We have located links that may give you full text access.
Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages.
BMC Medical Imaging 2010
BACKGROUND: We sought to compare quantification of left ventricular volumes and ejection fraction by different gated myocardial perfusion SPECT (MPS) programs with each other and to magnetic resonance (MR) imaging.
METHODS: N = 100 patients with known or suspected coronary artery disease were examined at rest with 99 mTc-tetrofosmin gated MPS and cardiac MR imaging. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were obtained by analysing gated MPS data with four different programs: Quantitative Gated SPECT (QGS), GE MyoMetrix, Emory Cardiac Toolbox (ECTb) and Exini heart.
RESULTS: All programs showed a mean bias compared to MR imaging of approximately -30% for EDV (-22 to -34%, p < 0.001 for all), ESV (-12 to -37%, p < 0.001 for ECTb, p < 0.05 for Exini, p = ns for QGS and MyoMetrix) and SV (-21 to -41%, p < 0.001 for all). Mean bias +/- 2 SD for EF (% of EF) was -9 +/- 27% (p < 0.01), 6 +/- 29% (p = ns), 15 +/- 27% (p < 0.001) and 0 +/- 28% (p = ns) for QGS, ECTb, MyoMetrix, and Exini, respectively.
CONCLUSIONS: Gated MPS, systematically underestimates left ventricular volumes by approximately 30% and shows a high variability, especially for ESV. For EF, accuracy was better, with a mean bias between -15 and 6% of EF. It may be of value to take this into consideration when determining absolute values of LV volumes and EF in a clinical setting.
METHODS: N = 100 patients with known or suspected coronary artery disease were examined at rest with 99 mTc-tetrofosmin gated MPS and cardiac MR imaging. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were obtained by analysing gated MPS data with four different programs: Quantitative Gated SPECT (QGS), GE MyoMetrix, Emory Cardiac Toolbox (ECTb) and Exini heart.
RESULTS: All programs showed a mean bias compared to MR imaging of approximately -30% for EDV (-22 to -34%, p < 0.001 for all), ESV (-12 to -37%, p < 0.001 for ECTb, p < 0.05 for Exini, p = ns for QGS and MyoMetrix) and SV (-21 to -41%, p < 0.001 for all). Mean bias +/- 2 SD for EF (% of EF) was -9 +/- 27% (p < 0.01), 6 +/- 29% (p = ns), 15 +/- 27% (p < 0.001) and 0 +/- 28% (p = ns) for QGS, ECTb, MyoMetrix, and Exini, respectively.
CONCLUSIONS: Gated MPS, systematically underestimates left ventricular volumes by approximately 30% and shows a high variability, especially for ESV. For EF, accuracy was better, with a mean bias between -15 and 6% of EF. It may be of value to take this into consideration when determining absolute values of LV volumes and EF in a clinical setting.
Full text links
Related Resources
Trending Papers
Executive Summary: State-of-the-Art Review: Unintended Consequences: Risk of Opportunistic Infections Associated with Long-term Glucocorticoid Therapies in Adults.Clinical Infectious Diseases 2024 April 11
Clinical practice guidelines on the management of status epilepticus in adults: A systematic review.Epilepsia 2024 April 13
Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.International Journal of Molecular Sciences 2024 April 13
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app