Naijia Liu, Wanrun Lin, Yan Wang, Zhigang Yao, Glorimar Rivera-Colon, Yan Li, Kelley S Carrick, Hao Chen, Elena Lucas, Wenxin Zheng
This study investigates the predictive value of biomarkers PTEN, PAX2, and β-catenin for therapeutic outcomes in patients with atypical endometrial hyperplasia or endometrioid intraepithelial neoplasia undergoing progestin therapy. In a retrospective study of 128 patients, we analyzed a total of 351 endometrial biopsy samples and categorized outcomes into responders (absence of residual disease) and nonresponders (presence of residual disease). We found aberrant biomarker expression in pretreatment cases: 48% for PTEN, 65% for PAX2, and 36% for β-catenin...
January 31, 2024: International Journal of Gynecological Pathology