Journal of Digestive Diseases

The discovery of the constitutive activation of KIT/PDGFRA tyrosine kinases in gastrointestinal stromal tumors (GISTs) led to the development of the targeted drug imatinib. However, the inevitable development of imatinib resistance remains a major issue. Ripretinib is a novel targeted drug that inhibits the activity of a broad spectrum of drug-resistant KIT/PDGFRA mutants. It was approved in 2020 and is currently recommended in major international guidelines as fourth-line and beyond therapy for advanced GISTs...

No abstract text is available yet for this article.

AIMS: This study aimed to compare the need for further examination with conventional gastroscopy between patients with gastrointestinal symptoms and asymptomatic patients who underwent magnetically assisted capsule endoscopy. METHODS: We retrospectively enrolled 372 patients with gastrointestinal symptoms and 372 asymptomatic patients who had undergone magnetically assisted capsule endoscopy at the First Affiliated Hospital of Sun Yat-sen University from January 1, 2019, to December 30, 2020...

BACKGROUND & AIM: Fecal microbiota transplantation (FMT) has been recommended for treating recurrent Clostridioides difficile infection (CDI). We aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT), a new method of FMT, for CDI across various medical settings. METHODS: This real-world cohort study included CDI patients from multiple centers who underwent WMT. The primary outcome was the clinical cure rate of CDI within 8-week post-WMT...

AIMS: Whipple's disease (WD) is a rare and potentially fatal infectious disease caused by Tropheryma whipplei. It is characterized by a long prodromal phase that mimics a rheumatological disease, often leading to treatment with immunosuppressants. Immune reconstitution inflammatory syndrome (IRIS) is currently the most important complication of WD, requiring prompt recognition and treatment as it can be fatal. However, data on the epidemiology of IRIS are scarce. We aimed to identify clinical and laboratory predictors of IRIS at time of WD diagnosis and to evaluate whether prevalence of IRIS has changed over time...

BACKGROUND: Traditional preoperative reminding services were applied to enhance the quality of bowel preparation. However, their effects might be affected. In this study, we proposed to use automated Electronic reminder system (E-reminder) and validated its effectiveness on improving bowel preparation and the quality of preoperative education before colonoscopy. METHODS: During August 2021 to March 2022, we included 833 outpatients aged 50-75 who underwent colonoscopy, and all patient were randomly assigned after obtaining informed consent...

OBJECTIVES: Neuroendocrine carcinoma of the esophagus is recognized to have a rare incidence, high malignancy, and poor prognosis. This retrospective study was designed to review the clinical characteristics of patients diagnosed with esophageal neuroendocrine carcinoma (ENEC), analyze prognostic factors and explore potential biomarkers and optimal treatment strategies. METHODS: We conducted a retrospective review of 82 patients diagnosed with ENEC between January 2009 and December 2020 in a single institute...

BACKGROUND AND AIM: Although natural orifice transluminal endoscopic surgery (NOTES) has gained in popularity, the preferred route of access to the peritoneal cavity is still debated. Here, we compare and discuss the safety and effectiveness of trans-gastric and trans-rectal pure NOTES cholecystolithotomy. PATIENTS AND METHODS: This was a single center retrospective comparative study of consecutive patients who underwent either pure NOTES trans-rectal or trans-gastric gallbladder preserving cholecystolithotomy at the First Affiliated Hospital of Zhengzhou University between September 2017 and April 2020...

BACKGROUND: As an critical component of the autophagic machinery, autophagy-related gene 5 (ATG5) is essential for autophagosome formation. Autophagy participates in various malignant tumor transformation and progression, but the role of ATG5 involved in hepatocellular carcinoma (HCC) remains to be illustrated. METHODS: The expression of ATG5 was evaluated in 89 pairs of liver tumor and adjacent normal tissues. The correlation between ATG5 expression and clinicopathological characteristics or prognosis were evaluated...

BACKGROUND: The IRF family of proteins involves in the tumor progression. However, the functions of IRF5 in the tumorigenesis are largely unknown. METHODS: The levels of IRF5 were analyzed through various techniques including qPCR, western blot and immunohistochemistry (IHC) in the hepatocellular carcinoma (HCC). The CCK8 assay, anchorage-independent assay and Edu assay were used to evaluate the role of IRF5. The molecular mechanisms were studied by analyzing the metabolites with mass spectrum and immunoprecipitation...

Surgical resection is regarded as the main modality for the treatment of gastrointestinal stromal tumors (GISTs). With the advancement of endoscopic techniques and the concept of super minimally invasive surgery (SMIS), endoscopic resection has been an alternative option for surgery. Recently, various endoscopic resection techniques have been used for the treatment of GISTs, including endoscopic submucosal dissection (ESD), endoscopic submucosal excavation (ESE), endoscopic full-thickness resection (EFR), submucosal tunneling endoscopic resection (STER), and laparoscopic and endoscopic cooperative surgery (LECS)...

OBJECTIVE: The nocebo effect, a phenomenon that pertains to the negative impacts experienced by patients due to their negative expectations, is not connected to the physiological mechanism of the treatment in question. Our article aims to evaluate the degree of the nocebo response in patients with functional dyspepsia and explore its influencing factors. METHODS: The researchers searched Embase, Pubmed and Cochrane Library databases through March 2021, including randomized, parallel-designed, placebo-controlled trials examining pharmacological interventions for patients with functional dyspepsia...

BACKGROUND: Eradication of Helicobacter pylori alters the gut microbiota. Prebiotics can regulate the gut microbiota, but their role in H. pylori eradication remains unclear. METHODS: This study conducted an unblinded randomised controlled trial at the Affiliated Hospital of Qingdao University, Shandong Province, China. Ninety patients tested positive for H. pylori were randomised into standard quadruple therapy (SQT) group (SQ group), SQT + fucoidan combination group (SF group) and fucoidan + SQT sequential group (FS group)...

OBJECTIVES: To determine whether hyperammonemia has a direct impact on steatohepatitis in mice fed with a high-fat diet (HFD). METHODS: Male C57BL/6 mice were randomly divided into two groups receiving either a chow diet or an HFD for NASH modeling. After 12 weeks of NASH modeling, hyperammonemia was induced by intragastric administration of the ammonium chloride solution (NH4 CL) or by liver-specific carbamoyl phosphate synthetase 1(CPS1) knockdown. In vitro experiments were performed in HepG2 cells induced by free fatty acid (FFA) and NH4 CL...

AIM: Bone loss is a common morbidity sign in patients with inflammatory bowel disease. Bone mineral density measurement is currently recommended for those with high risk of osteoporosis in patients with inflammatory bowel disease. However, there is lack of evidence in the need of bone mineral density measurement in patients who are young at the age of first onset. In this study, we aimed to investigate the prevalence of bone mineral density disorders in newly diagnosed Crohn's disease with young age and to determine potential risk factors...

BACKGROUND: There have been no studies that have systematically evaluated whether previously validated patient and procedural risk factors for PEP remain significant in patients receiving rectal indomethacin. METHODS: Data from a randomized controlled trial (RCT) of high-risk patients undergoing ERCP who received rectal indomethacin with or without topical epinephrine was evaluated. PEP was defined using the consensus criteria definition. Pancreatic stenting was excluded to avoid confounding results with the role of epinephrine spray...

No abstract text is available yet for this article.

OBJECTIVE: The impact of vitamin E supplementation on liver biomarkers in NAFLD patients remains controversial. Therefore, we conducted the present umbrella meta-analysis of randomized controlled trials to clarify the effects of vitamin E administration on alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), steatosis levels and fibrosis score in individuals diagnosed with NAFLD. METHODS: Four databases (PubMed/MEDLINE, Scopus, EMBASE, and Web of Science) were searched to identify pertinent papers published in international scientific journals from the inception of these search services and up to June 2023...

AIM: Autoimmune pancreatitis (AIP) is a rare and enigmatic immune-mediated inflammatory diseases associated with inflammatory bowel disease (IBD). We aimed to describe the prevalence, characteristics, and associated factors of AIP-IBD patients in China. METHODS: We performed a retrospective bidirectional case-control study from 1998 to 2021. The diagnosis of IBD was based on the European Crohn's and Colitis Organisation guidelines and of AIP was based on the International Consensus Diagnostic Criteria...

AIM: Primary biliary cholangitis (PBC) is a rare disease characterized by intrahepatic cholestasis, whereas gallstone disease (GD) is a common disease. Little is known about the prevalence and impact of GD on the clinical course of PBC. Therefore, we investigated the prevalence and impact of GD on the prognosis of PBC in China. METHODS: We retrospectively analyzed PBC patients and followed them by reviewing electronic records and a structured, standardized telephone interview...