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Clinical and Experimental Dermatology

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https://read.qxmd.com/read/30748034/vegetating-lesions-in-secondary-syphilis
#1
LETTER
P Del Giudice
I read with great interest the article by Thakrar et al.1 about oral ulcers as a presentation of secondary syphilis. However, I do not share this clinical description. Apart from an optical effect, photos seem to show elevated lesions from the basis rather than loss of substance, therefore such lesions should be named as vegetating lesions and not ulcers. Ulcers and ulcerations refer to a loss of substance from the base. Vegetating lesions are very classical in secondary syphilis. This article is protected by copyright...
February 12, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30746729/acute-unilateral-red-eye-in-a-patient-with-psoriasis
#2
H H Oon, G Ho, H Sandar, S P Chee
No abstract text is available yet for this article.
February 11, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30739338/papular-spreaded-necrobiosis-lipoidica-a-rare-clinical-presentation-of-this-pathology
#3
LETTER
C Matas-Nadal, J M Fernández-Armenteros, J M Casanova Seuma, F Vilardell, M Baradad, R S Aguayo-Ortiz
A 69-year-old Caucasian woman suffering from long-term diabetes mellitus type II was referred to our dermatology department with cutaneous lesions that appeared 3 years before. They were itchy and non-tender, and spreaded progressively, with no history of previous trauma. Examination revealed multiple erythematous to yellowish papules on the lower legs, which merged in plaques, of varying shapes and sizes (Fig.1). This article is protected by copyright. All rights reserved.
February 9, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30734963/multiple-pilomatrixomata-as-a-presentation-of-myotonic-dystrophy
#4
LETTER
J Kentley, S Nasir, K Lloyd, D Markiewicz, C A Harwood
A 38-year-old male patient presented to our dermatology department for excision of an inflamed nodule in the right postauricular region (Figure 1). Histology showed proliferating basaloid cells undergoing matrical differentiation. Multiple ghost cells were seen with a foreign body-type reaction in the stroma with numerous histiocytes including multiple multinucleated giant cells and dermal fibrosis (Figure 2). These findings were consistent with a pilomatrixoma. This article is protected by copyright. All rights reserved...
February 8, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30734345/clinical-and-genetic-features-of-chinese-patients-with-lichen-and-macular-primary-localized-cutaneous-amyloidosis
#5
P Lu, F-F Wu, Z-L Rong, C Fang, C-C Deng, L-H Bin, B Yang
BACKGROUND: Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic skin disorder. The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes, but the disease pathophysiology is not fully understood. AIM: To investigate the OSMR mutation spectrum in patients with sporadic (s)PLCA/fPLCA, lichen/macular PLCA in mainland China. METHODS: This study was carried out on 64 patients with sPLCA, along with 36 with fPLCA and 10 unaffected individuals collected from 23 unrelated Chinese families...
February 7, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30730077/cutaneous-shrinkage-after-surgical-resection-of-facial-skin-tumors-a-prospective-study-on-100-surgical-specimens
#6
LETTER
M Benzaquen, S Bruneau, N Graillon, J Berbis, L Guyot
Histological reports of skin tumor excisions frequently describe a lesser margin than the clinical excision margin. This study was aimed to evaluate the degree of shrinkage occurring in facial cutaneous specimens after excision and formalin fixation, and to assess the role of potentially influential factors. Our prospective study on 100 surgical specimens from 06/01/2017 to 10/31/2017 showed a mean shrinkage from in vivo (before excision) to in vitro (after 24h formalin fixation) of 12.8% in length and 11.2% in width for the surgical specimens, and of 10...
February 7, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30730068/hidradenitis-suppurativa-and-diabetes-mellitus-updated-systematic-review-and-adjusted-meta-analysis
#7
K Phan, O Charlton, S D Smith
BACKGROUND: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. There is also evolving evidence supporting the association between HS and cardiovascular risk factors, including smoking, obesity, hyperlipidaemia and metabolic syndrome. Notably, these are clinical features and risk factors that are closely associated with type 2 diabetes mellitus (DM). AIMS: We performed a pooled adjusted meta-analysis of comparative studies to investigate the relationship between HS and DM...
February 7, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30723930/a-novel-card14-variant-homozygous-c-526g-c-p-asp176his-in-an-adolescent-japanese-patient-with-palmoplantar-pustulosis
#8
R Tobita, C Egusa, T Maeda, N Abe, N Sakai, S Suzuki, H Kawashima, S Hokibara, J Ko, Y Okubo
No abstract text is available yet for this article.
February 5, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30719727/could-isotretinoin-flare-hidradentis-suppurativa-a-case-series
#9
C G Gallagher, S K Kirthi, C C Cotter, J R Revuz, A M T Tobin
We report eight cases of patients with severe acne who were treated with Isotretinoin and developed painful nodules in their axillae and groin consistent with Hidradenitis Suppurativa (HS). The pathogenesis of HS is still not completely understood; recent research from a study in 2011 of biopsies from HS lesions showed a reduction or absence of sebaceous glands compared to normal skin in HS patients and the author suggested this contributes to the pathogenesis of the disease. Interestingly the main effect of Isotretinoin is to decrease the size and action of sebaceous glands; so hypothetically, as Isotretinoin acts by reducing the sebaceous glands further it could potentially aggravate the condition...
February 5, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30710383/microneedle-fractional-radiofrequency-treatment-of-facial-photoageing-as-assessed-in-a-split-face-model
#10
T-M Liu, Y-M Sun, Z-Y Tang, Y-H Li
BACKGROUND: A new therapeutic device passes radiofrequency energy through microneedles to targeted tissue. Three-dimensional photography may be useful for evaluating the clinical efficacy of microneedle fractional radiofrequency (MFR) used on the appearance of rhytids and to improve facial laxity. AIM: To evaluate the efficacy and safety of MFR in the treatment of facial photoageing. METHODS: In total, participants with facial photoageing were enrolled in the study...
February 1, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706506/oropharyngeal-histoplasmosis-a-report-of-10-cases
#11
T Pincelli, M Enzler, M Davis, A J Tande, N Comfere, A Bruce
A wide differential diagnosis must be entertained in patients with unusual oral and pharyngeal ulcerations. A mucosal biopsy is essential. We retrospectively reviewed 10 cases from the Infectious Diseases Division at Mayo Clinic Rochester (MN, USA), in which the diagnosis proved to be Histoplasma capsulatum infection. Between 1995 and 2016, 10 patients were diagnosed with oropharyngeal histoplasmosis. Common presenting symptoms included weight loss, weakness and oropharyngeal pain with ulcerations. Despite specialty evaluation at other facilities, diagnostic delay occurred in six patients due to lack of biopsy or fungal staining...
February 1, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706554/the-causes-of-nail-apparatus-pigmentation-presenting-to-a-melanoma-screening-clinic-a-prospective-study
#12
A Alani, C Blasdale, T Oliphant, C Hackett, J A A Langtry
BACKGROUND: Advanced stage primary cutaneous malignant melanoma (PCMM) has a high mortality. PCMM may affect any area of the skin, including the nail apparatus (malignant melanoma or subungual melanoma). Although nail apparatus malignant melanoma (NAMM) is rare, delayed diagnosis carries a poor prognosis. AIM: The primary aim was to study the range of nail presentations and identify key patterns to aid in differential diagnosis. A secondary aim was to quantify the number of patients requiring surgery, indications for biopsy, and the incidence and characteristics of NAMM...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706549/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2016-part-1-treatment-and-prevention
#13
REVIEW
L Solman, A Lloyd-Lavery, D J C Grindlay, N K Rogers, K S Thomas, K E Harman
This review is part of a series of annual updates summarizing the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed during 2016 with a focus on treatment and prevention of AE. There is reasonable evidence of benefit for topical corticosteroids, calcineurin inhibitors, a glycyrrhetinic acid-containing preparation (Atopiclair® ), oral ciclosporin, oral azathioprine, narrowband ultraviolet B radiation and education programmes...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706539/topical-becaplermin-gel-is-an-effective-adjuvant-for-long-standing-ulcers-of-livedoid-vasculopathy-recalcitrant-to-anticoagulant-therapy
#14
S Mushtaq, S Singh, R Mudugal
No abstract text is available yet for this article.
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706515/assessment-of-telomerase-activity-in-nonsegmental-vitiligo-tissue-a-pilot-study
#15
N H Moftah, R El-Barbary, L Rashed, N El-Sammad
BACKGROUND: Vitiligo is characterized by loss of melanocytes; therefore, an increased risk of photoageing and cancer are expected. However, a low incidence of cancer and sun damage in vitiliginous skin has been reported. Telomerase is a specialized cellular enzyme catalysing the synthesis of telomeres, and an increased level of the telomerase activity has been highlighted in most of human cancer cells and cancer cell lines. AIM: To assess relative telomerase activity (RTA) among patients with nonsegmental vitiligo...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706514/the-mental-health-burden-in-acne-vulgaris-and-rosacea-an-analysis-of-the-us-national-inpatient-sample
#16
V Singam, S Rastogi, K R Patel, H H Lee, J I Silverberg
BACKGROUND: Little is known about the mental health (MH) hospitalization among patients with acne and rosacea. AIMS: To determine the MH disorders and cost burden associated with acne and rosacea. METHODS: Data were examined from the 2002-2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions). RESULTS: A diagnosis of ≥ 1 MH disorder was much more common among all inpatients with vs...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706507/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2016-part-3-nomenclature-and-outcome-assessment
#17
REVIEW
A Lloyd-Lavery, L Solman, D J C Grindlay, N K Rogers, K S Thomas, K E Harman
This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It presents the key findings from 11 systematic reviews published in 2016 that focus on AE outcome assessment, disease impact and nomenclature. Systematic reviews on the treatment and prevention of AE are summarized in Part 1 of this update, and systematic reviews on the epidemiology of and risk factors for AE are summarized in Part 2. Six reviews summarized what outcome measurement instruments have been used in published AE trials, or summarized validation studies for the available instruments...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30706503/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2016-part-2-epidemiology-aetiology-and-risk-factors
#18
REVIEW
A Lloyd-Lavery, L Solman, D J C Grindlay, N K Rogers, K S Thomas, K E Harman
This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It presents the key findings from 14 systematic reviews published in 2016, focusing on AE epidemiology, aetiology and risk factors. For systematic reviews on the treatment and prevention of AE and for nomenclature and outcome assessments, see Parts 1 and 3 of this update, respectively. The annual self-reported prevalence of AE is a range of 11...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30701578/vitamin-d-deficiency-in-solid-organ-transplant-recipients-from-a-spanish-mediterranean-population
#19
C Ferrándiz-Pulido, I B Torres, C Juárez-Dobjanschi, I Zarzoso-Muñoz, C Berastegui, L Castells, V García-Patos, F Moreso
BACKGROUND: Solid-organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin. AIM: To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D-deficient. METHODS: This was a cross-sectional, descriptive and observational study in a transplantation-specialized Dermatological Unit from a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements...
January 30, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30697781/inherited-desmoplastic-trichoepitheliomas
#20
LETTER
M-L Lovgren, N Rajan, S Joss, L Melly, M Porter
No abstract text is available yet for this article.
January 29, 2019: Clinical and Experimental Dermatology
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