journal
https://read.qxmd.com/read/38544780/aging-effects-on-the-encoding-retrieval-flip-in-associative-memory-fmri-evidence-from-incidental-contingency-learning
#1
JOURNAL ARTICLE
Else Schneider, Marko Rajkovic, Rudolf Krug, Marco P Caviezel, Carolin F Reichert, Oliver Bieri, André Schmidt, Stefan Borgwardt, Thomas Leyhe, Christoph Linnemann, Annette B Brühl, Undine E Lang, Tobias Melcher
INTRODUCTION: Associative memory is arguably the most basic memory function and therein constitutes the foundation of all episodic and semantic memory processes. At the same time, the decline of associative memory represents a core feature of age-related cognitive decline in both, healthy and pathological (i.e., dementia-related) aging. The neural mechanisms underlying age-related impairments in associative memory are still not fully understood, especially regarding incidental (i.e., non-intentional) learning...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38533425/analyzing-changes-in-parkinsonian-speech-over-time-a-diachronic-experimental-phonetics-study
#2
JOURNAL ARTICLE
Massimo Pettorino, Marta Maffia
In this contribution the use of web resources for the longitudinal study of speech rhythm of a 'well-known' person diagnosed with Parkinson's disease, the American actor Alan Alda, is proposed. A corpus of 20 speech samples produced in the period between 1979 and 2021 was collected from the web. A rhythmical analysis was conducted, based on two parameters: the percentage of vocalic portion on the total duration of the utterance (%V) and the VtoV, the mean duration of the interval between two consecutive vowel onset points...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38529054/short-term-effects-of-contralateral-tendon-vibration-on-motor-unit-discharge-rate-variability-and-force-steadiness-in-people-with-parkinson-s-disease
#3
JOURNAL ARTICLE
Changki Kim, Daryl J Wile, Sarah N Kraeutner, Kaylee A Larocque, Jennifer M Jakobi
BACKGROUND: Vibration of one limb affects motor performance of the contralateral limb, and this may have clinical implications for people with lateralized motor impairments through vibration-induced increase in cortical activation, descending neural drive, or spinal excitability. OBJECTIVE: The objective of this study was to evaluate the effects of acute biceps brachii tendon vibration on force steadiness and motor unit activity in the contralateral limb of persons with Parkinson's disease...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38524118/physical-exercise-frequency-and-cognition-a-multicenter-cross-sectional-cohort-study
#4
JOURNAL ARTICLE
Chen Wen, Jing-Huan Gan, Guo-Wei Huang, Xiao-Dan Wang, Yang Lü, Jian-Ping Niu, Xin-Ling Meng, Pan Cai, Yang Li, Bao-Zhi Gang, Yong You, Yan Lv, Zhi-Hong Ren, Shuai Liu, Yan Zeng, Yong Ji
BACKGROUND AND AIMS: Dementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency of physical exercise (physical exercise), we investigated the association between frequency of PE and cognition in Chinese old adults. METHODS: 16,181 Chinese participants aged 65 years or older were included in this study...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38524117/regional-covariance-of-white-matter-hyperintensity-volume-patterns-associated-with-hippocampal-volume-in-healthy-aging
#5
JOURNAL ARTICLE
Emily J Van Etten, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Georg A Hishaw, Matthew J Huentelman, Theodore P Trouard, Gene E Alexander
Hippocampal volume is particularly sensitive to the accumulation of total brain white matter hyperintensity volume (WMH) in aging, but how the regional distribution of WMH volume differentially impacts the hippocampus has been less studied. In a cohort of 194 healthy older adults ages 50-89, we used a multivariate statistical method, the Scaled Subprofile Model (SSM), to (1) identify patterns of regional WMH differences related to left and right hippocampal volumes, (2) examine associations between the multimodal neuroimaging covariance patterns and demographic characteristics, and (3) investigate the relation of the patterns to subjective and objective memory in healthy aging...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38524116/exploring-the-application-and-challenges-of-fnirs-technology-in-early-detection-of-parkinson-s-disease
#6
JOURNAL ARTICLE
Pengsheng Hui, Yu Jiang, Jie Wang, Congxiao Wang, Yingqi Li, Boyan Fang, Hujun Wang, Yingpeng Wang, Shuyan Qie
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that significantly benefits from early diagnosis for effective disease management and intervention. Despite advancements in medical technology, there remains a critical gap in the early and non-invasive detection of PD. Current diagnostic methods are often invasive, expensive, or late in identifying the disease, leading to missed opportunities for early intervention. OBJECTIVE: The goal of this study is to explore the efficiency and accuracy of combining fNIRS technology with machine learning algorithms in diagnosing early-stage PD patients and to evaluate the feasibility of this approach in clinical practice...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38524115/age-related-differences-in-affective-behaviors-in-mice-possible-role-of-prefrontal-cortical-hippocampal-functional-connectivity-and-metabolomic-profiles
#7
JOURNAL ARTICLE
Marcelo Febo, Rohit Mahar, Nicholas A Rodriguez, Joy Buraima, Marjory Pompilus, Aeja M Pinto, Matteo M Grudny, Adriaan W Bruijnzeel, Matthew E Merritt
INTRODUCTION: The differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have been reported, but the functional neural circuitry warrants further investigation. METHODS: We assessed age variations in affective behaviors and functional connectivity in male and female C57BL6/J mice. Mice aged 10, 30 and 60 weeks (wo) were tested over 8 weeks for open field activity, sucrose preference, social interactions, fear conditioning, and functional neuroimaging...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38524114/mitigating-cellular-aging-and-enhancing-cognitive-functionality-visual-arts-mediated-cognitive-activation-therapy-in-neurocognitive-disorders
#8
JOURNAL ARTICLE
Manuela Campisi, Luana Cannella, Dilek Celik, Carlo Gabelli, Donata Gollin, Marco Simoni, Cristina Ruaro, Elena Fantinato, Sofia Pavanello
The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological aging [leukocyte telomere length (LTL), DNA methylation age (DNAmAge)] and cognitive functionality. Aligning with a broader trend of integrating non-pharmacological approaches into dementia care...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38524113/effect-of-chemotherapy-on-hippocampal-volume-and-shape-in-older-long-term-breast-cancer-survivors
#9
JOURNAL ARTICLE
Ebenezer Daniel, Frank Deng, Sunita K Patel, Mina S Sedrak, Jonathan Young, Heeyoung Kim, Marianne Razavi, Can-Lan Sun, James C Root, Tim A Ahles, William Dale, Bihong T Chen
PURPOSE: The objective of this study was to assess changes in hippocampal volume and shape in older long-term breast cancer survivors who were exposed to chemotherapy 5-15 years prior. METHODS: This study recruited female long-term breast cancer survivors aged 65 years or older with a history of chemotherapy (C+), age-matched breast cancer survivors who did not receive chemotherapy (C-), and healthy controls (HC). The participants were recruited 5-15 years after chemotherapy at time point 1 (TP1) and were followed up for 2 years at time point 2 (TP2)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38515518/editorial-neurophysiology-in-alzheimer-s-disease-and-dementia-volume-ii
#10
EDITORIAL
Davide Vito Moretti
No abstract text is available yet for this article.
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38515517/secure-federated-learning-for-alzheimer-s-disease-detection
#11
JOURNAL ARTICLE
Angela Mitrovska, Pooyan Safari, Kerstin Ritter, Behnam Shariati, Johannes Karl Fischer
Machine Learning (ML) is considered a promising tool to aid and accelerate diagnosis in various medical areas, including neuroimaging. However, its success is set back by the lack of large-scale public datasets. Indeed, medical institutions possess a large amount of data; however, open-sourcing is prevented by the legal requirements to protect the patient's privacy. Federated Learning (FL) is a viable alternative that can overcome this issue. This work proposes training an ML model for Alzheimer's Disease (AD) detection based on structural MRI (sMRI) data in a federated setting...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38515516/editorial-bioinformatics-analysis-of-single-cell-sequencing-and-multi-omics-in-the-aging-and-age-associated-diseases
#12
EDITORIAL
Shouneng Peng, Ailan Wang, Junjun Ding, Lilach Soreq
No abstract text is available yet for this article.
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38515515/assessing-interstitial-fluid-dynamics-in-type-2-diabetes-mellitus-and-prediabetes-cases-through-diffusion-tensor-imaging-analysis-along-the-perivascular-space
#13
JOURNAL ARTICLE
Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki
BACKGROUND AND PURPOSE: Glymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial fluid dynamics using the DTI-ALPS in both Pre-DM and T2DM and association with insulin resistance...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38511197/the-mediating-effect-of-18-f-fdg-metabolism-in-right-caudate-between-depressive-symptoms-and-cognitive-function-in-alzheimer-s-disease
#14
JOURNAL ARTICLE
Bojun Wang, Chunlei Cui, Yifan Chen, Zhigang Liang
PURPOSE: The objective of this study was to investigate the accumulation of 18 F-fluorodeoxyglucose (18 F-FDG) in the whole brain between Alzheimer's disease (AD) with depressive (ADD) symptoms compared with AD without depressive (ADND) symptoms using positron emission tomography/magnetic resonance imaging (PET/MRI). Additionally, this study aimed to explore the associations among the accumulation of 18 F-FDG in the brain, depressive symptoms, and cognitive function in ADD patients. METHODS: In this study, 25 AD patients and 22 healthy controls were enrolled...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38511196/anosognosia-is-associated-with-increased-prevalence-and-faster-development-of-neuropsychiatric-symptoms-in-mild-cognitive-impairment
#15
JOURNAL ARTICLE
Sharon Wang, Kayden Mimmack, Federica Cacciamani, Michael Elnemais Fawzy, Catherine Munro, Jennifer Gatchel, Gad A Marshall, Geoffroy Gagliardi, Patrizia Vannini
INTRODUCTION: Both the loss of awareness for cognitive decline (a. k.a anosognosia) and neuropsychiatric symptoms (NPS) are common in patients with Alzheimer's disease (AD) dementia, even in prodromal stages, and may exacerbate functional impairment and negatively impact caregiver burden. Despite the high impact of these symptoms on patients and their caregivers, our knowledge of how they develop across the AD spectrum is limited. Here, we explored the cross-sectional and longitudinal associations between anosognosia and NPS in individuals with mild cognitive impairment (MCI)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38501060/impact-of-olfactory-function-on-the-trajectory-of-cognition-motor-function-and-quality-of-life-in-parkinson-s-disease
#16
JOURNAL ARTICLE
Chia-Yen Lin, Yu-Shan Tsai, Ming-Hong Chang
BACKGROUND: Olfactory dysfunction in Parkinson's disease (PD) is associated with more severe phenotypes, but trajectories of cognitive function, disease severity, and subdomains of quality-of-life measurements in patients with distinct olfactory profiles remain underexplored. OBJECTIVE: To analyze the influence of olfaction on trajectories of clinical parameters in patients with PD. DESIGN: Retrospective cohort study. SUBJECTS: From October 2016 to May 2021, the study tracked 58 participants over 3 years...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38501059/mir-3940-5p-reduces-amyloid-%C3%AE-production-via-selectively-targeting-psen1
#17
JOURNAL ARTICLE
Yanmei Qi, Xu Wang, Xihan Guo
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid beta (Aβ) in brain. Mounting evidence has revealed critical roles of microRNAs (miRNAs) in AD pathogenesis; however, the miRNAs directly targeting presenilin1 ( PSEN1 ), which encodes the catalytic core subunit of γ-secretase that limits the production of Aβ from amyloid precursor protein (APP), are extremely understudied. The present study aimed to identify miRNAs targeting PSEN1 and its effect on Aβ production...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38486858/improve-the-diagnosis-of-idiopathic-normal-pressure-hydrocephalus-by-combining-abnormal-cortical-thickness-and-ventricular-morphometry
#18
JOURNAL ARTICLE
Yifeng Yang, Meijing Yan, Xiao Liu, Shihong Li, Guangwu Lin
BACKGROUND: The primary imaging markers for idiopathic Normal Pressure Hydrocephalus (iNPH) emphasize morphological measurements within the ventricular system, with no attention given to alterations in brain parenchyma. This study aimed to investigate the potential effectiveness of combining ventricular morphometry and cortical structural measurements as diagnostic biomarkers for iNPH. METHODS: A total of 57 iNPH patients and 55 age-matched healthy controls (HC) were recruited in this study...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38482343/sensorineural-hearing-loss-and-cognitive-impairment-three-hypotheses
#19
REVIEW
He Zhao, Yan Wang, Limei Cui, Hanjing Wang, Sha Liu, Tiantian Liang, Dawei Liu, Jingjing Qiu, Liang Chen, Yan Sun
Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness and auditory trauma, results in cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers to an abnormality in the brain's higher intellectual processes related to learning, memory, thinking and judgment that can lead to severe learning and memory deficits. Studies have established a strong correlation between SNHL and CI, but it remains unclear how SNHL contributes to CI...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38476661/transcutaneous-vagus-nerve-stimulation-a-new-strategy-for-alzheimer-s-disease-intervention-through-the-brain-gut-microbiota-axis
#20
REVIEW
Long Yan, Hong Li, Yulin Qian, Junfeng Zhang, Shan Cong, Xuemin Zhang, Linna Wu, Yu Wang, Meng Wang, Tao Yu
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the vagus nerve distributed over the body surface. Studies suggest a correlation between the brain-gut-microbiota (BGM) axis and the pathogenesis of Alzheimer's disease (AD). The BGM axis represents a complex bidirectional communication system, with the vagus nerve being a crucial component. Therefore, non-invasive electrical stimulation of the vagus nerve might have the potential to modify-most of the time probably in a non-physiological way-the signal transmission within the BGM axis, potentially influencing the progression or symptoms of AD...
2024: Frontiers in Aging Neuroscience
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