journal
https://read.qxmd.com/read/38606779/impact-of-a-carrageenan-gel-on-viral-load-of-genital-human-papillomavirus-infections-in-sexually-active-women-findings-from-the-carrageenan-gel-against-transmission-of-cervical-human-papillomavirus-catch-trial
#1
JOURNAL ARTICLE
Cassandra Laurie, Mariam El-Zein, Joseph E Tota, Pierre-Paul Tellier, François Coutlée, Ann N Burchell, Eduardo L Franco
Previous research has shown that women's use of a carrageenan gel reduces the risk of acquiring genital human papillomavirus (HPV) infections but does not help to clear existing ones. Although gel use may not result in complete clearance, it may decrease the viral load of HPV infections. We tested this hypothesis in the Carrageenan-gel Against Transmission of Cervical Human papillomavirus (CATCH) randomized controlled trial. Participants of the CATCH study were selected for viral load testing if they had completed the first four study visits and tested positive for HPV42 or HPV51 in at least one of these visits...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38597375/metagenomic-insights-into-fungal-community-composition-of-the-nasopharyngeal-region-of-covid-19-associated-mucormycosis-patients-from-india
#2
JOURNAL ARTICLE
Bharathi Arunan, Daizee Talukdar, Satish Swain, Ashwin Varadarajan, Radhika Sarda, Gagandeep Singh, Neeraj Nischal, Manish Soneja, Susmita Bakshi, Pradipta Jana, Subhash Tanwar, Kapil Sikka, Hitesh Verma, Arulselvi Subramanian, Immaculata Xess, Naveet Wig, Bhabatosh Das, Animesh Ray
Coronavirus disease 2019 (COVID-19) associated mucormycosis (CAM) was reported predominantly from India during the second wave of COVID-19  and has a high mortality rate. The present study aims to understand the fungal community composition of the nasopharyngeal region of CAM-infected individuals and compare it with severe COVID-19 patients and healthy controls. The fungal community composition was decoded by analyzing the sequence homology of the internal transcribed spacer-2-(ITS-2) region of metagenomic DNA extracted from the upper respiratory samples...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38597349/cocirculation-and-coinfection-of-multiple-respiratory-viruses-during-autumn-and-winter-seasons-of-2023-in-beijing-china-a-retrospective-study
#3
JOURNAL ARTICLE
Yi Li, Jinhan Yu, Yao Wang, Jie Yi, Lina Guo, Qing Wang, Ge Zhang, Yingchun Xu, Ying Zhao
China experienced severe epidemics of multiple respiratory pathogens in 2023 after lifting "Zero-COVID" policy. The present study aims to investigate the changing circulation and infection patterns of respiratory pathogens in 2023. The 160 436 laboratory results of influenza virus and respiratory syncytial virus (RSV) from February 2020 to December 2023, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from June 2020 to December 2023, Mycoplasma pneumoniae, adenovirus, and human rhinovirus from January 2023 to December 2023 were analyzed...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38591240/differential-beta-coronavirus-infection-dynamics-in-human-bronchial-epithelial-organoids
#4
JOURNAL ARTICLE
Dongbin Park, Se-Mi Kim, Hobin Jang, Kanghee Kim, Ho Young Ji, Heedong Yang, Woohyun Kwon, Yeonglim Kang, Suhee Hwang, Hyunjoon Kim, Mark Anthony B Casel, Issac Choi, Jeong-Sun Yang, Joo-Yeon Lee, Young Ki Choi
The lower respiratory system serves as the target and barrier for beta-coronavirus (beta-CoV) infections. In this study, we explored beta-CoV infection dynamics in human bronchial epithelial (HBE) organoids, focusing on HCoV-OC43, SARS-CoV, MERS-CoV, and SARS-CoV-2. Utilizing advanced organoid culture techniques, we observed robust replication for all beta-CoVs, particularly noting that SARS-CoV-2 reached peak viral RNA levels at 72 h postinfection. Through comprehensive transcriptomic analysis, we identified significant shifts in cell population dynamics, marked by an increase in goblet cells and a concurrent decrease in ciliated cells...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38590253/prevalence-and-genetic-diversity-of-human-rhinovirus-among-patients-with-acute-respiratory-infections-in-china-2012-2021
#5
JOURNAL ARTICLE
Aili Cui, Baicheng Xia, Haoran Jiang, Qi Li, Liwei Sun, Jin Xu, Kongxin Hu, Zhibo Xie, Yage Wang, Runan Zhu, Chaoyang Huang, Zhong Li, Jing Xu, Wenyang Wang, Hui Zhang, Zhenguo Gao, Feng Zhang, Hui Xie, Yan Zhang
To understand the prevalence of rhinovirus (RV) among acute respiratory infection (ARI) patients, 10-year ARI surveillance in multiple provinces of China were conducted during 2012-2021. Of 15 645 ARI patients, 1180 (7.54%) were confirmed to have RV infection and 820 (69.49%) were children under 5 years of age. RV typing was performed on the 527 VP1 gene sequences, and species A, B, and C accounted for 73.24%, 4.93%, and 21.82%, respectively. Although no significant difference in the proportions of age groups or disease severity was found between RV species, RV-C was more frequently detected in children under 5 years of age, RV-A was more frequently detected in elderly individuals (≥60), and the proportions of pneumonia in RV-A and RV-C patients were higher than those in RV-B patients...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38590017/targeted-therapies-for-hpv-associated-cervical-cancer-harnessing-the-potential-of-exosome-based-chipsets-in-combating-leukemia-and-hpv-mediated-cervical-cancer
#6
JOURNAL ARTICLE
Swastika Maitra, Nobendu Mukerjee, Hanan M Alharbi, Arabinda Ghosh, Athanasios Alexiou, Nanasaheb D Thorat
Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease-specific biomarkers. This feature provides profound insights into the progression of diseases and the responses of patients to treatments. For example, in leukemia, exosomes convey critical information through the carriage of specific proteins and nucleic acids. In the case of human papillomavirus (HPV)-mediated cervical cancer, exosomes are particularly useful for noninvasive detection as they transport high-risk HPV DNA and specific biomolecules, which can be indicators of the disease...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38587217/evaluation-of-serum-epstein-barr-virus-envelope-glycoproteins-antibodies-and-their-association-with-systemic-autoimmune-diseases
#7
JOURNAL ARTICLE
Hui-Lan Li, Lan-Yi Zhong, Yin-Feng Kang, Yan-Lan Yang, Liang Shi, Ai-Xia Zhai, Chao Wu, Mu-Sheng Zeng, Qian-Ying Zhu
Systemic autoimmune diseases (SADs) are a growing spectrum of autoimmune disorders that commonly affect multiple organs. The role of Epstein-Barr virus (EBV) infection or reactivation as a trigger for the initiation and progression of SADs has been established, while the relationship between EBV envelope glycoproteins and SADs remains unclear. Here, we assessed the levels of IgG, IgA, and IgM against EBV glycoproteins (including gp350, gp42, gHgL, and gB) in serum samples obtained from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and found that RA and SLE patients exhibited a statistically significant increase in the levels of 8 and 11 glycoprotein antibodies, respectively, compared to healthy controls (p < 0...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38587211/the-abortive-sars-cov-2-infection-of-osteoclast-precursors-promotes-their-differentiation-into-osteoclasts
#8
JOURNAL ARTICLE
Franco Sviercz, Patricio Jarmoluk, Joshua Godoy Coto, Cintia Cevallos, Rosa Nicole Freiberger, Cinthya Alicia Marcela López, Irene Lucia Ennis, M Victoria Delpino, Jorge Quarleri
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in the loss of millions of lives, although a majority of those infected have managed to survive. Consequently, a set of outcomes, identified as long COVID, is now emerging. While the primary target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the respiratory system, the impact of COVID-19 extends to various body parts, including the bone. This study aims to investigate the effects of acute SARS-CoV-2 infection on osteoclastogenesis, utilizing both ancestral and Omicron viral strains...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38587204/obesity-fosters-severe-disease-outcomes-in-a-mouse-model-of-coronavirus-infection-associated-with-transcriptomic-abnormalities
#9
JOURNAL ARTICLE
Pallavi Rai, Jeffrey M Marano, Lin Kang, Sheryl Coutermarsh-Ott, Andrea R Daamen, Peter E Lipsky, James Weger-Lucarelli
Obesity has been identified as an independent risk factor for severe outcomes in humans with coronavirus disease 2019 (COVID-19) and other infectious diseases. Here, we established a mouse model of COVID-19 using the murine betacoronavirus, mouse hepatitis virus 1 (MHV-1). C57BL/6 and C3H/HeJ mice exposed to MHV-1 developed mild and severe disease, respectively. Obese C57BL/6 mice developed clinical manifestations similar to those of lean controls. In contrast, all obese C3H/HeJ mice succumbed by 8 days postinfection, compared to a 50% mortality rate in lean controls...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38587184/survival-benefits-of-human-papillomavirus-16-infection-in-patients-with-esophageal-squamous-cell-carcinoma-undergoing-chemoradiotherapy-a-retrospective-cohort-study
#10
JOURNAL ARTICLE
Fengyi Qu, Chao Ji, Ying Wang, Rui Zhu, Weibin Hu, Siqi Liu, Xu Zhao, Jing Li, Guo Miao, Mingxin Zhang, Xiaozhi Zhang, Yuchen Sun
The role of human papillomavirus 16 (HPV 16) in esophageal squamous cell carcinoma (ESCC) remains uncertain. Therefore, this study aimed to investigate the prevalence of HPV 16 in patients with ESCC and its impact on theirprognosis. HPV 16 was detected using FISH, and TP53 status was evaluated via immunohistochemistry. The factors influencing prognosis were ananalyzed using the Log-rank test and Cox regression analyses. Among 178 patients with ESCC, 105 and 73 patients were categorized into concurrent chemoradiotherapy (CCRT) and postoperative chemoradiotherapy (POCRT) cohorts, respectively...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38587173/triglicerydes-high-density-lipoprotein-ratio-as-a-risk-factor-of-post-covid-19-sinus-tachycardia-a-retrospective-study
#11
JOURNAL ARTICLE
Alina Kuryłowicz, Mateusz Babicki, Michał Wąsowski, Piotr Jankowski, Joanna Kapusta, Michał Chudzik
Inappropriate sinus tachycardia (IST) is one of the manifestations of the post-COVID-19 syndrome (PCS), which pathogenesis remains largely unknown. This study aimed to identify potential risk factors for IST in individuals with PCS. The 1349 patients with PCS were included into the study. Clinical examination, 24H Holter ECG, 24H ambulatory blood pressure monitoring and biochemical tests were performed 12-16 weeks after the COVID-19 in all participants. IST was found in 69 (3.5%) individuals. In the clinical assessment IST patients were characterized by a higher age (p < 0...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38587139/a-peptide-derived-from-sars-cov-2-nucleocapsid-protein-with-broad-spectrum-anti-coronavirus-activity
#12
LETTER
Guoguo Ye, Yimin Tang, Qin Yang, Chenhui Zhang, Huiping Shi, Jun Wang, Xiao Hu, Xiaofu Wan, Zhixiang Xu, Jinhu Liang, Yang Yang, Minghui Yang, Yingxia Liu
No abstract text is available yet for this article.
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38576317/discovery-of-low-molecular-weight-phenylalanine-derivatives-as-novel-hiv-capsid-modulators-with-improved-antiretroviral-activity-and-metabolic-stability
#13
JOURNAL ARTICLE
Xiangyi Jiang, Zhen Gao, Prem Prakash Sharma, Sumit Kumar, Brijesh Rathi, Xiangkai Ji, Jiaojiao Dai, Minghui Xie, Guanyu Dong, Shujing Xu, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Peng Zhan, Xinyong Liu
The HIV capsid (CA) protein is a promising target for anti-AIDS treatment due to its critical involvement in viral replication. Herein, we utilized the well-documented CA inhibitor PF74 as our lead compound and designed a series of low-molecular-weight phenylalanine derivatives. Among them, compound 7t exhibited remarkable antiviral activity with a high selection index (EC50  = 0.040 µM, SI = 2815), surpassing that of PF74 (EC50  = 0.50 µM, SI = 258)...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38576266/measles-outbreak-in-the-adult-age-group-clinical-laboratory-and-epidemiological-features-of-the-11-patients-admitted-to-the-hospital
#14
JOURNAL ARTICLE
Kultural Gungor, Sebnem Bukavaz, Galip Ekuklu
The measles virus, also known as the morbillivirus, or MV, is a virus that infects humans. The goal of this research is to assess to adult cases of measles. Eleven patients thought to be confirmed cases of measles were enrolled in the investigation. Following the identification of symptoms of tiredness, fever, and rash in one soldier, the results of 10 more troops from the pertinent military group were assessed. The diagnosis was made based on the presence of serum immunoglobulin M (IgM) and positive polymerase chain reaction (PCR) results...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38573018/trpv4-promotes-hbv-replication-and-capsid-assembly-via-methylation-modification-of-h3k4-and-hbc-ubiquitin
#15
JOURNAL ARTICLE
Yu Zhang, Xiaoxue Yuan, Jun Wang, Ming Han, Hongping Lu, Yun Wang, Shunai Liu, Song Yang, Hui-Chun Xing, Jun Cheng
Hepatitis B virus (HBV) infection poses a significant burden on global public health. Unfortunately, current treatments cannot fully alleviate this burden as they have limited effect on the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence. Consequently, the HBV life cycle should be further investigated to develop new anti-HBV pharmaceutical targets. Our previous study discovered that the host gene TMEM203 hinders HBV replication by participating in calcium ion regulation...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38572977/comparative-single-cell-rna-sequencing-analysis-of-immune-response-to-inactivated-vaccine-and-natural-sars-cov-2-infection
#16
JOURNAL ARTICLE
Shuai He, Shu-Qiang Liu, Xiang-Yun Teng, Jin-Yong He, Yang Liu, Jia-Hui Gao, Yue Wu, Wei Hu, Zhong-Jun Dong, Jin-Xin Bei, Jian-Hua Xu
Uncovering the immune response to an inactivated SARS-CoV-2 vaccine (In-Vac) and natural infection is crucial for comprehending COVID-19 immunology. Here we conducted an integrated analysis of single-cell RNA sequencing (scRNA-seq) data from serial peripheral blood mononuclear cell (PBMC) samples derived from 12 individuals receiving In-Vac compared with those from COVID-19 patients. Our study reveals that In-Vac induces subtle immunological changes in PBMC, including cell proportions and transcriptomes, compared with profound changes for natural infection...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38572976/retraction-small-interfering-rna-effectively-inhibits-protein-expression-and-negative-strand-rna-synthesis-from-a-full-length-hepatitis-c-virus-clone
#17
(no author information available yet)
Retraction: "Small Interfering RNA Effectively Inhibits Protein Expression and Negative Strand RNA Synthesis From a Full-Length Hepatitis C Virus Clone" by Prabhu, R., Vittal, P., Yin, Q., Flemington, E., Garry, R., Robichaux, W.H. and Dash, S, J. Med. Virol 2005, 76: 511-519. The above article, published online on 23 June 2005, in Wiley Online Library (https://doi.org/10.1002/jmv.20391), has been retracted by agreement between the journal Editor-in-Chief, Shou-Jiang Gao, and Wiley Periodicals, LLC. The retraction has been agreed due to following publication concerns which were raised by third parties regarding Figure 3...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38572940/global-burden-of-vaccine-associated-multiple-sclerosis-1967-2022-a-comprehensive-analysis-of-the-international-pharmacovigilance-database
#18
JOURNAL ARTICLE
Ho Geol Woo, Hyeon Jin Kim, Jaeyu Park, Jinseok Lee, Hayeon Lee, Min Seo Kim, Ai Koyanagi, Lee Smith, Masoud Rahmati, Seung Geun Yeo, Dong Keon Yon
Vaccine-associated multiple sclerosis (MS) is rare, with insufficient evidence from case reports. Given the scarcity of large-scale data investigating the association between vaccine administration and adverse events, we investigated the global burden of vaccine-associated MS and potential related vaccines from 1967 to 2022. Reports on vaccine-associated MS between 1967 and 2022 were obtained from the World Health Organization International Pharmacovigilance Database (total number of reports = 120 715 116)...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38572939/persistence-of-igg-and-neutralizing-antibodies-in-crimean-congo-hemorrhagic-fever-survivors
#19
JOURNAL ARTICLE
Abbas Ahmadi Vasmehjani, Mohammad Hassan Pouriayevali, Shohreh Shahmahmoodi, Mostafa Salehi-Vaziri
The World Health Organization classified Crimean-Congo hemorrhagic fever (CCHF) as a high-priority infectious disease and emphasized the performance of research studies and product development against it. Little information is available about the immune response due to natural CCHF virus (CCHFV) infection in humans. Here, we investigated the persistence of IgG and neutralizing antibodies in serum samples collected from 61 Iranian CCHF survivors with various time points after recovery (<12, 12-60, and >60 months after disease)...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38572935/measles-disease-outbreaks-and-vaccination-impacting-global-public-health
#20
LETTER
Hinh Ly
No abstract text is available yet for this article.
April 2024: Journal of Medical Virology
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