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Journal of Digestive Diseases

Qing-Wei Zhang, Xin-Tian Zhang, Yun-Jie Gao, Zhi-Zheng Ge
With endoscopic resection for early gastric cancers (EGCs) widely accepted by not only Asian endoscopists, but also endoscopists from Western countries, there was still lack of review about standardized treatment process before and after endoscopic resection (ER). In this article, we provided a narrative review of studies describing how to choose proper EGCs for endoscopic resection and how to follow up patients with EGCs after histological assessment of ER specimen. Before endoscopic resection, EGCs should be comprehensively assessed, including exact margin, depth of EGCs and risk of lymph node metastasis (LNM)...
February 12, 2019: Journal of Digestive Diseases
Mohamed A Abdallah, Muslim Atiq, Vladimir Kushnir, Koushik K Das, Maria B Doyle, William C Chapman, Adeel S Khan
Bouveret's syndrome is a rare condition characterized by gastric outlet obstruction caused by gallstone impaction in the stomach or duodenum. Gallstones that are too large to pass through the cystic and common bile ducts (CBD) can result in chronic irritation and inflammation of the gallbladder wall. This article is protected by copyright. All rights reserved.
February 12, 2019: Journal of Digestive Diseases
Jian Wan, Xuan Wang, Zhiping Yang, Kaichun Wu
AIM: To compare chromoendoscopy (CE) and white light endoscopy (WLE) for dysplasia surveillance in inflammatory bowel disease (IBD) patients. METHODS: We conducted a meta-analysis of six RCTs and five prospective studies and performed a comparison between CE and WLE groups. Fixed-effect model was used unless heterogeneity was high. RESULTS: CE could detect more patients with dysplasia (RR 2.05, 95% CI:1.62 to 2.61) and more dysplastic lesions (RR2...
February 12, 2019: Journal of Digestive Diseases
Zhen He, Jian Jun Yang, Rong Zhang, Hua Ting Li, Liang Wu, Feng Jiang, Wei Ping Jia, Cheng Hu
AIM: The early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic disease, including NAFLD. The aim of this study was to examine the association of serum miR-29a-c with NAFLD in a Chinese population. METHODS: 276 individuals were enrolled in this study and divided into non-diabetic and diabetic groups. Real-time PCR was performed to quantify the serum miR-29a-c expression levels...
February 12, 2019: Journal of Digestive Diseases
Jia-Yue Tang, Ke-Gong Tao, Li-Yuan Zhang, Kai-Ming Wu, Jian Shi, Xin Zeng, Yong Lin
OBJECTIVE: Ensuring the diagnosis and determining the malignant potential of gastrointestinal stromal tumors (GISTs) as early as possible is important when making clinical therapeutic decisions. Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable method for this task. This study aimed to estimate the ability of CH-EUS to discriminate GISTs from benign submucosal lesions (SMLs) and predict their malignant potential. METHODS: Two individuals independently screened the literature by searching the PubMed, MEDLINE, EMBASE, Web of Science and Cochrane Central Trials databases...
February 3, 2019: Journal of Digestive Diseases
Si Yi Yuan, Wei Wu, Jing Fu, Yi Xuan Lang, Ji Chi Li, Ye Guo, Ya Nan Wang, Jia Ming Qian, Jing Nan Li
OBJECTIVES: To investigate the performance of the quantitative immunochemical fecal occult blood test (qFIT), and determine the association between the fecal hemoglobin (Hb) level and the location, size of adenomas and the grades of colorectal cancer (CRC). METHODS: A total of 692 participants were included in the study. The fecal Hb level was measured using an OC-SENSA MICRO qFIT. The colonoscopy results, including the location, size, and histological features of the adenomas, as well as the relationship between the Hb level and different characteristics were analyzed...
February 3, 2019: Journal of Digestive Diseases
Jing Nan Li, Si Yi Yuan
Colorectal cancer (CRC) is currently the second leading cause of cancer-related mortality worldwide. CRC screening can reduce the mortality of CRC. The most important stool test for CRC screening is the fecal occult blood test (FOBT) which includes gFOBT and FIT. In this review, we discuss the development and application of the FOBT in CRC screening.
February 3, 2019: Journal of Digestive Diseases
Ze-Hua Zhao, Jonathan King-Lam Lai, Liang Qiao, Jian-Gao Fan
Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial liver disease and has emerged as a global challenge due to the increasing prevalence and lack of sustainable treatment options. The gut microbiota possesses vital functions in fermenting dietary nutrients and synthesizing bioactive molecules. This function is of great importance in maintaining health because these microbial metabolites are essential in regulating energy metabolism, immune response and other vital physiological processes. An altered gut flora can result in a change in gut microbial metabolites, affecting the onset and progression of multiple diseases...
January 31, 2019: Journal of Digestive Diseases
Masami Miki, Nao Fujimori, Takamasa Oono, Ken Kawabe, Akihisa Ohno, Kazuhide Matsumoto, Katsuhito Teramatsu, Yuichi Tachibana, Yoshihiro Ogawa
OBJECTIVE: Autoimmune pancreatitis (AIP) was autoimmune disorder accompanied by clinicopathological manifestation whose concept was established as IgG4-related disease (IgG4-RD). Other IgG4-RDs are often involved with autoimmune pancreatitis, sometimes relapsing despite the favorable response to a steroid therapy. This study aimed to clarify patterns and risk factors for extrapancreatic relapse. METHODS: We reviewed the data of 115 patients diagnosed with definite AIP type 1, followed up for >1 year...
January 31, 2019: Journal of Digestive Diseases
Xin Tian Zhang, Qing Wei Zhang, Fei Liu, Xiao Lu Lin, Jin Nan Chen, Xiao Bo Li
OBJECTIVE: Sessile serrated adenoma/polyps (SSA/Ps) are recognized as precancerous lesions in the colon and resemble hyperplastic polyps (HPs). Definite endoscopic features under narrow band imaging (NBI) with or without magnification may help differentiate between these two lesions. Our study was designed to identify specific endoscopic features of SSA/Ps by NBI. METHODS: A total of 199 patients with histopathologically proven colorectal SSA/Ps or HPs after polypectomy were enrolled...
January 28, 2019: Journal of Digestive Diseases
Sheng Xiang Rao, Jin Wang, Jian Wang, Xin Qing Jiang, Li Ling Long, Zi Ping Li, Zhen Lin Li, Wen Shen, Xin Ming Zhao, Dao Yu Hu, Hui Mao Zhang, Lin Zhang, Yi Huan, Chang Hong Liang, Bin Song, Meng Su Zeng
Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) helps improve the ability of detection and diagnosis of focal hepatic lesions, especially for evaluating smaller lesions (<1 cm in diameter) and the diseases of the biliary system. MRI-based function tests with Gd-EOB-DTPA have gained immense popularity in recent years as it can be integrated into clinical setup with a higher temporal and spatial resolution and without ionizing radiation. Gd-EOB-DTPA has been in use since 2011 in China...
January 28, 2019: Journal of Digestive Diseases
Yi Chao Shi, Zi Kai Wang, Yun Sheng Yang
Biobanks are collections of various biological samples and their related information. These samples include organs, tissues, cells, blood, body fluids, secretions, excretions and biological macromolecular derivatives from healthy or diseased individuals that are collected, processed, stored and utilized under standard procedures. Sample-related information consists of clinical information, test results, pathology, imaging, treatment, follow-up visits and informed patient consent as well as quality control, information management and application systems associated with the samples...
January 24, 2019: Journal of Digestive Diseases
Lei-Min Yu, Ke-Jia Zhao, Shuang-Shuang Wang, Xi Wang, Bin Lu
AIM: As a stress-related disorder, irritable bowel syndrome (IBS) has aberrant brain-gut communication and low-grade inflammation in the intestine. This study determined the effect of corticotropin-releasing factor (CRF) on regulating the NOD-like receptor pyrin domain-containing protein 6 (NLRP6)- inflammatory cytokine axis in a murine model of IBS. METHODS: C57BL/6 mice were subjected to water avoidance stress (WAS) for 1 h/day over the course of 10 days. We assessed the abdominal withdrawal reflex (AWR) and colon inflammation histology in IBS mice...
January 20, 2019: Journal of Digestive Diseases
Lu Ning Li, Xiao Yan Sun, Guang Chuan Wang, Xiang Guo Tian, Ming Yan Zhang, Kai Tong Jiang, Chun Qing Zhang
AIM: The efficacies in decreasing rebleeding and improving survival rate by transjugular intrahepatic portosystemic shunt(TIPS) and endoscopic variceal ligation(EVL) plus propranolol were compared in cirrhotic patients with cavernous transformation of the portal vein(CTPV). METHODS: Cirrhotic patients with CTPV and variceal bleeding history treated for a second prophylaxis of recurrent variceal bleeding between June 2010 and July 2016 were identified and classified based on the treatment that they received (TIPS or EVL + propranolol)...
January 10, 2019: Journal of Digestive Diseases
Huimin Guo, Tingsheng Ling, Lei Wang, Ying Lv, Xiaoqi Zhang, Tian Yang, Guifang Xu, Qi Sun, Ling Nie, Xiaoping Zou
AIM: Endoscopic submucosal dissection (ESD) for laterally spreading tumors (LSTs) involving the dentate line (LSTs-DL) is challenging, because of the specific anatomical features of the anorectum. The aim of this study was to evaluate the clinical outcomes of ESD for LSTs-DL. METHODS: Consecutive patients with LSTs-DL underwent ESD at our hospital between January 2010 and December 2015 were retrospectively enrolled in this study. Rates of En bloc resection, R0 resection rate, complications, pathological characteristics, and tumor recurrence were analyzed and compared with that of LSTs in rectum not involving the dentate line (LSTs-NDL)...
January 10, 2019: Journal of Digestive Diseases
Liuqin Jiang, Bixing Ye, Meifeng Wang, Lin Lin
AIM: The purpose of this study was to explore the correlation between reflux type and abnormal esophageal motility in patients with gastroesophageal reflux disease (GERD). METHODS: Subjects (GERD patients and controls) were studied retrospectively and underwent 24-himpedance-pH monitoring (MII-pH monitoring) and high-resolution manometry. Patients were divided into two groups (acid reflux type and nonacid reflux type) based on MII-pH monitoring data. Reflux episodes, endoscopy findings and esophageal dynamic parameters were assessed and compared...
January 10, 2019: Journal of Digestive Diseases
Yu Bai, De Feng Li, Shu Ling Wang, Sheng Bing Zhao, Shu Ren Ma, Shu Tian Zhang, Zhao Shen Li
Endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of hepatobiliary and pancreatic diseases for more than four decades.1 ERCP was initially used for diagnosing biliary and pancreatic diseases only. It is soon evolved into a therapeutic option owing to technical refinements.2,3 .
January 2, 2019: Journal of Digestive Diseases
Qi-Wei Zhang, Jun Shen, Qing Zheng, Zhi-Hua Ran
OBJECTIVE: We aimed to determine the potential predictors of loss of response (LOR) to infliximab (IFX) therapy for Crohn's disease (CD) in adults. METHODS: We searched for English-language articles published between 1990 and March 2017 in PubMed, Embase, and the Cochrane Library. After identifying eligible studies, data extraction was performed independently by two reviewers. Five potential prognostic variables were identified and dichotomized for meta-analysis...
December 23, 2018: Journal of Digestive Diseases
Ping Fang Hu, Wei Fen Xie
Drug-induced liver injury (DILI) is a liver toxicity induced by a drug or its metabolite. The incidence of DILI continues to increase and it has been an enormous challenge worldwide, while the prognosis is not optimistic. Currently, the most effective treatment for DILI is to suspend the offending drug(s) and to avoid re-exposure, with no definitive therapy available for idiosyncratic DILI with or without acute liver failure. Given the anti-inflammatory effects of corticosteroids, they have been widely used in DILI in clinical practice, although their efficacy remains controversial...
December 23, 2018: Journal of Digestive Diseases
Xiu-He Lv, Liang-Liang Ma, Wei-Yun Fu, Yan Xie
Sinistral portal hypertension (SPH), also known as left-sided portal hypertension, accounts for 5% of all portal hypertension (PH) cases. SPH is commonly secondary to acute or chronic pancreatitis and pancreatic cancer and rarely secondary to peritoneal inflammatory disease, abdominal tumors or diseases of the spleen1 . Splenic marginal zone lymphoma (SMZL) is a rare type of non-Hodgkin's lymphoma that originates from the lymphocytes of the splenic white pulp.
December 14, 2018: Journal of Digestive Diseases
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