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JOURNAL ARTICLE
Mukku Nisanth Kartheek, Munaga V N K Prasad, Raju Bhukya
Facial expressions can convey the internal emotions of a person within a certain scenario and play a major role in the social interaction of human beings. In automatic Facial Expression Recognition (FER) systems, the method applied for feature extraction plays a major role in determining the performance of a system. In this regard, by drawing inspiration from the Swastik symbol, three texture based feature descriptors named Symbol Patterns (SP1 , SP2 and SP3 ) have been proposed for facial feature extraction...
April 2024: Cognitive Neurodynamics
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REVIEW
Christopher J De Jonge, Christopher L R Barratt, R John Aitken, Richard A Anderson, Peter Baker, David Y L Chan, Mark P Connolly, Michael L Eisenberg, Nicolas Garrido, Niels Jørgensen, Sarah Kimmins, Csilla Krausz, Robert I McLachlan, Craig Niederberger, Moira K O'Bryan, Allan Pacey, Lærke Priskorn, Satu Rautakallio-Hokkanen, Gamal Serour, Joris A Veltman, Donna L Vogel, Mónica H Vazquez-Levin
BACKGROUND: The widespread interest in male reproductive health (MRH), fueled by emerging evidence, such as the global decline in sperm counts, has intensified concerns about the status of MRH. Consequently, there is a pressing requirement for a strategic, systematic approach to identifying critical questions, collecting pertinent information, and utilizing these data to develop evidence-based strategies. The methods for addressing these questions and the pathways toward their answers will inevitably vary based on the variations in cultural, geopolitical, and health-related contexts...
2024: Human Reproduction Open
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JOURNAL ARTICLE
Julian Theuriet, Marion Masingue, Anthony Behin, Ana Ferreiro, Guillaume Bassez, Pauline Jaubert, Oriana Tarabay, Frédéric Fer, Antoine Pegat, Françoise Bouhour, Juliette Svahn, Philippe Petiot, Laurentiu Jomir, Guy Chauplannaz, Catherine Cornut-Chauvinc, Véronique Manel, Emmanuelle Salort-Campana, Shahram Attarian, Etienne Fortanier, Annie Verschueren, Ludivine Kouton, Jean-Philippe Camdessanché, Céline Tard, Armelle Magot, Yann Péréon, Jean-Baptiste Noury, Marie-Christine Minot-Myhie, Maud Perie, Frederic Taithe, Yacine Farhat, Anne-Laure Millet, Pascal Cintas, Guilhem Solé, Marco Spinazzi, Florence Esselin, Dimitri Renard, Sabrina Sacconi, Andra Ezaru, Edoardo Malfatti, Martial Mallaret, Laurent Magy, Eva Diab, Philippe Merle, Maud Michaud, Maxime Fournier, Aleksandra Nadaj Pakleza, Jean-Baptiste Chanson, Claire Lefeuvre, Pascal Laforet, Pascale Richard, Damien Sternberg, Rocio-Nur Villar-Quiles, Tanya Stojkovic, Bruno Eymard
Congenital myasthenic syndromes (CMS) are clinically and genetically heterogeneous diseases caused by mutations affecting neuromuscular transmission. Even if the first symptoms mainly occur during childhood, adult neurologists must confront this challenging diagnosis and manage these patients throughout their adulthood. However, long-term follow-up data from large cohorts of CMS patients are lacking and the long-term prognosis of these patients is largely unknown. We report the clinical features, diagnostic difficulties, and long-term prognosis of a French nationwide cohort of 235 adult patients with genetically confirmed CMS followed in 23 specialized neuromuscular centres...
May 2, 2024: Brain
#4
JOURNAL ARTICLE
Ni Liang, Wenyi Song, Jing Li
BACKGROUND: Bisphenol A (BPA) is an industrial chemical that is commonly found in daily consumer products. BPA is reportedly associated with lung diseases. However, the impact of BPA on pulmonary fibrosis (PF) and its possible mechanisms of action both remain unclear. METHODS: A PF mouse model was induced by bleomycin (BLM). Mouse lung fibroblasts (MLG 2908) and mouse alveolar epithelial cells (MLE-12) were treated with BPA to establish a PF cell model. Tissue staining, CCK-8 assays, western blot experiments and relevant indicator kits were used to detect and evaluate the effect of BPA on PF...
April 30, 2024: Ecotoxicology and Environmental Safety
#5
JOURNAL ARTICLE
Minjae Bae, Jihyun Cho, Seunghee Won
INTRODUCTION: This study aimed to determine trait- and state-dependent markers of schizophrenia by investigating facial emotion-recognition (FER) deficits in remitted patients with schizophrenia and their first-degree relatives (FR). METHODS: Three groups were included: the Schizophrenia group ( n =66), their unaffected FR group ( n =40), and healthy controls ( n =50) who were matched for age, sex, and years of education. A facial-labeling task was used to examine FER deficits using the following eight standardized expressions: happy, fearful, disgusted, angry, sad, contemptuous, surprised, and neutral...
2024: Frontiers in Psychiatry
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JOURNAL ARTICLE
Jia Chen, Xiaoyu Deng, Ting Lin, Jiefeng Huang, Yisong Yang, Ningfang Lian
PURPOSE: Chronic intermittent hypoxia (CIH) related arterial endothelium injury is a common cause of cardiovascular system injury. However, the mechanism still needs to be clarified. In this study, we aimed to clarify the role and mechanism of ferrostatin-1 (Fer-1) in CIH-related rat arterial endothelial cells (ROAEC) ferroptosis. METHODS: ROAEC was divided into control group, CIH group, and CIH+ Fer-1 group. Cell viability was detected by cell counting kit 8 kits (CCK8)...
2024: Nature and Science of Sleep
#7
JOURNAL ARTICLE
Liang Zhou, Mei Dong, Ge Feng, Yiyi Zhang, Jiaqi Wang, Hening Kang, Zishan Dong, Jingyuan Ning, Zhiming Zhao, Chuan Wang
Diabetes is linked to male infertility, but the mechanisms and therapeutic options remain unclear. This study investigates the effects of semaglutide on testicular function in a diabetes mouse model. Clinical data shows that diabetes affects blood glucose, lipid levels, and sperm quality. Single-cell and transcriptome analyses reveal changes in testicular tissue cell proportions and activation of ferroptosis pathways in diabetic patients/rats. In the diabetes mouse model, sperm quality decreases significantly...
April 24, 2024: Biochemical and Biophysical Research Communications
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JOURNAL ARTICLE
Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa
Subretinal hemorrhages result in poor vision and visual field defects. During hemorrhage, several potentially toxic substances are released from iron-based hemoglobin and hemin, inducing cellular damage, the detailed mechanisms of which remain unknown. We examined the effects of excess intracellular iron on retinal pigment epithelial (RPE) cells. A Fe2+ probe, SiRhoNox-1 was used to investigate Fe2+ accumulation after treatment with hemoglobin or hemin in the human RPE cell line ARPE-19. We also evaluated the production of reactive oxygen species (ROS) and lipid peroxidation...
June 2024: Journal of Pharmacological Sciences
#9
JOURNAL ARTICLE
Jinming Zhang, Jiangzhou Du, Dongyu Liu, Jinzhong Zhuo, Lanhe Chu, Yanqun Li, Lin Gao, Mingming Xu, Weimou Chen, Wufeng Huang, Lingyan Xie, Junwei Chen, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Dong
Polystyrene microplastics (PS-MPs) are new types of environmental pollutant that have garnered significant attention in recent years since they were found to cause damage to the human respiratory system when they are inhaled. The pulmonary fibrosis is one of the serious consequences of PS-MPs inhalation. However, the impact and underlying mechanisms of PS-MPs on pulmonary fibrosis are not clear. In this study, we studied the potential lung toxicity and PS-MPs-developed pulmonary fibrosis by long-term intranasal inhalation of PS-MPs...
April 26, 2024: Ecotoxicology and Environmental Safety
#10
JOURNAL ARTICLE
Xingli Zhang, Jing Shi, Ruonan Wang, Junguo Ma, Xiaokang Li, Wenwen Cai, Tengfei Li, Wei Zou
Tris(2,4-di-tert-butylphenyl)phosphate (AO168 =O), a novel organophosphate ester, is prevalent and abundant in the environment, posing great exposure risks to ecological and public health. Nevertheless, the toxicological effects of AO168 =O remain entirely unknown to date. The results in this study indicated that acute exposure to AO168 =O at 10 and 100 μg/L for 5 days obviously impaired cardiac morphology and function of zebrafish larvae, as proofed by decreased heartbeat, stroke volume, and cardiac output and the occurrence of pericardial edema and ventricular hypertrophy...
April 23, 2024: Journal of Hazardous Materials
#11
JOURNAL ARTICLE
Xin-Xin Wang, Run-Jie Wang, Hua-Long Ji, Xiao-Yu Liu, Nai-Yu Zhang, Kai-Ming Wang, Kai Chen, Ping-Ping Liu, Ning Meng, Cheng-Shi Jiang
Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated cell death. It has been shown that high glucose (HG) could induce ferroptosis in vascular endothelial cells (VECs), consequently contributing to the development of various diseases. This study synthesized and evaluated a series of novel ferrostatin-1 (Fer-1) derivatives fused with a benzohydrazide moiety to prevent HG-induced VEC ferroptosis. Several promising compounds showed similar or improved inhibitory effects compared to positive control Fer-1...
April 24, 2024: RSC medicinal chemistry
#12
JOURNAL ARTICLE
Dominik Wupperfeld, Gert Fricker, Béatrice Bois De Fer, Branko Popovic
BACKGROUND: Essential phospholipids (EPL) are hepatoprotective. METHODS: The effects on interleukin (IL)-6 and -8 secretion and on certain lipid-metabolizing enzymes of non-cytotoxic concentrations of EPL (0.1 and 0.25 mg/ml), polyenylphosphatidylcholine (PPC), and phosphatidylinositol (PtdIns) (both at 0.1 and 1 mg/ml), compared with untreated controls, were assessed in human hepatocyte cell lines (HepG2, HepaRG, and steatotic HepaRG). RESULTS: Lipopolysaccharide (LPS)-induced IL-6 secretion was significantly decreased in HepaRG cells by most phospholipids, and significantly increased in steatotic HepaRG cells with at least one concentration of EPL and PtdIns...
April 26, 2024: Pharmacological Reports: PR
#13
REVIEW
Tianqing Zhang, Li Luo, Qi He, Sijie Xiao, Yuwei Li, Junpeng Chen, Tao Qin, Zhenni Xiao, Qingliang Ge
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF...
April 24, 2024: European Journal of Medical Research
#14
JOURNAL ARTICLE
Yufei Zhan, Yazhuo Zhang
Butylated hydroxyanisole (BHA) is one of the most commonly used antioxidants and is widely used in food, but whether it causes vascular damage has not been clearly studied. The present study demonstrated for the first time that BHA reduced the viability of human umbilical vein endothelial cells (HUVECs) and mouse brain microvascular endothelial cells (BEND3) in a dose- and time-dependent manner. Moreover, BHA inhibited the migration and proliferation of vascular endothelial cells (ECs). Further analysis revealed that in ECs, the ferroptosis inhibitor ferrostatin-1 (Fer-1) reversed the BHA-induced increase in Fe2+ and malonaldehyde (MDA) levels...
April 22, 2024: Food and Chemical Toxicology
#15
JOURNAL ARTICLE
Marco Bergamini, Alberto Dalla Volta, Carlotta Palumbo, Stefania Zamboni, Luca Triggiani, Manuel Zamparini, Marta Laganà, Luca Rinaudo, Nunzia Di Meo, Irene Caramella, Roberto Bresciani, Francesca Valcamonico, Paolo Borghetti, Andrea Guerini, Davide Farina, Alessandro Antonelli, Claudio Simeone, Gherardo Mazziotti, Alfredo Berruti
BACKGROUND: Among its extragonadal effects, follicle-stimulating hormone (FSH) has an impact on body composition and bone metabolism. Since androgen deprivation therapy (ADT) has a profound impact on circulating FSH concentrations, this hormone could potentially be implicated in the changes of fat body mass (FBM), lean body mass (LBM), and bone fragility induced by ADT. The objective of this study is to correlate FSH serum levels with body composition parameters, bone mineral density (BMD), and bone turnover markers at baseline conditions and after 12 months of ADT...
April 24, 2024: ELife
#16
JOURNAL ARTICLE
Ferroptosis is involved in trophoblast cells cytotoxicity induced by black phosphorus nanoparticles.
Ruolan You, Yaming Mu, Jiaqi Zhou, Chunying Wang, Zhenya Fang, Yu Liu, Shiyu Liu, Qingfeng Zhai, Changqing Zhang
Black phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta...
April 21, 2024: Toxicology
#17
JOURNAL ARTICLE
Yuanyuan Chen, Zhaohua Liu, Hongmei Chen, Yi Wen, Lang Fan, Man Luo
OBJECTIVE: This work aimed to investigate the role of rhythm gene PER1 in mediating granulosa cell ferroptosis and lipid metabolism of polycystic ovary syndrome (PCOS). METHODS: We injected dehydroepiandrosterone and Ferrostatin-1 (Fer-1) into mice to explore the mechanism of ferroptosis in PCOS. The effect of PER1 on ferroptosis-like changes in granulosa cells was explored by overexpression of PER1 plasmid transfection and Fer-1 treatment. RESULTS: We found that Fer-1 ameliorated the characteristic polycystic ovary morphology, suppressed ferroptosis in the PCOS mice...
April 21, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
#18
JOURNAL ARTICLE
Yi Chen, Ye Ma, Xiaoli Fan, Jiamin Lyu, Rongwang Yang
Attention deficit and hyperactive disorder (ADHD) is a chronic neurodevelopmental disorder characterized by inattention, hyperactivity-impulsivity, and working memory deficits. Social dysfunction is one of the major challenges faced by children with ADHD. It's found that children with ADHD perform less well than typically developing children on facial expression recognition (FER) tasks. Generally, children with ADHD have some difficulties in FER, while some researches suggest that they have no significant differences in accuracy of specific emotion recognition with typically developing children...
April 18, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
#19
JOURNAL ARTICLE
Yan-Qin Feng, Xuan Liu, Ning Zuo, Mu-Bin Yu, Wen-Meng Bian, Bao-Quan Han, Zhong-Yi Sun, Massimo De Felici, Wei Shen, Lan Li
Rationale: In recent years, nicotinamide adenine dinucleotide (NAD+ ) precursors (Npre) have been widely employed to ameliorate female reproductive problems in both humans and animal models. However, whether and how Npre plays a role in the male reproductive disorder has not been fully clarified. Methods: In the present study, a busulfan-induced non-obstructive azoospermic mouse model was used, and Npre was administered for five weeks following the drug injection, with the objective of reinstating spermatogenesis and fertility...
2024: Theranostics
#20
JOURNAL ARTICLE
Yoshiaki Ito, Keiichiro Nayuki, Yukichi Sasaki, Toru Wakihara, Tatsuya Okubo, Kenta Iyoki
The synthesis of zeolites from two-dimensional layered precursors through interlayer crosslinking of the layers is a promising avenue for realizing meticulously designed synthesis routes. However, the presence of defective silanol species in the precursors hinders the achievement of desirable synthesis outcomes. This study focuses on PREFER-a layered precursor for FER-type zeolites-which was synthesized and subjected to a liquid-mediated defect-healing treatment that we recently developed. The defect-healing process involves the use of fluoride compounds for reconstruction and organic pore fillers to stabilize the framework...
April 16, 2024: RSC Advances
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