journal
https://read.qxmd.com/read/38638193/lipocalin-type-prostaglandin-d-synthase-a-glymphopathy-marker-in-idiopathic-hydrocephalus
#1
JOURNAL ARTICLE
Namiko Nishida, Nanae Nagata, Keigo Shimoji, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Makio Takahashi, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki, Ryosuke Okumura, Masatsune Ishikawa, Hiroki Toda
Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called the glymphatic system. Tau is a representative waste material similar to amyloid-β. During neurodegeneration, lipocalin-type prostaglandin D synthase (L-PGDS), a major cerebrospinal fluid (CSF) protein, is reported to act as a chaperone that prevents the neurotoxic aggregation of amyloid-β. L-PGDS is also a CSF biomarker in idiopathic normal pressure hydrocephalus and significantly correlates with tau concentration, age, and age-related brain white matter changes detected by magnetic resonance imaging...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38638192/editorial-hospitalization-and-parkinson-s-disease-safety-quality-and-outcomes
#2
EDITORIAL
Hooman Azmi, Benjamin L Walter, Annie Brooks, Irene Hegeman Richard, Katherine Amodeo, Michael S Okun
No abstract text is available yet for this article.
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38638191/immediate-fall-prevention-the-missing-key-to-a-comprehensive-solution-for-falling-hazard-in-older-adults
#3
JOURNAL ARTICLE
Khashayar Misaghian, Jesus Eduardo Lugo, Jocelyn Faubert
The world is witnessing an unprecedented demographic shift due to increased life expectancy and declining birth rates. By 2050, 20% of the global population will be over 60, presenting significant challenges like a shortage of caregivers, maintaining health and independence, and funding extended retirement. The technology that caters to the needs of older adults and their caregivers is the most promising candidate to tackle these issues. Although multiple companies and startups offer various aging solutions, preventive technology, which could prevent trauma, is not a big part of it...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38633983/targeting-shared-pathways-in-tauopathies-and-age-related-macular-degeneration-implications-for-novel-therapies
#4
REVIEW
Michele Rinaldi, Antonio Pezone, Gaia Italia Quadrini, Gianmarco Abbadessa, Maria Paola Laezza, Maria Laura Passaro, Antonio Porcellini, Ciro Costagliola
The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement of oxidative stress and cellular senescence emerges as key drivers of pathogenesis in both conditions. Uncovering these shared elements not only has the potential to enhance our understanding of intricate neurodegenerative diseases but also sets the stage for pioneering therapeutic approaches in AMD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38633982/selection-of-lansoprazole-from-an-fda-approved-drug-library-to-inhibit-the-alzheimer-s-disease-seed-dependent-formation-of-tau-aggregates
#5
JOURNAL ARTICLE
Ahmed Imtiaz, Shotaro Shimonaka, Mohammad Nasir Uddin, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
The efficacy of current treatments is still insufficient for Alzheimer's disease (AD), the most common cause of Dementia. Out of the two pathological hallmarks of AD amyloid-β plaques and neurofibrillary tangles, comprising of tau protein, tau pathology strongly correlates with the symptoms of AD. Previously, screening for inhibitors of tau aggregation that target recombinant tau aggregates have been attempted. Since a recent cryo-EM analysis revealed distinct differences in the folding patterns of heparin-induced recombinant tau filaments and AD tau filaments, this study focused on AD seed-dependent tau aggregation in drug repositioning for AD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38633981/physical-activity-may-a-probably-protective-factor-for-postoperative-delirium-the-pndable-study
#6
JOURNAL ARTICLE
Jian Kong, Xu Lin, Bin Wang, Shanling Xu, Yuanlong Wang, Shuhui Hua, Hongyan Gong, Rui Dong, Yanan Lin, Chuan Li, Yanlin Bi
OBJECTIVE: This study aims to explore the relationship between physical activity (PA) and postoperative delirium (POD). METHODS: We selected 400 patients from the Perioperative Neurocognitive Disorder and Biomarkers Lifestyle (PNDABLE) database, and the patients in the PNDABLE database were sampled and tested Alzheimer's biomarkers. The diagnosis of POD was made using the Confusion Assessment Scale (CAM) and the severity was assessed using Memorial Delirium Assessment Scale (MDAS)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38633980/oxidative-stress-in-the-brain-lung-crosstalk-cellular-and-molecular-perspectives
#7
REVIEW
Jianda Kong, Rao Fan, Yuanqi Zhang, Zixuan Jia, Jing Zhang, Huixin Pan, Qinglu Wang
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to counteract their harmful effects, playing a key role in the pathogenesis of brain and lung-related diseases. This review comprehensively examines the intricate mechanisms by which oxidative stress influences cellular and molecular pathways, contributing to neurodegenerative, cardiovascular, and respiratory disorders. Emphasizing the detrimental effects on both brain and lung health, we discuss innovative diagnostic biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the potential of antioxidant therapies...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38628973/association-of-multiple-metabolic-and-cardiovascular-markers-with-the-risk-of-cognitive-decline-and-mortality-in-adults-with-alzheimer-s-disease-and-ad-related-dementia-or-cognitive-decline-a-prospective-cohort-study
#8
JOURNAL ARTICLE
Longjian Liu, Edward J Gracely, Xiaopeng Zhao, Gediminas P Gliebus, Nathalie S May, Stella L Volpe, Jingyi Shi, Rose Ann DiMaria-Ghalili, Howard J Eisen
BACKGROUND AND OBJECTIVES: There is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer's disease (AD) and AD-related dementia (ADRD). This study aimed to examine the effect of multiple metabolic factors and cardiovascular disorders on the risk of cognitive decline and AD/ADRD. METHODS: We analyzed a cohort of 6,440 participants aged 45-84 years at baseline...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38605862/assessing-the-cognitive-decline-of-people-in-the-spectrum-of-ad-by-monitoring-their-activities-of-daily-living-in-an-iot-enabled-smart-home-environment-a-cross-sectional-pilot-study
#9
JOURNAL ARTICLE
Margarita Grammatikopoulou, Ioulietta Lazarou, Vasilis Alepopoulos, Lampros Mpaltadoros, Vangelis P Oikonomou, Thanos G Stavropoulos, Spiros Nikolopoulos, Ioannis Kompatsiaris, Magda Tsolaki
INTRODUCTION: Assessing functional decline related to activities of daily living (ADLs) is deemed significant for the early diagnosis of dementia. As current assessment methods for ADLs often lack the ability to capture subtle changes, technology-based approaches are perceived as advantageous. Specifically, digital biomarkers are emerging, offering a promising avenue for research, as they allow unobtrusive and objective monitoring. METHODS: A study was conducted with the involvement of 36 participants assigned to three known groups (Healthy Controls, participants with Subjective Cognitive Decline and participants with Mild Cognitive Impairment)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38605861/spatial-temporal-parameters-during-unobstructed-walking-in-people-with-parkinson-s-disease-and-healthy-older-people-a-public-data-set
#10
JOURNAL ARTICLE
Tiago Penedo, Carlos Augusto Kalva-Filho, Jônatas Augusto Cursiol, Murilo Henrique Faria, Daniel Boari Coelho, Fabio Augusto Barbieri
No abstract text is available yet for this article.
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38605860/retraction-characteristics-of-cognitive-function-in-patients-with-cerebellar-infarction-and-its-association-with-lesion-location
#11
(no author information available yet)
[This retracts the article DOI: 10.3389/fnagi.2022.965022.].
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38605859/frequency-dependent-alterations-in-functional-connectivity-in-patients-with-alzheimer-s-disease-spectrum-disorders
#12
JOURNAL ARTICLE
Hanjun Hu, Luoyu Wang, Sammad Abdul, Xue Tang, Qi Feng, Yuzhu Mu, Xiuhong Ge, Zhengluan Liao, Zhongxiang Ding
BACKGROUND: In the spectrum of Alzheimer's Disease (AD) and related disorders, the resting-state functional magnetic resonance imaging (rs-fMRI) signals within the cerebral cortex may exhibit distinct characteristics across various frequency ranges. Nevertheless, this hypothesis has not yet been substantiated within the broader context of whole-brain functional connectivity. This study aims to explore potential modifications in degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) among individuals with amnestic mild cognitive impairment (aMCI) and AD, while assessing whether these alterations differ across distinct frequency bands...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38605858/retraction-qbd-based-rivastigmine-tartrate-loaded-solid-lipid-nanoparticles-for-enhanced-intranasal-delivery-to-the-brain-for-alzheimer-s-therapeutics
#13
(no author information available yet)
[This retracts the article DOI: 10.3389/fnagi.2022.960246.].
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38601850/two-sample-mendelian-randomization-analysis-of-91-circulating-inflammatory-protein-levels-and-amyotrophic-lateral-sclerosis
#14
JOURNAL ARTICLE
Chenxu Xiao, Xiaochu Gu, Yu Feng, Jing Shen
INTRODUCTION: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood pathophysiology. Recent studies have highlighted systemic inflammation, especially the role of circulating inflammatory proteins, in ALS. METHODS: This study investigates the potential causal link between these proteins and ALS. We employed a two-sample Mendelian Randomization(MR) approach, analyzing data from large-scale genome-wide association studies to explore the relationship between 91 circulating inflammatory proteins and ALS...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38596597/the-assessment-of-executive-function-abilities-in-healthy-and-neurodegenerative-aging-a-selective-literature-review
#15
REVIEW
Mojitola I Idowu, Andre J Szameitat, Andrew Parton
Numerous studies have examined executive function (EF) abilities in cognitively healthy older adults and those living with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, there are no standard accepted protocols for testing specific EFs; thus, researchers have used their preferred tool, which leads to variability in assessments of decline in a particular ability across studies. Therefore, there is a need for guidance as to the most sensitive tests for assessing EF decline. A search of the most current literature published between 2000 and 2022 on EF studies assessing cognitively healthy older adults and individuals living with MCI and AD was conducted using PubMed/Medline, PsycINFO, Embase, Web of Science, and Google Scholar...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38596596/editorial-therapeutic-neuromodulation-for-aging-related-disorders-associated-with-the-autonomic-nervous-system
#16
EDITORIAL
Stephanie Chee Yee Tjen-A-Looi, Liang-Wu Fu, Shaista Malik, Richard E Harris, Sae Uchida
No abstract text is available yet for this article.
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38596595/effects-of-electroacupuncture-on-postoperative-cognitive-dysfunction-and-its-underlying-mechanisms-a-literature-review-of-rodent-studies
#17
Wenbo Zhao, Wei Zou
With the aging of the population, the health of the elderly has become increasingly important. Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients following general anesthesia or surgery. It is characterized by cognitive decline that may persist for weeks, months, or even longer. Electroacupuncture (EA), a novel therapy that combines physical nerve stimulation with acupuncture treatment from traditional Chinese medicine, holds potential as a therapeutic intervention for preventing and treating POCD, particularly in elderly patients...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38590757/irreversible-atrophy-in-memory-brain-regions-over-7%C3%A2-years-is-predicted-by-glycemic-control-in-type-2-diabetes-without-mild-cognitive-impairment
#18
JOURNAL ARTICLE
Nádia Canário, Joana Crisóstomo, João Valente Duarte, Carolina Moreno, Hugo Quental, Leonor Gomes, Francisco Oliveira, Miguel Castelo-Branco
Memory-related impairments in type 2 diabetes may be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control and a decrease in hippocampal volumes, but only longitudinal studies can test this hypothesis directly. We performed a longitudinal morphometric study to provide a direct test of a possible role of higher levels of glycated hemoglobin with long term brain structural integrity in key regions of the memory system - hippocampus, parahippocampal gyrus and fusiform gyrus...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38586829/associative-role-of-hla-drb1-as-a-protective-factor-for-susceptibility-and-progression-of-parkinson-s-disease-a-chinese-cross-sectional-and-longitudinal-study
#19
JOURNAL ARTICLE
Raoli He, Yuqi Zeng, Chaodong Wang, Lina Chen, Guoen Cai, Ying Chen, Yingqing Wang, Qinyong Ye, Xiaochun Chen
BACKGROUND: Previous genome-wide association studies investigating the relationship between the HLA-DRB1 and the risk of Parkinson's disease (PD) have shown limited racial diversity and have not explored clinical heterogeneity extensively. METHODS: The study consisted of three parts: a case-control study, a cross-sectional study, and a longitudinal cohort study. The case-control study included 477 PD patients and 477 healthy controls to explore the relationship between rs660895 and PD susceptibility...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38586828/causal-role-of-immune-cells-on-risk-of-parkinson-s-disease-a-mendelian-randomization-study
#20
JOURNAL ARTICLE
Jian Gu, Yue Qiao, Shuyan Cong
BACKGROUND: Previous observational studies have suggested a correlation between immune cells and Parkinson's disease (PD), yet specific investigations into the causal relationship between the two remain limited. This study aims to explore this potential causal relationship. METHODS: We utilized genome-wide association study (GWAS) data on immune cells and Parkinson's Disease, conducting a two-sample Mendelian randomization (MR) analysis using single nucleotide polymorphisms (SNPs)...
2024: Frontiers in Aging Neuroscience
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