Mehmet Nuri Yakar, Rıza Kaan Köşker, Emel İbişoğlu, Fevzi Kara, Volkan Hancı
PURPOSE: To reveal factors related to gender parity on editorial boards of critical care journals indexing in SCI-E. METHODS: The genders were defined according to data obtained from journals' websites between 01-30 September 2022. Publisher properties and journal metrics were analyzed by using Chi-square, Fisher exact, Mann-Whitney U tests, and Spearman's correlation coefficient. Logistic regression analysis was used to reveal independent factors. RESULTS: Women's representation on editorial boards was 23...
March 17, 2023: Journal of Critical Care
Claire Michel, Scott Warming, Ary Serpa Neto, Vihangi Abeygunawardana, Caleb Fisher, Kartik Kishore, Stephen Warrillow, Rinaldo Bellomo
PURPOSE: To study patient characteristics, physiological changes, and outcomes associated with prolonged continuous hypertonic saline (HTS) infusion in acute liver failure (ALF). MATERIALS AND METHODS: Retrospective observational cohort study of adult patients with ALF. We collected clinical, biochemical, and physiological data six hourly for the first week, daily until day 30 or hospital discharge, and weekly, when documented, until day 180. RESULTS: Of 127 patients, 85 received continuous HTS...
March 16, 2023: Journal of Critical Care
Elie Azoulay, Virginie Souppart, Nancy Kentish-Barnes, Ygal Benhamou, Bérangère S Joly, Lara Zafrani, Adrien Joseph, Emmanuel Canet, Claire Presne, Maximilien Grall, Yoann Zerbib, François Provot, Jehane Fadlallah, Eric Mariotte, Tomas Urbina, Agnès Veyradier, Paul Coppo
Thrombotic thrombocytopenic purpura (iTTP) and atypical hemolytic-uremic syndrome (aHUS), once in remission, may cause long-term symptoms, among which mental-health impairments may be difficult to detect. We conducted telephone interviews 72 [48-84] months after ICU discharge to assess symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD) and the 36-item Short Form questionnaire (SF-36). Of 103 included patients, 52 had iTTP and 51 aHUS; 74% were female, median age was 39 y (31-54), and 39 (38%) patients were still taking treatment...
March 15, 2023: Journal of Critical Care
Simone Piva, Matteo Pozzi, Giacomo Bellani, Elena Peli, Nicola Gitti, Alberto Lucchini, Michele Bertoni, Alberto Goffi, John C Marshall, Stefano Calza, Francesco A Rasulo, Giuseppe Foti, Nicola Latronico
PURPOSE: This work aimed to compare physical impairment in survivors of classic ARDS compared with COVID-19-associated ARDS (CARDS) survivors. MATERIAL AND METHODS: This is a prospective observational cohort study on 248 patients with CARDS and compared them with a historical cohort of 48 patients with classic ARDS. Physical performance was evaluated at 6 and 12 months after ICU discharge, using the Medical Research Council Scale (MRCss), 6-min walk test (6MWT), handgrip dynamometry (HGD), and fatigue severity score (FSS)...
March 6, 2023: Journal of Critical Care
Carmen Andrea Pfortmueller, Wojciech Dabrowski, Manu L N G Malbrain
No abstract text is available yet for this article.
March 2, 2023: Journal of Critical Care
Jennie Johnstone, John Muscedere, Joanna Dionne, Erick Duan, Bram Rochwerg, John Centofanti, Simon Oczkowski, Francois Lauzier, John Marshall, Diane Heels-Ansdell, Nick Daneman, Sangeeta Mehta, Yaseen Arabi, Nicole Zytaruk, Peter Dodek, Neill K Adhikari, Tim Karachi, Emmanuel Charbonney, Henry T Stelfox, Arnold S Kristof, Ian Ball, Lori Hand, Rob Fowler, Ryan Zarychanski, Charles St Arnaud, Alyson Takaoka, James Kutsogiannis, Kosar Khwaja, Wendy Sligl, Osama Loubani, Jennifer Tsang, Daphnee Lamarche, Dawn Bowdish, Michael Surette, Deborah Cook
INTRODUCTION: We aimed to analyze intensive care unit (ICU)-acquired pneumonia according to 7 definitions, estimating associated hospital mortality. METHODS: This cohort study was nested within an international randomized trial, evaluating the effect of probiotics on ICU-acquired pneumonia in 2650 mechanically ventilated adults. Each clinically suspected pneumonia was adjudicated by two physicians blinded to allocation and center. The primary outcome was ventilator-associated pneumonia (VAP) informed by ventilation for ≥2 days, new, progressive or persistent infiltrate plus 2 of: temperature > 38 °C or < 36 °C; leukopenia (<3 × 10(Fernando et al...
March 2, 2023: Journal of Critical Care
Gabriele Martelli, Sabrina Congedi, Giulia Lorenzoni, Marco Nardelli, Vittorio Lucchetta, Dario Gregori, Ivo Tiberio
BACKGROUND: The reliability of echocardiographic methods for the assessment of pulmonary capillary wedge pressure (PCWP) is still a matter of debate. Since its first description, the E/e' ratio has been regarded as a suitable method. The aim of this study is to evaluate the evidence of how E/e' effectively estimates PCWP and its diagnostic accuracy for elevated PCWP. METHODS: We systematically searched MEDLINE and Embase databases for studies investigating the agreement between E/e' and PCWP, from inception to July 2022...
March 1, 2023: Journal of Critical Care
Christopher Rugg, Simon Woyke, Marco Ronzani, Andreas Markl-Le Levé, Patrick Spraider, Sebastian Loveys, Stefan Schmid, Janett Kreutziger, Mathias Ströhle
PURPOSE: To further analyse causes and effects of ICU-acquired hypernatremia. METHODS: This retrospective, single-centre study, analysed 994 patients regarding ICU-acquired hypernatremia. Non-hypernatremic patients (n = 617) were compared to early-hypernatremic (only before ICU-day 4; n = 87), prolonged-hypernatremic (before and after ICU-day 4; n = 169) and late-hypernatremic patients (only after ICU-day 4; n = 121). Trends in glomerular filtration rate (eGFR), urea-to-creatinine ratio (UCR), fraction of urea in total urine osmolality and urine sodium were compared...
February 27, 2023: Journal of Critical Care
Sadudee Peerapornratana, Marco Fiorentino, Priyanka Priyanka, Raghavan Murugan, John A Kellum
PURPOSE: To examine the effect of kidney recovery on mortality, dialysis and kidney transplantation up to 15 years after AKI. MATERIALS AND METHODS: We studied 29,726 survivors of critical illness and compared these outcomes stratified by AKI and recovery status at hospital discharge. Kidney recovery was defined as a return of serum creatinine to ≤150% of baseline without dialysis prior to hospital discharge. RESULTS: Overall AKI occurred in 59...
February 26, 2023: Journal of Critical Care
Sophie Eleanor Brown, Akshay Shah, Wladyslawa Czuber-Dochan, Suzanne Bench, Louise Stayt
PURPOSE: Fatigue is a common symptom after critical illness. However, evidence-based interventions for fatigue after critical illness are lacking. We aimed to identify interventions to support self-management of fatigue caused by physical conditions and assess their effectiveness and suitability for adaptation for those with fatigue after critical illness. MATERIALS AND METHODS: We conducted an umbrella review of systematic reviews. Databases included CINAHL, PubMed, Medline, PsycINFO, British Nursing Index (BNI), Web of Science, Cochrane Database of Systematic Reviews (CDSR), JBI Evidence Synthesis Database, and PROSPERO register...
February 22, 2023: Journal of Critical Care
Emma F M van der Heijden, Rens W J Kooken, Marieke Zegers, Koen S Simons, Mark van den Boogaard
PURPOSE: Determine differences in physical, mental and cognitive outcomes 1-year post-ICU between patients with persistent delirium (PD), non-persistent delirium (NPD) and no delirium (ND). MATERIALS AND METHODS: A longitudinal cohort study was performed in adult ICU patients of two hospitals admitted between July 2016-February 2020. Questionnaires on physical, mental and cognitive health, frailty and QoL were completed regarding patients' pre-ICU health status and 1-year post-ICU...
February 18, 2023: Journal of Critical Care
Prosenjit Mukherjee, Mohanchandra Mandal, Antonio M Esquinas
No abstract text is available yet for this article.
February 17, 2023: Journal of Critical Care
Rebecca van Grootveld, Martha T van der Beek, Nico A F Janssen, Mehmet Ergün, Karin van Dijk, Carina Bethlehem, Susanne Stads, Judith van Paassen, Leo M A Heunks, Catherine S C Bouman, Monique H E Reijers, Roger J Brüggeman, Frank L van de Veerdonk, Sjoerd H W van Bree, Charlotte H S B van den Berg, Marnix Kuindersma, Joost Wauters, Albertus Beishuizen, Paul E Verweij, Jeroen A Schouten
PURPOSE: COVID-19 associated pulmonary aspergillosis (CAPA) is associated with increased morbidity and mortality in ICU patients. We investigated the incidence of, risk factors for and potential benefit of a pre-emptive screening strategy for CAPA in ICUs in the Netherlands/Belgium during immunosuppressive COVID-19 treatment. MATERIALS AND METHODS: A retrospective, observational, multicentre study was performed from September 2020-April 2021 including patients admitted to the ICU who had undergone diagnostics for CAPA...
February 16, 2023: Journal of Critical Care
Zach Shahn, Aman Choudhri, Boris Jung, Daniel Talmor, Li-Wei H Lehman, Elias Baedorf-Kassis
BACKGROUND: The optimal approach for transitioning from strict lung protective ventilation to support modes of ventilation when patients determine their own respiratory rate and tidal volume remains unclear. While aggressive liberation from lung protective settings could expedite extubation and prevent harm from prolonged ventilation and sedation, conservative liberation could prevent lung injury from spontaneous breathing. RESEARCH QUESTION: Should physicians take a more aggressive or conservative approach to liberation? METHODS: Retrospective cohort study of mechanically ventilated patients from the Medical Information Mart for Intensive Care IV database (MIMIC-IV version 1...
February 14, 2023: Journal of Critical Care
Lada Lijović, Stipe Pelajić, Fatime Hawchar, Ivaylo Minev, Beatriz Helena Cermaria Soares da Silva, Alessandra Angelucci, Ari Ercole, Harm-Jan de Grooth, Patrick Thoral, Tomislav Radočaj, Paul Elbers
INTRODUCTION: Accurate and actionable diagnosis of Acute Kidney Injury (AKI) ahead of time is important to prevent or mitigate renal insufficiency. The purpose of this study was to evaluate the performance of Kinetic estimated Glomerular Filtration Rate (KeGFR) in timely predicting AKI in critically ill septic patients. METHODS: We conducted a retrospective analysis on septic ICU patients who developed AKI in AmsterdamUMCdb, the first freely available European ICU database...
February 10, 2023: Journal of Critical Care
Emma Schwager, Erina Ghosh, Larry Eshelman, Kalyan S Pasupathy, Erin F Barreto, Kianoush Kashani
PURPOSE: We developed and validated two parsimonious algorithms to predict the time of diagnosis of any stage of acute kidney injury (any-AKI) or moderate-to-severe AKI in clinically actionable prediction windows. MATERIALS AND METHODS: In this retrospective single-center cohort of adult ICU admissions, we trained two gradient-boosting models: 1) any-AKI model, predicting the risk of any-AKI at least 6 h before diagnosis (50,342 admissions), and 2) moderate-to-severe AKI model, predicting the risk of moderate-to-severe AKI at least 12 h before diagnosis (39,087 admissions)...
February 10, 2023: Journal of Critical Care
Alana Siev, Elana Levy, Jen-Ting Chen, Inessa Gendlina, Austin Saline, Parry Mendapara, Michelle Ng Gong, Ari Moskowitz
PURPOSE: Blood cultures are commonly ordered for patients with low risk of bacteremia. Indications for obtaining blood cultures are often broad and ill defined, and decision algorithms for appropriate blood cultures have not been comprehensively evaluated in critically-ill populations. METHODS: We conducted a retrospective analysis to assess the frequency of inappropriate blood cultures in the ICUs at Montefiore Medical Center based on an evidence-based guidance algorithm...
February 10, 2023: Journal of Critical Care
Daniel Agustin Godoy, Andres M Rubiano, Jorge Paranhos, Chiara Robba, Christos Lazaridis
Cerebral oxygenation represents the balance between oxygen delivery, consumption and utilization by the brain, and therefore reflects the adequacy of cerebral perfusion. Different factors can influence the amount of oxygen to the brain including arterial blood pressure, hemoglobin levels, systemic oxygenation, and transfer of oxygen from blood to the cerebral microcirculation. A mismatch between cerebral oxygen supply and demand results in cerebral hypoxia/ischemia, and is associated with secondary brain damage and worsened outcome after acute brain injury...
February 9, 2023: Journal of Critical Care
Ethan M Estoos, Kevin P Jocham, Chengda Zhang, Lauren M Benson, Anamaria Milas, Bishoy Zakhary
While mechanical ventilation practices on venovenous extracorporeal membrane oxygenation (VV ECMO) are variable, most institutions utilize a lung rest strategy utilizing relatively low positive end-expiratory pressure (PEEP). The effect of PEEP titration using esophageal manometry during VV ECMO on pulmonary and cardiac function is unknown. This was a retrospective study of 69 patients initiated on VV ECMO between March 2020 through November 2021. Patients underwent standard PEEP (typically 10 cm H2 O) or optimal PEEP (PEEP titrated to an end-expiratory transpulmonary pressure 0-3 cm H2 O) throughout the ECMO run...
February 8, 2023: Journal of Critical Care
Yuankai Zhou, Yi Chi, Huaiwu He, Na Cui, Xiaoting Wang, Yun Long
PURPOSE: This study aimed to evaluate the effects of high respiratory effort(HRE) on spleen, kidney, intestine, and peripheral perfusion in patients with respiratory failure during mechanical ventilation. METHODS: HRE was defined as a pressure muscle index (PMI) > 6 cmH2 O and airway pressure swing during occlusion (ΔPOCC) > 10 cmH2 O. Capillary refill time(CRT) and peripheral perfusion index (PPI) were determined when HRE occurred...
February 3, 2023: Journal of Critical Care
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