Skin and nail changes in children with sickle cell anemia receiving hydroxyurea therapy

E E O'branski, R E Ware, N S Prose, T R Kinney
Journal of the American Academy of Dermatology 2001, 44 (5): 859-61
Skin and nail changes from long-term hydroxyurea therapy are reported in adults. Skin and nail changes, including nail hyperpigmentation, longitudinal bands, and hyperpigmentation of the palms and other skin surfaces, developed in 7 children with sickle cell anemia after 6 to 16 weeks of hydroxyurea therapy. Cutaneous and nail changes may occur in children receiving hydroxyurea.

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