Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice

Y Ashani, S Shapira, D Levy, A D Wolfe, B P Doctor, L Raveh
Biochemical Pharmacology 1991 January 1, 41 (1): 37-41
Human butyrylcholinesterase (BChE, EC or acetylcholinesterase (AChE, EC from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately 1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated between blood-ChE levels and the protection conferred by exogeneously administered ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective prophylactic measure sufficient to protect mice from multiple LD50S of soman without the administration of post-treatment supportive drugs.

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