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Comparative Study
Journal Article
Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies.
Arteriosclerosis, Thrombosis, and Vascular Biology 2003 Februrary 2
OBJECTIVE: Carotid artery intima-media thickness (IMT) is an intermediate phenotype for atherosclerosis. In a community population (n=5400), we determined whether a parental history of myocardial infarction (MI) or stroke is associated with increased IMT and whether associations differ at specific sites in the carotid arterial tree.
METHODS AND RESULTS: Using regression modeling, the proportion of IMT that remains unexplained after controlling for vascular risk factors was determined. A parental history of stroke was associated with both increased common carotid artery (CCA) and increased internal carotid artery (ICA)-IMT, but in young individuals (
CONCLUSIONS: IMT has a significant familial component that is independent of conventional risk factors. Associations for stroke and MI differ at specific sites in the carotid arterial tree. Although commonly used aggregate CCA/ICA-IMT measures may be appropriate for candidate gene studies investigating stroke risk, these results suggest that CCA-IMT alone may be a better marker for MI risk.
METHODS AND RESULTS: Using regression modeling, the proportion of IMT that remains unexplained after controlling for vascular risk factors was determined. A parental history of stroke was associated with both increased common carotid artery (CCA) and increased internal carotid artery (ICA)-IMT, but in young individuals (
CONCLUSIONS: IMT has a significant familial component that is independent of conventional risk factors. Associations for stroke and MI differ at specific sites in the carotid arterial tree. Although commonly used aggregate CCA/ICA-IMT measures may be appropriate for candidate gene studies investigating stroke risk, these results suggest that CCA-IMT alone may be a better marker for MI risk.
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