journal
https://read.qxmd.com/read/37717361/previously-healthy-adults-among-septic-patients-population-level-epidemiology-and-outcomes
#1
JOURNAL ARTICLE
Lavi Oud, John Garza
PURPOSE: Previously healthy adults with community-onset sepsis were recently reported to have, counterintuitively, higher short-term mortality than those with comorbid conditions. However, the population-level generalizability of this finding and its applicability to all hospitalized septic patients are unclear. METHODS: We used a statewide dataset to identify hospitalizations aged ≥18 years with a diagnosis of sepsis in Texas during 2018-2019. Comorbidities were defined as those included in the Charlson Comorbidity Index and other prevalent conditions associated with mortality...
September 15, 2023: Journal of Critical Care
https://read.qxmd.com/read/37713997/malglycemia-in-the-critical-care-setting-part-ii-relative-and-absolute-hypoglycemia
#2
JOURNAL ARTICLE
Greg Roberts, James S Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R Rule, Michael Brownlee, Guillermo E Umpierrez, Irl B Hirsch
INTRODUCTION: The relationship between critical care mortality and hypoglycemia, both relative (>30% below average preadmission glycemia) and absolute (blood glucose (BG) <70 mg/dL (<10 mmol/L)) requires further definition. METHODS: We assessed the risk-adjusted relationship between hospital mortality with relative hypoglycemia using the Glycemic Ratio (GR), and with absolute hypoglycemia using BG in a retrospective cohort investigation (n = 4790)...
September 13, 2023: Journal of Critical Care
https://read.qxmd.com/read/37703745/letter-to-the-editor-etomidate-as-an-induction-agent-for-endotracheal-intubation-in-critically-ill-patients-a-meta-analysis-of-randomized-trials
#3
LETTER
Cassidy Lavin, Quincy K Tran, Jessica Downing, Ali Pourmand
No abstract text is available yet for this article.
September 11, 2023: Journal of Critical Care
https://read.qxmd.com/read/37696150/ventilatory-strategies-during-venovenous-ecmo-in-ards-peeping-at-the-elephant-in-the-room
#4
JOURNAL ARTICLE
Ryan Ruiyang Ling, Kollengode Ramanathan, Kiran Shekar
No abstract text is available yet for this article.
September 9, 2023: Journal of Critical Care
https://read.qxmd.com/read/37690924/authors-response-etomidate-as-an-induction-agent-for-endotracheal-intubation-in-critically-ill-patients-a-meta-analysis-of-randomized-trials
#5
LETTER
Yuki Kotani, Gioia Piersanti, Todd C Lee, Giovanni Landoni
No abstract text is available yet for this article.
September 8, 2023: Journal of Critical Care
https://read.qxmd.com/read/37690923/authors-response-etomidate-as-an-induction-agent-for-endotracheal-intubation-in-critically-ill-patients-a-meta-analysis-of-randomized-trials
#6
LETTER
Yuki Kotani, Gioia Piersanti, Giacomo Maiucci, Giovanni Landoni
No abstract text is available yet for this article.
September 8, 2023: Journal of Critical Care
https://read.qxmd.com/read/37690922/authors-response-etomidate-as-an-induction-agent-for-endotracheal-intubation-in-critically-ill-patients-a-meta-analysis-of-randomized-trials
#7
LETTER
Yuki Kotani, Matthew W Semler, Todd C Lee, Giovanni Landoni
No abstract text is available yet for this article.
September 8, 2023: Journal of Critical Care
https://read.qxmd.com/read/37690365/effects-of-different-positive-end-expiratory-pressure-titration-strategies-on-mechanical-power-during-ultraprotective-ventilation-in-ards-patients-treated-with-veno-venous-extracorporeal-membrane-oxygenation-a-prospective-interventional-study
#8
JOURNAL ARTICLE
Christoph Boesing, Laura Schaefer, Peter T Graf, Paolo Pelosi, Patricia R M Rocco, Thomas Luecke, Joerg Krebs
PURPOSE: Ultraprotective ventilation in acute respiratory distress syndrome (ARDS) patients with veno-venous extracorporeal membrane oxygenation (VV ECMO) reduces mechanical power (MP) through changes in positive end-expiratory pressure (PEEP); however, the optimal approach to titrate PEEP is unknown. This study assesses the effects of three PEEP titration strategies on MP, hemodynamic parameters, and oxygen delivery in twenty ARDS patients with VV ECMO. MATERIAL AND METHODS: PEEP was titrated according to: (A) a PEEP of 10 cmH2 O representing the lowest recommendation by the Extracorporeal Life Support Organization (PEEPELSO ), (B) the highest static compliance of the respiratory system (PEEPCstat,RS ), and (C) a target end-expiratory transpulmonary pressure of 0 cmH2 O (PEEPPtpexp )...
September 8, 2023: Journal of Critical Care
https://read.qxmd.com/read/37689564/letter-to-the-editor-etomidate-as-an-induction-agent-for-endotracheal-intubation-in-critically-ill-patients-a-meta-analysis-of-randomized-trials
#9
LETTER
Caitlin S Brown, Lucas Oliveira J E Silva
No abstract text is available yet for this article.
September 7, 2023: Journal of Critical Care
https://read.qxmd.com/read/37689563/letter-to-the-editor-etomidate-as-an-induction-agent-for-endotracheal-intubation-in-critically-ill-patients-a-meta-analysis-of-randomized-trials
#10
LETTER
Karen Utz Horst, Mariana Berger do Rosário, Tatiana Helena Rech
No abstract text is available yet for this article.
September 7, 2023: Journal of Critical Care
https://read.qxmd.com/read/37659243/prospective-evaluation-of-bleeding-risk-among-thrombocytopenic-patients-admitted-in-intensive-care-unit
#11
JOURNAL ARTICLE
Geoffroy Hariri, Vincent Belossi, Louis Perol, Louai Missri, Paul Gabarre, Vincent Bonny, Tomas Urbina, Jean-Luc Baudel, Bertrand Guidet, Jeremie Joffre, Eric Maury, Guillaume Dumas, Hafid Ait-Oufella
PURPOSE: Bleeding risk evaluation of thrombocytopenic patients admitted in ICU has been poorly investigated. METHODS: A prospective observational study conducted in an 18-bed medical ICU. Consecutive patients with thrombocytopenia (<150 Giga/L) and no bleeding at admission were included. RESULTS: Over one year, 91 patients were included, mainly men (63%), with an age of 61 [46-68] years and a SOFA score of 6 [3-8]. Twenty-three patients (25%) had an hemorrhagic event during ICU stay, mainly digestive (n = 9; 39%) and urological (n = 6; 26%)...
August 31, 2023: Journal of Critical Care
https://read.qxmd.com/read/37651780/choice-of-creep-or-maintenance-fluid-type-and-their-impact-on-total-daily-icu-sodium-burden-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Jan Waskowski, Sarah M Salvato, Martin Müller, Debora Hofer, Niels van Regenmortel, Carmen A Pfortmueller
PURPOSE: Maintenance and hidden/creep fluids are a major source of fluid and sodium intake in intensive care unit (ICU) patients. Recent research indicates that low versus high sodium content maintenance fluids could decrease fluid and sodium burden. We conducted a systematic review (SR) with meta-analysis to summarize the impact of maintenance fluid choice on total daily sodium in ICU patients. MATERIALS AND METHODS: Systematic literature search in Pubmed, Embase, the Cochrane Library and the...
August 29, 2023: Journal of Critical Care
https://read.qxmd.com/read/37647817/mortality-of-in-hospital-cardiac-arrest-among-patients-with-and-without-preceding-sepsis-a-national-inpatient-sample-analysis
#13
JOURNAL ARTICLE
Daisuke Hasegawa, Aniket Sharma, Siddharth Dugar, Young Im Lee, Ryota Sato
INTRODUCTION: The impact of preceding sepsis on in-hospital cardiac arrest (IHCA)-related mortality has not been established. This study aimed to determine the association between IHCA-related mortality and sepsis. METHODS: This retrospective study used the National Inpatient Sample data from 01/2017 to 12/2019. The study included adults (≥18 years) who suffered from IHCA. The study classified cardiac arrest rhythms as ventricular tachycardia/ventricular fibrillation or pulseless electronic activity/asystole...
August 28, 2023: Journal of Critical Care
https://read.qxmd.com/read/37639921/awake-prone-positioning-in-acute-hypoxaemic-respiratory-failure-an-international-expert-guidance
#14
REVIEW
Ivan Pavlov, Jie Li, Aileen Kharat, Jian Luo, Miguel Ibarra-Estrada, Yonatan Perez, Bairbre McNicolas, Daniele Poole, Oriol Roca, David Vines, Elsa Tavernier, Thérèse Allen, Murali Shyamsundar, Stephan Ehrmann, Steven Q Simpson, Claude Guérin, John G Laffey
BACKGROUND: Awake prone positioning (APP) of non-intubated patients with acute hypoxaemic respiratory failure (AHRF) has been inconsistently adopted into routine care of patients with COVID-19, likely due to apparent conflicting evidence from recent trials. This short guideline aims to provide evidence-based recommendations for the use of APP in various clinical scenarios. METHODS: An international multidisciplinary panel, assembled for their expertise and representativeness, and supported by a methodologist, performed a systematic literature search, summarized the available evidence derived from randomized clinical trials, and developed recommendations using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) methodology...
August 26, 2023: Journal of Critical Care
https://read.qxmd.com/read/37634293/population-pharmacokinetics-and-model-based-dosing-optimization-of-teicoplanin-in-elderly-critically-ill-patients-with-pneumonia
#15
JOURNAL ARTICLE
Sung Wook Kang, Hyeong Geun Jo, Donghyun Kim, Kyeoul Jeong, Jaeok Lee, Hwa Jeong Lee, Seungwon Yang, Sohyun Park, Sandy Jeong Rhie, Eun Kyoung Chung
PURPOSE: To evaluate the population pharmacokinetics and pharmacodynamics of teicoplanin in elderly critically ill patients with pneumonia for optimal dosages. METHODS: Fifteen critically ill patients (9 men) ≥ 60 years received teicoplanin 6 mg/kg for three doses followed by standard maintenance doses (6 mg/kg q24h) with renal dosing adjustment. Serial plasma samples from all patients were analyzed simultaneously by population pharmacokinetic modeling using NONMEM...
August 25, 2023: Journal of Critical Care
https://read.qxmd.com/read/37625951/letter-to-the-editor-clinical-significance-of-thrombocytopenia-in-patients-with-septic-shock-an-observational-retrospective-study
#16
LETTER
Yawen Deng, Suyi Yang, Rui Chen, Guocong Chen, Ruifeng Zeng, Jun Li
No abstract text is available yet for this article.
August 23, 2023: Journal of Critical Care
https://read.qxmd.com/read/37573158/fluids-fluids-everywhere-but-do-we-stop-to-think
#17
JOURNAL ARTICLE
David A Kaufman
No abstract text is available yet for this article.
August 10, 2023: Journal of Critical Care
https://read.qxmd.com/read/37556968/outcome-and-factors-associated-with-mortality-in-patients-receiving-urgent-chemotherapy-in-the-icu-a-retrospective-study
#18
JOURNAL ARTICLE
Jean Bernard, Charles-Hervé Vacheron, Nicolas Vantard, Emmanuel Bachy, Jean Christophe Richard, Frédéric Aubrun, Martin Cour, Anne Claire Lukaszewicz, Julien Bohe, Bernard Allaouchiche, Arnaud Friggeri, Florent Wallet
PURPOSE: This study aimed to assess the outcome and factors associated with mortality in patients who received urgent chemotherapy (CT) in the intensive care unit (ICU) in Lyon, France. MATERIAL AND METHODS: A total of 147 adult patients diagnosed with cancer and requiring urgent CT during ICU stay between October 2014 and December 2019 were included in this retrospective study. RESULTS: Hematological cancer was found in 77% of patients, and acute respiratory failure was the leading cause of ICU admission (46...
August 7, 2023: Journal of Critical Care
https://read.qxmd.com/read/37544047/cannabis-use-in-the-intensive-care-setting-a-scoping-review
#19
JOURNAL ARTICLE
Laura Renger, Kevin Pathmanathan, Rosie Glynn, Kevin B Laupland
PURPOSE: Cannabis is the most used recreational drug worldwide, and is increasingly used for medicinal purposes, however little is known about its impact on patients in intensive care units (ICU). Our objective was to identify key themes in the literature surrounding cannabis in the ICU and identify future research priorities. METHODS: Four databases were systematically searched for literature investigating the impact of cannabis, and evidence for its therapeutic use, in adult ICU patients...
August 4, 2023: Journal of Critical Care
https://read.qxmd.com/read/37542750/population-pharmacokinetics-of-dexamethasone-in-critically-ill-covid-19-patients-does-inflammation-play-a-role
#20
JOURNAL ARTICLE
Letao Li, Sebastiaan Sassen, Nicole Hunfeld, Tim Smeets, Tim Ewoldt, Sjoerd A A van den Berg, Birgit Koch, Henrik Endeman
PURPOSE: The aim of this study is to design a population pharmacokinetic study to gain a deeper understanding of the pharmacokinetics of dexamethasone in critically ill COVID-19 patients in order to identify relevant covariates that can be used to personalize dosing regimens. METHODS: Blood samples from critically ill patients receiving fixed-dose intravenous dexamethasone (6 mg/day) for the treatment of COVID-19 were sampled in a retrospective pilot study...
August 3, 2023: Journal of Critical Care
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