Validity of muscle activation estimated with predicted ground reaction force in inverse dynamics based musculoskeletal simulation during gait.

The inverse dynamics based musculoskeletal simulation needs ground reaction forces (GRF) as an external force input. GRF can be predicted from kinematic data. However, the validity of estimated muscle activation using the predicted GRF has remained unclear. Therefore, the purpose of this study was to determine the validity of estimated muscle activation with predicted GRF in the inverse dynamics based musculoskeletal simulation. To perform musculoskeletal simulations, an open-source motion capture dataset that contains gait data from 50 healthy subjects was used. CusToM was used for the musculoskeletal simulations. Two sets of inverse dynamics and static optimization were performed, one used predicted GRF (PRED) and another used experimentally measured GRF (EXP). Pearson's correlation was calculated to evaluate the similarity between EMG and estimated muscle activations for both PRED and EXP. To compare PRED and EXP, paired t-tests were used to compare the trial-wise muscle activation similarity and residuals. Relationships between joint moments and residuals were also tested. The overall muscle activation similarity was comparable in PRED (R = 0.477) and EXP (R = 0.475). The residuals were 2-4 times higher in EXP compared to PRED (P < 0.001). The hip flexion-extension moment was correlated to sagittal plane residual moment (R = 0.467). The muscle activations estimated using predicted GRF were comparable to that with measured GRF in the inverse dynamics based musculoskeletal simulation. Prediction of GRF helps to perform musculoskeletal simulations where the force plates are not available.