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Having the cake and eating it? Clofazimine boosts immunotherapy while limiting side effects.
Cancer Cell 2024 March 26
Combined immune checkpoint blockade (ICB) for cancer exhibits good efficacy in a subset of patients but also associates with immune-related adverse events. Xue et al. use an elegant drug screening strategy to identify the antimicrobial drug clofazimine as an agent that both potentiates ICB efficacy and decreases immune-related adverse events.
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