Stimulation of cerebral angiogenesis and neurogenesis with transcatheter intracerebral laser photobiomodulation therapy during dementia in patients with Alzheimer's and Binswanger's disease.

BACKGROUND: The research investigates stimulation of cerebral angiogenesis and neurogenesis with Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT) in patients with dementia with Alzheimer's disease (AD) and Binswanger's disease (BD).

MATERIALS & METHODS: Examined 120 patients suffering from dementia. Accomplished: CDR assessment, Tomography Dementia Rating scale (TDR), MMSE, cerebral CT, MRI, SG, rheoencephalography (REG), cerebral MUGA. We chose 48 patients suffering from AD aged 34-80 (mean age 67.5), 17 men (35.42%) and 31 women (54.58%). The patients were subdivided according to dementia severity: preclinical stage (TDR-0 dementia level) - 4, mild stage (TDR-1 dementia level) - 16, moderately severe stage (TDR-2 dementia level) - 21, severe stage (TDR-3 dementia level) - 7 patients. 17 patients with BD aged 58-81 (mean age 78) were selected, 11 men (64.71%) and 6 women (35.29%). According to dementia severity, the patients were subdivided: mild stage (dementia level CDR-1) - 9, moderately severe stage (dementia level CDR-2) - 5 patients. In hospital setting, all patients underwent Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT).

RESULTS: All 48 (100%) patients with AD showed cerebral microcirculation improvement, as well as a 10-20% increase in cerebral temporal lobes volume, which indicates cerebral neurogenesis development and tissue regeneration. The process was accompanied by dementia level decline and cognitive functions restoration. As a result, patients were transferred to the milder TDR stage group. Depending on the initial dementia severity, the obtained positive effect has been observed for 2-10 years. All 17 (100%) patients with BD showed cerebral microcirculation improvement and cerebral involutional changes decline, which indicates neurogenesis development and tissue regeneration. The process was accompanied by dementia level decline and cognitive functions restoration. The resulting positive effect has been observed for over 10 years.

CONCLUSIONS: Despite the differences in the etiology of AD and BD, Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT) is an effective treatment for dementia during these diseases. The method improves cerebral blood flow; it stimulates neurogenesis and tissue structure restoration, which lead to dementia decline and cognitive functions improvement. The resulting effect lasts for a long time.