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CONSULT-II: Accurate taxonomic identification and profiling using locality-sensitive hashing.
Bioinformatics 2024 March 17
MOTIVATION: Taxonomic classification of short reads and taxonomic profiling of metagenomic samples are well-studied yet challenging problems. The presence of species belonging to ranks without close representation in a reference dataset is particularly challenging. While k-mer-based methods have performed well in terms of running time and accuracy, they tend to have reduced accuracy for such novel species. Thus, there is a growing need for methods that combine the scalability of k-merswith increased sensitivity.
RESULTS: Here, we show that using locality-sensitive hashing (LSH) can increase the sensitivity of the k-mer-based search. Our method, which combines LSH with several heuristics techniques including soft LCA labeling and voting is, more accurate than alternatives in both taxonomic classification of individual reads and abundance profiling.
AVAILABILITY AND IMPLEMENTATION: CONSULT-II is implemented in C ++, and the software, together with reference libraries, is publicly available on GitHub https://github.com/bo1929/CONSULT-II.
CONTACT: Siavash Mirarab. E-mail: [email protected]. Address: UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA 92093-0407.
SUPPLEMENTARY INFORMATION: Supplementary information is available at Bioinformatics online.
RESULTS: Here, we show that using locality-sensitive hashing (LSH) can increase the sensitivity of the k-mer-based search. Our method, which combines LSH with several heuristics techniques including soft LCA labeling and voting is, more accurate than alternatives in both taxonomic classification of individual reads and abundance profiling.
AVAILABILITY AND IMPLEMENTATION: CONSULT-II is implemented in C ++, and the software, together with reference libraries, is publicly available on GitHub https://github.com/bo1929/CONSULT-II.
CONTACT: Siavash Mirarab. E-mail: [email protected]. Address: UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA 92093-0407.
SUPPLEMENTARY INFORMATION: Supplementary information is available at Bioinformatics online.
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