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Journals International Journal of Gynec...

International Journal of Gynecological Pathology

https://read.qxmd.com/read/38501593/a-novel-epc1-kdm2b-fusion-in-high-grade-endometrial-stromal-sarcoma
#1
JOURNAL ARTICLE
Katherine M Vroobel, Sana Khalid, Silvia Cavalchini, Ayoma D Attygalle
The spectrum of endometrial stromal sarcoma (ESS) has expanded substantially since the publication of the most recent World Health Organisation (WHO) Classification of Female Genital Tumours and the advent of widely available genomic testing. We describe a uterine mesenchymal tumor harboring a novel EPC1::KDM2B fusion, best classified within the umbrella of high-grade endometrial stromal sarcoma (HGESS). This tumor was composed of a uniform population of spindled cells with some myxoid stroma, a mitotic rate of up to 21/10 high-power fields, and a largely pushing margin with focal vascular invasion...
March 11, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38436360/her2-low-and-overexpression-in-mucinous-ovarian-cancer-analysis-of-asco-cap-and-toga-immunohistochemical-scoring
#2
JOURNAL ARTICLE
Rachel Han, Ainhoa Madariaga, Eduardo Gonzalez-Ochoa, Adam C Smith, Lisa Wang, Stephanie Lheureux, Marjan Rouzbahman
Mucinous ovarian carcinoma is an uncommon malignancy characterized by resistance to chemotherapy and poor survival in the metastatic setting. HER2 amplification is a frequent late event in carcinogenesis, yet the incidence of HER2-low in mucinous ovarian carcinoma is unknown. Further, the optimal method for determining overexpression in these tumors is not established. We sought to assess the ASCO/CAP and ToGA trial scoring methods for HER2 IHC with correlation to FISH, p53, and mismatch repair protein status and to determine the incidence of HER2-low in mucinous ovarian carcinoma...
March 4, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38436404/gynecologic-pathology-journal-club-a-2-year-worldwide-virtual-learning-experience-with-a-focus-on-mentorship-and-inclusion
#3
JOURNAL ARTICLE
Natalie Banet, Carlos Parra-Herran, Joseph T Rabban, Esther Oliva, Lora H Ellenson, Kay J Park, Naveena Singh, Kyle M Devins, Sameera Rashid, Karen L Talia
Journal clubs (JCs) are a common format used in teaching institutions to promote trainee engagement and develop skills in seeking out evidence-based medicine and critically evaluating literature. Digital technology has made JC accessible to worldwide audiences, which allows for increased inclusion of globally diverse presenters and attendees. Herein we describe the experience of the first 2 years of a virtual gynecologic pathology JC designed with the goal of providing mentorship and increasing inclusivity...
February 19, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38426544/novel-foxl2-mutation-in-an-ovarian-adult-granulosa-cell-tumor-report-of-a-case-with-diagnostic-and-clinicopathologic-implications
#4
JOURNAL ARTICLE
Agnes Nagy, Na Niu, Elena Ratner, Pei Hui, Natalia Buza
Adult granulosa cell tumor, the most common malignant ovarian sex cord-stromal tumor, harbors the characteristic mutation c.402C>G (p.C134W) in the FOXL2 gene in ~90% to 95% of cases. To date, no other variants of FOXL2 mutations have been identified in these tumors. Here we report the first case of an adult granulosa cell tumor with a novel FOXL2 point mutation c.398C>T (p.A133V) presenting in a 64-year-old postmenopausal woman. The patient underwent total hysterectomy and bilateral salpingo-oophorectomy for atypical endometrial hyperplasia and gross examination revealed an incidental 3...
February 19, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38303111/pd-l1-expression-in-hpv-associated-versus-hpv-independent-invasive-vulvar-squamous-cell-carcinoma
#5
JOURNAL ARTICLE
Chau Minh Bui, Fabiola Medeiros, Mahzad Azimpouran, Mariza Venturina, Bonnie Balzer
Two etiological pathways have been implicated in the pathogenesis of vulvar squamous cell carcinoma (VSCC): a high-risk human papillomavirus (HPV)-associated route and an HPV-independent pathway characterized by TP53 mutations. Programmed cell death ligand 1 (PD-L1) has become increasingly useful in predicting the response to checkpoint inhibitor therapy in squamous cell carcinomas at various anatomical sites. This study aimed to assess the association between PD-L1 expression and the VSCC subtype to evaluate the utility of PD-L1 in prognostication and therapeutic selection based on HPV status...
February 2, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38303108/does-one-size-fits-all-rethinking-figo-depth-of-invasion-measurements-in-vulvar-cancer
#6
JOURNAL ARTICLE
Maaike C G Bleeker, Tjalling Bosse, Koen K van de Vijver, Joost Bart, Hugo Horlings, Trudy G N Jonges, Nicole C M Visser, Loes F S Kooreman, Johan Bulten, Patricia C Ewing-Graham
Depth of invasion (DOI) is an important diagnostic parameter in patients with vulvar carcinoma, where a cutoff value of 1 mm largely determines the tumor stage and the need for groin surgery. DOI measurement should be reproducible and straightforward. In light of the new recommendation on how to measure DOI in the International Federation of Gynecology and Obstetrics (FIGO) staging system 2021, an exploratory study was conducted on the current practice of DOI measurement in vulvar cancer. In this study of 26 selected cases, 10 pathologists with high exposure to vulvar cancer cases in daily practice assessed both the conventional (FIGO 2009) and alternative (FIGO 2021) DOI methods for applicability and preference...
February 2, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38303106/endometrial-carcinosarcomas-are-almost-exclusively-of-p53abn-molecular-subtype-after-exclusion-of-mimics
#7
JOURNAL ARTICLE
Jutta Huvila, Amy Jamieson, Jennifer Pors, Lynn Hoang, Jelena Mirkovic, Dawn Cochrane, Jessica N McAlpine, C Blake Gilks
INTRODUCTION: Our aim was to assess the molecular subtype(s) and perform a detailed morphologic review of tumors diagnosed as carcinosarcoma in a population-based cohort. METHODS: Forty-one carcinosarcomas were identified from a cohort of 973 endometrial carcinomas diagnosed in 2016. We assessed immunostaining and sequencing data and undertook expert pathology reviews of these cases as well as all subsequently diagnosed (post-2016) carcinosarcomas of no specific molecular profile (NSMP) molecular subtype (n=3) from our institutions...
February 2, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38294060/high-risk-human-papillomavirus-associated-mixed-intestinal-type-mucinous-adenocarcinoma-and-low-grade-neuroendocrine-tumor-of-the-uterine-cervix-report-of-a-case-harboring-shared-arid1a-and-smad4-mutations-between-morphologically-distinct-components
#8
JOURNAL ARTICLE
Rofieda Alwaqfi, Kaitlyn Gill, David N Brown, Britta Weigelt, Kay J Park, M Herman Chui
No abstract text is available yet for this article.
January 31, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38294049/risk-factors-affecting-clinical-outcomes-of-low-risk-early-stage-human-papillomavirus-associated-endocervical-adenocarcinoma-treated-by-surgery-alone-application-of-silva-pattern
#9
JOURNAL ARTICLE
Bong Kyung Bae, Hyunsik Bae, Won Kyung Cho, Byoung-Gie Kim, Chel Hun Choi, Tae-Joong Kim, Yoo-Young Lee, Jeong-Won Lee, Hyun-Soo Kim, Won Park
This study aimed to report the clinical outcomes and risk factors for survival of patients with low-risk early-stage human papillomavirus-associated (HPVA) endocervical adenocarcinoma (EAC) treated with surgery alone. This retrospective study obtained the clinicopathological data of patients with early-stage HPVA EAC who underwent surgery between 2012 and 2018. The Silva pattern of invasion was determined by reviewing pathology slides. Locoregional recurrence-free survival (RFS), RFS, and overall survival were calculated, and the risk factors for survival were analyzed...
January 31, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38293999/pd-l1-expression-and-silva-invasion-pattern-in-villoglandular-adenocarcinoma-of-the-uterine-cervix
#10
JOURNAL ARTICLE
Anna K Dietl, Matthias W Beckmann, Frederik A Stuebs, Paul Gass, Julius Emons, Arndt Hartmann, Ramona Erber
Villoglandular adenocarcinoma (VGA) of the uterine cervix is a rare subtype of endocervical adenocarcinoma in young women. Between 2007 and 2020, all women with endocervical adenocarcinoma were retrospectively reviewed to find patients with VGA. Eight patients in whom pure VGA had been diagnosed were included. The mean age at initial diagnosis was 36.3 years (range 24-46). After surgical treatment, patients were followed up for 59 months (range 16-150). To date, all patients are alive with no evidence of disease...
January 31, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38293998/predicting-progestin-therapy-response-with-pten-pax2-and-%C3%AE-catenin-in-patients-with-endometrioid-precancer
#11
JOURNAL ARTICLE
Naijia Liu, Wanrun Lin, Yan Wang, Zhigang Yao, Glorimar Rivera-Colon, Yan Li, Kelley S Carrick, Hao Chen, Elena Lucas, Wenxin Zheng
This study investigates the predictive value of biomarkers PTEN, PAX2, and β-catenin for therapeutic outcomes in patients with atypical endometrial hyperplasia or endometrioid intraepithelial neoplasia undergoing progestin therapy. In a retrospective study of 128 patients, we analyzed a total of 351 endometrial biopsy samples and categorized outcomes into responders (absence of residual disease) and nonresponders (presence of residual disease). We found aberrant biomarker expression in pretreatment cases: 48% for PTEN, 65% for PAX2, and 36% for β-catenin...
January 31, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38291567/evaluation-of-combined-p57kip2-immunohistochemistry-and-fluorescent-in-situ-hybridization-analysis-for-hydatidiform-moles-compared-with-genotyping-diagnosis
#12
JOURNAL ARTICLE
Hirokazu Usui, Kazufusa Hoshimoto, Asuka Sato, Motofumi Kano, Toshio Fukusato, Yukio Nakatani, Makio Shozu
Immunostaining with p57KIP2 is a widely used diagnostic technique to differentiate complete hydatidiform moles (CHMs) from partial hydatidiform moles (PHM) and non-molar hydropic abortion. However, distinguishing between PHMs and non-molar hydropic abortions using histopathology alone is often challenging. This study aimed to evaluate the technical validity and additional benefits of using fluorescence in situ hybridization (FISH) in combination with p57KIP2 immunostaining to diagnose molar and non-molar conceptuses...
January 31, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289148/possible-role-of-netrin-1-deleted-in-colorectal-cancer-vascular-endothelial-growth-factor-signaling-pathway-in-the-pathogenesis-of-placenta-accreta-spectrum-a-case-control-study
#13
JOURNAL ARTICLE
Dalia M Badary, Huda Elsaied, Mahmoud R Abdel-Fadeil, Mohammed K Ali, Hisham Abou-Taleb, Heba M Iraqy
Netrin-1, an epithelial-secreted protein, plays a key role in placental formation through the promotion of cytotrophoblast proliferation and placental vascular development. These effects are mediated through several receptors, including the deleted in colorectal cancer (DCC) receptor. Placenta accreta spectrum (PAS) is an exaggerated trophoblastic invasion into the uterine myometrium. The exact etiology is unknown, but it is believed that increased trophoblastic invasion, defect decidualization, and/or abnormal angiogenesis might play a role...
January 29, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38329416/well-differentiated-squamous-cell-carcinoma-with-sarcomatous-differentiation-in-patient-with-a-history-of-recurrent-verrucous-carcinoma
#14
REVIEW
Komal Ijaz, Eric Johannesen, Van Nguyen T
Human papillomavirus-independent vulvar squamous cell carcinoma has a peak incidence in about the eighth decade of life. A variable portion of the vulvar squamous cell carcinoma are human papillomavirus-independent comprising 20% to 80% of all cases. Verrucous carcinoma (VC) is part of the spectrum of human papillomavirus-independent carcinomas and its combination with well-differentiated squamous cell carcinoma with sarcomatous differentiation is an extremely unusual neoplasm. The available literature on VC is currently limited to case reports and small single-institution studies...
March 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38329415/lawrence-m-roth-md-1936-2023
#15
JOURNAL ARTICLE
Thomas M Ulbright
No abstract text is available yet for this article.
March 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37922952/ovarian-endometrioid-adenocarcinomas-with-infiltrative-adenofibroma-like-morphology-and-aberrant-%C3%A3-catenin-expression-tumors-that-coexpress-cdx2-and-lef1-with-frequent-neuroendocrine-marker-expression-diminished-lost-pax8-and-possible-association-with-endometrioid
#16
JOURNAL ARTICLE
https://read.qxmd.com/read/38289183/smarcb1-ini1-deficient-tumours-of-the-uterine-cervix-report-of-two-cases-including-one-associated-with-an-ntrk-fusion
#17
JOURNAL ARTICLE
Rubina Razack, Jennifer L Butt, Isabelle Hostein, Valerie Velasco, Sabrina Croce, Carel Olory, Lili Fu, William D Foulkes, W Glenn McCluggage
Pathogenic variants (mutations) and other molecular events involving subunits of the SWItch/Sucrose Non-Fermentable chromatin remodelling complex are common in a wide variety of malignancies. Many of these neoplasms are characterized by undifferentiated morphology. They arise at a variety of sites in the female genital tract but have rarely been reported in the uterine cervix. We report 2 primary cervical neoplasms arising in young women (ages 28 and 29 yr) exhibiting loss of nuclear immunoreactivity with SMARCB1 (INI1)...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289161/cxcr4-expression-and-cancer-associated-fibroblasts-may-play-an-important-role-in-the-invasion-of-low-grade-endometrioid-carcinoma
#18
JOURNAL ARTICLE
Chihiro Fukumitsu, Sakiko Sanada, Sachiko Ogasawara, Naotake Tsuda, Kenta Murotani, Mayuka Akao, Kimio Ushijima, Jun Akiba, Hirohisa Yano
Well-differentiated endometrioid carcinoma (EC) is a low-grade cancer with relatively indolent behavior. However, even with well-differentiated histology, it sometimes tends to invade extensively and shows metastatic potential, suggesting that this is a group of cancers with heterogeneous behavior. In contrast, due to its tendency for younger onset, the treatment strategy for EC frequently considers fertility preservation, highlighting the need for a more accurate evaluation of myometrial invasion through biopsy and imaging diagnostics...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289149/adenoid-cystic-carcinoma-of-the-vulva-and-vagina-a-clinicopathologic-immunohistochemical-and-molecular-characterization-of-five-cases
#19
JOURNAL ARTICLE
Delfim Doutel, Diana Venda, Fernanda Silva, Carmo Martins, Ana Félix, Joana Ferreira
Adenoid cystic carcinoma (ACC) is a rare neoplasm most frequently observed in the salivary glands, that can occur in other organs, including the vulva and vagina. Oncogenic mechanisms involving MYB, NFIB, and MYB-NFIB rearrangements have been described, but evidence in the vulva and vagina remains scarce. Our aim is to report the clinicopathologic features, immunohistochemical, and molecular findings in a series of vulvar and vaginal ACCs. Five cases were included. Medical records and slides were reviewed. Formalin-fixed paraffin-embedded material was available in 4 cases, where additional immunohistochemical and molecular studies were carried out...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289146/clinical-significance-of-tumor-immune-microenvironment-in-endometrial-endometrioid-carcinoma-grade-1-with-dna-mismatch-repair-protein-loss
#20
JOURNAL ARTICLE
Kazuhisa Hachisuga, Minoru Kawakami, Hiroshi Tomonobe, Shoji Maenohara, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Hideaki Yahata, Yoshinao Oda, Kiyoko Kato
The administration of immune checkpoint inhibitors (ICIs) is increasing in endometrial cancer, especially in the mismatch repair (MMR)-deficient group. To prevent unnecessary immune-related adverse events, ICIs need to be administered to more appropriate patients. The tumor immune microenvironment has been reported to be a predictive marker of the efficacy of ICI therapies. This study evaluated CD8, FoxP3, CD68, PD-L1, and β-catenin expression in endometrial endometrioid carcinoma, grade 1 (G1) with DNA mismatch repair protein loss (MMR loss), and their association with clinicopathological features...
January 22, 2024: International Journal of Gynecological Pathology
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