We have located links that may give you full text access.
Moderating effect of cognitive reserve on brain integrity and cognitive performance.
BACKGROUND: Dementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance. One issue is that cognitive performance sometimes does not match the corresponding level of neuropathology, affecting diagnostic accuracy. Cognitive reserve (CR), which can preserve cognitive function despite underlying neuropathology, explains at least some variability in cognitive performance. We examined the influence of CR proxies (education and occupational position) on the relationship between hippocampal or total gray matter volume and cognition.
METHODS: We used data from the Czech Brain Aging Study. Participants were clinically confirmed to be without dementia ( n = 457, including subjective cognitive decline and amnestic mild cognitive impairment) or with dementia syndrome ( n = 113).
RESULTS: For participants without dementia, higher education magnified the associations between (a) hippocampal volume and executive control ( b = 0.09, p = 0.033), (b) total gray matter volume and language ( b = 0.12, p < 0.001), and (c) total gray matter volume and memory ( b = 0.08, p = 0.018). Similarly, higher occupational position magnified the association between total gray matter volume and (a) attention/working memory ( b = 0.09, p = 0.009), (b) language ( b = 0.13, p = 0.002), and (c) memory ( b = 0.10, p = 0.013). For participants with dementia, the associations between hippocampal ( b = -0.26, p = 0.024) and total gray matter ( b = -0.28, p = 0.024) volume and visuospatial skills decreased in magnitude with higher education.
CONCLUSION: We found that the association between brain volume and cognitive performance varies based on CR, with greater CR related to a stronger link between brain volume and cognition before, and a weaker link after, dementia diagnosis.
METHODS: We used data from the Czech Brain Aging Study. Participants were clinically confirmed to be without dementia ( n = 457, including subjective cognitive decline and amnestic mild cognitive impairment) or with dementia syndrome ( n = 113).
RESULTS: For participants without dementia, higher education magnified the associations between (a) hippocampal volume and executive control ( b = 0.09, p = 0.033), (b) total gray matter volume and language ( b = 0.12, p < 0.001), and (c) total gray matter volume and memory ( b = 0.08, p = 0.018). Similarly, higher occupational position magnified the association between total gray matter volume and (a) attention/working memory ( b = 0.09, p = 0.009), (b) language ( b = 0.13, p = 0.002), and (c) memory ( b = 0.10, p = 0.013). For participants with dementia, the associations between hippocampal ( b = -0.26, p = 0.024) and total gray matter ( b = -0.28, p = 0.024) volume and visuospatial skills decreased in magnitude with higher education.
CONCLUSION: We found that the association between brain volume and cognitive performance varies based on CR, with greater CR related to a stronger link between brain volume and cognition before, and a weaker link after, dementia diagnosis.
Full text links
Related Resources
Trending Papers
Obesity pharmacotherapy in older adults: a narrative review of evidence.International Journal of Obesity 2024 May 7
Haemodynamic monitoring during noncardiac surgery: past, present, and future.Journal of Clinical Monitoring and Computing 2024 April 31
SGLT2 Inhibitors in Kidney Diseases-A Narrative Review.International Journal of Molecular Sciences 2024 May 2
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app