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Journals Annals of Clinical and Laborat...

Annals of Clinical and Laboratory Science

https://read.qxmd.com/read/38514050/large-malignant-testicular-paratesticular-tumors-in-adolescence-assessment-of-gross-tumor-size-in-a-vulnerable-age-group
#1
JOURNAL ARTICLE
Ava G Stechschulte, Andrea C Bakker, Jasmine Steele, Sara O Vargas
OBJECTIVE: We hypothesized that reticence to address a groin mass may result in late presentation of testicular/paratesticular malignancy in early puberty through adolescence. METHODS: Malignant testicular and paratesticular tumors (malignant germ cell tumors and rhabdomyosarcomas) diagnosed at our institution from 1994-2023 for patients aged 11-20 were included. Clinicopathologic features were recorded, and statistically analyzed. RESULTS: Eighty-five cases were identified...
March 21, 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38182154/deep-learning-provides-rapid-screen-for-breast-cancer-metastasis-with-sentinel-lymph-nodes
#2
JOURNAL ARTICLE
Kareem Allam, Xiaohong Iris Wang, Songlin Zhang, Jianmin Ding, Kevin Chiu, Karan Saluja, Amer Wahed, Hongxia Sun, Andy N D Nguyen
OBJECTIVE: Deep learning has been shown to be useful in detecting breast cancer metastases by analyzing whole slide images (WSI) of sentinel lymph nodes; however, it requires extensive analysis of all the lymph node slides. Our deep learning study attempts to provide a rapid screen for metastasis by analyzing only a small set of image patches to detect changes in tumor environment. METHODS: We designed a convolutional neural network to build a diagnostic model for metastasis detection...
January 4, 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38182144/evolution-of-sars-cov-2-viral-mutations-in-individuals-with-prolonged-infections
#3
JOURNAL ARTICLE
Luna Jiang-Qin, Kevin Weitemier, Guang Fan, Xuan Qin
OBJECTIVE: The world has been faced with the repeat rise of SARS-CoV-2 variants since late 2020, including Alpha, Beta, Gamma, Delta, and the latest simultaneous emergence of far-flung spawn of Omicron sub-lineages in different parts of the globe. This has brought us the challenge of determining what factor(s) have been the selective force behind these immune evasive and therapy resistant mutations. It is very possible that such variants evolved in limited host individuals with prolonged infections, or from a localized community of patients...
January 4, 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38182143/microrna-193a-promotes-apoptosis-in-retinal-neuronal-cells-in-early-stage-diabetic-dm-rat-via-wilms-tumor-gene-1
#4
JOURNAL ARTICLE
Juan Yu, Kehai Che, Chong Gao, Xuemei Pu, Lijun Ren
OBJECTIVE: This study aimed to investigate the role and mechanism of microRNA (miR)-193a in promoting apoptosis of retinal neuronal cells in early diabetic (DM) rats. METHODS: Seventy-two male SD-grade rats were selected to establish a DM model by intraperitoneal injection of streptozotocin (STZ), and randomly divided into a control group (blank control group), a DM group (diabetic model group), a DM+miR-NC inhibitor group (miR-193a inhibition negative control group), a DM+miR-193a inhibitor group (miR-193a inhibitor group), DM+miR-NC mimic group (miR-193a overexpression negative control group), DM+miR-193a mimic group (miR-193a overexpression group), with12 rats in each group...
January 4, 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514069/the-monocyte-to-lymphocyte-ratio-on-the-6-th-day-postburn-is-associated-with-clinical-outcome-of-severe-burns
#5
JOURNAL ARTICLE
Lizhu Zhi, Yilan Xia, Fang Jin, Xiaojie He, Xingang Wang, Xuanliang Pan
OBJECTIVE: As an immune/inflammatory indicator, the application of monocyte-lymphocyte ratio (MLR) in the treatment of severe burns is lacking. The aim of this study was to investigate the dynamic changes of the MLR value in the early stage of severe burns and its clinical value. METHODS: This is a 5-year retrospective cohort study involving 100 patients with severe burns (II-III degree and total body surface area (TBSA) >50%), in which the lymphocyte count, monocyte count, MLR value, C-reactive protein (CRP), creatinine (Scr), and capillary leakage index (CLI) were evaluated soon after injury, and 30-day mortality rates were investigated...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514068/hnrnpc-regulates-glut1-ldha-pathway-by-stabilizing-foxm1-mrna-to-promote-the-progression-and-aerobic-glycolysis-of-multiple-myeloma
#6
JOURNAL ARTICLE
Ningning Wu, Yao Zhu
OBJECTIVE: Multiple Myeloma (MM) is a malignant hematological disease. Heterogeneous nuclear ribonucleoprotein C1/C2 (HNRNPC) acts as an oncogene in a variety of cancers. However, the role of HNRNPC in MM has not been reported so far. METHODS: The mRNA and protein expressions of HNRN-PC and FOXM1 were detected by qRT-PCR and western blot. CCK8, EDU staining, flow cytometry and western blot were used to detect cell viability and cell cycle. The extracellular flux analyzer XF96 was used to detect the production of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR)...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514067/a-rare-autopsy-case-of-aggressive-combined-hepatocellular-cholangiocarcinoma-in-59-year-old-female
#7
JOURNAL ARTICLE
Ahmed A Ahmed, Brandon Gehris, Michelle McDonald, Suhair Al Salihi, L Maximilian Buja
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514066/combined-use-of-helicobacter-pylori-genotyping-and-cdx2-expression-as-a-predictor-of-malignant-potential-in-gastric-intestinal-metaplasia
#8
JOURNAL ARTICLE
Mengyuan Zhang, Zhong Zhang, Lanlan Jiao, Li Liang, Wei Bo, Min Zhang, Xiaobo Li, Xingwei Fu, Xuguang Wang
OBJECTIVE: Gastrointestinal metaplasia (GIM) has a close relationship with gastric cancer (GC), but it is unclear how to judge which GIM could develop into GC. This study aimed to assess the role of CDX2 and its association with Helicobacter pylori ( H.pylori ) genotypes in GIM. METHODS: CagA and vacA genes were identified via PCR in 466 H. pylori -positive gastric tissues, including gastritis (n=104), GIM diagnosed endoscopically (GIM-1; n=82), gastric cancer (GC; n=173), and paired adjacent GIM tumors resected surgically (GIM-2; n=107)...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514065/upregulation-of-mir-499a-targets-beclin1-to-modulate-astrocyte-autophagy-and-promote-ischemic-stroke
#9
JOURNAL ARTICLE
Guanxiu Xian, Daihong Song, Ying Wei, Fugao Huang, Hongcheng Luo
OBJECTIVE: To investigate the clinical significance of miR-499a expression in the serum of ischemic stroke patients and its potential mechanism in regulating astrocytes to promote ischemic stroke. METHODS: Serum samples from 99 ischemic stroke patients and 99 healthy individuals were collected and analyzed for miR-499a expression through RT-PCR. Statistical analysis was performed to compare the expression differences between the two groups, and correlation between miR-499a expression and clinical pathological indices in stroke patients was analyzed...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514064/predictive-and-carcinogenic-roles-of-necroptosis-related-mir-425-5p-and-mir-16-5p-in-esophageal-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Xue Zhidan, Xi Kedi, Xi Dan, Song Xing, Sun Rui
OBJECTIVE: To examine the expression and function of necroptosis-associated miRNAs in esophageal squamous cell carcinoma. METHODS: A total of three microarray datasets, i.e., GSE122497, GSE114110, and GSE43732, were selected from the GEO database for differential analysis of necroptosis-related miRNA expression. The differentially expressed miRNAs were screened for target miRNAs using Kaplan-Meier survival analysis in the OncomiR database. The expression of the target miRNAs in the HEEC, KYSE-450, TE-1, and KYSE-410 cell lines was measured via qPCR...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514063/dexmedetomidine-alleviates-propofol-infusion-syndrome-induced-myocardial-injury-through-inhibiting-ferroptosis-associated-with-accumulation-of-reactive-oxygen-species
#11
JOURNAL ARTICLE
Jinhui Sun, Bing Zhang, Qiang Geng, Jiayinati Halimujiang, Chang Song, Min Xi, Ting Wang
OBJECTIVE: To observe the effect of dexmedetomidine (Dex) on propofol infusion syndrome (PRIS)-induced myocardial injury and explore the roles of ferroptosis and accumulation of reactive oxygen species (ROS). METHODS: Eighteen male Sprague-Dawley rats were evenly divided into the control group, model group and test group (n=6/group) based on a computer-generated random number table. The PRIS-induced myocardial injury model was prepared in the model group and test group through a 12 h-caudal vein infusion of 1% propofol medium and long chain fat emulsion injection at a rate of 20 mg·Kg-1 ·h-1 for the first 6 h and 40 mg·Kg-1 ·h--1 for the last 6 h, and meanwhile the test group was treated by Dex...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514062/-technical-note-comparison-of-alinity-c-hemoglobin-a1c-immunoassay-with-premier-hb9210-automated-hplc-assay-a-preliminary-report
#12
JOURNAL ARTICLE
Ashton Walton, Jonathan Meador, Kelsey Woodard, Sean Tucker, Susan McIntyre, Amitava Dasgupta
OBJECTIVE: We utilized Premier Hb9210 analyzer (HPLC method; Trinity Biotech, Jamestown, NY) for measuring HBA1c in whole blood. As our laboratory is transitioning to Abbott system, we compared HbA1c values obtained by Alinity c and Premier Hb9210. METHODS: The Premier Hb9210 analyzer is based on boronate affinity high performance liquid chromatography with analytical measurement range of 3.8 to 18.5%. The Alinity c Hemoglobin A1c assay measured both total hemoglobin and HbA1c (enzymatic assay) in whole blood and then calculated %HbA1c...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514061/idiopathic-hypereosinophilic-syndrome-in-a-professional-athlete
#13
JOURNAL ARTICLE
Sarah Shidid, Pakinam Mekki, Tamar A Smith-Norowitz
OBJECTIVE: To present the case of an athlete with hypereosinophilic syndrome (HES). CASE REPORT: We present a 25-year-old female athlete, with no significant past medical history, who had a two-month history of progressive dry cough, wheezing, exertional dyspnea, and chest pain. Physical examination revealed patient to be febrile to 101.6 degrees Fahrenheit and tachycardic to 120 beats per minute with new leukocytosis of 35.9x109 /L and eosinophilia of 24,000/μL...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514060/shenmai-injection-alleviates-myocardial-ferroptosis-via-activating-the-akt1-mtor-pathway-in-rats-with-acute-myocardial-infarction
#14
JOURNAL ARTICLE
Ming Lu, Yeying Zhang, Xuhui Ma, Mingqiu Cen, Shidong Lin, Xiaolu Qian, Jia Yu, Xiaoying Huang, Zhuxiu Jiang
OBJECTIVE: Acute myocardial infarction (AMI) poses a serious burden on public health. Shenmai Injection (SMI) has been reported to have a cardioprotective effect and is used clinically attributed to its targeting of ferroptosis. This study aims to explore the underlying mechanisms of SMI in treating AMI through the application of network pharmacology analysis. METHODS: This study utilized network pharmacology to identify the bioactive ingredients and potential targets of SMI in treating AMI...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514059/rapid-and-reliable-hla-b-59-01-genotyping-to-prevent-carbonic-anhydrase-inhibitor-induced-severe-cutaneous-adverse-reactions
#15
JOURNAL ARTICLE
Ji Young Huh, Yong Ju Song, Geon Park
OBJECTIVE: Carbonic anhydrase inhibitors (CAIs) are intraocular pressure-reducing medications used in ophthalmology. Human leukocyte antigen- B*59:01 ( HLA-B*59:01 ) is strongly associated with CAI-induced severe cutaneous adverse reactions (SCARs). This study aimed to develop and validate a rapid and economical screening method for HLA-B*59:01 to prevent carbonic anhydrase inhibitor-induced SCARs. METHODS: Duplex allele-specific polymerase chain reaction (PCR) with an internal control was performed for HLA-B*59:01 genotyping...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514058/role-of-nf-%C3%AE%C2%BAb-p65-tnf-%C3%AE-in-cell-apoptosis-in-the-fetal-membranes-of-pregnant-women-with-preterm-premature-rupture-of-membranes
#16
JOURNAL ARTICLE
Shi-Huan Tang, Xian Tang, Ling Liu, Lu Peng, Hong-Mei Zhang, Hui Zhang, Ting Long, Pei-Ling Wu, Xian-Ping Zhang
OBJECTIVE: This study aimed to investigate the roles of nuclear factor-kappa B p65 (NF-[Formula: see text]B p65) and tumor necrosis factor- α (TNF- α ) in cell apoptosis occurring in the fetal membranes of pregnant women who experience preterm premature rupture of membranes (PPROM). METHODS: This was a case-control study involving 57 pregnant women who delivered in the obstetric department of Affiliated Loudi Hospital, Hengyang Medical School, University of South China, from June 2021 to June 2022...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514057/elevated-mmp1-expression-in-carcinoma-associated-fibroblasts-of-breast-cancer-contributes-to-tumor-progression-and-unfavorable-prognosis
#17
JOURNAL ARTICLE
Chunfang Xi, Zhendi Song, Qingyu Cui, Ye Zhao, Kaifu Li, Hua Kang
OBJECTIVE: Previous studies have shown that cancer-associated fibroblasts (CAFs) may play a role in tumor growth and development through paracrine action. Several studies reported upregulated matrix metallopeptidase 1 (MMP1) expression in various cancers. The aim is to investigate the role of elevated MMP1 expression in CAFs of breast cancer. METHODS: A total of 203 cases were used for immunohistochemical analysis based on multiple clinical parameters. Tissues for primary cultures of CAFs were collected from 10 breast cancer patients who underwent complete surgical resection of their tumors...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514056/annals-of-clinical-and-laboratory-science-information-for-authors
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514055/the-role-and-mechanism-of-stim1-orai1-regulated-ca-2-influx-in-myocardial-hypertrophy-in-type-2-diabetes-mellitus
#19
JOURNAL ARTICLE
Sisi Zhang, Wenping Zang
OBJECTIVE: Diabetic cardiomyopathy (DCM) is the most common cardiovascular complication of type 2 diabetes mellitus (T2DM). Patients affected with DCM face a notably higher risk of progressing to congestive heart failure compared to other populations. Myocardial hypertrophy, a clearly confirmed pathological change in DCM, plays an important role in the development of DCM, with abnormal Ca2+ homeostasis serving as the key signal to induce myocardial hypertrophy. Therefore, investigating the mechanism of Ca2+ transport is of great significance for the prevention and treatment of myocardial hypertrophy in T2DM...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38514054/idiopathic-thrombocytosis-in-alpha-thalassemia-trait-patient
#20
JOURNAL ARTICLE
Mohammed Makkawi, Sultan Alasmari, Obaid Albulym, Husain Alkhaldy
Platelet count increases are typically a reactionary response to one of a variety of pathophysiological events. We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 ( ACKR1 ) (c...
January 2024: Annals of Clinical and Laboratory Science
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