The molecular biology of midgut neuroendocrine neoplasms.

Midgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumours, and the unexplained occurrence of multi-focal tumours makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the understanding of the interplay of the genetic, epigenetic and transcriptomic landscape in the development of midgut NENs; a topic which is critical to understanding their biology and improving treatment options and outcomes for patients.