JOURNAL ARTICLE

Montelukast alleviates inflammation in experimental autoimmune encephalomyelitis by altering Th17 differentiation in a mouse model

Bing Han, Yan-Yan Zhang, Ze-Qing Ye, Yun Xiao, Javad Rasouli, Wen-Cheng Wu, Su-Min Ye, Xin-Yue Guo, Lin Zhu, Abdolmohamad Rostami, Li-Bin Wang, Yuan Zhang, Xing Li
Immunology 2021 January 22
33480040
Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotrienes receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through disrupting chemotaxis of infiltrating T cells. However, the role of CysLTR1 in the pathogenesis of MS is not well understood. Here, we show that MS patients had higher expression of CysLTR1 in the circulation and central nervous system (CNS). The majority of CD4+ T cells expressed CysLTR1 in MS lesions. Among T cell subsets, Th17 cells had the highest expression of CysLTR1, and blocking CysLTR1 signaling abrogated their development in vitro. Inhibition of CysLTR1 by montelukast suppressed EAE development in both a prophylactic and therapeutic manner and inhibited myelin loss in EAE mice. Similarly, the in vivo results showed that montelukast inhibited Th17 response in EAE mice and that Th17 cells treated with montelukast had reduced encephalitogenic in adoptive EAE. Our findings strongly suggest that targeting Th17 response by inhibiting CysLTR1 signaling could be a promising therapeutic strategy for the treatment of MS and CNS inflammatory diseases.

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