Tina Damodar, Cordelia Dunai, Namratha Prabhu, Maria Jose, L Akhila, Uddhava V Kinhal, K Anusha Raj, Srilatha Marate, A V Lalitha, Fulton Sebastian Dsouza, Sushma Veeranna Sajjan, Vykuntaraju K Gowda, G V Basavaraja, Bhagteshwar Singh, P V Prathyusha, Kukatharmini Tharmaratnam, Vasanthapuram Ravi, Ruwanthi Kolamunnage-Dona, Tom Solomon, Lance Turtle, Ravi Yadav, Benedict D Michael, Reeta S Mani
Acute encephalitis syndrome (AES) in children poses a significant public health challenge in India. This study aims to explore the utility of host inflammatory mediators and neurofilament (NfL) levels in distinguishing etiologies, assessing disease severity, and predicting outcomes in AES. We assessed 12 mediators in serum (n = 58) and 11 in cerebrospinal fluid (CSF) (n = 42) from 62 children with AES due to scrub typhus, viral etiologies, and COVID-associated multisystem inflammatory syndrome (MIS-C) in Southern India...
May 2024: Journal of Medical Virology