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International Journal of Radiation Oncology, Biology, Physics

https://read.qxmd.com/read/38641234/salvage-stereotactic-radiosurgery-for-recurrent-who-grade-2-and-3-meningiomas-a-multicenter-study-storm
#1
JOURNAL ARTICLE
Matthew Gallitto, Geoffrey Sedor, Albert Lee, Jared Pasetsky, Connor J Kinslow, Genesis De Los Santos, Derrick Obiri-Yeboah, Varun R Kshettry, Corbin A Helis, Michael D Chan, Thomas H Beckham, Susan L McGovern, Jennifer Matsui, Joshua D Palmer, Jonathan B Bell, Eric A Mellon, David Lakomy, Jiayi Huang, Ian Boor, Chad G Rusthoven, Michael B Sisti, Tony J C Wang
PURPOSE: The role of stereotactic radiosurgery (SRS) in the management of grade 2 and 3 meningiomas is not well elucidated. Unfortunately, local recurrence rates are high, and guidelines for management of recurrent disease are lacking. To address this knowledge gap, we conducted STORM, a multicenter retrospective cohort study of patients treated with primary SRS for recurrent grade 2 and 3 meningiomas. METHODS AND MATERIALS: Data on patients with recurrent grade 2 and 3 meningioma treated with SRS at first recurrence were retrospectively collected from eight academic centers in the United States...
April 17, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38631540/toxicity-evaluation-of-dose-escalation-in-hypofractionated-regional-nodal-irradiation-for-breast-cancer-a-retrospective-study
#2
JOURNAL ARTICLE
Euidam Kim, Ji Sung Yoo, Yeon-Joo Kim, Jungnam Joo, Eun Sang Oh, Yoonsun Chung, Seung Hyun Chung, Tae Hyun Kim
PURPOSE: Regional nodal irradiation (RNI) to the axilla and supraclavicular area presents distinct toxicities, such as lymphedema and shoulder stiffness, compared to whole-breast irradiation. There is insufficient evidence on the safety of dose-escalation in hypofractionated RNI. We aimed to evaluate and compare toxicity rates in patients with breast cancer who received hypofractionated RNI with and without dose-escalation. METHODS: We retrospectively analyzed 381 patients with breast cancer treated with hypofractionated RNI between March 2015 and February 2017...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38631539/involved-site-radiotherapy-is-equally-effective-and-less-toxic-than-involved-field-radiotherapy-in-patients-receiving-combined-modality-treatment-for-early-stage-unfavorable-hodgkin-lymphoma-an-analysis-of-the-randomized-phase-iii-hd17-trial-of-the-german-hodgkin
#3
JOURNAL ARTICLE
Johannes Rosenbrock, Helen Kaul, Michael Oertel, Eren Celik, Philipp Linde, Jiaqi Fan, Dennis A Eichenauer, Paul J Broeckelmann, Bastian von Tresckow, Carsten Kobe, Markus Dietlein, Michael Fuchs, Peter Borchmann, Hans Theodor Eich, Christian Baues
PURPOSE: Combined modality treatment (CMT) with chemotherapy followed by consolidation radiotherapy (RT), provides excellent outcomes for patients with early-stage Hodgkin lymphoma (HL). The international standard of care for consolidation RT, involved-site/involved-node radiotherapy (ISRT/INRT), has never been evaluated in a randomized phase III trial against the former standard involved-field radiotherapy (IFRT). METHODS AND MATERIALS: In the multicenter phase III AnonymizedStudyGroupXXX AnonymizedStudyYYY trial, patients with early stage unfavorable HL were randomized between the standard CMT group and a positron-emission tomography (PET) -guided group...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38631538/incorporating-functional-lung-imaging-fli-into-radiation-therapy-planning-in-patients-with-lung-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Julie Midroni, Rohan Salunkhe, Zhihui Liu, Ronald Chow, Gabriel Boldt, David Palma, Douglas Hoover, Yevgeniy Vinogradskiy, Srinivas Raman
PURPOSE: To provide an understanding of current FLI techniques, and their potential to improve dosimetry and outcomes for lung cancer patients receiving radiation therapy (RT). METHODS: EMBASE, PubMed, and Cochrane Library were searched from 1990 until April 2023. Articles were included if they reported on FLI in one of: techniques, incorporation into RT planning for lung cancer, quantification of RT-related outcomes for lung cancer patients. Studies involving all RT modalities, including stereotactic body radiotherapy and particle therapy, were included...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38631537/radiation-induced-xerostomia-is-related-to-stem-cell-dose-dependent-reduction-of-saliva-production
#5
JOURNAL ARTICLE
Maria I van Rijn-Dekker, Sacha la Bastide-van Gemert, Monique A Stokman, Arjan Vissink, Robert P Coppes, Johannes A Langendijk, Peter van Luijk, Roel J H M Steenbakkers
BACKGROUND AND PURPOSE: Previous studies have shown that the mean dose to the parotid gland stem cell rich regions (Dmean,SCR ) is the strongest dosimetric predictor for the risk of patient-reported daytime xerostomia. This study aimed to test whether the relationship between patient-reported xerostomia and Dmean,SCR is explained by a dose-dependent reduction of saliva production. MATERIAL/METHODS: In 570 head and neck cancer patients treated with definitive radiation therapy (RT), flow from the parotid (FLOWPAR ) and submandibular/sublingual glands (FLOWSMSL ) and patient-reported daytime (XERDAY ) and nighttime xerostomia (XERNIGHT ) were prospectively measured before, and at 6 and 12 months after RT...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38631536/efficacy-and-toxicity-of-moderately-hypofractionated-radiotherapy-with-helical-tomotherapy-versus-conventional-radiotherapy-in-patients-with-unresectable-stage-iii-non-small-cell-lung-cancer-receiving-concurrent-chemotherapy-a-multicentre-randomized-phase-iii
#6
REVIEW
Qi Zhang, Shaonan Fan, Xiaohong Xu, Shisuo Du, Guangying Zhu, Chaoyang Jiang, Shi-An Xia, Qiwen Li, Qifeng Wang, Dong Qian, Ming Zhang, Han Xiao, Gang Chen, Zhaochong Zeng, Jian He
PURPOSE: The standard treatment schedule for unresectable stage III non-small-cell lung cancer (NSCLC) is chemotherapy with concurrent radiotherapy (60 Gy delivered in 30 fractions), although moderately hypofractionated radiotherapy (Hypo-RT) has also been considered as an alternative strategy. This study aimed to compare the efficacy and toxicity of moderately Hypo-RT with helical TomoTherapy versus conventionally fractionated radiotherapy (Con-RT) in patients with unresectable stage III NSCLC receiving concurrent chemotherapy...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38621608/impact-of-radiation-therapy-modalities-on-loco-regional-control-in-inflammatory-breast-cancer
#7
JOURNAL ARTICLE
Maximilien Rogé, Youlia Kirova, Emilie Lévêque, Marin Guigo, Alison Johnson, Rafik Nebbache, Eleonor Rivin Del Campo, Ioana Lazarescu, Stéphanie Servagi, Augustin Mervoyer, Axel Cailleteau, Sébastien Thureau, Juliette Thariat
INTRODUCTION: In inflammatory breast cancer (IBC), radiotherapy intensification is considered a standard of care by some teams, although the level of evidence remains low. We sought to analyze the impact of radiotherapy modalities on the risk of loco-regional and distant relapse. METHODS: A retrospective multicenter study included patients with localized IBC treated between 2010 and 2017. Standard post-mastectomy radiotherapy consisted of daily fractions to a total dose of 50 Gy equivalent without a boost or bolus, while intensified radiotherapy referred to the use of a boost or bolus...
April 13, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38621607/safety-and-efficacy-of-stereotactic-body-radiotherapy-for-ultra-central-thoracic-tumours-a-single-centre-retrospective-review
#8
JOURNAL ARTICLE
George J Li, Hendrick Tan, Humza Nusrat, Joe Chang, Hanbo Chen, Ian Poon, Jeevin Shahi, May Tsao, Yee Ung, Patrick Cheung, Alexander V Louie
PURPOSE/OBJECTIVE(S): We sought to evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for ultra-central thoracic tumours at our institution. MATERIALS/METHODS: Patients with ultra-central lung tumours or nodes, defined as having the planning target volume (PTV) overlapping or abutting the central bronchial tree and/or esophagus, treated at our institution with SBRT between 2009 and 2019 were retrospectively reviewed. All SBRT plans were generated with the goal of creating homogenous dose distributions...
April 13, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38621606/thoracic-proton-minibeam-radiation-therapy-tissue-preservation-and-survival-advantage-over-conventional-proton-therapy
#9
JOURNAL ARTICLE
Annaïg Bertho, Ramon Ortiz, Mathieu Maurin, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Gabriel Ramasamy, Annalisa Patriarca, Ludovic De Marzi, Frédéric Pouzoulet, Yolanda Prezado
PURPOSE: Proton Minibeam Radiotherapy (pMBRT) is an innovative radiation therapy approach that highly modulates the spatial dimension of the dose delivery using narrow, parallel, and submillimetric proton beamlets. pMBRT has proven its remarkable healthy tissue preservation in the brain and skin. This study assesses the potential advantages of pMBRT for thoracic irradiations compared to conventional radiotherapy in terms of normal tissue toxicity. The challenge here was the influence of respiratory motion on the typical peak and valley dose patterns of pMBRT and its potential biological impact...
April 13, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38615888/dose-incorporated-deep-ensemble-learning-for-improving-brain-metastasis-srs-outcome-prediction
#10
JOURNAL ARTICLE
Jingtong Zhao, Eugene Vaios, Yuqi Wang, Zhenyu Yang, Yunfeng Cui, Zachary J Reitman, Kyle Lafata, Peter Fecci, John Kirkpatrick, Fang-Fang Yin, Scott Floyd, Chunhao Wang
PURPOSE/OBJECTIVE(S): To develop a novel deep ensemble learning model for accurate prediction of brain metastasis(BM) local control outcomes following stereotactic radiosurgery(SRS). MATERIALS/METHODS: A total of 114 BMs from 82 patients were evaluated, including 26 BMs that developed biopsy-confirmed local failure post-SRS. The SRS spatial dose distribution(Dmap ) of each BM was registered to the planning contrast-enhanced T1(T1-CE) MR. Axial slices of the Dmap , T1-CE, and PTV segmentation(PTVseg ) intersecting the BM center were extracted within a fixed field-of-view determined by the V60% in Dmap ...
April 12, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38615887/first-in-human-phase-i-clinical-trial-of-stereotactic-irradiation-to-achieve-lung-volume-reduction-silvr-in-severe-emphysema
#11
JOURNAL ARTICLE
Devanish N Kamtam, Michael S Binkley, Ntemena Kapula, Cheyenne Sadeghi, Shannon Nesbit, Haiwei Henry Guo Md, Joon Chang, Peter G Maxim, Maximilian Diehn, Billy W Loo, Joseph B Shrager
PURPOSE: Only a subset of patients with severe emphysema qualify for lung volume reduction surgery or endobronchial valves. We previously demonstrated that Stereotactic Ablative Radiotherapy (SABR) of lung tumors reduces lung volume in treated lobes by creating localized lung fibrosis. We aimed to determine the safety and, secondarily, explore the efficacy of Stereotactic Irradiation for Lung Volume Reduction (SILVR) over 18 months following intervention in patients with severe emphysema...
April 12, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38613562/diagnostic-ct-enabled-planning-dart-results-of-a-randomized-trial-in-palliative-radiation-therapy
#12
JOURNAL ARTICLE
Melissa O'Neil, Joanna M Laba, Timothy K Nguyen, Michael Lock, Christopher D Goodman, Elizabeth Huynh, Jonatan Snir, Vikki Munro, Jenna Alce, Lidia Schrijver, Sylvia Lemay, Tara MacDonald, Andrew Warner, David A Palma
PURPOSE: Using diagnostic computed tomography (dCT) scans instead of CT simulation (CTsim) scans can increase departmental efficiency and reduce patient burden. The goal of the DART trial was to assess the efficacy and acceptability of dCT-based planning workflows with a focus on patient experiences, plan deliverability and adequacy of target coverage, and workflows. METHODS AND MATERIALS: Patients undergoing same-day CTsim and treatment for palliative radiation therapy to thoracic, abdominopelvic, or proximal limb targets with a recent dCT (within 28 days) in a reproducible position were eligible...
April 12, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38614279/stereotactic-radiation-for-ultra-central-non-small-cell-lung-cancer-a-safety-and-efficacy-trial-sunset
#13
JOURNAL ARTICLE
E Giuliani Meredith, Edith Filion, Sergio Faria, Vijayananda Kundapur, Toni Vu Thi Trinh Thuc, Benjamin H Lok, Srinivas Raman, Houda Bahig, Joanna M Laba, Pencilla Lang, Alexander V Louie, Andrew Hope, George B Rodrigues, Andrea Bezjak, Marie-Pierre Campeau, Marie Duclos, Scott Bratman, Anand Swaminath, Rohan Salunkhe, Andrew Warner, David A Palma
INTRODUCTION: The use of stereotactic body radiotherapy (SBRT) for tumors in close proximity to the central mediastinal structures has been associated with a high risk of toxicity. This study (BLINDED FOR REVIEW) aimed to determine the maximally tolerated dose (MTD) of SBRT for ultra-central (UC) non-small cell lung carcinoma (NSCLC), using a time-to-event continual reassessment methodology (TITE-CRM). METHODS: Patients with T1-3N0M0 (≤ 6 cm) NSCLC were eligible...
April 11, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38614278/prospective-trial-of-functional-lung-avoidance-radiation-therapy-for-lung-cancer-quality-of-life-report
#14
JOURNAL ARTICLE
Joseph Lombardo, Edward Castillo, Richard Castillo, Ryan Miller, Bernard Jones, Moyed Miften, Brian Kavanagh, Adam Dicker, Cullen Boyle, Benjamin Leiby, Joshua Banks, Nicole L Simone, Benjamin Movsas, Inga Grills, Thomas Guerrero, Chad G Rusthoven, Yevgeniy Vinogradskiy
PURPOSE: A novel form of lung function imaging has been developed that uses 4DCT data to generate lung ventilation images (4DCT-ventilation). Functional avoidance uses 4DCT-ventilation to reduce doses to functional lung with the aim of reducing pulmonary side-effects. A 4DCT-ventilation functional avoidance, phase II, multi-center clinical trial was completed. The purpose of this work is to quantify patient reported outcomes (PRO) changes for patients treated with functional avoidance and to determine which metrics are predictive of PRO changes...
April 11, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38588868/vestibular-schwannoma-international-study-of-active-surveillance-versus-stereotactic-radiosurgery-the-visas-study
#15
JOURNAL ARTICLE
Othman Bin-Alamer, Hussam Abou-Al-Shaar, Selcuk Peker, Yavuz Samanci, Isabelle Pelcher, Sabrina Begley, Anuj Goenka, Michael Schulder, Jean-Nicolas Tourigny, David Mathieu, Andréanne Hamel, Robert G Briggs, Cheng Yu, Gabriel Zada, Steven L Giannotta, Herwin Speckter, Sarai Palque, Manjul Tripathi, Saurabh Kumar, Rupinder Kaur, Narendra Kumar, Brandon Rogowski, Matthew J Shepard, Bryan A Johnson, Daniel M Trifiletti, Ronald E Warnick, Samantha Dayawansa, Elad Mashiach, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Zane Schnurman, Juan Alzate, Douglas Kondziolka, Jason P Sheehan
BACKGROUND: The present study assesses the safety and efficacy of stereotactic radiosurgery (SRS) versus observation for Koos grade I and II vestibular schwannoma (VS), benign tumors affecting hearing and neurological function. METHODS: This multicenter study analyzed data from Koos grade I and II VS patients managed with SRS (SRS group) or observation (observation group). Propensity score matching balanced patient demographics, tumor volume, and audiometry. Outcomes measured were tumor control, serviceable hearing preservation (SHP), and neurological outcomes...
April 6, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38583496/carotid-artery-stenosis-and-ischemic-stroke-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy-a-critical-review
#16
REVIEW
Justin Smith, Danielle Margalit, Jonathan Golledge, Domenico Nastasi, Anju Nohria, Lachlan McDowell
PURPOSE: The purpose of this review is to summarize the literature on carotid artery stenosis (CAS) and ischemic stroke (IS) in head and neck cancer (HNC) patients treated with radiotherapy (RT) to guide assessment, screening, and management strategies. RESULTS: Patients treated with RT for HNC are at an elevated risk of developing CAS with published meta-analyses demonstrating that CAS >50% occurs in approximately 25% of patients. Previous research suggests a 10-year cumulative incidence of stroke between 5...
April 5, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38583495/stereotactic-body-radiotherapy-combined-with-lenvatinib-with-or-without-pd-1-inhibitors-as-initial-treatment-for-unresectable-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Quan Wang, Xiaoquan Ji, Jing Sun, Aimin Zhang, Jun Jiaa, Teng Zhang, Wengang Li, Xuezhang Duan
PURPOSE: The aim of this study was to compare the clinical benefit and safety of the triple combination of stereotactic body radiotherapy (SBRT), lenvatinib and programmed death 1 (PD-1) inhibitors with the dual combination of SBRT and lenvatinib in patients with unresectable hepatocellular carcinoma (uHCC). METHODS AND MATERIALS: Patients with uHCC who received SBRT in combination with lenvatinib and PD-1 inhibitors or SBRT in combination with lenvatinib alone as first-line treatment from October 2018 to July 2022 were reviewed in this study...
April 5, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38583494/evaluation-of-radiotherapy-treatment-plans-in-a-randomized-phase-ii-trial-comparing-two-schedules-of-twice-daily-thoracic-radiotherapy-in-limited-stage-small-cell-lung-cancer
#18
JOURNAL ARTICLE
Nina Levin, Kristin T Killingberg, Tarje O Halvorsen, Signe Danielsen, Bjørn Henning Grønberg
PURPOSE: There is limited clinical data for recommendations on how to deliver thoracic radiotherapy (TRT) concurrently with chemotherapy in limited stage (LS) small-cell lung cancer (SCLC). We reviewed radiotherapy treatment plans in a randomized phase II trial comparing high-dose with standard-dose twice-daily TRT to assess treatment planning techniques, dose-volume data for target volumes and organs at risk (OARs), evaluate compliance with the protocol, associations with radiation-induced toxicity and whether an imbalance in treatment planning parameters might be a reason for the large survival benefit of the higher dose (median overall survival 43...
April 5, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38582234/evaluation-of-a-national-radiation-oncology-research-and-mentorship-program
#19
JOURNAL ARTICLE
Ruijia Jin, Che Hsuan David Wu, Meredith Giuliani, Corinne Doll, Jolie Ringash, Danny Lavigne, Paris Ann Ingledew
PURPOSE: The XXX Annual Scientific Meeting Medical Student Research and Mentorship Award (XXX ASM MSRMA) was established in 2020 to support medical students pursuing radiation oncology (RO) research and RO as a career. This study is an evaluation of the impact of this national research and mentorship award on medical students, resident mentors, and research supervisors over three iterations. METHODS: Three separate surveys were created for: medical student mentees, RO resident mentors, and attending research supervisors...
April 4, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38582233/radiation-doses-received-by-major-organs-at-risk-in-children-and-young-adolescents-treated-for-cancer-with-external-beam-radiation-therapy-a-large-scale-study-from-12-european-countries
#20
JOURNAL ARTICLE
Ibrahima Diallo, Rodrigue S Allodji, Cristina Veres, Stéphanie Bolle, Damien Llanas, Safaa Ezzouhri, Wael Zrafi, Ghazi Debiche, Vincent Souchard, Romain Fauchery, Nadia Haddy, Neige Journy, Charlotte Demoor-Goldschmidt, David L Winter, Lars Hjorth, Thomas Wiebe, Riccardo Haupt, Charlotte Robert, Leontien Kremer, Edit Bardi, Carlotta Sacerdote, Monica Terenziani, Claudia E Kuehni, Christina Schindera, Roderick Skinner, Jeanette Falck Winther, Päivi Lähteenmäki, Julianne Byrn, Zsuzsanna Jakab, Elisabeth Cardis, Elisa Pasqual, Soile Tapio, Sarah Baatout, Mike Atkinson, Mohammed Abderrafi Benotmane, Elaine Sugden, Lorna Zadravec Zaletel, Cecile Ronckers, Raoul C Reulen, Mike M Hawkins, Florent de Vathaire
BACKGROUND: Childhood cancer survivors are at high risk of long-term iatrogenic events, in particular those treated with radiotherapy. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. PURPOSE: We aimed to set up a standardised organ dose table in order to help former patients and clinician in charge of long term follow-up clinics...
April 4, 2024: International Journal of Radiation Oncology, Biology, Physics
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