Analysis of Clinical Factors Associated with the Occurrence Time of AllergicTransfusion Reactions or Febrile Non-HemolyticTransfusion Reactions.

OBJECTIVE: Among transfusion-associated adverse reactions, allergic transfusion reactions (ATRs) and febrile non-hemolytic transfusion reactions (FNHTRs) have a particularly high incidence. However, details of their occurrence time and related clinical factors are unknown; this was this study's aim.

METHODS: This was a retrospective study. We analyzed the data of 304 patients with ATR and 59 with FNHTR.

RESULTS: The median (range) occurrence time of ATR and FNHTR was 86 (0-400) min and 50 (2-343) min, respectively. The difference between the number of onsets of ATR or FNHTR and the occurrence time was not observed. In the multivariate analysis, which was limited to cases with the first ATR or FNHTR onset, severe ATR occurred earlier, whereas ATR developed later in patients in the intensive care unit and emergency ward. On the other hand, FNHTR was more likely to develop earlier in patients with blood type A than in those with type B.

CONCLUSION: Patient-related clinical factors may affect the occurrence time of ATR or FNHTR diversely. Further research is expected to enable medical staff to observe transfused patients more accurately and aid in detection and management of ATR and FNHTR.