journal
https://read.qxmd.com/read/36967830/white-matter-and-gray-matter-changes-related-to-cognition-in-community-populations
#1
JOURNAL ARTICLE
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
OBJECTIVE: Further studies are needed to improve the understanding of the pathological process underlying cognitive impairments. The purpose of this study is to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. METHODS: A cross-sectional analysis was performed based on 995 subjects (aged 56.8 ± 9.1 years, 34.8% males) from the Shunyi study, a community-dwelling cohort...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967829/mechanisms-underlying-tdp-43-pathology-and-neurodegeneration-an-updated-mini-review
#2
REVIEW
Benjamin I Nilaver, Henryk F Urbanski
TAR DNA binding protein 43 kDa (TDP-43) plays an important role in several essential cell functions. However, TDP-43 dysfunction has been implicated in the development of various brain diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and limbic predominant age-related TDP-43 encephalopathy (LATE). Recent investigations into the individual components of TDP-43 pathology show how broader TDP-43 dysfunction may precede these disease end states, and therefore could help to explain why TDP-43 dysfunction continues to be implicated in a rapidly expanding category of neurodegenerative diseases...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967828/protective-effects-of-intrathecal-injection-of-aav9-rabggtb-gfp-in-sod1-g93a-mice
#3
JOURNAL ARTICLE
Tianchu Gao, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Liu
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that widely affects motor neurons of the CNS. About 20% of patients with ALS have familial ALS (fALS). One of the classic models of ALS are SOD1G93A mice. Misfolded SOD1 protein can be overexpressed in motor neurons, which results in progressive paralysis of the limbs of mice. There is still no effective treatment for ALS. In recent years, the treatment of ALS by regulating autophagy has become a research hotspot...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967827/chemokines-in-patients-with-alzheimer-s-disease-a-meta-analysis
#4
Hecheng Wang, Yu Zong, Lei Zhu, Weiyi Wang, Yanshuo Han
BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly people. Many researches have reported that neuroinflammation is related to AD. Chemokines are a class of small cytokines that play important roles in cell migration and cell communication, which involved in neuroinflammation. Up to now there is no meta-analysis to explore the difference of chemokines between AD patients and healthy elderly individuals. METHOD: We searched PubMed, Web of science, Cochrane library, EMBASE and Scopus databases from inception to January 2022...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967826/alterations-in-white-matter-integrity-and-network-topological-properties-are-associated-with-a-decrease-in-global-motion-perception-in-older-adults
#5
JOURNAL ARTICLE
Shizhen Yan, Yuping Zhang, Xiaojuan Yin, Juntao Chen, Ziliang Zhu, Hua Jin, Han Li, Jianzhong Yin, Yunpeng Jiang
Previous studies have mainly explored the effects of structural and functional aging of cortical regions on global motion sensitivity in older adults, but none have explored the structural white matter (WM) substrates underlying the age-related decrease in global motion perception (GMP). In this study, random dot kinematogram and diffusion tensor imaging were used to investigate the effects of age-related reductions in WM fiber integrity and connectivity across various regions on GMP. We recruited 106 younger adults and 94 older adults and utilized both tract-based spatial statistics analysis and graph theoretical analysis to comprehensively investigate group differences in WM microstructural and network connections between older and younger adults at the microscopic and macroscopic levels...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967825/erratum-cannabinoids-for-behavioral-symptoms-in-severe-dementia-safety-and-feasibility-in-a-long-term-pilot-observational-study-in-nineteen-patients
#6
(no author information available yet)
[This corrects the article DOI: 10.3389/fnagi.2022.957665.].
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967824/cortical-activation-and-functional-connectivity-during-locomotion-tasks-in-parkinson-s-disease-with-freezing-of-gait
#7
JOURNAL ARTICLE
HongSheng Feng, YanNa Jiang, JinPeng Lin, WenTing Qin, LingJing Jin, Xia Shen
BACKGROUND: Freezing of gait (FoG) is a severely disabling symptom in Parkinson's disease (PD). The cortical mechanisms underlying FoG during locomotion tasks have rarely been investigated. OBJECTIVES: We aimed to compare the cerebral haemodynamic response during FoG-prone locomotion tasks in patients with PD and FoG (PD-FoG), patients with PD but without FoG (PD-nFoG), and healthy controls (HCs). METHODS: Twelve PD-FoG patients, 10 PD-nFoG patients, and 12 HCs were included in the study...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967823/altered-neuroimaging-patterns-of-cerebellum-and-cognition-underlying-the-gait-and-balance-dysfunction-in-cerebral-small-vessel-disease
#8
JOURNAL ARTICLE
Yuting Mo, Chenglu Mao, Dan Yang, Zhihong Ke, Lili Huang, Zhiyuan Yang, Ruomeng Qin, Yanan Huang, Weiping Lv, Zheqi Hu, Yun Xu
BACKGROUND: The mechanism of gait and balance dysfunction (GBD) in cerebral small vessel disease (CSVD) remains unclear. Evidence supports cognition engages in GBD of CSVD. The cerebellum is important in motor and cognition, while little is known about the influence of the cerebellum on GBD in CSVD. METHODS: This study is a retrospective cohort study. All participants of this study were enrolled from the CSVD individuals in Nanjing Drum Tower Hospital from 2017 to 2021...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967822/effect-of-pcsk9-inhibition-in-combination-with-statin-therapy-on-intracranial-atherosclerotic-stenosis-a-high-resolution-mri-study
#9
JOURNAL ARTICLE
Lingshan Wu, Qianqian Kong, Hao Huang, Shabei Xu, Wensheng Qu, Ping Zhang, Zhiyuan Yu, Xiang Luo
INTRODUCTION: Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke worldwide. Evolocumab, a proprotein convertase subtilisin/kexin type-9 inhibitor (PCSK9i), effectively lowers low-density lipoprotein (LDL) and produces favorable changes in coronary atherosclerosis. This study aimed to determine the effects of PCSK9i on intracranial plaques in moderate-intensity statin-treated individuals with ICAS. METHODS: This prospective, observational study monitored the imaging and clinical outcomes of individuals with ICAS who were consecutively treated with moderate-intensity statins with or without PCSK9i...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967821/striatal-fibrinogen-extravasation-and-vascular-degeneration-correlate-with-motor-dysfunction-in-an-aging-mouse-model-of-alzheimer-s-disease
#10
JOURNAL ARTICLE
Hanna E Berk-Rauch, Arnab Choudhury, Allison T Richards, Pradeep K Singh, Zu-Lin Chen, Erin H Norris, Sidney Strickland, Hyung Jin Ahn
Introduction: Alzheimer's Disease (AD) patients exhibit signs of motor dysfunction, including gait, locomotion, and balance deficits. Changes in motor function often precede other symptoms of AD as well as correlate with increased severity and mortality. Despite the frequent occurrence of motor dysfunction in AD patients, little is known about the mechanisms by which this behavior is altered. Methods and Results: In the present study, we investigated the relationship between cerebrovascular impairment and motor dysfunction in a mouse model of AD (Tg6799)...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967820/effectiveness-of-non-pharmacological-therapies-on-cognitive-function-in-patients-with-dementia-a-network-meta-analysis-of-randomized-controlled-trials
#11
Guangxin Luo, Junqiu Zhang, Zeyi Song, Ying Wang, Xiaojing Wang, Haifeng Qu, Fang Wang, Chengjiang Liu, Fujia Gao
OBJECTIVE: Non-pharmacological therapies (NPTs) have received increasing attention from researchers as a category of treatment to improve cognitive impairment in patients with dementia because of their fewer side effects. In this study, photobiomodulation (PBM), enriched environment (EE), exercise therapy (ET), computerized cognitive training (CCT), and cognitive stimulation therapy (CST) were selected to compare the effects of NPTs that improve dementia by quantifying information from randomized controlled trials (RCTs)...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967819/characteristics-of-fatigue-in-parkinson-s-disease-a-longitudinal-cohort-study
#12
JOURNAL ARTICLE
Xiaoxia Zhou, Yaqin Xiang, Tingwei Song, Yuwen Zhao, Hongxu Pan, Qian Xu, Yase Chen, Qiying Sun, Xinyin Wu, Xinxiang Yan, Jifeng Guo, Beisha Tang, Lifang Lei, Zhenhua Liu
OBJECTIVE: To assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patients with Parkinson's disease (PD). MATERIALS AND METHODS: A total of 2,100 PD patients were enrolled from the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), and their motor and non-motor symptoms were assessed biennially using comprehensive scales, including the 16-item Parkinson Fatigue Scale (PFS-16)...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967818/language-impairment-in-parkinson-s-disease-fmri-study-of-sentence-reading-comprehension
#13
JOURNAL ARTICLE
Lubomira Novakova, Martin Gajdos, Jana Markova, Alice Martinkovicova, Zuzana Kosutzka, Jana Svantnerova, Peter Valkovic, Zsolt Csefalvay, Irena Rektorova
Parkinson's disease (PD) affects the language processes, with a significant impact on the patients' daily communication. We aimed to describe specific alterations in the comprehension of syntactically complex sentences in patients with PD (PwPD) as compared to healthy controls (HC) and to identify the neural underpinnings of these deficits using a functional connectivity analysis of the striatum. A total of 20 patients PwPD and 15 HC participated in the fMRI study. We analyzed their performance of a Test of sentence comprehension (ToSC) adjusted for fMRI...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967817/the-role-of-periodontitis-in-the-link-between-alpha-tocopherol-intake-and-cognitive-performance-a-mediation-analysis-in-older-adults
#14
JOURNAL ARTICLE
Heming Zhang, Li Sun, Lin Zhang, Jiangjing Li, Yongfei Liu, Zhiyang Chen, Shuang Wang, Changjun Gao, Xude Sun
BACKGROUND: Epidemiological evidence on alpha (α)-tocopherol intake and cognitive performance in older individuals is controversial and the effect of periodontitis in this chain is sparse and limited. The goal of this study was to characterize the association between α-tocopherol intake and cognitive performance and the mediating role of periodontitis in a nationally representative sample of older adults. METHODS: Data from the National Health and Nutrition Examination Survey (NHANES), 2011-2014, were used...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967816/consistency-of-the-anesthesia-consciousness-index-versus-the-bispectral-index-during-laparoscopic-gastrointestinal-surgery-with-sevoflurane-anesthesia-a-prospective-multi-center-randomized-controlled-clinical-study
#15
JOURNAL ARTICLE
Jian Zhan, Feng Chen, Zhuoxi Wu, Zhenxin Duan, Qiangting Deng, Jun Zeng, Lihong Hou, Jun Zhang, Yongyu Si, Kexuan Liu, Mingjun Wang, Hong Li
BACKGROUND: This study aimed to compare the consistency of anesthesia consciousness index (Ai) with that of bispectral index (BIS) in monitoring the depth of anesthesia (DOA) during sevoflurane anesthesia, to reveal the optimal cutoff values in different states of consciousness, and explore the stability of DOA monitoring during intraoperative injurious stimulation. METHODS: We enrolled 145 patients (97 men and 48 women) from 10 medical centers. General anesthesia was induced using intravenous anesthetics and maintained with sevoflurane...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36967815/utility-of-quantitative-mri-metrics-in-brain-ageing-research
#16
JOURNAL ARTICLE
Pavel Filip, Viktória Kokošová, Zdeněk Valenta, Marek Baláž, Silvia Mangia, Shalom Michaeli, Lubomír Vojtíšek
The advent of new, advanced quantitative MRI metrics allows for in vivo evaluation of multiple biological processes highly relevant for ageing. The presented study combines several MRI parameters hypothesised to detect distinct biological characteristics as myelin density, cellularity, cellular membrane integrity and iron concentration. 116 healthy volunteers, continuously distributed over the whole adult age span, underwent a multi-modal MRI protocol acquisition. Scatterplots of individual MRI metrics revealed that certain MRI protocols offer much higher sensitivity to early adulthood changes while plateauing in higher age (e...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36960422/effectiveness-and-safety-of-ginkgo-biloba-preparations-in-the-treatment-of-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#17
Dawei Li, Jinlong Ma, Baojian Wei, Shuang Gao, Yanmei Lang, Xueying Wan
OBJECTIVE: To conduct a meta-analysis of the effectiveness and safety of ginkgo biloba preparations combined with donepezil hydrochloride vs. donepezil for the treatment of Alzheimer's disease (AD). METHODS: Three English databases (Cochrane Library, PubMed, EMBASE), and four Chinese databases [the China National Knowledge Infrastructure (CKNI), the Chinese Biomedical Literature database (CBM), the Chongqing VIP database, and WANFANG DATA)] were manually searched for literature published from the respective dates of inception of the databases to December 2022...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36960421/whole-body-vibration-as-a-passive-alternative-to-exercise-after-myocardial-damage-in-middle-aged-female-rats-effects-on-the-heart-the-brain-and-behavior
#18
JOURNAL ARTICLE
Kata Tóth, Tamás Oroszi, Csaba Nyakas, Eddy A van der Zee, Regien G Schoemaker
BACKGROUND: Females with cardiovascular disease seem more vulnerable to develop concomitant mental problems, such as depression and cognitive decline. Although exercise is shown beneficial in cardiovascular disease as well as in mental functions, these patients may be incapable or unmotivated to perform exercise. Whole body vibration (WBV) could provide a passive alternative to exercise. Aim of the present study was to compare WBV to exercise after isoproterenol (ISO)-induced myocardial damage in female rats, regarding effects on heart, brain and behavior...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36949776/are-tai-chi-and-qigong-effective-in-the-treatment-of-tbi-a-systematic-review-protocol
#19
JOURNAL ARTICLE
Nicole Alexandra Laskosky, Patricia Huston, Wai Ching Lam, Charlotte Anderson, Ya Zheng, Linda L D Zhong
BACKGROUND: Traumatic brain injury (TBI) adversely affects both young and old and is a growing public health issue. A number of recent trends in managing TBI, such as recommending sub-threshold aerobic activity, tailoring multi-modal treatment strategies, and studying the possible role of low-grade inflammation in those with persistent symptoms, all suggest that the physical and cognitive exercise of tai chi/qigong could have benefit. METHOD: Designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the following databases will be searched: MEDLINE, CINAHL, Cochrane Library, Embase, China National Knowledge Infrastructure Database, Wanfang Database, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36949775/aging-related-changes-in-reward-based-decision-making-depend-on-punishment-frequency-an-fmri-study
#20
JOURNAL ARTICLE
Ping Ren, Guozhi Luo, Jiayin Huang, Meiling Tan, Donghui Wu, Han Rong
INTRODUCTION: Aging is often accompanied by significant cognitive decline and altered decision making. Previous studies have found that older adults have difficulty in processing reward/risk information, leading to suboptimal decision strategy. However, it is still under investigated about the neural substrates of risky decision-making under ambiguity in aging. METHODS: Using the Iowa Gambling Task, the current study investigated inter-individual differences of risk-taking behaviors in healthy older adults with task-related functional magnetic resonance imaging...
2023: Frontiers in Aging Neuroscience
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