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Adenosine A 2A receptor and glia.
The adenosine A2A receptor (A2A R) is abundantly expressed in the brain, including both neurons and glial cells. While the expression of A2A R is relative low in glia, its levels elevate robustly in astrocytes and microglia under pathological conditions. Elevated A2A R appears to play a detrimental role in a number of disease states, by promoting neuroinflammation and astrocytic reaction to contribute to the progression of neurodegenerative and psychiatric diseases.
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