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Nature Medicine

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https://read.qxmd.com/read/30903101/author-correction-adrenergic-nerve-degeneration-in-bone-marrow-drives-aging-of-the-hematopoietic-stem-cell-niche
#1
Maria Maryanovich, Ali H Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara, Noboru Asada, Qiaozhi Wei, Xizhe Wang, Paul Ciero, Jianing Xu, Avigdor Leftin, Paul S Frenette
In the version of this article originally published, the key for Fig. 4c was incorrect. The symbols for 'Sham' and 'Den' were reversed. The error has been corrected in the PDF and HTML versions of the manuscript.
March 22, 2019: Nature Medicine
https://read.qxmd.com/read/30886409/the-repertoire-of-maternal-anti-viral-antibodies-in-human-newborns
#2
Christian Pou, Dieudonné Nkulikiyimfura, Ewa Henckel, Axel Olin, Tadepally Lakshmikanth, Jaromir Mikes, Jun Wang, Yang Chen, Anna Karin Bernhardsson, Anna Gustafsson, Kajsa Bohlin, Petter Brodin
All circulating immunoglobulin G (IgG) antibodies in human newborns are of maternal origin1 and transferred across the placenta to provide passive immunity until newborn IgG production takes over 15 weeks after birth2 . However, maternal IgG can also negatively interfere with newborn vaccine responses3 . The concentration of IgG increases sharply during the third trimester of gestation and children delivered extremely preterm are believed to largely lack this passive immunity1,2,4 . Antibodies to individual viruses have been reported5-12 , but the global repertoire of maternal IgG, its variation in children, and the epitopes targeted are poorly understood...
March 18, 2019: Nature Medicine
https://read.qxmd.com/read/30858617/causal-associations-of-blood-lipids-with-risk-of-ischemic-stroke-and-intracerebral-hemorrhage-in-chinese-adults
#3
Luanluan Sun, Robert Clarke, Derrick Bennett, Yu Guo, Robin G Walters, Michael Hill, Sarah Parish, Iona Y Millwood, Zheng Bian, Yiping Chen, Canqing Yu, Jun Lv, Rory Collins, Junshi Chen, Richard Peto, Liming Li, Zhengming Chen
Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2 . Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2 . Stroke incidence and ICH proportion are higher in China than in Western populations3-5 , despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of LDL-C with IS than with coronary heart disease (CHD)6,7 , but LDL-C-lowering trials demonstrated similar risk reductions for IS and CHD8-10 ...
March 11, 2019: Nature Medicine
https://read.qxmd.com/read/30858616/altered-neuronal-migratory-trajectories-in-human-cerebral-organoids-derived-from-individuals-with-neuronal-heterotopia
#4
Johannes Klaus, Sabina Kanton, Christina Kyrousi, Ane Cristina Ayo-Martin, Rossella Di Giaimo, Stephan Riesenberg, Adam C O'Neill, J Gray Camp, Chiara Tocco, Malgorzata Santel, Ejona Rusha, Micha Drukker, Mariana Schroeder, Magdalena Götz, Stephen P Robertson, Barbara Treutlein, Silvia Cappello
Malformations of the human cortex represent a major cause of disability1 . Mouse models with mutations in known causal genes only partially recapitulate the phenotypes and are therefore not unlimitedly suited for understanding the molecular and cellular mechanisms responsible for these conditions2 . Here we study periventricular heterotopia (PH) by analyzing cerebral organoids derived from induced pluripotent stem cells (iPSCs) of patients with mutations in the cadherin receptor-ligand pair DCHS1 and FAT4 or from isogenic knockout (KO) lines1,3 ...
March 11, 2019: Nature Medicine
https://read.qxmd.com/read/30846883/publisher-correction-microbial-network-disturbances-in-relapsing-refractory-crohn-s-disease
#5
Bahtiyar Yilmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E H Pittet, Michel H Maillard, Gerhard Rogler, Reiner Wiest, Jörg Stelling, Andrew J Macpherson
Owing to an error during typesetting, a number of references were deleted from the Methods reference list. This altered all of the references in the Methods section and some of the references in Extended Data Fig. 5, making them inaccurate. References 121-134 were added back into the Methods reference list, and the references in the Methods section and in Extended Data Fig. 5 were renumbered accordingly. The error has been corrected in the PDF and HTML versions of this article.
March 7, 2019: Nature Medicine
https://read.qxmd.com/read/30842679/the-microbiome-cancer-and-cancer-therapy
#6
REVIEW
Beth A Helmink, M A Wadud Khan, Amanda Hermann, Vancheswaran Gopalakrishnan, Jennifer A Wargo
With the advent of next-generation sequencing, we have an unprecedented ability to study tumor and host genomes as well as those of the vast array of microorganisms that exist within living organisms. Evidence now suggests that these microbes may confer susceptibility to certain cancers and may also influence response to therapeutics. A prime example of this is seen with immunotherapy, for which gut microbes have been implicated in influencing therapeutic responses in preclinical models and patient cohorts...
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842678/dysregulation-of-a-long-noncoding-rna-reduces-leptin-leading-to-a-leptin-responsive-form-of-obesity
#7
Olof S Dallner, Jill M Marinis, Yi-Hsueh Lu, Kivanc Birsoy, Emory Werner, Gulya Fayzikhodjaeva, Brian D Dill, Henrik Molina, Arden Moscati, Zoltán Kutalik, Pedro Marques-Vidal, Tuomas O Kilpeläinen, Niels Grarup, Allan Linneberg, Yinxin Zhang, Roger Vaughan, Ruth J F Loos, Mitchell A Lazar, Jeffrey M Friedman
Quantitative changes in leptin concentration lead to alterations in food intake and body weight, but the regulatory mechanisms that control leptin gene expression are poorly understood. Here we report that fat-specific and quantitative leptin expression is controlled by redundant cis elements and trans factors interacting with the proximal promoter together with a long noncoding RNA (lncOb). Diet-induced obese mice lacking lncOb show increased fat mass with reduced plasma leptin levels and lose weight after leptin treatment, whereas control mice do not...
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842677/genomic-correlates-of-response-to-immune-checkpoint-blockade
#8
REVIEW
Tanya E Keenan, Kelly P Burke, Eliezer M Van Allen
Despite impressive durable responses, immune checkpoint inhibitors do not provide a long-term benefit to the majority of patients with cancer. Understanding genomic correlates of response and resistance to checkpoint blockade may enhance benefits for patients with cancer by elucidating biomarkers for patient stratification and resistance mechanisms for therapeutic targeting. Here we review emerging genomic markers of checkpoint blockade response, including those related to neoantigens, antigen presentation, DNA repair, and oncogenic pathways...
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842676/targeting-epigenetic-modifications-in-cancer-therapy-erasing-the-roadmap-to-cancer
#9
REVIEW
Helai P Mohammad, Olena Barbash, Caretha L Creasy
Epigenetic dysregulation is a common feature of most cancers, often occurring directly through alteration of epigenetic machinery. Over the last several years, a new generation of drugs directed at epigenetic modulators have entered clinical development, and results from these trials are now being disclosed. Unlike first-generation epigenetic therapies, these new agents are selective, and many are targeted to proteins which are mutated or translocated in cancer. This review will provide a summary of the epigenetic modulatory agents currently in clinical development and discuss the opportunities and challenges in their development...
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842675/a-clinically-meaningful-metric-of-immune-age-derived-from-high-dimensional-longitudinal-monitoring
#10
Ayelet Alpert, Yishai Pickman, Michael Leipold, Yael Rosenberg-Hasson, Xuhuai Ji, Renaud Gaujoux, Hadas Rabani, Elina Starosvetsky, Ksenya Kveler, Steven Schaffert, David Furman, Oren Caspi, Uri Rosenschein, Purvesh Khatri, Cornelia L Dekker, Holden T Maecker, Mark M Davis, Shai S Shen-Orr
Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering quantification of an individual's immune age. Here, we use multiple 'omics' technologies to capture population- and individual-level changes in the human immune system of 135 healthy adult individuals of different ages sampled longitudinally over a nine-year period. We observed high inter-individual variability in the rates of change of cellular frequencies that was dictated by their baseline values, allowing identification of steady-state levels toward which a cell subset converged and the ordered convergence of multiple cell subsets toward an older adult homeostasis...
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842674/developmental-origins-and-emerging-therapeutic-opportunities-for-childhood-cancer
#11
REVIEW
Mariella Filbin, Michelle Monje
Cancer is the leading disease-related cause of death in children in developed countries. Arising in the context of actively growing tissues, childhood cancers are fundamentally diseases of dysregulated development. Childhood cancers exhibit a lower overall mutational burden than adult cancers, and recent sequencing studies have revealed that the genomic events central to childhood oncogenesis include mutations resulting in broad epigenetic changes or translocations that result in fusion oncoproteins. Here, we will review the developmental origins of childhood cancers, epigenetic dysregulation in tissue stem/precursor cells in numerous examples of childhood cancer oncogenesis and emerging therapeutic opportunities aimed at both cell-intrinsic and microenvironmental targets together with new insights into the mechanisms underlying long-term sequelae of childhood cancer therapy...
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842673/think-globally-about-cancer
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842672/immunoprofiling-comes-of-age
#13
Soumya Raychaudhuri, Rajat M Gupta
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842671/molecular-responses-to-immune-checkpoint-blockade-in-glioblastoma
#14
Hirotaka Ito, Hiroshi Nakashima, E Antonio Chiocca
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842670/direct-to-stomach-delivery
#15
Hannah Stower
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842669/depression-linked-to-the-microbiome
#16
Hannah Stower
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842667/mosquito-deterrent
#17
Hannah Stower
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842666/linking-alzheimer-s-disease-and-frailty
#18
Hannah Stower
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842665/spreading-the-search
#19
Brianna Abbott
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
https://read.qxmd.com/read/30842664/making-a-difference-to-many
#20
Georgina V Long
No abstract text is available yet for this article.
March 6, 2019: Nature Medicine
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