journal
Journals International Journal of Gynec...

International Journal of Gynecological Pathology

https://read.qxmd.com/read/38289148/possible-role-of-netrin-1-deleted-in-colorectal-cancer-vascular-endothelial-growth-factor-signaling-pathway-in-the-pathogenesis-of-placenta-accreta-spectrum-a-case-control-study
#21
JOURNAL ARTICLE
Dalia M Badary, Huda Elsaied, Mahmoud R Abdel-Fadeil, Mohammed K Ali, Hisham Abou-Taleb, Heba M Iraqy
Netrin-1, an epithelial-secreted protein, plays a key role in placental formation through the promotion of cytotrophoblast proliferation and placental vascular development. These effects are mediated through several receptors, including the deleted in colorectal cancer (DCC) receptor. Placenta accreta spectrum (PAS) is an exaggerated trophoblastic invasion into the uterine myometrium. The exact etiology is unknown, but it is believed that increased trophoblastic invasion, defect decidualization, and/or abnormal angiogenesis might play a role...
January 29, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289183/smarcb1-ini1-deficient-tumours-of-the-uterine-cervix-report-of-two-cases-including-one-associated-with-an-ntrk-fusion
#22
JOURNAL ARTICLE
Rubina Razack, Jennifer L Butt, Isabelle Hostein, Valerie Velasco, Sabrina Croce, Carel Olory, Lili Fu, William D Foulkes, W Glenn McCluggage
Pathogenic variants (mutations) and other molecular events involving subunits of the SWItch/Sucrose Non-Fermentable chromatin remodelling complex are common in a wide variety of malignancies. Many of these neoplasms are characterized by undifferentiated morphology. They arise at a variety of sites in the female genital tract but have rarely been reported in the uterine cervix. We report 2 primary cervical neoplasms arising in young women (ages 28 and 29 yr) exhibiting loss of nuclear immunoreactivity with SMARCB1 (INI1)...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289161/cxcr4-expression-and-cancer-associated-fibroblasts-may-play-an-important-role-in-the-invasion-of-low-grade-endometrioid-carcinoma
#23
JOURNAL ARTICLE
Chihiro Fukumitsu, Sakiko Sanada, Sachiko Ogasawara, Naotake Tsuda, Kenta Murotani, Mayuka Akao, Kimio Ushijima, Jun Akiba, Hirohisa Yano
Well-differentiated endometrioid carcinoma (EC) is a low-grade cancer with relatively indolent behavior. However, even with well-differentiated histology, it sometimes tends to invade extensively and shows metastatic potential, suggesting that this is a group of cancers with heterogeneous behavior. In contrast, due to its tendency for younger onset, the treatment strategy for EC frequently considers fertility preservation, highlighting the need for a more accurate evaluation of myometrial invasion through biopsy and imaging diagnostics...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289149/adenoid-cystic-carcinoma-of-the-vulva-and-vagina-a-clinicopathologic-immunohistochemical-and-molecular-characterization-of-five-cases
#24
JOURNAL ARTICLE
Delfim Doutel, Diana Venda, Fernanda Silva, Carmo Martins, Ana Félix, Joana Ferreira
Adenoid cystic carcinoma (ACC) is a rare neoplasm most frequently observed in the salivary glands, that can occur in other organs, including the vulva and vagina. Oncogenic mechanisms involving MYB, NFIB, and MYB-NFIB rearrangements have been described, but evidence in the vulva and vagina remains scarce. Our aim is to report the clinicopathologic features, immunohistochemical, and molecular findings in a series of vulvar and vaginal ACCs. Five cases were included. Medical records and slides were reviewed. Formalin-fixed paraffin-embedded material was available in 4 cases, where additional immunohistochemical and molecular studies were carried out...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38289146/clinical-significance-of-tumor-immune-microenvironment-in-endometrial-endometrioid-carcinoma-grade-1-with-dna-mismatch-repair-protein-loss
#25
JOURNAL ARTICLE
Kazuhisa Hachisuga, Minoru Kawakami, Hiroshi Tomonobe, Shoji Maenohara, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Hideaki Yahata, Yoshinao Oda, Kiyoko Kato
The administration of immune checkpoint inhibitors (ICIs) is increasing in endometrial cancer, especially in the mismatch repair (MMR)-deficient group. To prevent unnecessary immune-related adverse events, ICIs need to be administered to more appropriate patients. The tumor immune microenvironment has been reported to be a predictive marker of the efficacy of ICI therapies. This study evaluated CD8, FoxP3, CD68, PD-L1, and β-catenin expression in endometrial endometrioid carcinoma, grade 1 (G1) with DNA mismatch repair protein loss (MMR loss), and their association with clinicopathological features...
January 22, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38081059/two-rare-cases-of-paratubal-leydig-cell-nodules-clinical-relevance-and-debated-terminology-of-a-noteworthy-incidentaloma
#26
JOURNAL ARTICLE
Edgar G Fischer
Cells with cytologic and immunohistochemical features of Leydig cells are normally present in the ovary and the ovarian hilum, are testosterone-producing, and have been referred to as ovarian hilus cells. Rarely these cells form nests or nodules in extraovarian sites such as the mesovarium or mesosalpinx. Because they are so rare, these nodules can present a diagnostic challenge when first encountered. This report describes 2 such incidental nodules in the mesosalpinx associated with a small paratubal cyst and suggests that the term Leydig cell nodule be preferred over the nonspecific and confusing historical term ovarian hilus cell nest...
January 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38081058/dr-naveena-singh-december-4-1964-october-5-2023-president-elect-international-society-of-gynecological-pathologists
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37668341/uterine-sarcoma-with-eml4-ntrk3-fusion-a-spectrum-of-mesenchymal-neoplasms-harboring-actionable-gene-fusions
#28
JOURNAL ARTICLE
João Víctor Alves de Castro, Pedro José Silva Dos Santos, Henrique Mantoan, Glauco Baiocchi, Graziele Bovolim, Giovana Torrezan, Marcelo Corassa, Antônio Geraldo do Nascimento, Marina De Brot, Felipe D'Almeida Costa, Louise De Brot
NTRK gene fusions are part of a paradigm shift in oncology, arising as one of the main genomic alterations with actionability in the so-called "agnostic setting." In gynecologic pathology, the recent description of uterine sarcoma resembling fibrosarcoma and with NTRK rearrangements ( NTRK -rearranged uterine sarcoma) highlights the importance of recognizing clinicopathological cues that can lead to genomic profiling. Herein, we report the case of a 43-year-old woman presenting with vaginal bleeding and pelvic mass...
January 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37406360/a-case-of-uterine-tumor-resembling-ovarian-sex-cord-tumor-with-prominent-myxoid-features
#29
JOURNAL ARTICLE
Koki Ise, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Hirokazu Sugino, Yusuke Ishida, Masumi Tsuda, Yuko Gotoda, Kunihiko Nishiwaki, Hiroyuki Yanai, Tadashi Hasegawa, Kazuo Nagashima, Shinya Tanaka
Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare tumor with low malignant potential that commonly occurs in middle age. Although more than 100 cases have been reported to date, myxoid morphology is not well documented. Here, we present a 75-yr-old woman with abnormal vaginal bleeding, with an 8-cm mass in the uterine corpus detected by irregular, high-intensity signaling on T2-weighted imaging. The uterine mass had a glistening mucinous appearance on gross examination. Microscopically, most of the tumor cells were floating in the myxoid stroma...
January 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37255420/reconsideration-of-the-diagnostic-criteria-for-an-atypical-placental-site-nodule-comparing-typical-placental-site-nodule-of-the-uterus-a-report-of-two-cases
#30
JOURNAL ARTICLE
Uiree Jo, Gi Hwan Kim, Kyu-Rae Kim
Placental site nodules (PSNs) are non-neoplastic remnants of chorionic-type intermediate trophoblastic cells from a previous gestation that form a well-defined single nodule or multiple nodules in the uterine and extrauterine sites. As the cases of PSNs transformed into gestational trophoblastic tumors were described in the literature, "atypical placental site nodules" (APSNs) have been considered as putative transitional lesions between PSNs and gestational trophoblastic tumors. Although histologic criteria and cutoff point of Ki-67 proliferation index for differentiating an APSN from a typical PSN have not been clearly defined, nodules larger than 5 mm with increased cellularity, a corded or nested appearance, marked nuclear atypia, increased mitotic activity, and an increased Ki-67 proliferation index (>5% or >8%) of intermediate trophoblastic cells seem to be accepted as diagnostic criteria for APSNs...
January 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37043646/uterine-meis1-ncoa2-fusion-sarcoma-with-lung-metastasis-a-case-report-and-review-of-the-literature
#31
REVIEW
Deyin Xing, Christian F Meyer, John M Gross, Pedram Argani, Chien-Fu Hung, T-C Wu, Russell Vang, Deborah K Armstrong, Stéphanie L Gaillard
MEIS1::NCOA1/2 fusion sarcomas are a recently described novel entity arising in a variety of locations with a predilection for the genitourinary tract and gynecologic organs. Despite multiple locoregional recurrences, these tumors are thought to behave in a low-grade malignant manner. Here we report a uterine MEIS1::NCOA2 fusion sarcoma with lung metastasis. The patient was a 47-yr-old woman with a history of abnormal uterine bleeding who was found to have a myometrial mass confirmed by pathology to be uterine sarcoma...
January 1, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38113031/smarca4-brg1-deficient-uterine-neoplasm-with-hybrid-adenosarcoma-and-carcinoma-features-expanding-the-molecular-morphologic-spectrum-of-smarca4-driven-gynecologic-malignancies
#32
JOURNAL ARTICLE
Christina H Wei, Evita Sadimin, Mark Agulnik, Susan E Yost, Teri A Longacre, Oluwole Fadare
SMARCA4 gene encodes BRG1, a member of the SWItch/sucrose non-fermentable protein family involved in epigenetic transcriptional regulation of important cellular processes. In the uterine corpus, SMARCA4/BRG1 deficiency is associated with a novel class of undifferentiated uterine sarcomas, characterized by younger age onset, rhabdoid histology, focal phyllodiform architecture, high-risk pathologic findings, and dismal prognosis. Herein, we report a case of a 34-year-old Asian woman with a SMARCA4/BRG1-deficient uterine tumor fulfilling the clinicopathologic features of an undifferentiated uterine sarcoma...
December 12, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38085951/prame-immunohistochemistry-for-distinguishing-vulvar-and-vaginal-melanoma-from-benign-melanocytic-nevi
#33
JOURNAL ARTICLE
Spencer D Martin, Karina C Martin, C Blake Gilks, Richard I Crawford, Lien N Hoang
Vulvovaginal melanoma (VVM) is a rare but deadly disease, accounting for 5% of all vulvar malignancies, with a 5-yr survival rate of only 47% for all stages of the disease. VVM is a distinct subset of melanoma, with a unique genomic profile and underlying pathogenesis unassociated with sun exposure. Distinguishing these rare malignancies from very common pigmented lesions of the vulva and vagina is challenging as histologic features often overlap between entities. PReferentially expressed Antigen in MElanoma (PRAME) is a melanoma-associated protein, and immunohistochemistry (IHC) for PRAME distinguishes cutaneous, oral mucosal, and retinal melanoma from atypical nevi...
December 6, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38085958/preferentially-expressed-antigen-in-melanoma-expression-in-uterine-and-ovarian-carcinosarcomas
#34
JOURNAL ARTICLE
Alaaeddin Alrohaibani, Yun Yu, Lina Gao, Kimberly M McLean, Jonathon Hetts, Ozlen Saglam
Carcinosarcoma (CS) is an aggressive form of gynecologic malignancy that accounts for ~5% of carcinomas in the endometrium and ovaries. There has been no significant improvement in survival over the last decades despite additional treatment options. PReferentially Expressed Antigen in MElanoma (PRAME) is an immunotherapy target used for the treatment of several solid tumors. We explored the PRAME protein expression levels in ovarian and uterine CS (n = 29). The expression levels were recorded by H-score (percentage of positively stained cells multiplied by staining intensity) in carcinomatous and sarcomatous components separately and compared by paired t-test...
November 13, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38085954/ovarian-mesonephric-like-adenocarcinoma-recurring-with-a-rhabdomyosarcoma-component-a-case-report
#35
JOURNAL ARTICLE
Akiko Yamamoto, Takeshi Nagai, Aoi Sukeda, Manami Kajiwara, Masaharu Fukunaga, Toru Sasaki, Yuta Kinoshita, Motoshige Hayashi, Shigehiro Hayashi, Masataka Ono, Masayuki Futagami, Hirotaka Nishi
Mesonephric-like adenocarcinoma (MLA) has recently been described as a tumor of the endometrium or ovaries, which, morphologically and immunohistochemically, resembles mesonephric adenocarcinoma arising mostly in the uterine cervix. Herein, we report, to our knowledge, the first case of ovarian MLA that developed into an extremely rapidly growing recurrent mesonephric-like carcinosarcoma, as confirmed by a genomic profiling test. A 51-year-old woman underwent chemotherapy with complete debulking surgery for ovarian carcinoma...
November 13, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38085960/immunohistochemical-expression-of-lymphoid-enhancer-binding-factor-1-in-low-grade-endometrial-stromal-tumors
#36
JOURNAL ARTICLE
Shuo Niu, Haiyan Lu, Wencheng Li, Yanjun Hou
Endometrial stromal tumors (ESTs) are uncommon uterine mesenchymal lesions. Nuclear expression of β-catenin, an indication of activated Wnt/β-catenin signaling pathway, was described in 50% to 92% of low-grade ESTs, including endometrial stromal nodule and low-grade endometrial stromal sarcoma. Activation of the Wnt/β-catenin signaling pathway leads to the translocation of β-catenin into the nucleus and interaction with the T-cell factor/lymphoid enhancer-binding factor-1 (LEF1) family of transcription factors to regulate cell proliferation, differentiation, migration, and survival...
November 10, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38085957/proposal-of-novel-binary-grading-systems-for-cervical-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
Simona Stolnicu, Aaron M Praiss, Douglas Allison, Basile Tessier-Cloutier, Jessica Flynn, Alexia Iasonos, Lien Hoang, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R Lastra, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle Devins, Nadeem Abu-Rustum, Robert A Soslow
We compared grading systems and examined associations with tumor stroma and survival in patients with cervical squamous cell carcinoma. Available tumor slides were collected from 10 international institutions. Broders tumor grade, Jesinghaus grade (informed by the pattern of tumor invasion), Silva pattern, and tumor stroma were retrospectively analyzed; associations with overall survival (OS), progression-free survival (PFS), and presence of lymph node metastases were examined. Binary grading systems incorporating tumor stromal changes into Broders and Jesinghaus grading systems were developed...
November 9, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37562066/zc3h7b-bcor-fusion-high-grade-endometrial-stromal-sarcoma-with-morphologic-features-of-low-grade-endometrial-stromal-sarcoma-a-case-report-and-review-of-literature
#38
REVIEW
Longmei Zhao, Yu-Wei Cheng, Maria Luisa C Policarpio-Nicolas
High-grade endometrial stromal sarcomas with ZC3H7B-BCOR fusion are rare. They are predominantly located in the endomyometrium, with morphologic features characterized as haphazardly arranged fascicles of spindle cells with mild to moderate atypia, abundant myxoid matrix, high mitotic index, and tongue-like/pushing patterns of myometrial invasion. Furthermore, conventional or variant low-grade endometrial stromal sarcomas are often not present. Clinically, they present at a higher stage and are associated with worse prognosis compared with low-grade endometrial stromal sarcoma...
November 1, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/36867505/ovarian-immature-teratoma-with-nodal-gliomatosis-a-case-report-and-literature-review
#39
REVIEW
Marwa Alna'irat, W Glenn McCluggage, Maysa Al-Hussaini
Gliomatosis involving lymph nodes (nodal gliomatosis) is rarely encountered in association with an ovarian teratoma, with 12 cases previously reported. We report this rare occurrence in a 23-yr-old female with an ovarian immature teratoma. The ovary contained a grade 3 immature teratoma, with immature neuroepithelium. A subcapsular liver mass contained metastatic immature teratoma with neuroepithelium. The omentum and peritoneum contained mature glial tissue, consistent with gliomatosis peritonei with no evidence of immature elements...
November 1, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/36706438/ovarian-clear-cell-carcinoma-and-markers-of-epithelial-mesenchymal-transition-emt-immunohistochemical-characterization-of-tumor-budding
#40
JOURNAL ARTICLE
Lawrence Hsu Lin, Ronaldo DeLeon Zamuco, Pratibha S Shukla
Tumor budding, largely considered a manifestation of epithelial-mesenchymal transition (EMT) is an established prognostic marker for several cancers. In a recent study, tumor budding was associated with poor clinical outcomes in early-stage ovarian clear cell carcinoma. Here, we evaluated the immune expression of 3 proteins shown to be associated with EMT (E-cadherin, β-catenin, and glypican-3) in 72 primary tumors of ovarian clear cell carcinoma with median follow-up of 39.47 mo. E-cadherin and β-catenin expression was further evaluated in tumor buds in 29 (40%) cases...
November 1, 2023: International Journal of Gynecological Pathology
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