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Lemneolemnanes A-D, Four Uncommon Sesquiterpenoids from the Soft Coral Lemnalia sp.
Marine Drugs 2024 March 27
Four undescribed sesquiterpenoids, lemneolemnanes A-D ( 1 - 4 ), have been isolated from the marine soft coral Lemnalia sp. The absolute configurations of the stereogenic carbons of 1 - 4 were determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 are epimers at C-3 and have an unusual skeleton with a formyl group on C-6. Compound 3 possesses an uncommonly rearranged carbon skeleton, while 4 has a 6/5/5 tricyclic system. Compound 1 showed significant anti-Alzheimer's disease (AD) activity in a humanized Caenorhabditis elegans AD pathological model.
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