journal
https://read.qxmd.com/read/38738582/noncanonical-functions-of-telomerase-and-telomeres-in-viruses-associated-cancer
#21
REVIEW
Sara Rasouli, Aleksandra Dakic, Qi-En Wang, Darrion Mitchell, Dukagjin M Blakaj, Nagireddy Putluri, Jenny Li, Xuefeng Liu
The cause of cancer is attributed to the uncontrolled growth and proliferation of cells resulting from genetic changes and alterations in cell behavior, a phenomenon known as epigenetics. Telomeres, protective caps on the ends of chromosomes, regulate both cellular aging and cancer formation. In most cancers, telomerase is upregulated, with the telomerase reverse transcriptase (TERT) enzyme and telomerase RNA component (TERC) RNA element contributing to the maintenance of telomere length. Additionally, it is noteworthy that two viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), utilize telomerase for their replication or persistence in infected cells...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38738569/diagnostic-markers-of-acute-encephalitis-syndrome-and-covid-associated-multisystem-inflammatory-syndrome-in-children-from-southern-india
#22
JOURNAL ARTICLE
Tina Damodar, Cordelia Dunai, Namratha Prabhu, Maria Jose, L Akhila, Uddhava V Kinhal, K Anusha Raj, Srilatha Marate, A V Lalitha, Fulton Sebastian Dsouza, Sushma Veeranna Sajjan, Vykuntaraju K Gowda, G V Basavaraja, Bhagteshwar Singh, P V Prathyusha, Kukatharmini Tharmaratnam, Vasanthapuram Ravi, Ruwanthi Kolamunnage-Dona, Tom Solomon, Lance Turtle, Ravi Yadav, Benedict D Michael, Reeta S Mani
Acute encephalitis syndrome (AES) in children poses a significant public health challenge in India. This study aims to explore the utility of host inflammatory mediators and neurofilament (NfL) levels in distinguishing etiologies, assessing disease severity, and predicting outcomes in AES. We assessed 12 mediators in serum (n = 58) and 11 in cerebrospinal fluid (CSF) (n = 42) from 62 children with AES due to scrub typhus, viral etiologies, and COVID-associated multisystem inflammatory syndrome (MIS-C) in Southern India...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38738567/a-potential-antiviral-role-for-ccr5-cd8-t-cells-in-children-with-hepatitis-b
#23
JOURNAL ARTICLE
Aoxue Tan, Yi He, Yingzhi Zhou, Xiaorong Peng, Yunan Chang, Mingli Peng, Hong Ren, Hongmei Xu
While dysfunctional exhausted CD8+ T cells hamper viral control when children acquire hepatitis B virus (HBV) infection, it's crucial to recognize that CD8+ T cells have diverse phenotypes and functions. This study explored a subset of CD8+ T cells expressing C-C chemokine receptor type 5 (CCR5) in children with HBV infection. Thirty-six patients in the immune tolerant group, 33 patients in the immune active group, 55 patients in the combined response group, and 22 healthy control children were enrolled...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38738524/assessing-herpes-zoster-vaccine-efficacy-in-patients-with-diabetes-a-community-based-cohort-study
#24
JOURNAL ARTICLE
Edy Kornelius, Shih-Chang Lo, Chien-Ning Huang, Chi-Chih Wang, Yu-Hsun Wang, Yi-Sun Yang
The effectiveness of herpes zoster (HZ) vaccines in patients with diabetes over the age of 50 remains an active area of research. Utilizing a real-world database from the US community, this study spanning from 2006 to 2023, aimed to evaluate the impact of HZ vaccination on newly diagnosed diabetes patients who received an HZ vaccination within 1 year of diagnosis. Exclusion criteria were established to omit patients with immune deficiencies. The cohort consisted of 53 885 patients, with an average age of 63...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727137/prevalence-and-diversity-of-imported-severe-acute-respiratory-syndrome-coronavirus-2-variants-in-china-2021-2022
#25
JOURNAL ARTICLE
Yenan Feng, Xiang Zhao, Zhixiao Chen, Yuchao Wu, Lili Li, Changcheng Wu, Kai Nie, Xiaoyu Yang, Peihua Niu, Ji Wang, Shiwen Wang, Cao Chen
The causative agent of coronavirus disease 2019 (COVID-19), known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread accumulatively to 240 countries and continues to evolve. To gain a comprehensive understanding of the epidemiological characteristics of imported variants in China and their correlation with global circulating variants, genomic surveillance data from 11 139 imported COVID-19 cases submitted by Chinese provincial CDC laboratories between 2021 and 2022 were analyzed...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727136/exploring-viral-infections-role-in-kawasaki-disease-onset-a-study-during-the-covid-19-pandemic
#26
JOURNAL ARTICLE
Taku Ishii, Nobutoshi Nawa, Susumu Hosokawa, Tomohiro Morio, Takeo Fujiwara
During the coronavirus disease 2019 (COVID-19) pandemic, known viral diseases declined in all ages. By using the current situation as a natural experiment, this study aimed to evaluate whether the change in the incidence of Kawasaki disease (KD) during the COVID-19 pandemic varies with age and whether a specific infectious disease mediates the occurrence of KD. Monthly number of KD patients were extracted from the nationwide inpatient database. Segmented regression analysis was conducted on the interrupted time series data...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727133/major-changes-in-prevalence-and-genotypes-of-rotavirus-diarrhea-in-beijing-china-after-rv5-rotavirus-vaccine-introduction
#27
JOURNAL ARTICLE
Yi Tian, Lingyu Shen, Weihong Li, Hanqiu Yan, Jiamei Fu, Baiwei Liu, Yu Wang, Lei Jia, Gang Li, Luodan Suo, Daitao Zhang, Zhiyong Gao, Quanyi Wang
To analyze the epidemiological characteristics of group A rotavirus (RVA) diarrhea in Beijing between 2019 and 2022 and evaluate the effectiveness of the RV5 vaccine. Stool specimens were collected from patients with acute diarrhea, and RVA was detected and genotyped. The whole genome of RVA was sequenced by fragment amplification and Sanger sequencing. Phylogenetic trees were constructed using Bayesian and maximum likelihood methods. Descriptive epidemiological methods were used to analyze the characteristics of RVA diarrhea...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727099/molecular-epidemiology-of-human-herpesvirus-8-in-patients-with-hhv-8-related-diseases-in-ireland
#28
JOURNAL ARTICLE
Sadhbh O'Rourke, Bairbre Ni Laoi, Susan Clarke, Brendan Crowley
Human Herpesvirus 8 (HHV-8) has been classified by sequence analysis of open reading frame (ORF) K1, ORF K15, and variable sequence loci within the central constant region. The purpose of this study was to examine the molecular epidemiology of HHV-8 in an Irish population. This retrospective study included 30 patients who had HHV-8 DNA detected in plasma. Nested end-point PCR was used to characterise four regions of the HHV-8 genome, K1, T0.7 (K12), ORF 75, and K15. Sequencing data were obtained for 23 specimens from 19 patients...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727091/human-coronavirus-229e-inactivation-on-porous-and-nonporous-materials-using-dielectric-barrier-discharge-dbd-plasma
#29
JOURNAL ARTICLE
Sekar Ashokkumar, Jun Sup Lim, Nagendra Kumar Kaushik, Ihn Han, Han Sup Uhm, Yung Oh Shin, Eun Ha Choi
Viruses can spread through contaminated aerosols and contaminated surface materials, and effective disinfection techniques are essential for virus inactivation. Nonthermal plasma-generated reactive oxygen and nitrogen species can effectively inactivate the coronavirus. We aim to interpret the coronavirus inactivation level and mechanism of surface interaction with materials with and without dielectric barrier discharge (DBD) plasma treatment. Nonthermal plasma, particularly surface-type DBD plasma, can inactivate human coronavirus 229E (HCoV-229E) on porous (paper, wood, mask) and nonporous (plastic, stainless steel, glass, Cu) materials...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727088/retrospective-investigation-of-overlooked-mpox-virus-infection-in-saliva-samples-from-patients-with-suspected-syphilis-in-japan
#30
LETTER
Azusa Onodera, Kazuo Imai, Akihiro Sato, Masashi Tanaka, Ryuha Omachi, Takuya Maeda
No abstract text is available yet for this article.
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727085/clinical-effectiveness-of-nirmatrelvir-plus-ritonavir-on-the-short-and-long-term-outcome-in-high-risk-children-with-covid-19
#31
JOURNAL ARTICLE
Jheng-Yan Wu, Chia-Chen Chen, Mei-Yuan Liu, Wan-Hsuan Hsu, Ya-Wen Tsai, Ting-Hui Liu, Sung Pin-Chien, Po-Yu Huang, Min-Hsiang Chuang, Mei-Chuan Lee, Kuo-Chuan Hung, Tsung Yu, Chih-Cheng Lai
This study investigated the clinical effectiveness of nirmatrelvir plus ritonavir (NMV-r) on short-term outcome and the risk of postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) among pediatric patients with coronavirus disease 2019 (COVID-19). This retrospective cohort study used the TriNetX research network to identify pediatric patients between 12 and 18 years with COVID-19 between January 1, 2022 and August 31, 2023. The propensity score matching (PSM) method was used to match patients receiving NMV-r (NMV-r group) with those who did not receive NMV-r (control group)...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727043/molecular-characterization-of-emerging-echovirus-11-e11-shed-light-on-the-recombinant-origin-of-a-variant-associated-with-severe-hepatitis-in-neonates
#32
JOURNAL ARTICLE
Antonio Piralla, Federica Giardina, Guglielmo Ferrari, Stefano Gaiarsa, Greta Romano, Laura Pellegrinelli, Cristina Galli, Arlinda Seiti, Sandro Binda, Antonino Maria Guglielmo Pitrolo, Angelo Genoni, Francesca Drago Ferrante, Federica Novazzi, Nicasio Mancini, Francesca Rovida, Elena Pariani, Fausto Baldanti
Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. Due to the limited data available, the World Health Organization (WHO) considers public health risk to the general population to be low. The present study investigated the genetic variation and molecular evolution of E11 genomes collected from May to December 2023. Whole genome sequencing (WGS) was performed for 16 E11 strains. Phylogenetic analysis on WG showed how all Italian strains belonged to genogroup D5, similarly to other E11 strains recently reported in France and Germany all together aggregated into separate clusters...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727035/characterizing-the-antigenic-evolution-of-pandemic-influenza-a-h1n1-pdm09-from-2009-to-2023
#33
JOURNAL ARTICLE
Peiwen Cheng, Ke Zhai, Wenjie Han, Jinfeng Zeng, Zekai Qiu, Yilin Chen, Kang Tang, Jing Tang, Haoyu Long, Taijiao Jiang, Xiangjun Du
The H1N1pdm09 virus has been a persistent threat to public health since the 2009 pandemic. Particularly, since the relaxation of COVID-19 pandemic mitigation measures, the influenza virus and SARS-CoV-2 have been concurrently prevalent worldwide. To determine the antigenic evolution pattern of H1N1pdm09 and develop preventive countermeasures, we collected influenza sequence data and immunological data to establish a new antigenic evolution analysis framework. A machine learning model (XGBoost, accuracy = 0...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727032/prior-covid-19-vaccination-and-reduced-risk-of-cerebrovascular-diseases-among-covid-19-survivors
#34
MULTICENTER STUDY
Sheng-Yin Chen, Tina Yi Jin Hsieh, Yao-Min Hung, Jae Won Oh, Shen-Kai Chen, Shiow-Ing Wang, Renin Chang, James Cheng-Chung Wei
The effects of COVID-19 vaccination on short-term and long-term cerebrovascular risks among COVID-19 survivors remained unknown. We conducted a national multi-center retrospective cohort study with 151 597 vaccinated and 151 597 unvaccinated COVID-19 patients using the TriNetX database, from January 1, 2020 to December 31, 2023. Patients baseline characteristics were balanced with propensity score matching (PSM). The outcomes were incident cerebrovascular diseases occurred between 1st and 30th days (short-term) after COVID-19 diagnosis...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727029/hpv-genotyping-in-clinical-samples-using-long-read-single-molecule-real-time-sequencing
#35
JOURNAL ARTICLE
Christophe Pasquier, Stéphanie Raymond, Romain Carcenac, Sofia Demmou, Noémie Ranger, Florence Nicot, Jacques Izopet
Human papillomavirus (HPV) genotyping is widely used, particularly in combination with high-risk (HR) HPV tests for cervical cancer screening. We developed a genotyping method using sequences of approximately 800 bp in the E6/E7 region obtained by PacBio single molecule real-time sequencing (SMRT) and evaluated its performance against MY09-11 L1 sequencing and after the APTIMA HPV genotyping assay. The levels of concordance of PacBio E6/E7 SMRT sequencing with MY09-11 L1 sequencing and APTIMA HPV genotyping were 100% and 90...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727013/analysis-of-the-diagnostic-performance-of-pax1-sox1-gene-methylation-in-cervical-precancerous-lesions-and-its-role-in-triage-diagnosis
#36
JOURNAL ARTICLE
Chunli Fan, Junbo Hu, Ting Luo, Binhua Dong, Hongying Li, Weipeng Wang, Jiong Yan, Hongning Cai
Methylation panels, tools for investigating epigenetic changes associated with diseases like cancer, can identify DNA methylation patterns indicative of disease, providing diagnostic or prognostic insights. However, the application of methylation panels focusing on the sex-determining region Y-box 1 (SOX1) and paired box gene 1 (PAX1) genes for diagnosing cervical lesions is under-researched. This study aims to examine the diagnostic performance of PAX1/SOX1 gene methylation as a marker for cervical precancerous lesions and its potential application in triage diagnosis...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38712753/high-risk-human-papillomavirus-genotypes-among-healthy-males-from-one-hospital-in-beijing-china
#37
LETTER
Juan Du, Qin-Yi Ma, Shuai Wang, Wan-Xue Zhang, Peng Wang, Yiguo Zhou, Ming Wei, Li Gu, Fuqiang Cui, Qing-Bin Lu
No abstract text is available yet for this article.
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38712746/period-prevalence-of-uveitis-in-human-t-lymphotropic-virus-1%C3%A2-carriers-versus-noncarriers-in-a-highly-endemic-area-the-nagasaki-islands-study
#38
JOURNAL ARTICLE
Jun Miyata, Hirotomo Yamanashi, Yoshinori Dake, Kenichi Nobusue, Yusuke Doi, Yukiko Honda, Fumiaki Nonaka, Kazuhiko Arima, Mami Tamai, Daisuke Sasaki, Yuji Shimizu, Hiroo Hasegawa, Takashi Kitaoka, Katsunori Yanagihara, Kiyoshi Aoyagi, Atsushi Kawakami, Takahiro Maeda
The magnitude of the effect of human T-lymphotropic virus 1 (HTLV-1) infection on uveitis remains unclear. We conducted a cross-sectional study in a highly endemic area of HTLV-1 in Japan. The study included 4265 residents (men, 39.2%), mostly middle-aged and older individuals with a mean age of 69.9 years, who participated in our surveys between April 2016 and September 2022. We identified HTLV-1 carriers by screening using chemiluminescent enzyme immunoassays and confirmatory tests, and the proportion of carriers was 16...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38712743/the-burden-of-infectious-diseases-throughout-and-after-the-covid-19-pandemic-2020-2023-and-russo-ukrainian-war-migration
#39
JOURNAL ARTICLE
Piotr Rzymski, Dorota Zarębska-Michaluk, Miłosz Parczewski, Agnieszka Genowska, Barbara Poniedziałek, Birute Strukcinskiene, Anna Moniuszko-Malinowska, Robert Flisiak
Understanding how the infectious disease burden was affected throughout the COVID-19 pandemic is pivotal to identifying potential hot spots and guiding future mitigation measures. Therefore, our study aimed to analyze the changes in the rate of new cases of Poland's most frequent infectious diseases during the entire COVID-19 pandemic and after the influx of war refugees from Ukraine. We performed a registry-based population-wide study in Poland to analyze the changes in the rate of 24 infectious disease cases from 2020 to 2023 and compared them to the prepandemic period (2016-2019)...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38708824/deregulation-of-immune-response-contributing-to-fulminant-hepatitis-in-hev-infected-pregnant-women
#40
JOURNAL ARTICLE
Yining Liang, Jiayue Zhang, Dehong Luo, Lixin Cheng, Yijin Wang
Hepatitis E virus (HEV) infection in pregnant women is associated with a wide spectrum of adverse consequences for both mother and fetus. The high mortality in this population appears to be associated with hormonal changes and consequent immunological changes. This study conducted an analysis of immune responses in pregnant women infected with HEV manifesting varying severity. Data mining analysis of the GSE79197 was utilized to examine differentially biological functions in pregnant women with HEV infection (P-HEV) versus without HEV infection (P-nHEV), P-HEV progressing to ALF (P-ALF) versus P-HEV, and P-HEV versus non-pregnant women with HEV infection (nP-HEV)...
May 2024: Journal of Medical Virology
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