journal
Journals International Review of Neurob...

International Review of Neurobiology

https://read.qxmd.com/read/37993180/involvement-of-brain-metabolism-in-neurodevelopmental-disorders
#1
JOURNAL ARTICLE
Pavel Kotchetkov, Nicole Blakeley, Baptiste Lacoste
Neurodevelopmental disorders (NDDs) affect a significant portion of the global population and have a substantial social and economic impact worldwide. Most NDDs manifest in early childhood and are characterized by deficits in cognition, communication, social interaction and motor control. Due to a limited understanding of the etiology of NDDs, current treatment options primarily focus on symptom management rather than on curative solutions. Moreover, research on NDDs is problematic due to its reliance on a neurocentric approach...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37993179/a-review-of-the-use-of-psychotropic-medication-to-address-challenging-behaviour-in-neurodevelopmental-disorders
#2
JOURNAL ARTICLE
Maria G Valdovinos, Claire Epperson, Carissa Johnson
Engagement in challenging behaviour (e.g., aggression, self-injury) is reported to occur in neurodevelopmental disorders such as intellectual disabilities (ID), autism spectrum disorder (ASD), and fragile X syndrome (FXS). Common interventions to address these behaviours include both behavioural and pharmacological approaches. Although psychotropic medications are commonly used to address challenging behaviour in ID, ASD, and FXS, demonstration of the effectiveness of treatment is limited. Furthermore, research examining interaction effects between psychotropic medication, challenging behaviour, and environmental events within specific neurodevelopmental disorders such as ID, ASD, and FXS is scarce...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37993178/glial-mediated-dysregulation-of-neurodevelopment-in-fragile-x-syndrome
#3
JOURNAL ARTICLE
M Napier, K Reynolds, A L Scott
Astrocytes are highly involved in a multitude of developmental processes that are known to be dysregulated in Fragile X Syndrome. Here, we examine these processes individually and review the roles astrocytes play in contributing to the pathology of this syndrome. As a growing area of interest in the field, new and exciting insight is continually emerging. Understanding these glial-mediated roles is imperative for elucidating the underlying molecular mechanisms at play, not only in Fragile X Syndrome, but also other ASD-related disorders...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37993177/how-dendritic-spines-shape-is-determined-by-mmp-9-activity-in-fxs
#4
JOURNAL ARTICLE
Magdalena Dziembowska
Matrix metalloproteinase-9 (MMP-9) belongs to the family of endopeptidases expressed in neurons and secreted at the synapse in response to neuronal activity. It regulates the pericellular environment by cleaving its protein components. MMP9 is involved in activity-dependent reorganization of spine architecture. In the mouse model of fragile X syndrome (FXS), the most common inherited intellectual disability and the most common single-gene cause of autism, increased synaptic expression of MMP-9 is responsible for the observed dendritic spine abnormalities...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37993176/toward-an-understanding-of-the-role-of-the-exposome-on-fragile-x-phenotypes
#5
JOURNAL ARTICLE
Cara J Westmark
Fragile X syndrome (FXS) is the leading known monogenetic cause of autism with an estimated 21-50% of FXS individuals meeting autism diagnostic criteria. A critical gap in medical care for persons with autism is an understanding of how environmental exposures and gene-environment interactions affect disease outcomes. Our research indicates more severe neurological and metabolic outcomes (seizures, autism, increased body weight) in mouse and human models of autism spectrum disorders (ASD) as a function of diet...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37993175/cholesterol-alterations-in-fragile-x-syndrome-autism-spectrum-disorders-and-other-neurodevelopmental-disorders
#6
JOURNAL ARTICLE
Sérine Benachenhou, Asma Laroui, Olivier Dionne, Daniela Rojas, Amanda Toupin, Artuela Çaku
Neurodevelopmental disorders (NDDs) are a group of etiologically diverse diseases primarily associated with abnormal brain development, impaired cognition, and various behavioral problems. The majority of NDDs present a wide range of clinical phenotypes while sharing distinct cellular and biochemical alterations. Low plasma cholesterol levels have been reported in a subset of NNDs including, autism spectrum disorder (ASD) and fragile X syndrome (FXS). The present review focuses on cholesterol metabolism and discusses the current evidence of lipid disruption in ASD, FXS, and other genetically related NDDs...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37993174/the-dopamine-hypothesis-of-autism-spectrum-disorder-a-comprehensive-analysis-of-the-evidence
#7
JOURNAL ARTICLE
Denis Pavăl
Despite intensive research into the etiopathogenesis of autism spectrum disorder (ASD), limited progress has been achieved so far. Among the plethora of models seeking to clarify how ASD arises, a coherent dopaminergic model was lacking until recently. In 2017, we provided a theoretical framework that we designated "the dopamine hypothesis of ASD". In the meantime, numerous studies yielded empirical evidence for this model. 4 years later, we provided a second version encompassing a refined and reconceptualized framework that accounted for these novel findings...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833019/neuromodulation-and-quality-of-life-for-patient-with-spasticity-after-spinal-cord-injury
#8
JOURNAL ARTICLE
Artur Biktimirov, Igor Bryukhovetskiy, Aruna Sharma, Hari Shanker Sharma
RATIONALE: Spasticity develops in 80% of spinal cord injury cases and negatively affects the patents' quality of life. The most common method of surgical treatment for severe spasticity is a long-term intrathecal baclofen therapy (ITB). Long-term spinal cord stimulation is another possible treatment technique. This paper aims to evaluate the changes in quality of life for patients with spasticity who have been treated with neuromodulation (SCS or ITB) in 12 months after the surgery, as well to compare the changes in quality of life for patients who have been treated with spinal cord stimulation and those who received long-term intrathecal baclofen therapy...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833018/nanodelivery-of-histamine-h3-receptor-inverse-agonist-bf-2649-with-h3-receptor-antagonist-and-h4-receptor-agonist-clobenpropit-induced-neuroprotection-is-potentiated-by-antioxidant-compound-h-290-51-in-spinal-cord-injury
#9
JOURNAL ARTICLE
Anca D Buzoianu, Aruna Sharma, Dafin F Muresanu, Lianyuan Feng, Hongyun Huang, Lin Chen, Z Ryan Tian, Ala Nozari, José Vicente Lafuente, Per-Ove Sjöqvist, Lars Wiklund, Hari Shanker Sharma
Military personnel are often victims of spinal cord injury resulting in lifetime disability and decrease in quality of life. However, no suitable therapeutic measures are still available to restore functional disability or arresting the pathophysiological progression of disease in victims for leading a better quality of life. Thus, further research in spinal cord injury using novel strategies or combination of available neuroprotective drugs is urgently needed for superior neuroprotection. In this regard, our laboratory is engaged in developing TiO2 nanowired delivery of drugs, antibodies and enzymes in combination to attenuate spinal cord injury induced pathophysiology and functional disability in experimental rodent model...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833017/case-report-of-epileptic-seizure-during-awake-craniotomy-of-functional-area-glioma-and-literature-study
#10
JOURNAL ARTICLE
Sheng-Ping Zhang, Chao He, Xiang-Peng Wang, Bo Wang, Zhi-Wei Tang
Intraoperative seizure is the most prevalent and serious complication of awake craniotomy in functional areas, which may not only trigger complications of the surgical procedure or even the failure of awake craniotomy but also may result in adverse consequences to patients. The influencing factors of intraoperative seizures are unclear, and only the possible influencing factors can be acquired from the examination and summary of existing cases to offer guidance for the seizure prevention of intraoperative epilepsy...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833016/a-review-of-traditional-chinese-medicine-curcumae-rhizoma-for-treatment-of-glioma
#11
JOURNAL ARTICLE
Qijia Tan, Jiamin Lu, Jingtong Liang, Yuchen Zhou, Chunrong Yang, Zhiqiang Zhang, Cong Li
Glioma is the most common primary central nervous tumor and its malignant and high recurrence rate are seriously threatening patient's life. The prognosis of glioma patients is still poor with a variety of modern treatments. Traditional Chinese medicine (TCM) is widely used in the adjuvant treatment or alternative medicine of glioma. Curcumae Rhizoma is one of the most commonly used in traditional Chinese medicine prescriptions for its anti-tumor characteristics. There are also many studies that reveals the anti-tumor effect of its active ingredients and some of which have been made into drugs and have been used in clinical practice...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833015/spinal-cord-injury-induced-exacerbation-of-alzheimer-s-disease-like-pathophysiology-is-reduced-by-topical-application-of-nanowired-cerebrolysin-with-monoclonal-antibodies-to-amyloid-beta-peptide-p-tau-and-tumor-necrosis-factor-alpha
#12
JOURNAL ARTICLE
Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharma
Hallmark of Alzheimer's disease include amyloid beta peptide and phosphorylated tau deposition in brain that could be aggravated following traumatic of concussive head injury. However, amyloid beta peptide or p-tau in spinal cord following injury is not well known. In this investigation we measured amyloid beta peptide and p-tau together with tumor necrosis factor-alpha (TNF-α) in spinal cord and brain following 48 h after spinal cord injury in relation to the blood-spinal cord and blood-brain barrier, edema formation, blood flow changes and cell injury in perifocal regions of the spinal cord and brain areas...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833014/an-overview-of-twist1-in-glioma-progression-and-recurrence
#13
JOURNAL ARTICLE
Cong Li, Zixuan Li, Mengyi Zhang, Jiaxuan Dai, Yunmin Wang, Zhiqiang Zhang
Glioma cells are characterized by high migration ability, resulting in the aggressive growth of the tumors and poor prognosis of patients. Epithelial-to-mesenchymal transition (EMT) is one of the most important steps for tumor migration and metastasis and be elevated during glioma progression and recurrence. Twist1 is a basic helix-loop-helix transcription factor and a key transcription factor involved in the process of EMT. Twist1 is related to glioma mesenchymal change, invasion, heterogeneity, self-renewal of tumor stem cells, angiogenesis, etc...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833013/technology-of-genomic-balancing-of-chromatin-of-autologous-hematopoietic-stem-cells-for-gene-therapy-of-fatal-immune-mediated-diseases-of-civilization-extended-life-expectancy-and-sudden-human-death-prevention
#14
JOURNAL ARTICLE
A S Bryukhovetskiy, L Yu Grivtsova, S S Bogachev, A A Ustyugov, V O Nebogatikov, M A Shurdov
A biotechnology for personalized ex vivo gene therapy based on molecular genomic balancing of hematopoietic stem cell (HSC) chromatin with nucleosome monomers of human genomic DNA (hDNAnmr ) has been developed and implemented in the clinic to change (to "correct") mutant chromosome loci genomes of dominant HSC clones that form mono- and oligoclonal hematopoiesis during aging and major (oncological, cardiovascular, neurodegenerative and autoimmune) fatal immune-mediated diseases of civilization. A fundamentally new biotechnological approach has been applied to the delivery of genetic material into eukaryotic stem and progenitor cells by establishing an artificial "recombinogenic situation" in them to induce homologous recombination (equivalent replacement) of mutant DNA regions with healthy hDNAnmr ...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833012/nicotine-neurotoxicity-exacerbation-following-engineered-ag-and-cu-50-60%C3%A2-nm-nanoparticles-intoxication-neuroprotection-with-nanowired-delivery-of-antioxidant-compound-h-290-51-together-with-serotonin-5-ht3-receptor-antagonist-ondansetron
#15
JOURNAL ARTICLE
Z Ryan Tian, Aruna Sharma, Dafin F Muresanu, Suraj Sharma, Lianyuan Feng, Zhiqiang Zhang, Cong Li, Anca D Buzoianu, José Vicente Lafuente, Ala Nozari, Per-Ove Sjöqvisst, Lars Wiklund, Hari Shanker Sharma
Nicotine abuse is frequent worldwide leading to about 8 millions people die every year due to tobacco related diseases. Military personnel often use nicotine smoking that is about 12.8% higher than civilian populations. Nicotine smoking triggers oxidative stress and are linked to several neurodegenerative diseases such as Alzheimer's disease. Nicotine neurotoxicity induces significant depression and oxidative stress in the brain leading to neurovascular damages and brain pathology. Thus, details of nicotine neurotoxicity and factors influencing them require additional investigations...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833011/co-administration-of-dl-3-n-butylphthalide-and-neprilysin-is-neuroprotective-in-alzheimer-disease-associated-with-mild-traumatic-brain-injury
#16
JOURNAL ARTICLE
Zhenguo G Wang, Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Hongyun Huang, Lin Chen, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharma
dl-3-n-Butylphthalide is a potent synthetic Chinese celery extract that is highly efficient in inducing neuroprotection in concussive head injury (CHI), Parkinson's disease, Alzheimer's disease, stroke as well as depression, dementia, anxiety and other neurological diseases. Thus, there are reasons to believe that dl-3-n-butylphthalide could effectively prevent Alzheimer's disease brain pathology. Military personnel during combat operation or veterans are often the victims of brain injury that is a major risk factor for developing Alzheimer's disease in their later lives...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37833010/efficacy-of-invasive-and-non-invasive-methods-for-the-treatment-of-parkinson-s-disease-nanodelivery-and-enriched-environment
#17
JOURNAL ARTICLE
Andrea Vaquero-Rodríguez, Jone Razquin, Maider Zubelzu, Raphaelle Bidgood, Harkaitz Bengoetxea, Cristina Miguelez, Teresa Morera-Herreras, Jose Angel Ruiz-Ortega, José Vicente Lafuente, Naiara Ortuzar
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta and the subsequent motor disability. The most frequently used treatments in clinics, such as L-DOPA, restore dopaminergic neurotransmission in the brain. However, these treatments are only symptomatic, have temporary efficacy, and produce side effects. Part of the side effects are related to the route of administration as the consumption of oral tablets leads to unspecific pulsatile activation of dopaminergic receptors...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37783564/nanowired-delivery-of-antibodies-to-tau-and-neuronal-nitric-oxide-synthase-together-with-cerebrolysin-attenuates-traumatic-brain-injury-induced-exacerbation-of-brain-pathology-in-parkinson-s-disease
#18
JOURNAL ARTICLE
Asya Ozkizilcik, Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharma
Concussive head injury (CHI) is one of the major risk factors for developing Parkinson's disease in later life of military personnel affecting lifetime functional and cognitive disturbances. Till date no suitable therapies are available to attenuate CHI or PD induced brain pathology. Thus, further exploration of novel therapeutic agents are highly warranted using nanomedicine in enhancing the quality of life of veterans or service members of US military. Since PD or CHI induces oxidative stress and perturbs neurotrophic factors regulation associated with phosphorylated tau (p-tau) deposition, a possibility exists that nanodelivery of agents that could enhance neurotrophic factors balance and attenuate oxidative stress could be neuroprotective in nature...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37783563/nanowired-delivery-of-dl-3-n-butylphthalide-with-antibodies-to-alpha-synuclein-potentiated-neuroprotection-in-parkinson-s-disease-with-emotional-stress
#19
JOURNAL ARTICLE
Lianyuan Feng, Aruna Sharma, Zhenguo Wang, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Cong Li, Ziquiang Zhang, Chen Lin, Hongyun Huang, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharma
Stress is one of the most serious consequences of life leading to several chronic diseases and neurodegeneration. Recent studies show that emotional stress and other kinds of anxiety and depression adversely affects Parkinson's disease symptoms. However, the details of how stress affects Parkinson's disease is still not well known. Traumatic brain injury, stroke, diabetes, post-traumatic stress disorders are well known to modify the disease precipitation, progression and persistence. However, show stress could influence Parkinson's disease is still not well known...
2023: International Review of Neurobiology
https://read.qxmd.com/read/37783562/susac-syndrome-can-be-diagnosed-by-examination-and-cured-by-comprehensive-therapy
#20
JOURNAL ARTICLE
Feifei Jiang, Zhiming Ma, Zhizhi Chen, Ming Yang, Hongyun Huang, Lin Chen, Chao He
No abstract text is available yet for this article.
2023: International Review of Neurobiology
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