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World Journal of Cardiology

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https://read.qxmd.com/read/30705741/contemporary-characteristics-and-outcomes-of-adults-with-familial-dilated-cardiomyopathy-listed-for-heart-transplantation
#1
Mohamed Khayata, Sadeer G Al-Kindi, Guilherme H Oliveira
BACKGROUND: Familial dilated cardiomyopathy (FDCM) account for 20%-30% of non-ischemic cardiomyopathies (NICM). Previous published data showed that some patients with FDCM tend to have rapidly progressive disease; however, five-year mortality was not significantly different in the familial and non-familial forms of NICM with optimal medical therapy. AIM: To better define the characteristics and clinical outcomes of FDCM patients listed for heart transplantation (HT)...
January 26, 2019: World Journal of Cardiology
https://read.qxmd.com/read/30705740/subclinical-carotid-atherosclerosis-predicts-all-cause-mortality-and-cardiovascular-events-in-obese-patients-with-negative-exercise-echocardiography
#2
Rafael Vidal-Perez, Raúl Franco-Gutiérrez, Alberto J Pérez-Pérez, Virginia Franco-Gutiérrez, Alberto Gascón-Vázquez, Andrea López-López, Ana María Testa-Fernández, Carlos González-Juanatey
BACKGROUND: Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques (CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients...
January 26, 2019: World Journal of Cardiology
https://read.qxmd.com/read/30705739/current-evidence-of-drug-elution-therapy-for-infrapopliteal-arterial-disease
#3
REVIEW
Stavros Spiliopoulos, Nikiforos Vasiniotis Kamarinos, Elias Brountzos
New and sophisticated endovascular devices, such as drug-eluting stents (DES) and drug-coated balloons (DCB), provide targeted drug delivery to affected vessels. The invention of these devices has made it possible to address the reparative cascade of arterial wall injury following balloon angioplasty that results in restenosis. DESs were first used for the treatment of infrapopliteal lesions almost 20 years ago. More recently, however, DCB technology is being investigated to improve outcomes of endovascular below-the-knee arterial procedures, avoiding the need for a metallic scaffold...
January 26, 2019: World Journal of Cardiology
https://read.qxmd.com/read/30705738/heart-disease-in-friedreich-s-ataxia
#4
REVIEW
Emily Hanson, Mark Sheldon, Brenda Pacheco, Mohammed Alkubeysi, Veena Raizada
Friedreich's ataxia (FRDA), which occurs in 1/50000 live births, is the most prevalent inherited neuromuscular disorder. Nearly all FRDA patients develop cardiomyopathy at some point in their lives. The clinical manifestations of FRDA include ataxia of the limbs and trunk, dysarthria, diabetes mellitus, and cardiac diseases. However, the broad clinical spectrum makes FRDA difficult to identify. The diagnosis of FRDA is based on the presence of suspicious clinical factors, the use of the Harding criteria and, more recently, the use of genetic testing for identifying the expansion of a triplet nucleotide sequence...
January 26, 2019: World Journal of Cardiology
https://read.qxmd.com/read/30622685/instantaneous-wave-free-ratio-ifr-%C3%A2-to-determine-hemodynamically-significant-coronary-stenosis-a-comprehensive-review
#5
REVIEW
Stefan Baumann, Leonard Chandra, Elizaveta Skarga, Matthias Renker, Martin Borggrefe, Ibrahim Akin, Dirk Lossnitzer
Coronary angiography is considered to be the gold standard in the morphological evaluation of coronary artery stenosis. The morphological assessment of the severity of a coronary lesion is very subjective. Thus, the invasive fractional flow reserve (FFR) measurement represents the current standard for estimation of the hemodynamic significance of coronary artery stenosis. The FFR-guided revascularization strategy was initially classified as a Class-IA-recommendation in the 2014 European Society of Cardiology/European Association for Cardio-Thoracic Surgery guidelines on myocardial revascularization...
December 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30622684/cardiac-implications-of-thrombotic-thrombocytopenic-purpura
#6
REVIEW
Szymon L Wiernek, Bo Jiang, Gregory M Gustafson, Xuming Dai
Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on platelet-mediated micro-thrombi formation, leading to microvascular thrombosis. Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death...
December 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30622683/risk-of-sudden-cardiac-death-are-coronary-chronic-total-occlusions-an-additional-risk-factor
#7
EDITORIAL
Ioannis Merinopoulos, Natasha Corballis, Simon C Eccleshall, Vassilios S Vassiliou
Sudden arrhythmic cardiac death remains a significant, potentially reversible, cardiological challenge in terms of creating accurate risk prediction models. The current guidelines for implantable cardioverter defibrillator (ICD) therapy are mainly based on left ventricular ejection fraction despite its low sensitivity and specificity in predicting sudden cardiac death (SCD). Chronic total occlusions have been associated with increased mortality but further research is required to clarify if they should be incorporated in a risk model predicting SCD aiming to identify patients that would benefit from ICD therapy even with preserved ejection fraction...
December 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510641/surgical-left-atrial-appendage-occlusion-during-cardiac-surgery-a-systematic-review-and-meta-analysis
#8
Varunsiri Atti, Mahesh Anantha-Narayanan, Mohit K Turagam, Scott Koerber, Sunil Rao, Juan F Viles-Gonzalez, Rakesh M Suri, Poonam Velagapudi, Dhanunjaya Lakkireddy, David G Benditt
AIM: To evaluate the safety and efficacy of surgical left atrial appendage occlusion (s-LAAO) during concomitant cardiac surgery. METHODS: We performed a comprehensive literature search through May 31st 2018 for all eligible studies comparing s-LAAO vs no occlusion in patients undergoing cardiac surgery. Clinical outcomes during follow-up included: embolic events, stroke, all-cause mortality, atrial fibrillation (AF), reoperation for bleeding and postoperative complications...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510640/incidence-and-risk-factors-for-potentially-suboptimal-serum-concentrations-of-vancomycin-during-cardiac-surgery
#9
Paolo Cotogni, Cristina Barbero, Mauro Rinaldi
AIM: To investigate the incidence and risk factors for vancomycin concentrations less than 10 mg/L during cardiac surgery. METHODS: In this prospective study, patients undergoing cardiac surgery received a single dose of 1000 mg of vancomycin. Multiple arterial samples were drawn during surgery. Exclusion criteria were hepatic dysfunction; renal dysfunction; ongoing infectious diseases; solid or hematologic tumors; severe insulin-dependent diabetes; body mass index of < 17 or > 40 kg/m2 ; pregnancy or lactation; antibiotic, corticosteroid, or other immunosuppressive therapy; vancomycin or nonsteroidal anti-inflammatory drug therapy in the previous 2 wk; chemotherapy or radiation therapy in the previous 6 mo; allergy to vancomycin or cefazolin; drug abuse; cardiac surgery in the previous 6 mo; previous or scheduled organ transplantation; preoperative stay in the intensive care unit for more than 24 h; emergency procedure or lack of adequate preparation for surgery; and participation in another trial...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510639/safety-and-efficacy-of-frequency-domain-optical-coherence-tomography-in-evaluating-and-treating-intermediate-coronary-lesions
#10
Mohammad Reeaze Khurwolah, Hao-Yu Meng, Yong-Sheng Wang, Lian-Sheng Wang, Xiang-Qing Kong
AIM: To establish whether frequency-domain optical coherence tomography (FD-OCT) is safe and effective in the evaluation and treatment of angiographically-intermediate coronary lesions (ICL). METHODS: Sixty-four patients with 2-dimensional quantitative coronary angiography (2D-QCA) demonstrating ICL were included. OCT imaging was performed. According to predetermined OCT criteria, patients were assigned to either of 2 groups: OCT-guided percutaneous coronary intervention (PCI) or OCT-guided optimal medical therapy (OMT)...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510638/clinical-applications-of-feature-tracking-cardiac-magnetic-resonance-imaging
#11
REVIEW
Daniele Muser, Simon A Castro, Pasquale Santangeli, Gaetano Nucifora
Cardiovascular diseases represent the leading cause of mortality and morbidity in the western world. Assessment of cardiac function is pivotal for early diagnosis of primitive myocardial disorders, identification of cardiac involvement in systemic diseases, detection of drug-related cardiac toxicity as well as risk stratification and monitor of treatment effects in patients with heart failure of various etiology. Determination of ejection fraction with different imaging modalities currently represents the gold standard for evaluation of cardiac function...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510637/coronary-spasm-it-s-common-but-it-s-still-unsolved
#12
EDITORIAL
Hiroki Teragawa, Chikage Oshita, Tomohiro Ueda
Coronary spasm is caused by a transient coronary narrowing due to the constriction of epicardial coronary artery, which leads to myocardial ischemia. More than 50 years have passed since the first recognition of coronary spasm, and many findings on coronary spasm have been reported. Coronary spasm has been considered as having pivotal roles in the cause of not only rest angina but also exertional angina, acute coronary syndrome, and heart failure. In addition, several new findings of the mechanism of coronary spasm have emerged recently...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510636/revisiting-endovascular-treatment-in-below-the-knee-disease-are-drug-eluting-stents-the-best-option
#13
EDITORIAL
Stavros Spiliopoulos, Panagiotis M Kitrou, Elias N Brountzos
Patients with below-the-knee arterial disease are primarily individuals suffering from critical limb ischemia (CLI), while a large percentage of these patients are also suffering from diabetes or chronic renal failure or both. Available data from randomized controlled trials and their meta-analysis demonstrated that the use of infrapopliteal drug-eluting stents (DES), in short- to medium- length lesions, obtains significantly better results compared to plain balloon angioplasty and bare metal stenting with regards to vascular restenosis, target lesion revascularization, wound healing and amputations...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30510635/thin-and-crush-the-new-mantra-in-left-main-stenting
#14
EDITORIAL
Gianluca Rigatelli, Marco Zuin, Debradata Dash
Complex bifurcations have been suggested to be better approached by a planned double stent technique; however, recent randomized trials have shown better outcomes of provisional compared to planned two-stent strategy, in terms of both short-term efficacy and safety. In left main (LM) bifurcations, double kissing (DK)-Crush has demonstrated its superiority over Culotte and provisional-T in terms of restenosis and stent thrombosis, gaining respect as one of the most performant techniques for bifurcations stenting...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30386495/takotsubo-syndrome-different-presentations-for-a-single-disease-a-case-report-and-review-of-literature
#15
Alberto Fuensalida, Maurice Cortés, Luigi Gabrielli, Manuel Méndez, Alejandro Martínez, Gonzalo Martínez
We report three cases of Takotsubo syndrome (TS) with atypical myocardial involvement. All three cases were triggered by physical or mental stress, resulting in transient myocardial compromise. However, the clinical presentation, localization and extent of myocardial damage varied in each case, ranging from low-risk acute chest pain to cardiogenic shock with low ejection fraction and dynamic obstruction of the left ventricular outflow tract. These cases outline the range of possible presentations of this rare entity and illustrate atypical forms of TS...
October 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30386494/undiscovered-pathology-of-transient-scaffolding-t1remains-a-driver-of-failures-in-clinical-trials
#16
Alexander N Kharlamov
AIM: To statistically examine the released clinical trials and meta-analyses of polymeric bioresorbable scaffolds resuming the main accomplishments in the field with a translation to the routine clinical practice. METHODS: The statistical power in clinical trials such as ABSORB Japan, ABSORB China, EVERBIO II, AIDA, and few meta-analyses by the post hoc odds ratio-based sample size calculation, and the patterns of artery remodeling published in papers from ABSORB A and B trials were evaluated...
October 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30386493/incidental-congenital-coronary-artery-vascular-fistulas-in-adults-evaluation-with-adenosine-13-n-ammonia-pet-ct
#17
Salah Am Said, Aly Agool, Arno Hm Moons, Mounir Wz Basalus, Nils Rl Wagenaar, Rogier Lg Nijhuis, Jutta M Schroeder-Tanka, Riemer Hja Slart
AIM: To assess the functionality of congenital coronary artery fistulas (CAFs) using adenosine stress 13 N-ammonia positron emission tomography computed tomography (PET-CT). METHODS: Congenital CAFs were incidentally detected during coronary angiography (CAG) procedures in 11 adult patients (six males and five females) with a mean age of 64.3 years (range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas (origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG...
October 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30386492/successful-endovascular-treatment-in-patients-with-acute-thromboembolic-ischemia-of-the-lower-limb-including-the-crural-arteries
#18
Sorin Giusca, Dorothea Raupp, Dirk Dreyer, Christoph Eisenbach, Grigorios Korosoglou
AIM: To examine the efficacy and safety of the 6 French (6F) Rotarex® S catheter system in patients with acute limb ischemia (ALI) involving thromboembolic occlusion of the proximal and mid-crural vessels. METHODS: The files of patients in our department with ALI between 2015 and 2017 were examined. In seven patients, the Rotarex® S catheter was used in the proximal segment of the crural arteries. Data related to the clinical examination, Doppler sonography, angiography and follow-up from these patients were further used for analysis...
October 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30386491/chronic-ischemic-mitral-valve-regurgitation-and-surgical-perspectives
#19
REVIEW
Salah Eldien Altarabsheh, Salil V Deo, Abeer Rababa'h, Yagthan M Obeidat, Osama Haddad
Chronic ischemic mitral valve regurgitation is a result of disturbed left ventricular geometry secondary to myocardial ischemia in the absence of intrinsic mitral valve pathology. It is a common complication after myocardial infarction, and patients who have ischemic mitral regurgitation (IMR) have a worse prognosis compared to patients who have ischemic heart disease alone, and this is directly related to the severity of IMR. Medical therapy has limited efficacy, and surgical options including various repair techniques and valve replacement had been tried with variable success...
October 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30386490/overview-of-coronary-artery-variants-aberrations-and-anomalies
#20
REVIEW
Stylianos Kastellanos, Konstantinos Aznaouridis, Charalambos Vlachopoulos, Eleftherios Tsiamis, Evangelos Oikonomou, Dimitris Tousoulis
Coronary artery anomalies and variants are relatively uncommon congenital disorders of the coronary artery anatomy and constitute the second most common cause of sudden cardiac death in young competitive athletes. The rapid advancement of imaging techniques, including computed tomography, magnetic resonance imaging, intravascular ultrasound and optical coherence tomography, have provided us with a wealth of new information on the subject. Anomalous origin of a coronary artery from the contralateral sinus is the anomaly most frequently associated with sudden cardiac death, in particular if the anomalous coronary artery has a course between the aorta and the pulmonary artery...
October 26, 2018: World Journal of Cardiology
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