Nikhil Yegya-Raman, Abigail T Berman, Christine A Ciunci, Cole Friedes, Eva Berlin, Michelle Iocolano, Xingmei Wang, Ching Lai, William P Levin, Keith A Cengel, Shannon E O'Reilly, Roger B Cohen, Charu Aggarwal, Melina E Marmarelis, Aditi P Singh, Lova Sun, Jeffrey D Bradley, John P Plastaras, Charles B Simone, Corey J Langer, Steven J Feigenberg
INTRODUCTION: Reirradiation (reRT) with proton beam therapy (PBT) may offer a chance of cure while minimizing toxicity for patients with isolated intrathoracic recurrences of non-small cell lung cancer (NSCLC). However, distant failure remains common, necessitating strategies to integrate more effective systemic therapy. METHODS: This was a phase II, single-arm trial (NCT03087760) of consolidation pembrolizumab after PBT reRT for locoregional recurrences of NSCLC...
August 29, 2023: International Journal of Radiation Oncology, Biology, Physics