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Journal Article
Review
Recent Advances in Zirconium-89 Chelator Development.
The interest in zirconium-89 (89 Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it must be stably bound to a targeting ligand, and the most successfully used 89 Zr chelator is desferrioxamine B (DFO), which is commercially available as the iron chelator Desferal® . Despite the prevalence of DFO in 89 Zr-immuno-PET applications, the development of new ligands for this radiometal is an active area of research. This review focuses on recent advances in zirconium-89 chelation chemistry and will highlight the rapidly expanding ligand classes that are under investigation as DFO alternatives.
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