journal
https://read.qxmd.com/read/37737678/explore-the-optimal-timing-for-administering-the-second-dose-of-the-varicella-vaccine-in-china
#1
JOURNAL ARTICLE
Xiang Sun, Yong Wang, Lei Zhang, Yuanbao Liu, Ling-Xiao Xu, Qiang Chen, Hui Sun, Fangfang Wang, Zhiguo Wang, Wen Wang
The prevalence of varicella in China has been increasing annually, with a relatively high incidence rate of breakthrough cases. Administering two doses of the varicella vaccine (Varv) proves to be the most effective measure. The objective of this study is to assess the immunogenicity of two doses of the Varv at varying intervals and explore the optimal timing for administering the second dose of the Varv. Utilizing a prospective cohort study design, the quantification of varicella immunoglobulin G (IgG) antibodies' geometric mean concentrations (GMC) is conducted through glycoprotein-based enzyme-linked immunosorbent assay (gpELISA)...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37732629/association-of-seizure-with-covid-19-vaccines-in-persons-with-epilepsy-a-systematic-review-and-meta-analysis
#2
REVIEW
Ali Rafati, Melika Jameie, Mobina Amanollahi, Mana Jameie, Yeganeh Pasebani, Delaram Sakhaei, Saba Ilkhani, Sina Rashedi, Mohammad Yazdan Pasebani, Mohammadreza Azadi, Mehran Rahimlou, Churl-Su Kwon
Seizure aggravation following coronavirus disease 2019 (COVID-19) vaccines is a major cause behind vaccine hesitancy among persons with epilepsy (PwE), resulting in lower immunization rates. We systematically reviewed seizure-activity-related events in PwE following COVID-19 vaccination. We systematically searched PubMed, Web of Science, Scopus, and Cochrane Library, until January 31, 2023, and included articles reporting seizure activity-related events in PwE receiving COVID-19 vaccination. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37728394/evaluation-of-a-rapid-chip-based-micro-pcr-assay-for-detection-of-rabies-virus-in-human-and-canine-specimens
#3
JOURNAL ARTICLE
Lonika Lodha, Ashwini M Ananda, Arya Ramachandran, Sathya Priya Manuel, Sujatha Valagere Sannaiah, Anita Mahadevan, Reeta S Mani
Rabies, a lethal zoonotic encephalitis, remains a significant global health concern, causing an estimated 60 000 annual fatalities worldwide. Dogs serve as the primary reservoirs and vectors for transmitting this infection to humans. Definitive diagnosis of rabies in both human and animal cases necessitates laboratory testing involving various clinical specimens. However, the complexity of laboratory infrastructure and the need for skilled personnel, along with the challenge of maintaining cold-chain integrity during sample referral, hinder the decentralization of diagnostic facilities...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37728300/correlates-of-postnatal-human-cytomegalovirus-transmission-in-term-babies-in-the-first-year
#4
JOURNAL ARTICLE
Piera d'Angelo, Paola Zelini, Federica Zavaglio, Stefania Piccini, Daniela Cirasola, Alessia Arossa, Arsenio Spinillo, Daniele Lilleri, Fausto Baldanti
Postnatal human cytomegalovirus (HCMV) infection in newborns is well characterized for preterm infants but less so for term infants. We sought to analyze the rates and routes of HCMV transmission in full-term infants during the first year of life. A cohort of 120 HCMV seropositive mothers and their 122 newborns were tested after delivery for HCMV-DNA shedding in different bodily fluids. Postnatal HCMV infection was defined as the detection of >2.5 × 102 HCMV-DNA copies/mL in infants' saliva swabs...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37724347/infection-with-covid-19-is-no-longer-a-public-emergency-but-what-about-degenerative-dementia
#5
JOURNAL ARTICLE
Burak Yulug, Behçet Ayyıldız, Sevilay Ayyıldız, Dila Sayman, Ali Behram Salar, Seyda Cankaya, Ece Ozdemir, Ahmet Ozsimsek, Cagla Ceren Kurt, Hatice Lakadamyalı, Aynur Akturk, Özlem Altay, Lutfu Hanoglu, Halil Aziz Velioglu, Adil Mardinoglu
Although no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer's disease (AD). We compared 17 COVID patients with 20 controls and evaluated the effects of COVID-19 on general cognitive performance, hippocampal volume, and connections using structural and seed-based connectivity analysis...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37724346/molecular-epidemiology-of-sars-cov-2-variants-in-circulation-in-the-state-of-maranh%C3%A3-o-brazil
#6
JOURNAL ARTICLE
Luis Artur Ferreira de Sousa, Lucas Salomão de Sousa Ferreira, Luis Felipe Lima Lobato, Hivylla Lorrana Dos Santos Ferreira, Lucas Henrique Dos Santos Sousa, Valdenice Ferreira Dos Santos, Paulo Ricardo Silva Nunes, Carlos Eduardo Campos Maramaldo, Sebastião Silveira Neto, Hellen Lobato Sampaio, Fabiano Vieira da Silva, Marcelo da Costa Brito, Washington Kleber Rodrigues Lima, Claudia Zeneida Gomes Parente Alves Lima, Lidio Gonçalves Lima Neto
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus belonging to the beta CoV genus, responsible for SARS in humans, which became known as COVID-19. The emergence of variants of this virus is related to the presence of cases of reinfection, reduced vaccine effectiveness and greater transmission of the virus. Objective: In this study, we evaluated the molecular epidemiology of SARS-CoV-2 lineages circulating in the state of Maranhão. This is a cross-sectional and retrospective epidemiological study of genomic surveillance of SARS-CoV-2...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721473/monitoring-of-plasma-torque-teno-virus-total-anelloviridae-and-human-pegivirus-1-viral-load-for-the-prediction-of-infectious-events-and-acute-graft-versus-host-disease-in-the-allogeneic-hematopoietic-stem-cell-transplantation-setting
#7
JOURNAL ARTICLE
Lorena Forqué, Eliseo Albert, José L Piñana, Ariadna Pérez, Rafael Hernani, Carlos Solano, David Navarro, Estela Giménez
Anelloviridae and Human Pegivirus 1 (HPgV-1) blood burden have been postulated to behave as surrogate markers for immunosuppression in transplant recipients. Here, we assessed the potential utility plasma Torque teno virus (TTV), total Anelloviridae (TAV), and HPgV-1 load monitoring for the identification of allogeneic hematopoietic stem cell transplantation recipients (allo-HSCT) at increased risk of infectious events or acute graft versus host disease (aGvHD). In this single-center, observational study, plasma TTV DNA, TAV DNA, and HPgV-1 RNA loads were monitored in 75 nonconsecutive allo-HSCT recipients (median age, 54 years)...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721443/establishment-of-nucleic-acid-sensing-pathways-based-model-in-predicting-response-to-immunotherapy-and-targeted-drug-in-hepatitis-virus-related-hepatocellular-carcinoma
#8
JOURNAL ARTICLE
Xinhao Peng, Ying Shi, Biqin Zhang, Chuan Xu, Jinyi Lang
Hepatocellular carcinoma (HCC) accounts for 80% of liver cancers, while 70%-80% of HCC developed from chronic liver disease with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection as the major etiology. Immunotherapy is assuming a role as a pillar of HCC treatment, but the remarkable immune-mediated responses are restricted in a minority of patients. Nucleic acid sensing (NAS) pathways are the central pathway of the innate immune system and antiviral immune response to viral infection, but their role in hepatitis virus-related HCC remains undetermined...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721411/sads-cov-nsp1-inhibits-the-ifn-%C3%AE-production-by-preventing-tbk1-phosphorylation-and-inducing-cbp-degradation
#9
JOURNAL ARTICLE
Yingjie Xiang, Chunxiao Mou, Kaichuang Shi, Xiang Chen, Xia Meng, Wenbin Bao, Zhenhai Chen
Swine acute diarrhea syndrome (SADS) is first reported in January 2017 in Southern China. It subsequently causes widespread outbreaks in multiple pig farms, leading to economic losses. Therefore, it is an urgent to understand the molecular mechanisms underlying the pathogenesis and immune evasion of Swine acute diarrhea syndrome coronavirus (SADS-CoV). Our research discovered that SADS-CoV inhibited the production of interferon-β (IFN-β) during viral infection. The nonstructural protein 1 (nsp1) prevented the phosphorylation of TBK1 by obstructing the interaction between TBK1 and Ub protein...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721406/kinetics-of-hbcrag-and-hbsag-using-highly-sensitive-itact-assays-in-chronic-hepatitis-b-patients-with-hbsag-seroclearance
#10
JOURNAL ARTICLE
Takanori Suzuki, Kentaro Matsuura, Takehisa Watanabe, Takeshi Matsui, Shintaro Ogawa, Hayato Kawamura, Kayoko Kuno, Kei Fujiwara, Shunsuke Nojiri, Hiromi Kataoka, Yasuhito Tanaka
Two novel assays have been developed, iTACT-hepatitis B core-related antigen (iTACT-HBcrAg) and iTACT-hepatitis B surface antigen (iTACT-HBsAg) assays. We investigated the longitudinal profiles of iTACT-HBcrAg- and -HBsAg in patients with HBsAg seroclearance (SC) (<0.05 IU/mL). This study comprises 60 HBV-infected patients with HBsAg SC, 27 in chronic hepatitis/liver cirrhosis (CH/LC) group and 33 in inactive carrier (IC) group. Longitudinal profiles of iTACT-HBcrAg and -HBsAg were examined using stored serum samples...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721385/infection-with-chickenpox-may-not-enhance-the-risk-of-various-subtypes-of-dementia
#11
LETTER
Sijun Li, Shizheng Qiu, Shixiong Yang
No abstract text is available yet for this article.
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721366/construction-and-characterization-of-a-new-hepatitis-c-virus-genotype-6a-subgenomic-replicon-that-is-prone-to-render-the-sofosbuvir-resistance
#12
JOURNAL ARTICLE
Chaolun Liu, Mingzhe Guo, Lin Han, Jie Lu, Xiaogang Xiang, Qing Xie, Janin Nouhin, Veasna Duong, Yimin Tong, Jin Zhong
Hepatitis C virus (HCV) infection remains a challenge to human public health despite the development of highly effective direct-acting antivirals (DAAs). Sofosbuvir (SOF), a key component in most DAA-based anti-HCV cocktail regimens, is a potent viral RNA polymerase (NS5B) inhibitor with a high barrier to drug resistance. The serine-to-threonine mutation at NS5B 282 (S282T) confers the SOF resistance, but severely impairs viral replication in most HCV genotypes (GTs) and cannot be stably maintained after the termination of the SOF-based therapies...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37721355/clinical-effectiveness-of-oral-antiviral-agents-in-older-patients-with-covid-19-based-on-real-world-data
#13
LETTER
Ya-Wen Tsai, Jheng-Yan Wu, Ting-Hui Liu, Min-Hsiang Chuang, Wan-Hsuan Hsu, Po-Yu Huang, Chih-Cheng Lai, Kang-Ting Tsai, Yow-Ling Shiue
No abstract text is available yet for this article.
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37715715/a-booster-administration-of-the-oka-sk-strain-causes-fatal-disseminated-varicella%C3%A2-in-an-immunocompetent-child
#14
JOURNAL ARTICLE
Hyun Mi Kang, Kyu Ri Kang, Ye Ji Kim, Jin Han Kang, Soo-Young Lee
Live varicella vaccines are known to provide robust immunity against varicella zoster virus (VZV) infections. However, problems with viral attenuation have led to pathogenic VZV vaccine strains causing varicella-like rash and herpes zoster in immunocompetent children after immunization. We report the first fatal case of VZV infection caused by OKA/SK strain contained in the vaccine administrated as a booster shot in an immunocompetent child, which has been independently developed from any currently available varicella vaccines that are OKA strain or MAV/06 strain based...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37712255/clinical-epidemiological-and-genomic-characteristics-of-a-seasonal-influenza-a-virus-outbreak-in-beijing-a-descriptive-study
#15
JOURNAL ARTICLE
Wentao Zhu, Li Gu
China experienced a severe influenza season that began at the end of February 2023. The aim of this post hoc analysis was to investigate the clinical, epidemiological, and genomic features of this outbreak in Beijing. The number of cases increased rapidly from the end of February and reached its peak in March, with 7262 confirmed cases included in this study. The median age was 33 years, and 50.3% of them were male. The average daily positive rate reached 69% during the peak period. The instantaneous reproduction number (Rt) showed a median of 2...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37707416/risk-factors-associated-with-covid-19-pneumonia-in-chinese-patients-with-pre-existing-interstitial-lung-disease-during-the-sars-cov-2-pandemic
#16
JOURNAL ARTICLE
Chi Shao, Yujie Shi, Ruxuan Chen, Xiangning Liu, Hui Huang, Yang Zhao, Kai Xu, Keqi Chen, Mengzhao Wang, Zuojun Xu
In China, the emergence of a nationally widespread epidemic infection of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has appeared within a month since December 7, 2022. To evaluate the risk factors for suffering from coronavirus disease 2019 (COVID-19) pneumonia due to infection with SARS-CoV-2 in different kinds of interstitial lung disease (ILD) patients with diverse immunizations, we conducted this retrospective study on 525 patients with ILDs who underwent regular follow-up in our ILD clinic...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37707319/whole-genome-crispr-screening-strategy-to-identify-genes-contributing-to-sars-cov-2-spike-and-vsv-g-mediated-entry
#17
JOURNAL ARTICLE
Md Saddam Hossain, Jason G Kerkvliet, Adam D Hoppe
Understanding the cellular host factors that promote and inhibit viral entry is important for identifying viral countermeasures. CRISPR whole-genome screens can be used to rapidly discover host factors that contribute to or impair viral entry. However, when using live viruses and cellular lethality for selection, these screens can identify an overwhelming number of genes without specificity for the stage of the viral infection cycle. New screening methods are needed to identify host machinery contributing to specific steps of viral infection...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37706751/role-of-human-papillomavirus-and-associated-viruses-in-bladder-cancer-an-updated-review
#18
REVIEW
Xiangyang Yao, Zhenzhen Xu, Chen Duan, Yangjun Zhang, Xiaoliang Wu, Huahui Wu, Kai Liu, Xiongmin Mao, Bo Li, Yang Gao, Hua Xu, Xinghuan Wang
Bladder cancer (BC) is a complex disease affecting the urinary system and is regulated by several carcinogenic factors. Viral infection is one such factor that has attracted extensive attention in BC. Human papillomavirus (HPV) is the most common sexually transmitted infection, and although multiple researchers have explored the role of HPV in BC, a consensus has not yet been reached. In addition, HPV-associated viruses (e.g., human immunodeficiency virus, herpes simplex virus, BK virus, and JC virus) appear to be responsible for the occurrence and progression of BC...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37705228/risk-of-cytomegalovirus-diseases-among-coronavirus-disease-survivors-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
Bin Zhang, Ya-Wen Tsai, Jheng-Yan Wu, Ting-Hui Liu, Min-Hsiang Chuang, Wan-Hsuan Hsu, Po-Yu Huang, Chih-Cheng Lai
This study was aimed at investigating the risk of cytomegalovirus (CMV) disease among coronavirus disease 2019 (COVID-19) survivors. In this retrospective cohort study, we used the TriNetX research network to identify adults with and without COVID-19 between January 1, 2022 and December 31, 2022. Propensity score matching was used to match the patients with and without COVID-19. The primary outcome was the risk of CMV disease during the 90-day follow-up period. Two matched cohorts comprising 2 501 634 patients with balanced baseline characteristics were created using propensity score matching...
September 2023: Journal of Medical Virology
https://read.qxmd.com/read/37702580/a-natural-variation-in-the-rna-polymerase-of-severe-fever-with-thrombocytopenia-syndrome-virus-enhances-viral-replication-and-in-vivo-virulence
#20
JOURNAL ARTICLE
Kyeongseok Jeon, Hyo-Jin Ro, Jun-Gu Kang, Da-Eun Jeong, Joowan Kim, Yebeen Lee, Ga-Yeon Yoon, Ju-Il Kang, Joon-Yong Bae, Jin Il Kim, Man-Seong Park, Keun Hwa Lee, Hyun-Soo Cho, Yuri Kim, Nam-Hyuk Cho
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with high mortality in Eastern Asia. The disease is caused by the SFTS virus (SFTSV), also known as Dabie bandavirus, which has a segmented RNA genome consisting of L, M, and S segments. Previous studies have suggested differential viral virulence depending on the genotypes of SFTSV; however, the critical viral factor involved in the differential viral virulence is unknown. Here, we found a significant difference in viral replication in vitro and virulence in vivo between two Korean isolates belonging to the F and B genotypes, respectively...
September 2023: Journal of Medical Virology
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