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Journal Article
Review
Recent Updates on Pyroptosis in Tumors of the Digestive Tract.
Journal of Digestive Diseases 2023 December 8
Pyroptosis is an inflammasome-dependent form of programmed cell death that is mediated by caspase-1,caspase-4/5/11 and the gasdermin protein family. It is characterized by the rupture of cell membranes, the release of cell contents and interleukins, the associated inflammatory reaction and immune system activation. Recent studies have suggested that pyroptosis plays a role in the development of digestive tract tumors,both impeding tumor generation and progression, as well as providing a favorable microenvironment for tumor growth. This review outlines the current knowledge regarding the implications of pyroptosis in gastrointestinal cancers with a focus on providing insights into their pathogenesis and potential treatments. This article is protected by copyright. All rights reserved.
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