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[What do the results of the ORAL surveillance study mean for the treatment of rheumatoid arthritis with tofacitinib?].
Nederlands Tijdschrift Voor Geneeskunde 2022 June 10
Tofacitinib is a relatively new oral drug for the treatment of rheumatoid arthritis. The ORAL surveillance study shows in a direct comparison that more patients with RA develop a 'major adverse cardiovascular event' (MACE) or malignancy during treatment with tofacitinib than during treatment with a tumor necrosis factor (TNF) inhibitor. The reliability of the study, the generalisability and interpretation of the results, as well as their implication for daily practice are discussed here.
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