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Journals Alzheimer's & Dementia : the J...

Alzheimer's & Dementia : the Journal of the Alzheimer's Association

https://read.qxmd.com/read/38899634/premenopausal-bilateral-oophorectomy-and-brain-white-matter-brain-integrity-in-later-life
#1
JOURNAL ARTICLE
Michelle M Mielke, Ryan D Frank, Luke R Christenson, Robert I Reid, Julie A Fields, Zhenya E Knyazhanskaya, Firat Kara, Prashanthi Vemuri, Walter A Rocca, Kejal Kantarci
INTRODUCTION: Premenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity. METHODS: Female participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45 years; 39 with PBO 46-49 years; 907 referents without PBO < 50 years)...
June 20, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38899570/tpa-supplementation-preserves-neurovascular-and-cognitive-function-in-tg2576-mice
#2
JOURNAL ARTICLE
Ken Uekawa, Antoine Anfray, Sung Ji Ahn, Nicole Casey, James Seo, Ping Zhou, Costantino Iadecola, Laibaik Park
INTRODUCTION: Amyloid beta (Aβ) impairs the cerebral blood flow (CBF) increase induced by neural activity (functional hyperemia). Tissue plasminogen activator (tPA) is required for functional hyperemia, and in mouse models of Aβ accumulation tPA deficiency contributes to neurovascular and cognitive impairment. However, it remains unknown if tPA supplementation can rescue Aβ-induced neurovascular and cognitive dysfunction. METHODS: Tg2576 mice and wild-type littermates received intranasal tPA (0...
June 20, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38895994/association-of-estimated-pulse-wave-velocity-with-cognitive-function-in-a-multiethnic-diverse-population-the-northern-manhattan-study
#3
JOURNAL ARTICLE
Botagoz Aimagambetova, Taylor Ariko, Hannah Gardener, Bonnie Levin, Xiaoyan Sun, Jose Gutierrez, Mitchell Sv Elkind, Clinton B Wright, Tatjana Rundek
INTRODUCTION: Arterial stiffness is linked to age-related cognitive dysfunction. Estimated pulse wave velocity (ePWV) is associated with cerebrovascular disease. We sought to determine whether ePWV was associated with cognition in a multiethnic population. METHODS: We included 1257 participants enrolled in a Northern Manhattan Study magnetic resonance imaging MRI-cognitive study (mean age 64 ± 8 years, 61% women, 67% Hispanic, 18% non-Hispanic Black, 15% non-Hispanic white) and analyzed cognitive performance at two time points, at enrollment and on an average 5...
June 19, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38895921/potential-role-of-blood-pressure-variability-and-plasma-neurofilament-light-in-the-mechanism-of-comorbidity-between-alzheimer-s-disease-and-cerebral-small-vessel-disease
#4
JOURNAL ARTICLE
Qin Li, Shu Su, Yuxue Feng, Meng Jia, Jiehong Zhan, Zixuan Liao, Jiayu Li, Xiaofeng Li
INTRODUCTION: Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pNfL, and their association with the comorbidity of AD and CSVD remains unknown. METHODS: Participants with normal cognition and mild cognitive impairment from the Alzheimer's Disease Neuroimaging Initiative study were included in the data analysis...
June 19, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38889280/effect-of-apolipoprotein-e-%C3%AE%C2%B54-and-its-modification-by-sociodemographic-characteristics-on-cognitive-measures-in-south-asians-from-lasi-dad
#5
JOURNAL ARTICLE
Yi Zhe Wang, Wei Zhao, Priya Moorjani, Alden L Gross, Xiang Zhou, Aparajit B Dey, Jinkook Lee, Jennifer A Smith, Sharon L R Kardia
BACKGROUND: We investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD). METHODS: Linear regression was used to assess the association between APOE ε4 and global- and domain-specific cognitive function in 2563 participants (mean age 69.6 ± 7.3 years; 53% female)...
June 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38889242/development-of-a-prediction-model-for-cognitive-impairment-of-sarcopenia-using-multimodal-neuroimaging-in-non-demented-older-adults
#6
JOURNAL ARTICLE
Sunghwan Kim, Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Han Min Yoon, Soyoung Lee, Yeong Sim Choe, Regina Ey Kim, Donghyeon Kim, Chang Uk Lee, Hyun Kook Lim
INTRODUCTION: Despite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking. METHODS: We used data from 528 non-demented older adults with or without sarcopenia in the Catholic Aging Brain Imaging (CABI) database, containing magnetic resonance imaging scans, positron emission tomography scans, and clinical data. We also measured three key components of sarcopenia: skeletal muscle index (SMI), hand grip strength (HGS), and the five times sit-to-stand test (5STS)...
June 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38885334/relationships-between-pet-and-blood-plasma-biomarkers-in-corticobasal-syndrome
#7
JOURNAL ARTICLE
Neha Atulkumar Singh, Alla Alnobani, Jonathan Graff-Radford, Mary M Machulda, Michelle M Mielke, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, Takahisa Kanekiyo, Keith A Josephs, Jennifer L Whitwell
INTRODUCTION: Corticobasal syndrome (CBS) can result from underlying Alzheimer's disease (AD) pathologies. Little is known about the utility of blood plasma metrics to predict positron emission tomography (PET) biomarker-confirmed AD in CBS. METHODS: A cohort of eighteen CBS patients (8 amyloid beta [Aβ]+; 10 Aβ-) and 8 cognitively unimpaired (CU) individuals underwent PET imaging and plasma analysis. Plasma concentrations were compared using a Kruskal-Wallis test...
June 17, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38884346/characterization-of-neurofibrillary-tangle-immunophenotype-signatures-to-classify-tangle-maturity-in-alzheimer-s-disease
#8
JOURNAL ARTICLE
Danica Hamlin, Cameron Ryall, Clinton Turner, Richard L M Faull, Helen C Murray, Maurice A Curtis
INTRODUCTION: Tau aggregation into neurofibrillary tangles in Alzheimer's disease (AD) is a dynamic process involving changes in tau phosphorylation, isoform composition, and morphology. To facilitate studies of tangle maturity, we developed an image analysis pipeline to study antibody labeling signatures that can distinguish tangle maturity levels in AD brain tissue. METHODS: Using fluorescent immunohistochemistry, we co-labeled AD brain tissue with four antibodies that bind different tau epitopes...
June 17, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38884283/a-small-molecule-microtubule-stabilizing-agent-safely-reduces-a%C3%AE-plaque-and-tau-pathology-in-transgenic-mouse-models-of-alzheimer-s-disease
#9
JOURNAL ARTICLE
Yuemang Yao, Megan Muench, Thibault Alle, Bin Zhang, Bobby Lucero, Roxanne Perez-Tremble, Dominic McGrosso, Mira Newman, David J Gonzalez, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunden
INTRODUCTION: Intraneuronal inclusions composed of tau protein are found in Alzheimer's disease (AD) and other tauopathies. Tau normally binds microtubules (MTs), and its disengagement from MTs and misfolding in AD is thought to result in MT abnormalities. We previously identified triazolopyrimidine-containing MT-stabilizing compounds that provided benefit in AD mouse models and herein describe the characterization and efficacy testing of an optimized candidate, CNDR-51997. METHODS: CNDR-51997 underwent pharmacokinetic, pharmacodynamic, safety pharmacology, and mouse tolerability testing...
June 17, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38881491/cerebral-amyloid-angiopathy-and-the-immune-system
#10
REVIEW
Danielle Munsterman, Sarina Falcione, Rebecca Long, Roobina Boghozian, Twinkle Joy, Richard Camicioli, Eric E Smith, Glen C Jickling
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid protein in the walls of cerebral blood vessels. This deposition of amyloid causes damage to the cerebral vasculature, resulting in blood-brain barrier disruption, cerebral hemorrhage, cognitive decline, and dementia. The role of the immune system in CAA is complex and not fully understood. While the immune system has a clear role in the rare inflammatory variants of CAA (CAA related inflammation and Abeta related angiitis), the more common variants of CAA also have immune system involvement...
June 17, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38877688/in-vivo-effect-of-late-nc-on-integrity-of-white-matter-connections-to-the-hippocampus
#11
JOURNAL ARTICLE
Ashley Heywood, Jane Stocks, Julie A Schneider, Konstantinos Arfanakis, David A Bennett, Mirza Faisal Beg, Lei Wang
INTRODUCTION: TAR DNA-binding protein 43 (TDP-43) is a highly prevalent proteinopathy that is involved in neurodegenerative processes, including axonal damage. To date, no ante mortem biomarkers exist for TDP-43, and few studies have directly assessed its impact on neuroimaging measures utilizing pathologic quantification. METHODS: Ante mortem diffusion-weighted images were obtained from community-dwelling older adults. Regression models calculated the relationship between post mortem TDP-43 burden and ante mortem fractional anisotropy (FA) within each voxel in connection with the hippocampus, controlling for coexisting Alzheimer's disease and demographics...
June 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38877668/entorhinal-vessel-density-correlates-with-phosphorylated-tau-and-tdp-43-pathology
#12
JOURNAL ARTICLE
Josué Llamas Rodríguez, André J W van der Kouwe, Jan Oltmer, Emma Rosenblum, Nathaniel Mercaldo, Bruce Fischl, Michael Marshall, Matthew P Frosch, Jean C Augustinack
INTRODUCTION: The entorhinal cortex (EC) and perirhinal cortex (PC) are vulnerable to Alzheimer's disease. A triggering factor may be the interaction of vascular dysfunction and tau pathology. METHODS: We imaged post mortem human tissue at 100 μm3 with 7 T magnetic resonance imaging and manually labeled individual blood vessels (mean = 270 slices/case). Vessel density was quantified and compared per EC subfield, between EC and PC, and in relation to tau and TAR DNA-binding protein 43 (TDP-43) semiquantitative scores...
June 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38877664/patterns-of-cognitive-domain-abnormalities-enhance-discrimination-of-dementia-risk-prediction-the-aric-study
#13
JOURNAL ARTICLE
David S Knopman, James Russell Pike, Rebecca F Gottesman, A Richey Sharrett, B Gwen Windham, Thomas H Mosley, Kevin Sullivan, Marilyn S Albert, Keenan A Walker, Sevil Yasar, Sheila Burgard, David Li, Alden L Gross
INTRODUCTION: The contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated. METHODS: We analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities (ARIC) study. We examined associations of index domain-specific neuropsychological test performance with incident dementia using cumulative incidence curves and Cox proportional hazards models. RESULTS: Among 5296 initially dementia-free participants (mean [standard deviation] age of 75...
June 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38877658/mild-behavioral-impairment-domains-are-longitudinally-associated-with-ptau-and-metabolic-biomarkers-in-dementia-free-older-adults
#14
JOURNAL ARTICLE
Emmanuel Gonzalez-Bautista, Marie Momméja, Adelaïde de Mauléon, Zahinoor Ismail, Bruno Vellas, Julien Delrieu, Maria E Soto Martin
BACKGROUND: The mechanisms linking mild behavioral impairment (MBI) and Alzheimer's disease (AD) have been insufficiently explored, with conflicting results regarding tau protein and few data on other metabolic markers. We aimed to evaluate the longitudinal association of the MBI domains and a spectrum of plasma biomarkers. METHODS: Our study is a secondary analysis of data from NOLAN. The longitudinal association of the MBI domains with plasma biomarkers, including pTau181, was tested using adjusted linear mixed-effects models...
June 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38874322/gender-specific-analysis-of-social-connection-patterns-and-risk-of-dementia-in-community-dwelling-older-people
#15
JOURNAL ARTICLE
Htet Lin Htun, Achamyeleh Birhanu Teshale, Joanne Ryan, Alice J Owen, Robyn L Woods, Trevor T-J Chong, Anne M Murray, Raj C Shah, Suzanne G Orchard, Rosanne Freak-Poli
INTRODUCTION: Poor social connection is considered a risk factor for dementia. Since socializing behaviors may cluster together or act compensatorily, we aimed to investigate social connection patterns and their association with dementia, for men and women separately. METHODS: A total of 12,896 community-dwelling older adults (mean ± SD age: 75.2 ± 4.3 years, 54% women) without major cognitive impairment were included. Latent class analysis was conducted using 24 baseline social connection indicators...
June 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38874317/long-term-impact-of-type-2-diabetes-onset-on-dementia-incidence-rate-among-new-zealanders-with-impaired-glucose-tolerance-a-tapered-matched-landmark-analysis-over-25-years
#16
JOURNAL ARTICLE
Dahai Yu, Zheng Wang, Uchechukwu Levi Osuagwu, Karen Pickering, John Baker, Richard Cutfield, Yamei Cai, Brandon J Orr-Walker, Gerhard Sundborn, Bingjie Qu, Zhanzheng Zhao, David Simmons
INTRODUCTION: We aimed to investigate the association between the onset of type 2 diabetes (T2D) and dementia incidence rates (IR) in the population with impaired glucose tolerance (IGT) identified in primary care in New Zealand (NZ) over 25 years. METHODS: Tapered matching and landmark analysis (accounting for immortal bias) were used to control for potential effects of known confounders. The association between T2D onset and 5- and 10-year IR of dementia was estimated by weighted Cox models...
June 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38872387/gray-matter-volume-mediates-the-association-of-long-term-blood-pressure-variability-with-cognitive-function-in-an-adult-population
#17
JOURNAL ARTICLE
Xiaoshuai Li, Ying Hui, Huijing Shi, Rui Li, Han Lv, Yuntao Wu, Jing Li, Shun Zhang, Xiaoliang Liang, Shuohua Chen, Pengfei Zhao, Shouling Wu, Zhenchang Wang
INTRODUCTION: We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function. METHODS: We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020. Brain magnetic resonance imaging (MRI) and Montreal Cognitive Assessment (MoCA) were conducted in 2020. RESULTS: Higher systolic BPV (SBPV) and diastolic BPV (DBPV) were associated with lower total and frontal gray matter (GM) volume, and higher SBPV was associated with lower temporal GM volume...
June 13, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38867417/remote-and-unsupervised-digital-memory-assessments-can-reliably-detect-cognitive-impairment-in-alzheimer-s-disease
#18
JOURNAL ARTICLE
David Berron, Emil Olsson, Felix Andersson, Shorena Janelidze, Pontus Tideman, Emrah Düzel, Sebastian Palmqvist, Erik Stomrud, Oskar Hansson
INTRODUCTION: Remote unsupervised cognitive assessments have the potential to complement and facilitate cognitive assessment in clinical and research settings. METHODS: Here, we evaluate the usability, validity, and reliability of unsupervised remote memory assessments via mobile devices in individuals without dementia from the Swedish BioFINDER-2 study and explore their prognostic utility regarding future cognitive decline. RESULTS: Usability was rated positively; remote memory assessments showed good construct validity with traditional neuropsychological assessments and were significantly associated with tau-positron emission tomography and downstream magnetic resonance imaging measures...
June 12, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38865440/non-hemorrhagic-imaging-markers-of-cerebral-amyloid-angiopathy-in-memory-clinic-patients
#19
JOURNAL ARTICLE
Ana Sofia Costa, Milena Albrecht, Arno Reich, Omid Nikoubashman, Jörg B Schulz, Kathrin Reetz, João Pinho
INTRODUCTION: The Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) incorporated non-hemorrhagic imaging markers. Their prevalence and significance in patients with cognitive impairment remain uncertain. METHODS: We studied 622 memory clinic patients with available magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers. Two raters assessed non-hemorrhagic markers, and we explored their association with clinical characteristics through multivariate analyses...
June 12, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38865433/concurrent-nutrient-deficiencies-are-associated-with-dementia-incidence
#20
JOURNAL ARTICLE
Annick P M van Soest, Lisette C P G M de Groot, Renger F Witkamp, Debora Melo van Lent, Sudha Seshadri, Ondine van de Rest
INTRODUCTION: While observational research suggests a protective role for nutrition in brain aging, intervention studies remain inconclusive. This failing translation from observational to interventional research may result from overlooking nutrient interactions. METHODS: We developed a nutrient status index capturing the number of suboptimal statuses of omega-3 fatty acids, homocysteine, and vitamin D (range 0 to 3). We associated this index with dementia incidence in a subsample (age ≥ 50 years) of the Framingham Heart Study Offspring cohort...
June 12, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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