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Journals
Alzheimer's & Dementia : the J...
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
#1
JOURNAL ARTICLE
Kevin P Kotredes, Ravi S Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W Miner, Kathryn A Haynes, Diogo Francisco S Santos, Sean-Paul Williams, Nicholas Heaton, Cynthia M Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel-Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T Lamb, Paul R Territo, Stacey J Sukoff Rizzo, Gregory W Carter, Gareth R Howell, Adrian L Oblak
INTRODUCTION: MODEL-AD (Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease) is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to capture the trajectory and progression of late-onset Alzheimer's disease (LOAD) more accurately. METHODS: We created the LOAD2 model by combining apolipoprotein E4 (APOE4), Trem2*R47H, and humanized amyloid-beta (Aβ). Mice were subjected to a control diet or a high-fat/high-sugar diet (LOAD2+HFD)...
May 12, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#2
JOURNAL ARTICLE
Martina Valletta, Davide Liborio Vetrano, Debora Rizzuto, Bengt Winblad, Marco Canevelli, Sarah Andersson, Matilda Dale, Claudia Fredolini, Laura Fratiglioni, Giulia Grande
INTRODUCTION: We explored the variations of blood biomarkers of Alzheimer's disease (AD) by chronic diseases and systemic inflammation. METHODS: We explored the association of AD blood biomarkers with chronic diseases and systemic inflammation (interleukin-6 [IL-6]), in 2366 dementia-free participants of the Swedish National Study on Aging and Care-in Kungsholmen, using quantile regression models. RESULTS: A greater number of co-occurring chronic diseases was associated with higher concentrations of phosphorylated-tau 181 (p-tau181), total-tau (t-tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) (p < 0...
May 8, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#3
JOURNAL ARTICLE
Jaime Ramos-Cejudo, June K Corrigan, Chunlei Zheng, Kaitlin N Swinnerton, Sean R Jacobson, Jennifer La, Rebecca A Betensky, Ricardo S Osorio, Sharon Madanes, Nunzio Pomara, Dan Iosifescu, Mary Brophy, Nhan V Do, Nathanael R Fillmore
INTRODUCTION: The use of antidepressants in major depressive disorder (MDD) has been reported to influence long-term risk of Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), but studies are conflicting. METHODS: We used inverse probability weighted (IPW) Cox models with time-varying covariates in a retrospective cohort study among midlife veterans with MDD within the US Veterans Affairs healthcare system from January 1, 2000 to June 1, 2022. RESULTS: A total of 35,200 patients with MDD were identified...
May 8, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#4
JOURNAL ARTICLE
Nicola Andrea Marchi, Véronique Daneault, Claire André, Marie-Ève Martineau-Dussault, Andrée-Ann Baril, Cynthia Thompson, Jacques Yves Montplaisir, Danielle Gilbert, Dominique Lorrain, Arnaud Boré, Maxime Descoteaux, Julie Carrier, Nadia Gosselin
INTRODUCTION: The limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied. METHODS: Polysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55-86 years, including 70 cognitively unimpaired participants and 56 participants with mild cognitive impairment (MCI)...
May 8, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#5
JOURNAL ARTICLE
Stéphane Tuffier, Jiawei Zhang, Marie Bergmann, Rina So, George Maria Napolitano, Thomas Cole-Hunter, Matija Maric, Sonja Antic, Jørgen Brandt, Matthias Ketzel, Steffen Loft, Youn-Hee Lim, Zorana Jovanovic Andersen
INTRODUCTION: We examined the association of long-term exposure to air pollution and road traffic noise with dementia incidence in the Danish Nurse Cohort. METHODS: Female nurses were followed for dementia incidence (hospital contact or medication prescription) from 1993/1999 to 2020. Air pollution and road traffic noise levels were estimated at nurses' residences, and their associations with dementia were examined using Cox regression models. RESULTS: Of 25,233 nurses 1409 developed dementia...
May 8, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#6
JOURNAL ARTICLE
Jiyong Liu, Yi Xiao, Xiaoting Zheng, Yangfan Cheng, Sirui Zhang, Yuanzheng Ma, Qirui Jiang, Shichan Wang, Chunyu Li, Huifang Shang
INTRODUCTION: The impact of early-life tobacco exposure on dementia has remained unknown. METHODS: Using the UK Biobank, the associations of maternal smoking during pregnancy (MSDP) and age of smoking initiation (ASI) with the onset time of all-cause dementia were estimated with accelerated failure time models. The effects of MSDP and ASI on brain structure and their genetic correlation to Alzheimer's disease (AD) were analyzed. A Mendelian randomization (MR) analysis was conducted...
May 7, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#7
JOURNAL ARTICLE
Aleksandra M Wojtas, Eric B Dammer, Qi Guo, Lingyan Ping, Ananth Shantaraman, Duc M Duong, Luming Yin, Edward J Fox, Fatemeh Seifar, Edward B Lee, Erik C B Johnson, James J Lah, Allan I Levey, Yona Levites, Srikant Rangaraju, Todd E Golde, Nicholas T Seyfried
INTRODUCTION: Cerebrovascular dysfunction is a pathological hallmark of Alzheimer's disease (AD). Nevertheless, detecting cerebrovascular changes within bulk tissues has limited our ability to characterize proteomic alterations from less abundant cell types. METHODS: We conducted quantitative proteomics on bulk brain tissues and isolated cerebrovasculature from the same individuals, encompassing control (N = 28), progressive supranuclear palsy (PSP) (N = 18), and AD (N = 21) cases...
May 7, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#8
JOURNAL ARTICLE
Kristen D Onos, Peter B Lin, Ravi S Pandey, Scott A Persohn, Charles P Burton, Ethan W Miner, Kierra Eldridge, Jonathan Nyandu Kanyinda, Kate E Foley, Gregory W Carter, Gareth R Howell, Paul R Territo
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein Eε4 (APOEε4) being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection. METHODS: PET imaging was used to assess metabolism-perfusion in both sexes of aging C57BL/6J, and hAPOE mice, and were verified by transcriptomics, and immunopathology. RESULTS: All hAPOE strains showed AD phenotype progression by 8 months, with females exhibiting the regional changes, which correlated with GO-term enrichments for glucose metabolism, perfusion, and immunity...
May 7, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#9
JOURNAL ARTICLE
Jiajia Fu, Xiaohui Lai, Chongwei Zhang, Qianqian Wei, Xueping Chen, Huifang Shang
INTRODUCTION: Platelets serve as the primary peripheral reservoir of amyloid beta (Aβ). However, there is limited research on platelet markers in routine blood examinations, particularly with regard to the large platelet ratio (P-LCR) in Alzheimer's disease (AD). METHODS: This study included 512 AD patients and 205 healthy controls (HCs). Platelet markers and apolipoprotein E (APOE) 4 status were assessed in all participants. RESULTS: The study revealed that P-LCR was significantly elevated in AD patients compared to HCs...
May 7, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#10
REVIEW
Yiqi Zhu, Soobin Park, Ramana Kolady, Wenqing Zha, Ying Ma, Amanda Dias, Katherine McGuire, Angela Hardi, Sunny Lin, Zahinoor Ismail, Paris B Adkins-Jackson, Jean-Francois Trani, Ganesh M Babulal
We investigate Alzheimer's disease and related dementia (ADRD) prevalence, incidence rate, and risk factors in individuals racialized as Asian and/or Asian-American and assess sample representation. Prevalence, incidence rate, risk factors, and heterogeneity of samples were assessed. Random-effects meta-analysis was conducted, generating pooled estimates. Of 920 records across 14 databases, 45 studies were included. Individuals racialized as Asian and/or Asian-American were mainly from Eastern and Southern Asia, had higher education, and constituted a smaller sample relative to non-Hispanic white cohorts...
May 6, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#11
JOURNAL ARTICLE
James E Galvin, Jeffrey L Cummings, Mihaela Levitchi Benea, Carl de Moor, Ricardo F Allegri, Alireza Atri, Howard Chertkow, Claire Paquet, Verna R Porter, Craig W Ritchie, Sietske A M Sikkes, Michael R Smith, Christina Marsica Grassi, Ivana Rubino
Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes in the real world is challenging owing to variation in data collected across centers and specialties and greater heterogeneity of patients compared with trial participants. Here, we share considerations for observational postapproval studies designed to collect harmonized longitudinal data from individuals with mild cognitive impairment or mild dementia stage of disease who receive therapies targeting the underlying pathological processes of AD in routine practice...
May 6, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#12
JOURNAL ARTICLE
Shixie Jiang, Jingyu Huang, Hao Yang, Richard Czuma, Lauren Farley, Alexis Cohen-Oram, Kimberly Hartney, Kristina Chechotka, F Andrew Kozel, Huabei Jiang
INTRODUCTION: Delirium is associated with mortality and new onset dementia, yet the underlying pathophysiology remains poorly understood. Development of imaging biomarkers has been difficult given the challenging nature of imaging delirious patients. Diffuse optical tomography (DOT) offers a promising approach for investigating delirium given its portability and three-dimensional capabilities. METHODS: Twenty-five delirious and matched non-delirious patients (n = 50) were examined using DOT, comparing cerebral oxygenation and functional connectivity in the prefrontal cortex during and after an episode of delirium...
May 3, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#13
REVIEW
Raj Kalaria, Gladys Maestre, Simin Mahinrad, Daisy M Acosta, Rufus Olusola Akinyemi, Suvarna Alladi, Ricardo F Allegri, Faheem Arshad, David Oluwasayo Babalola, Olusegun Baiyewu, Thomas H Bak, Tarek Bellaj, David K Brodie-Mends, Maria C Carrillo, Kaputu-Kalala-Malu Celestin, Albertino Damasceno, Ranil Karunamuni de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope H Farombi, Robert P Friedland, Noe Garza, Antoine Gbessemehlan, Eliza Eleni-Zacharoula Georgiou, Ishtar Govia, Lea T Grinberg, Maëlenn Guerchet, Seid Ali Gugssa, Joy Louise Gumikiriza-Onoria, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Thomas Gregor Issac, Linus Jönsson, Wambui M Karanja, Joseph H Lee, Iracema Leroi, Gill Livingston, Facundo Francisco Manes, Lingani Mbakile-Mahlanza, Bruce L Miller, Christine Wayua Musyimi, Victoria N Mutiso, Noeline Nakasujja, David M Ndetei, Sam Nightingale, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius A Ogeng'o, Adesola Ogunniyi, Maira Okada de Oliveira, Njideka U Okubadejo, Martin Orrell, Stella-Maria Paddick, Margaret A Pericak-Vance, Zvezdan Pirtosek, Felix Claude Victor Potocnik, Rema Raman, Mie Rizig, Mónica Rosselli, Marufjon Salokhiddinov, Claudia L Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire E Sexton, Ingmar Skoog, Peter H St George-Hyslop, Claudia Kimie Suemoto, Prekshy Thapa, Chinedu Theresa Udeh-Momoh, Victor Valcour, Jeffery M Vance, Mathew Varghese, Jaime H Vera, Richard W Walker, Henrik Zetterberg, Yared Z Zewde, Ozama Ismail
Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high-income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC-focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations...
May 2, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#14
JOURNAL ARTICLE
Nancy Kerner, Terry E Goldberg, Hannah R Cohen, Julia G Phillips, Daniel E Cohen, Howard Andrews, Gregory Pelton, Davangere P Devanand
INTRODUCTION: The effects of sleep-wake behavior on perceived fatigability and cognitive abilities when performing daily activities have not been investigated across levels of cognitive reserve (CR). METHODS: CR Index Questionnaire (CRIq) data were collected and subjected to moderated mediation analysis. RESULTS: In amnestic mild cognitive impairment (aMCI; n = 41), CR moderated sleep-related impairments (SRIs), and fatigability at low CR (CRIq < 105...
May 1, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#15
JOURNAL ARTICLE
(no author information available yet)
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The Special Report discusses the larger health care system for older adults with cognitive issues, focusing on the role of caregivers and non-physician health care professionals. An estimated 6.9 million Americans age 65 and older are living with Alzheimer's dementia today...
April 30, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#16
JOURNAL ARTICLE
Michael Sasner, Christoph Preuss, Ravi S Pandey, Asli Uyar, Dylan Garceau, Kevin P Kotredes, Harriet Williams, Adrian L Oblak, Peter Bor-Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee-Gosselin, Bruce T Lamb, Gareth R Howell, Gregory W Carter
INTRODUCTION: Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer's disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease relevance and mechanism of action. METHODS: Candidate genetic risk variants were informatically prioritized and individually engineered into a LOAD-sensitized mouse model that carries the AD risk variants APOE ε4/ε4 and Trem2*R47H. The potential disease relevance of each model was assessed by comparing brain transcriptomes measured with the Nanostring Mouse AD Panel at 4 and 12 months of age with human study cohorts...
April 30, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#17
REVIEW
Duncan Sinclair, Alison J Canty, Jenna M Ziebell, Adele Woodhouse, Jessica M Collins, Sharn Perry, Eddy Roccati, Maneesh Kuruvilla, Jacqueline Leung, Rachel Atkinson, James C Vickers, Anthony L Cook, Anna E King
Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia...
April 30, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#18
JOURNAL ARTICLE
Tom Earnest, Abdalla Bani, Sung Min Ha, Diana A Hobbs, Deydeep Kothapalli, Braden Yang, John J Lee, Tammie L S Benzinger, Brian A Gordon, Aristeidis Sotiras
INTRODUCTION: Previous approaches pursuing in vivo staging of tau pathology in Alzheimer's disease (AD) have typically relied on neuropathologically defined criteria. In using predefined systems, these studies may miss spatial deposition patterns which are informative of disease progression. METHODS: We selected discovery (n = 418) and replication (n = 132) cohorts with flortaucipir imaging. Non-negative matrix factorization (NMF) was applied to learn tau covariance patterns and develop a tau staging system...
April 29, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#19
JOURNAL ARTICLE
Ravi S Pandey, Mattias Arnold, Richa Batra, Jan Krumsiek, Kevin P Kotredes, Dylan Garceau, Harriet Williams, Michael Sasner, Gareth R Howell, Rima Kaddurah-Daouk, Gregory W Carter
INTRODUCTION: Increasing evidence suggests that metabolic impairments contribute to early Alzheimer's disease (AD) mechanisms and subsequent dementia. Signals in metabolic pathways conserved across species can facilitate translation. METHODS: We investigated differences in serum and brain metabolites between the early-onset 5XFAD and late-onset LOAD1 (APOE4.Trem2*R47H) mouse models of AD to C57BL/6J controls at 6 months of age. RESULTS: We identified sex differences for several classes of metabolites, such as glycerophospholipids, sphingolipids, and amino acids...
April 27, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#20
LETTER
Pasquale Gallina, Francesco Lolli, Berardino Porfirio
No abstract text is available yet for this article.
April 27, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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