Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapy

Editha A Krueger, Benedick A Fraass, Daniel L McShan, Robin Marsh, Lori J Pierce
International Journal of Radiation Oncology, Biology, Physics 2003 July 15, 56 (4): 1023-37

PURPOSE: To develop an intensity modulated radiotherapy (IMRT) technique for postmastectomy RT that improves target coverage while sparing all appropriate normal tissues.

MATERIALS AND METHODS: IMRT plans were generated using an in-house optimization system. Priority was given to matching the heart doses achieved with partially wide tangent fields (PWTFs) while maintaining 50 Gy +/- 5% to the chest wall, internal mammary nodes, and supraclavicular nodes. Other normal tissue doses were then minimized. Metrics for plan comparisons included minimal, maximal, and mean doses and normal tissue complication probability.

RESULTS: IMRT resulted in more uniform chest wall coverage than did PWTFs. The average chest wall minimal dose was 43.7 +/- 1.1 Gy for IMRT and 31.2 +/- 16.5 Gy for PWTFs (p = 0.04). The average internal mammary node minimal dose was 42.8 +/- 2.1 Gy for IMRT and 21.8 +/- 13.2 Gy for PWTFs (p = 0.001). IMRT matched the <1% heart normal tissue complication probability achieved using PWTFs. The average contralateral breast mean dose was 2.8 +/- 1.7 Gy for IMRT, but a greater breast volume was exposed compared with PWTFs. The mean ipsilateral lung normal tissue complication probability was lower for IMRT (0.0) than for PWTFs (0.07 +/- 0.07; p = 0.02). The mean contralateral lung dose was greater for IMRT (5.8 +/- 1.8 Gy) than for PWTFs (1.6 +/- 0.1 Gy; p = <0.0001).

CONCLUSION: A new IMRT technique achieves full target coverage while maintaining similar doses to heart and ipsilateral lung as conventional techniques. However, contralateral lung and breast volumes exposed to low doses were increased with IMRT and will need to be reduced in future studies.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"