Olga M Klimecki, Maxie Liebscher, Malo Gaubert, Dayana Hayek, Alexis Zarucha, Martin Dyrba, Claudia Bartels, Katharina Buerger, Michaela Butryn, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Matthias H Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris-Stephan Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Eike Jakob Spruth, Annika Spottke, Stefan J Teipel, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Düzel, Frank Jessen, Michael Wagner, Sandra Roeske, Miranka Wirth
BACKGROUND: Sustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk of developing Alzheimer's disease. This cross-sectional cohort study investigated the association between long-term EE in young adulthood through middle life and microstructure of fiber tracts associated with the memory system in older adults. METHODS: N = 201 cognitively unimpaired participants (≥ 60 years of age) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) baseline cohort were included...
2023: Frontiers in Aging Neuroscience