUND: umor cells, immune cells and stromal cells jointly modify tumor development and progression. We aim to explore the potential effects of tumor purity on the immune microenvironment, genetic landscape and prognosis in prostate cancer (PCa). METHODS: Tumor purity of prostate cancer patients was extracted from The cancer genome atlas (TCGA). Immune cellular proportions were calculated by the CIBERSORT. To identify critical modules related to tumor purity, we used weighted gene co-expression network analysis (WGCNA)...
November 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38017518/a-global-bibliometric-and-visualized-analysis-of-the-status-and-trends-of-gastroparesis-research
#18
REVIEW
Meng Li, Ning Gao, Shaoli Wang, Yufeng Guo, Zhen Liu
BACKGROUND: Gastroparesis has a substantial impact on the quality of life but has limited treatment options, which makes it a public health concern. No bibliometric studies on gastroparesis have been published thus far. Thus, this article aims to summarize and analyze research hotspots to provide a reference for clinical researchers. MATERIALS AND METHODS: Gastroparesis-related research articles were searched in the Web of Science Core Collection (WOSCC), and relevant information was extracted after screening...
November 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38017514/network-pharmacology%C3%A2-based-investigation-of-potential-targets-of-triptonodiol-acting-on-non-small-cell-lung-cancer
#19
JOURNAL ARTICLE
Feng Jin, Xiaochen Ni, Shilong Yu, Xiaomin Jiang, Jun Zhou, Defang Mao, Yanqing Liu, Feng Wu
BACKGROUND: Triptonodiol is a very promising antitumor drug candidate extracted from the Chinese herbal remedy Tripterygium wilfordii Hook. F., and related studies are underway. METHODS: To explore the mechanism of triptonodiol for lung cancer treatment, we used network pharmacology, molecular docking, and ultimately protein validation. Gene ontology (GO) analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment analysis were performed through the David database...
November 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38008731/higher-plasma-aldosterone-concentrations-in-patients-with-aortic-diseases-and-hypertension-a-retrospective-observational-study
#20
JOURNAL ARTICLE
Yuting Pu, Guifang Yang, Xiaogao Pan, Yang Zhou, Aifang Zhong, Ning Ding, Yingjie Su, Wen Peng, Mengping Zeng, Tuo Guo, Xiangping Chai
BACKGROUND: Aortic diseases remain a highly perilous macrovascular condition. The relationship between circulating aldosterone and aortic diseases is rarely explored, thus we investigated the difference in plasma aldosterone concentration (PAC) between patients with and without aortic disease in hypertensive people. METHODS: We analyzed 926 patients with hypertension, ranging in age from 18 to 89 years, who had their PAC measured from the hospital's electronic database...
November 26, 2023: European Journal of Medical Research
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