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Sonia Muliyil
No abstract text is available yet for this article.
November 28, 2023: Nature Medicine
#2
Hanane Laklai, Yekaterina A Miroshnikova, Michael W Pickup, Eric A Collisson, Grace E Kim, Alex S Barrett, Ryan C Hill, Johnathon N Lakins, David D Schlaepfer, Janna K Mouw, Valerie S LeBleu, Nilotpal Roy, Sergey V Novitskiy, Julia S Johansen, Valeria Poli, Raghu Kalluri, Christine A Iacobuzio-Donahue, Laura D Wood, Matthias Hebrok, Kirk Hansen, Harold L Moses, Valerie M Weaver
No abstract text is available yet for this article.
November 28, 2023: Nature Medicine
#3
Author Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis.
Charlotte Fenioux, Baptiste Abbar, Samia Boussouar, Marie Bretagne, John R Power, Javid J Moslehi, Paul Gougis, Damien Amelin, Agnès Dechartres, Lorenz H Lehmann, Pierre-Yves Courand, Jennifer Cautela, Joachim Alexandre, Adrien Procureur, Antoine Rozes, Sarah Leonard-Louis, Juan Qin, Rémi Cheynier, Benedicte Charmeteau-De Muylder, Alban Redheuil, Florence Tubach, Jacques Cadranel, Audrey Milon, Stéphane Ederhy, Thomas Similowski, Douglas B Johnson, Ian Pizzo, Toniemarie Catalan, Olivier Benveniste, Salim S Hayek, Yves Allenbach, Michelle Rosenzwajg, Charles Dolladille, Joe-Elie Salem
No abstract text is available yet for this article.
November 27, 2023: Nature Medicine
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2023: Nature Medicine
#5
JOURNAL ARTICLE
Raymond Duch, Edward Asiedu, Ryota Nakamura, Thomas Rouyard, Alberto Mayol, Adrian Barnett, Laurence Roope, Mara Violato, Dorcas Sowah, Piotr Kotlarz, Philip Clarke
We implemented a clustered randomized controlled trial with 6,963 residents in six rural Ghana districts to estimate the causal impact of financial incentives on coronavirus disease 2019 (COVID-19) vaccination uptake. Villages randomly received one of four video treatment arms: a placebo, a standard health message, a high cash incentive (60 Ghana cedis) and a low cash incentive (20 Ghana cedis). For the first co-primary outcome-COVID-19 vaccination intentions-non-vaccinated participants assigned to the cash incentive treatments had an average rate of 81% (1,733 of 2,168) compared to 71% (1,895 of 2,669) for those in the placebo treatment arm...
November 27, 2023: Nature Medicine
#6
JOURNAL ARTICLE
Mohamed Amgad, James M Hodge, Maha A T Elsebaie, Clara Bodelon, Samantha Puvanesarajah, David A Gutman, Kalliopi P Siziopikou, Jeffery A Goldstein, Mia M Gaudet, Lauren R Teras, Lee A D Cooper
Breast cancer is a heterogeneous disease with variable survival outcomes. Pathologists grade the microscopic appearance of breast tissue using the Nottingham criteria, which are qualitative and do not account for noncancerous elements within the tumor microenvironment. Here we present the Histomic Prognostic Signature (HiPS), a comprehensive, interpretable scoring of the survival risk incurred by breast tumor microenvironment morphology. HiPS uses deep learning to accurately map cellular and tissue structures to measure epithelial, stromal, immune, and spatial interaction features...
November 27, 2023: Nature Medicine
#7
Jong-Seok Moon, Kiichi Nakahira, Kuei-Pin Chung, Gina M DeNicola, Michael Jakun Koo, Maria A Pabón, Kristen T Rooney, Joo-Heon Yoon, Stefan W Ryter, Heather Stout-Delgado, Augustine M K Choi
No abstract text is available yet for this article.
November 24, 2023: Nature Medicine
#8
JOURNAL ARTICLE
Lorenzo Leggio, Christian S Hendershot, Mehdi Farokhnia, Anders Fink-Jensen, Mette Kruse Klausen, Joseph P Schacht, W Kyle Simmons
No abstract text is available yet for this article.
November 24, 2023: Nature Medicine
#9
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2023: Nature Medicine
#10
JOURNAL ARTICLE
Rick Essers, Igor N Lebedev, Ants Kurg, Elizaveta A Fonova, Servi J C Stevens, Rebekka M Koeck, Ulrike von Rango, Lloyd Brandts, Spyridon Panagiotis Deligiannis, Tatyana V Nikitina, Elena A Sazhenova, Ekaterina N Tolmacheva, Anna A Kashevarova, Dmitry A Fedotov, Viktoria V Demeneva, Daria I Zhigalina, Gleb V Drozdov, Salwan Al-Nasiry, Merryn V E Macville, Arthur van den Wijngaard, Jos Dreesen, Aimee Paulussen, Alexander Hoischen, Han G Brunner, Andres Salumets, Masoud Zamani Esteki
Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental lineages during intrauterine development remain elusive. In this study, we analyzed 1,745 spontaneous pregnancy losses and found that roughly half (50.4%) of the products of conception (POCs) were karyotypically abnormal, with maternal and paternal age independently contributing to the increased genomic aberration rate. We applied genome haplarithmisis to a subset of 94 pregnancy losses with normal parental and POC karyotypes...
November 23, 2023: Nature Medicine
#11
Karen O'Leary
No abstract text is available yet for this article.
November 23, 2023: Nature Medicine
#12
Pablo Sánchez Vela, Jennifer J Trowbridge, Ross L Levine
No abstract text is available yet for this article.
November 20, 2023: Nature Medicine
#13
JOURNAL ARTICLE
Kai Cao, Yingda Xia, Jiawen Yao, Xu Han, Lukas Lambert, Tingting Zhang, Wei Tang, Gang Jin, Hui Jiang, Xu Fang, Isabella Nogues, Xuezhou Li, Wenchao Guo, Yu Wang, Wei Fang, Mingyan Qiu, Yang Hou, Tomas Kovarnik, Michal Vocka, Yimei Lu, Yingli Chen, Xin Chen, Zaiyi Liu, Jian Zhou, Chuanmiao Xie, Rong Zhang, Hong Lu, Gregory D Hager, Alan L Yuille, Le Lu, Chengwei Shao, Yu Shi, Qi Zhang, Tingbo Liang, Ling Zhang, Jianping Lu
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental detection is associated with prolonged survival, but screening asymptomatic individuals for PDAC using a single test remains unfeasible due to the low prevalence and potential harms of false positives. Non-contrast computed tomography (CT), routinely performed for clinical indications, offers the potential for large-scale screening, however, identification of PDAC using non-contrast CT has long been considered impossible...
November 20, 2023: Nature Medicine
#14
JOURNAL ARTICLE
Jörg Kleeff, Ulrich Ronellenfitsch
No abstract text is available yet for this article.
November 20, 2023: Nature Medicine
#15
JOURNAL ARTICLE
Lindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, Daniel Landi, Jasper van der Lugt, Sarah E S Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J Waanders, David S Ziegler, Olaf Witt, Patricia A Baxter, Hyoung Jin Kang, Timothy E Hassall, Jung Woo Han, Darren Hargrave, Andrea T Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche, Cassie Kline, Mohamed S Abdelbaki, Nada Jabado, Nicholas G Gottardo, Nicolas U Gerber, Nicholas S Whipple, Devorah Segal, Susan N Chi, Liat Oren, Enrica E K Tan, Sabine Mueller, Izzy Cornelio, Lisa McLeod, Xin Zhao, Ashley Walter, Daniel Da Costa, Peter Manley, Samuel C Blackman, Roger J Packer, Karsten Nysom
BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 (n = 77) of the ongoing phase 2 FIREFLY-1 (PNOC026) trial investigated the efficacy of the oral, selective, central nervous system-penetrant, type II RAF inhibitor tovorafenib (420 mg m- 2 once weekly; 600 mg maximum) in patients with BRAF-altered, relapsed/refractory pLGG. Arm 2 (n = 60) is an extension cohort, which provided treatment access for patients with RAF-altered pLGG after arm 1 closure...
November 17, 2023: Nature Medicine
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
November 16, 2023: Nature Medicine
#17
JOURNAL ARTICLE
Annie Y Ng, Cary J G Oberije, Éva Ambrózay, Endre Szabó, Orsolya Serfőző, Edit Karpati, Georgia Fox, Ben Glocker, Elizabeth A Morris, Gábor Forrai, Peter D Kecskemethy
Artificial intelligence (AI) has the potential to improve breast cancer screening; however, prospective evidence of the safe implementation of AI into real clinical practice is limited. A commercially available AI system was implemented as an additional reader to standard double reading to flag cases for further arbitration review among screened women. Performance was assessed prospectively in three phases: a single-center pilot rollout, a wider multicenter pilot rollout and a full live rollout. The results showed that, compared to double reading, implementing the AI-assisted additional-reader process could achieve 0...
November 16, 2023: Nature Medicine
#18
JOURNAL ARTICLE
Michael Spencer Chapman, Alyssa H Cull, Marioara F Ciuculescu, Erica B Esrick, Emily Mitchell, Hyunchul Jung, Laura O'Neill, Kirsty Roberts, Margarete A Fabre, Nicholas Williams, Jyoti Nangalia, Joanne Quinton, James M Fox, Danilo Pellin, Julie Makani, Myriam Armant, David A Williams, Peter J Campbell, David G Kent
Gene therapy (GT) provides a potentially curative treatment option for patients with sickle cell disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials has prompted concern, with several postulated mechanisms. Here, we used whole-genome sequencing to track hematopoietic stem cells (HSCs) from six patients with SCD at pre- and post-GT time points to map the somatic mutation and clonal landscape of gene-modified and unmodified HSCs. Pre-GT, phylogenetic trees were highly polyclonal and mutation burdens per cell were elevated in some, but not all, patients...
November 16, 2023: Nature Medicine
#19
JOURNAL ARTICLE
Jae-Young Yoo, Seyong Oh, Wissam Shalish, Woo-Youl Maeng, Emily Cerier, Emily Jeanne, Myung-Kun Chung, Shasha Lv, Yunyun Wu, Seonggwang Yoo, Andreas Tzavelis, Jacob Trueb, Minsu Park, Hyoyoung Jeong, Efe Okunzuwa, Slobodanka Smilkova, Gyeongwu Kim, Junha Kim, Gooyoon Chung, Yoonseok Park, Anthony Banks, Shuai Xu, Guilherme M Sant'Anna, Debra E Weese-Mayer, Ankit Bharat, John A Rogers
The human body generates various forms of subtle, broadband acousto-mechanical signals that contain information on cardiorespiratory and gastrointestinal health with potential application for continuous physiological monitoring. Existing device options, ranging from digital stethoscopes to inertial measurement units, offer useful capabilities but have disadvantages such as restricted measurement locations that prevent continuous, longitudinal tracking and that constrain their use to controlled environments...
November 16, 2023: Nature Medicine
#20
Sonia Muliyil
No abstract text is available yet for this article.
November 16, 2023: Nature Medicine
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