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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Nature Medicine 2018 December
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.
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