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Ultrastructural Pathology

Waleed N Hassan, Ismaeel Bin-Jaliah, Mohamed A Haidara, Refaat A Eid, El Hassan A Heidar, Mohammad Dallak, Bahjat Al-Ani
We recently reported an animal model of osteoarthritis (OA) induced by a combination of the chondrocyte glycolysis inhibitor, monoiodoacetate (MIA) and the agent that induces diabetes mellitus, streptozotocin (STZ). Here we investigated the potential protective effect of the antioxidant and anti-inflammatory agent, vitamin E against MIA+STZ-induced OA. Therefore, rats were either injected once with MIA (2 mg/50 μL) + 65 mg/kg STZ before being sacrificed after 8 weeks (model group) or were treated immediately after MIA+STZ injections with vitamin E (600 mg/kg; thrice a week) before being sacrificed after 8 weeks (treatment group)...
June 9, 2019: Ultrastructural Pathology
Yong-Xin Ru, Shu-Xu Dong, Shi-Xuan Zhao, Yuan Li, Hao-Yue Liang, M M Fengkui Zhang, Xiaofan Zhu, Yizhou Zheng
Hematopoietic microenvironments have been extensively studied, especially focusing on regulation of hematopoietic stem cells (HSCs) in HSC niche following progress of molecular biology in resent years. Based on prior morphological achievements from 1970s, the characteristics of cellular compartments and bone marrow stromal cells (BMSCs) were studied ultrastructurally in human and mice bone marrow in the present study. The samples, human bone marrow granules, were collected from bone marrow aspirations (BMAs) of 20 patients with hematocytopenia and isolated BMSCs were found undesignedly in nucleated cells of BMAs of the patients...
May 28, 2019: Ultrastructural Pathology
John M Carney, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli
A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in morphology between diseases caused by dust inhalation (mineral pneumoconiosis) and other lung diseases. In such cases, analytical scanning electron microscopy (SEM) can provide valuable information to assist the pathologist in making the correct diagnosis...
May 21, 2019: Ultrastructural Pathology
Abeer M El-Mahalaway, Nahla El-Eraky El-Azab
Lithium (Li) is used for the treatment and prophylaxis of mental disorders, associated with many serious hazards. Resveratrol (RSV) has various beneficial therapeutic effects. Platelet-rich plasma (PRP) is a new promising curative tool. This study aimed to assess the impacts of RSV versus PRP on lithium-induced thyroid follicular cell toxicity in adult male rats. Forty-nine adult male rats were divided into four groups: group I: control rats; group II: lithium-treated rats; group III: lithium- and resveratrol-treated rats; group IV: lithium and PRP-treated rats...
April 13, 2019: Ultrastructural Pathology
Tuğçe Sapmaz, Leman Sencar Gündoğdu, Mehmet Turan Çetin, Ibrahim Ferhat Ürünsak, Sait Polat
Hydrosalpinx is a disease commonly observed in women and characterized by the obstruction which is in the shape of a fluid-filled sac at the distal part of tuba uterina closed to the ovary. In this study, we aimed to obtain endometrial tissue samples from the hydrosalpinx patients, before and after the surgical treatment and compare these endometrial tissue samples by using light and electron microscope. Endometrial tissue samples were obtained from the 24 women with bilateral hydrosalpinx range 19-46 years before and after the surgical treatment, and normal endometrial tissues were collected from five women without hydrosalpinx and evaluated as a control group...
April 9, 2019: Ultrastructural Pathology
Tugce Eskazan, Salime Pelin Erturkuner, Basak Isildar, Ahmet Emre Eskazan, Muhlis Cem Ar, Kadri Atay, Zafer Baslar, Mustafa Tasyurekli
Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder consisting of oculocutaneous albinism, platelet storage pool deficiency, and lysosomal accumulation of ceroid lipofuscin. The storage pool deficiency of HPS is associated with the lack of dense bodies in the platelets, resulting in impaired response in the secondary phase of aggregation. Patients with HPS have normal coagulation tests; however, their bleeding time is usually prolonged despite normal or increased platelet counts. Essential thrombocythemia (ET) is an uncommon condition, with an incidence of approximately 1...
April 1, 2019: Ultrastructural Pathology
Ereny F Y Makary, A A Rahman, Mona M Awny, Samy Makary
Cisplatin (CP) is a chemotherapy medication used to treat different types of organs cancers. It has damaging effects on testes. Mirtazapine is an antidepressant, which is used primarily in the treatment of depression and other anxiety disorders. Ginger is a naturally growing plant with antioxidant properties. Thirty-six adult male albino rats, subdivided into six groups (six animals each) received treatment for 30 days. Group I (control) received saline solution orally; group II received mirtazapine (20 mg/kg)...
March 30, 2019: Ultrastructural Pathology
Sandra A McDonald, Yuwei Fan, William R Welch, Daniel W Cramer, Rebecca C Stearns, Liam Sheedy, Marshall Katler, John J Godleski
Perineal talc use is associated with ovarian carcinoma in many case-control studies. Such talc may migrate to pelvic organs and regional lymph nodes, with both clinical and legal significance. Our goal was to differentiate talc in pelvic lymph nodes due to exposure, versus contamination with talc in the laboratory. We studied 22 lymph nodes from ovarian tumor patients, some of which had documented talc exposure, to quantify talc using digestion of tissue taken from paraffin blocks and scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDX)...
March 21, 2019: Ultrastructural Pathology
Fatemeh Nili, Fatemeh Saboori, Issa Jahanzad, Mitra Mehrazma
Distinction between minimal change disease and unsampled Focal Segmental Glomerulosclerosis is a challenging concept in kidney biopsy of patients with nephrotic syndrome with minimal histopathological findings. This study was performed to compare electron microscopic findings in patients with steroid-resistant nephrotic syndrome with minimal histopathological abnormalities and cases with Focal Segmental Glomerulosclerosis. This Cohort study was conducted in Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran...
March 5, 2019: Ultrastructural Pathology
Svetlana S Kirikovich, Oleg S Taranov, Vladimir V Omigov, Ekaterina A Potter, Evgenia V Dolgova, Anastasia S Proskurina, Yaroslav R Efremov, Sergey S Bogachev
Electron-microscopic analysis of the ultrastructure of the Krebs-2 carcinoma ascites cells in the first 90 min immediately after their exposure to fragmented double-stranded DNA has been performed. Morphological attributes of the treated cancer cells indicate the induction in these cells of destructive processes of presumably apoptotic type. The predominance of dystrophic-destructive changes in cells after the addition of DNA is supposed to be a consequence of the disturbance in metabolic processes caused by the experimental action...
February 13, 2019: Ultrastructural Pathology
Fatma Y Meligy, Amal T Abo Elgheed, Shymaa M Alghareeb
Infertility represents a major medical, economic, and psychological problem. Stem cells therapy for infertility has a great interest nowadays especially for cancer survivors at pre-reproductive and reproductive age.  Thirty-two adult male albino rats were used, divided equally into four groups; Group I (Control group) received isotonic saline intraperitoneally (i.p.) as vehicle. Group II (Cisplatin-treated group) received Cisplatin (i.p.) at a single dose of 7 mg/kg, and then were sacrificed after 5 days...
February 9, 2019: Ultrastructural Pathology
Victor L Roggli, Cynthia L Green
Asbestos is well-recognized as the cause of a variety of disorders of the respiratory tract, including neoplastic as well as non-neoplastic conditions. Fiber dimensions and biopersistence are important determinants of the pathologic response, and analytical electron microscopy is a powerful technique for determining the fiber content of lung tissue samples. For decades our laboratory has examined lung tissue samples counting fibers measuring 5 µm or greater in length. More recent observations have indicated that fibers 10 µm or greater in length are pathogenic, and that a length of 10 µm and diameter less than 1...
January 22, 2019: Ultrastructural Pathology
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No abstract text is available yet for this article.
2019: Ultrastructural Pathology
Dalia G Mostafa, Salwa Fares Ahmed, Ola A Hussein
Cadmium (Cd) has been recognized as one of the most important environmental and industrial pollutants. This study investigated the impact of acute exposure to Cd on oxidative stress and the inflammatory marker interleukin-6 (IL-6) in the plasma of rats and the histological picture of liver and kidney, as well as to examine the potential protective effect of tetrahydrobiopterin (BH4). METHODS: Rats were divided into control group, Cd group that received a single intraperitoneal (i.p.) dose of 4 mg/kg b...
December 29, 2018: Ultrastructural Pathology
Tijana Subotički, Olivera Mitrović Ajtić, Mileva Mićić, Tamara Kravić Stevović, Dragoslava Đikić, Miloš Diklić, Danijela Leković, Mirjana Gotić, Vladan P Čokić
In accordance with increased proliferation in myeloproliferative neoplasm (MPN), the goal is to evaluate the immunoexpression of: β-catenin, PPAR-γ and Ki67 protein, to compare them with bone marrow ultrastructural characteristics in patients with MPN. Immunoexpression and electron microscopy of bone marrow was analyzed in 30 Ph-negative MPN patients, including per 10 patients with polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The quantity of β-catenin immunoreactive cells was significantly higher in PV then in ET (p < 0...
December 24, 2018: Ultrastructural Pathology
Asterios Triantafyllou, Lauge Hjorth Mikkelsen, Douglas R Gnepp, Simon Andreasen, Jennifer L Hunt, Kenneth O Devaney, Vincent Vander Poorten, Alessandra Rinaldo, Stefan M Willems, Alfio Ferlito
Salivary myoepithelial cells bear particular appendages and are involved in processes that have received incomplete attention in previous reviews. Here, cilia on myoepithelial cells are reviewed as regards substructure, occurrence, detection (electron microscopy, double immunofluorescence together with confocal microscopy), and roles (sensory reception, evolutionary homology, paracrine interaction). Attention is drawn to regressive changes affecting those cells (e.g. accumulation of lipofuscin), possible alterations of their cytoskeleton, internalization of apoptotic bodies and haemosiderin, and role in salivary microcalcification...
December 10, 2018: Ultrastructural Pathology
Mohamed A Haidara, Mohammad Dallak, Abbas O El Karib, Mohamed Abd Ellatif, Refaat A Eid, El Hassan A Heidar, Bahjat Al-Ani
Diabetic complications that affect vital organs such as the heart and liver represent a major public health concern. The potential protective effects of the hormone insulin against hepatocyte ultrastructural alterations induced secondary to type 1 diabetes mellitus (T1DM) in a rat model of the disease have not been investigated before. Therefore, rats were injected once with 65 mg/kg streptozotocin (T1DM group) and the protection group (T1DM+Ins) received a daily injection of insulin 48 h post diabetic induction by streptozotocin and continued until being sacrificed at week 8...
November 29, 2018: Ultrastructural Pathology
Ida Perrotta
Atherosclerotic plaque formation starts early in life, develops silently over decades, and often displays clear evidence of accelerated biological aging. Lipofuscin has been classically defined as "the most consistent and phylogenetically conserved cellular morphologic change of aging," however, despite this traditional view different lines of evidence have recently demonstrated that, besides aging, various noxious influences can engeder its accumulation in cells and also that specific experimental conditions can revert this effect...
November 22, 2018: Ultrastructural Pathology
Arafah Maha
Podocytes can handle proteins when the glomerular filtration barrier is injured with leak of proteins out of the vasculature into the urine. The correlation between the number of podocytes involved in handling leaked proteins, as well as the extent of up-taken proteins in podocytes cytoplasm on one side, and the level of proteinuria in the concerned patients on the other side, is evaluated. A retrospective study of 22 patients with clinical proteinuria caused by various glomerulopathies was retrieved and analyzed...
November 1, 2018: Ultrastructural Pathology
Lucio Díaz-Flores, Ricardo Gutiérrez, Hugo Alvarez-Argüelles, Lucio Díaz-Flores, Rebeca González, Pablo Martín-Vasallo, José Luis Carrasco
Extracellular vesicles (EVs) are a heterogeneous population involved in intercellular communication. Little attention has been paid to a peculiar EV type with the appearance of a multivesicular body: extracellular multivesicular body (EMVB), also termed matrix vesicle cluster/multivesicular cargo. The aim of this work is to assess the ultrastructural characteristics, participation, and tissue location of EMVBs in inflammation/repair and tumors (with physiopathological processes involving intense intercellular communication), for which representative specimens were used...
September 2018: Ultrastructural Pathology
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