Ultrastructural Pathology | Page 2

Ronald F Dodson, Lee W Poye
Two cases with diagnosis of mesothelioma were referred to our laboratories with a request for tissue burden analysis in order to determine the presence of ferruginous bodies and uncoated elongated mineral particles in tissue samples. The individuals shared in common a past background of working in tile manufacturing facilities where industrial talc was used in the production of the products. Both were found to have ferruginous bodies in their lung tissues as well as elongated talc fibers/ribbons and elevated numbers of noncommercial amphiboles in their tissues...
January 9, 2020: Ultrastructural Pathology
Ali Doğukan Anğın, Ismet Gün, Önder Sakin, Muzaffer Seyhan Çıkman, Engin Ersin Şimşek, Resul Karakuş, Kayhan Başak, Asuman Orçun Kaptanağası
To investigate whether Dehydroepiandrosterone (DHEA) and Caffeic acid phenethyl ester (CAPE) had any preventive effect against the ovarian damage caused by cisplatin (CP) (cis-diamminedichloroplatinum) in rats. On the first day ovaries were removed, Anti-Müllerian hormone (AMH) was measured (Group1, n:6), in the other groups 7.5 mg/kg cisplatin was administered intraperitoneally. In Group 2 (n = 6), 0.1 ml saline, in Group 3 (n = 5), 20 umol/kg CAPE, in Group 4 (n = 7), DHEA 6 mg/kg were administered every day...
January 7, 2020: Ultrastructural Pathology
Yong-Xin Ru, Hong-Cai Shang, Shu-Xu Dong, Shi-Xuan Zhao, Hao-Yue Liang, Chao-Jun Zhu
To clarify foam cell origination in atherosclerosis, a series of morphologic and ultrastructural alterations of vascular smooth muscle cells (VSMCs) and foam cells were studied by light and electron microscopy in atherosclerotic aortas from hyperlipidemic rabbits induced for 5 weeks. The study exhibited that VSMCs were severely degenerated and damaged, including irregular shapes, expanded mitochondria, aplenty lipid droplets, and disarranged myofilaments in cytoplasm in media adjacent to atheromatic bottoms...
January 7, 2020: Ultrastructural Pathology
Yin He, Maojing Shi, Jiatong Wu, Zhifu Sun, Jihong Guo, Yuansheng Liu, Dong Han
A high-fat diet is often associated with cardiovascular diseases. Research has suggested that consumption of a high-fat diet for 10 weeks is associated with cardiac dysfunction, including arrhythmias, through alterations in cardiac remodeling and myocardial intracellular calcium (Ca2+ ) handling. In this study, rats were randomly divided into two groups: the standard diet (N = 5) and high-fat diet (N = 5) groups. To evaluate the effects of a high-fat diet on cardiac remodeling, we investigated the myocardium obtained from male Wistar rats fed a high-fat diet or standard diet for ten weeks via scanning electron microscopy, polarization microscopy, and RT-PCR...
January 5, 2020: Ultrastructural Pathology
Guillermo A Herrera
No abstract text is available yet for this article.
January 2, 2020: Ultrastructural Pathology
Mikako Warren, Mai Shimura, Eric P Wartchow, Shoji Yano
Background : Although the role of electron microscopy is diminishing in several areas of adult pathology, it remains an essential tool for the study of pediatric liver biopsies. Methods : Clinical charts, histologic slides and EM materials of native liver biopsies from patients <1 year old (1991-2017) were reviewed. Results : 677 biopsies were performed on 353 males and 324 females. This study presents the concrete numbers for both the indications and the diseases, and describes the role of EM. EM was performed on 24...
January 2, 2020: Ultrastructural Pathology
Madiha M M Makhlouf
Aflatoxins are mycotoxins produced by Aspergillus spp. which is a common contaminant of food items such as corn, spices, rice, nuts, and flour. Aflatoxin contamination of foods is a worldwide problem. Chronic aflatoxin exposure is found to be associated with Sciatic nerve damage. In vivo study was carried out to evaluate the toxic effect of aflatoxin B1 (AFB1 ) on the Sciatic nerve. Twenty-one adult male rats were included and divided equally into 3 groups (7 rats each): Group I (control group), group II (olive oil group) and group III: (AflatoxinB1 group)...
January 1, 2020: Ultrastructural Pathology
A A Titova, M O Mavlikeev, M S Kaligin, D M Suleymanova, I A Chekmaryeva, A P Kiyasov, R V Deev
An adequate experimental model is important to understand pathophysiological processes ongoing in the pancreas with diabetes mellitus. Our study was aimed to describe early ultra- and microstructural changes in the rat pancreas in 12-48 h after alloxan administration in a dose of 180 mg/kg. A histopathological examination of the endocrine pancreas revealed the loss of borders between endocrine cells, granular dystrophy and degranulation, sings of necrosis in central cells of the Langerhans islets and apoptosis of their peripheral ones manifested as DNA fragmentation and an increased expression of apoptosis markers...
December 31, 2019: Ultrastructural Pathology
Giulio Gabbiani
No abstract text is available yet for this article.
December 25, 2019: Ultrastructural Pathology
Iuliia Taskaeva, Nataliya Bgatova, Izabella Gogaeva
Hepatocellular carcinoma (HCC) is one of the most commonly malignant tumors worldwide, characterized by the presence of many heterogeneous molecular cell events that contribute to tumor growth and progression. Endocytic processes are intimately involved in various pathological conditions, including cancer, since they interface with various cellular signaling programs. The ability of lithium to induce cell death and autophagy and affect cell proliferation and intracellular signaling has been shown in various experimental tumor models...
December 11, 2019: Ultrastructural Pathology
Raquel Albero-González, Jessica Munné-Collado, Lara Pijuan, Mercedes Simón, Javier Gimeno-Beltrán, Sergi Mojal, Marta Salido, Sergi Clavé, Nuria Juanpere, Alba Dalmases, Laura Comerma, Ivonne Vázquez, Albert Sánchez-Font, Álvaro Taus, Silvia Hernández, Belén Lloveras, Josep Lloreta Trull
With the identification of therapeutic targets for lung adenocarcinoma, it has become mandatory to distinguish it from other entities. Some cases remain classified as non-small cell lung carcinoma, not otherwise specified (NSCLC-NOS) with immunohistochemistry. Electron microscopy (EM) can be useful, allowing the identification of glandular differentiation. The aim of this study was to determine the complementary value of immunohistochemistry and EM.Forty-eight NSCLC-NOS cases were selected (PSMAR-Biobank, Barcelona, Spain)...
December 6, 2019: Ultrastructural Pathology
Hassan Reda Hassan Elsayed, Eman Mohammad El Nashar, Mostafa Mohammed Abd-Elmonem
Background and objectives : Hepatocyte ultra-structure is influenced by feeding status, circadian rhythm, and zone location. The goal of the present study was to study the effect of overnight fasting on the hepatocyte ultrastructure and the zonal heterogeneity and to discuss the functional correlation. Methods : A total of 14 male albino rats were divided into two groups: negative control group fed ad libitum and overnight fasting rats for 16 hours. The different subcellular structures of both centrilobular and periportal hepatocytes in both control and fasted groups were compared by transmission electron microscopy...
December 2, 2019: Ultrastructural Pathology
Dauda Abdullahi, Azlina Ahmad Annuar, Junedah Sanusi
Spinal cord injury (SCI) results from penetrating or compressive traumatic injury to the spine in humans or by the surgical compression of the spinal cord in experimental animals. In this study, the neuroprotective potential of Spirulina platensis was investigated on ultrastructural and functional recovery of the spinal cord following surgical-induced injury. Twenty-four Sprague-Dawley rats were divided into three groups; sham group, control (trauma) group, and experimental ( S. platensis ) group (180 mg/kg) of eight rats each...
November 28, 2019: Ultrastructural Pathology
Paweł Kurzawa, Martin K Selig, Patryk Kraiński, Michał Dopierała, G Petur Nielsen
Primary intraosseous myoepithelial tumors are rare neoplasms with only a handful of cases described in the medical literature. To date, intraosseous variant of benign myoepithelioma, due to its rarity, has not been studied ultrastructurally, and only one case of a malignant intraosseous myoepithelioma has been described. Three cases were retrieved from the files at the Massachusetts General Hospital (MGH). A diagnosis of benign myoepithelioma was made in case 1 and malignant epithelioma in cases 2 and 3. Ultrastructurally, intermediate filaments (without dense bodies) were found in each case with an abundance in case 1 and lesser amounts in cases 2 and 3...
November 25, 2019: Ultrastructural Pathology
Murray Martin Finkelstein
Roggli and Green have reported their study of the dimensions of fibers extracted from the tissues of cases examined in their laboratory, and have drawn conclusions about the pathogenicity of Elongated Mineral Particles and their classification as asbestiform versus cleavage fragments. There are aspects of their methodology and discussion that would benefit from examination. Roggli and Green have relied upon a paper by Harper et al. for their definitions of asbestiform and cleavage fragments. Unfortunately, they have misinterpreted the work of those authors who have concluded that the best criterion is a particle width <1μm...
November 23, 2019: Ultrastructural Pathology
Sandra A McDonald, Yuwei Fan, Rick A Rogers, John J Godleski
Talc may lodge in human tissues through various routes, and has been associated with the development of ovarian carcinoma in case control epidemiologic studies. Talc is detected in tissues with scanning electron microscopy and energy dispersive X-ray analysis (SEM/EDS), with expected magnesium (Mg) and silicon (Si) peaks. The theoretical atomic weight % Mg/Si ratio for talc is 0.649, and for diagnostic purposes, a range of ± 5% (~0.617 to 0.681) is often used as a standard. Our goal was to establish empirically the quantitative range for talc identification by SEM/EDS using two source materials: a Johnson's Baby PowderTM (cosmetic-grade) consumer sample, and talc from Sigma-Aldrich (particle-grade material intended for scientific use)...
November 16, 2019: Ultrastructural Pathology
Viscardo Paolo Fabbri, Valentina Papa, Antonio Fioravanti, Monica Messia, Giovanni Tallini, Sofia Asioli, Giovanna Cenacchi
Intracranial extra-axial ependymomas (IEAEs) are extremely uncommon tumors and they could have a wide spectrum of clinical and radiological features. Here we report morphological features of an extra-axial ependymoma (radiology, histology and ultrastructural details) which mimicked the presentation of meningioma.
November 4, 2019: Ultrastructural Pathology
Sanjeet Roy, Aasma Nalwa, Jared Keith, Karen Weck, Harsharan Singh, Volker Nickeleit
C4d positive glomerulopathies with pseudolinear capillary wall deposits caused by basement membrane (GBM) remodeling have sporadically been reported in renal transplants. Here we describe the case of a hypertensive 60 year-old male with a 5 month history of nephrotic range proteinuria in the setting of normal serum creatinine, complement and ANA levels. Work-up showed MGUS (IgG/kappa restricted). A diagnostic renal biopsy to search for monoclonal gammopathy of renal significance demonstrated thickened glomerular capillary walls with strong pseudolinear complement factor C4d deposits by immunofluorescence microscopy (IF); all other IF studies including stains for Col4A3 were unrevealing with only minor abnormalities seen for Col4A5 ...
November 4, 2019: Ultrastructural Pathology
Ellinoora Sirviö, Jopi J W Mikkonen, Arto P Koistinen, Ilkka Miinalainen, Arja M Kullaa
The purpose of the present study was to demonstrate the localization of transmembrane mucin MUC1 on the outer layer of oral mucosal cells and the involvement of apical cell surface microplicae (MPL) in bioadhesion of MUC1. Tissue samples of six healthy subjects were obtained. First, the presence of MUC1 was examined with an immunohistochemical method using a monoclonal MUC1 antigen called HFMG1. Second, the localization of MUC1 was examined with immuno-scanning electron microscopy. Immunohistochemically, high intense staining for MUC1 (antigen HFMG1) was detected in the epithelial superficial layers...
November 2, 2019: Ultrastructural Pathology
Reham Zakaria Hamza, Najah M Al-Baqami
Ellagic acid (EA) has significant protective and antioxidant effects on several tissues. Monosodium glutamate (MG) is known as a flavor promoter that reversibly influences the male reproductive system. This study aims to assess the ameliorative effect of EA on oxidative stress and testicular damage induced by MG. In total, 48 male rats were included in this study and separated into six groups: control, EA (20 mg/kg), MG (low dose) (17.5 mg/kg), MG (high dose) (60 mg/kg), MG (low dose) combined with EA, and MG (high dose) combined with EA...
October 28, 2019: Ultrastructural Pathology
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