Hanna Cho, Nidhi S Mundada, Liana G Apostolova, Maria C Carrillo, Ranjani Shankar, Alinda N Amuiri, Ehud Zeltzer, Charles C Windon, David N Soleimani-Meigooni, Jeremy A Tanner, Courtney Lawhn Heath, Orit H Lesman-Segev, Paul Aisen, Ani Eloyan, Hye Sun Lee, Dustin B Hammers, Kala Kirby, Jeffrey L Dage, Anne Fagan, Tatiana Foroud, Lea T Grinberg, Clifford R Jack, Joel Kramer, Walter A Kukull, Melissa E Murray, Kelly Nudelman, Arthur Toga, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily J Rogalski, Stephen Salloway, Sharon Sha, Raymond Scott Turner, Thomas S Wingo, David A Wolk, Robert Koeppe, Leonardo Iaccarino, Bradford C Dickerson, Renaud La Joie, Gil D Rabinovici
INTRODUCTION: We aimed to describe baseline amyloid-beta (Aβ) and tau-positron emission tomograrphy (PET) from Longitudinal Early-onset Alzheimer's Disease Study (LEADS), a prospective multi-site observational study of sporadic early-onset Alzheimer's disease (EOAD). METHODS: We analyzed baseline [18F]Florbetaben (Aβ) and [18F]Flortaucipir (tau)-PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged < 65 years...
September 10, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association