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Metabolism: Clinical and Experimental

Meijiao Wang, Dan Zhao, Liangzhi Xu, Wenjing Guo, Li Nie, Yi Lei, Yun Long, Min Liu, Yichen Wang, Xueqin Zhang, Li Zhang, Hanna Li, Jinhu Zhang, Dongzhi Yuan, Limin Yue
BACKGROUND: Proprotein convertase subtilisin / kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. METHODS: We firstly investigated the serum levels of PCSK9 in 46 PCOS patients compared with 49 healthy women as controls, and then developed a PCOS mouse model induced by dehydroepiandrosterone (DHEA) and a high-fat diet (HFD) to determine the role of PCSK9 in abnormal lipid metabolism and ovarian dysfunction of PCOS in four groups (n = 40 per group): control, PCOS mice, PCOS plus alirocumab group, and PCOS plus vehicle group...
February 12, 2019: Metabolism: Clinical and Experimental
Xiaoling Jiang, Huazhen Liu, Yongxian Shao, Mingzhi Peng, Wen Zhang, Duan Li, Xiuzhen Li, Yanna Cai, Ting Tan, Xinshuo Lu, Jianan Xu, Xueying Su, Yunting Lin, Zongcai Liu, Yonglan Huang, Chunhua Zeng, Ya-Ping Tang, Li Liu
BACKGROUND: GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic diseases involving phenylalanine catabolism, neurotransmitter synthesis, nitric oxide production and so on. Though improvements could be achieved by tetrahydrobiopterin and neurotransmitter precursor levodopa supplementation, residual motor and mental deficits remain in some patients. An appropriate GTPCH deficiency animal model with clinical symptoms, especially the motor impairments, is still not available for mechanism and therapy studies yet...
February 8, 2019: Metabolism: Clinical and Experimental
Li Wei, Ya-Ting Wen, Mon-Chien Lee, Hua-Ming Ho, Chi-Chang Huang, Yi-Ju Hsu
OBJECTIVE: Postpartum women are at an increased risk for obesity and metabolic diseases because of excessive weight gain during pregnancy and weight retention after delivery. Maintenance of good nutrition and regular physical activity is used as a therapeutic approach for promotion of health and well-being in postpartum women. The aim of this study is to assess the independent and additive effects of isolated soy protein (ISP) and strength exercise training (ET) on weight management, exercise performance and health maintenance in postpartum mice...
February 4, 2019: Metabolism: Clinical and Experimental
Zheng Zhou, Bao Sun, Shiqiong Huang, Wenrui Jia, Dongsheng Yu
Diabetes mellitus (DM) is a complex endocrine and metabolic disorder for human health and well-being. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease. Transfer RNAs (tRNAs) are considered to mainly participate in protein translation and may contribute to complex human pathologies. Although the molecular mechanisms remain, for the most part, unknown, accumulating evidence indicates that tRNAs play a vital role in the pathogenesis of DM. This paper reviews different aspects of tRNA-associated dysregulation in DM, such as tRNA mutations, tRNA modifications, tRNA aminoacylation and tRNA derivatives, aiming at a better understanding of the pathogenesis of DM and providing new ideas for the personalized treatment of this metabolism-associated disease...
January 31, 2019: Metabolism: Clinical and Experimental
Peng Huang, Fei-Zhou Huang, Huai-Zheng Liu, Tian-Yi Zhang, Ming-Shi Yang, Chuan-Zheng Sun
BACKGROUND: Hepatic lipogenesis dysregulation is essential for the development of non-alcoholic fatty liver disease (NAFLD). Emerging evidence indicates the importance of the involvement of long non-coding RNAs (LncRNAs) in lipogenesis. However, the specific mechanism underlying this process is not clear. OBJECTIVE: This study aimed to investigate the functional implication of LncRNA MEG3 (MEG3) in fatty degeneration of hepatocytes and in the pathogenesis of NAFLD...
January 31, 2019: Metabolism: Clinical and Experimental
Megan M Marron, Iva Miljkovic, Robert M Boudreau, Kaare Christensen, Mary F Feitosa, Joseph H Lee, Paola Sebastiani, Bharat Thyagarajan, Mary K Wojczynski, Joseph M Zmuda, Anne B Newman, KatherineM Detre
BACKGROUND: Long-lived individuals and their offspring have healthier metabolic characteristics than expected, such as more favorable levels of fasting glucose, insulin, and lipids than controls without longevity. Dysregulation in metabolic pathways have also shown to predict accelerated aging. Using information from the Long Life Family Study (LLFS), a multi-center study of two-generation families selected for exceptional longevity, we developed an indicator of healthy metabolism to determine whether metabolic health was more prevalent in a subset of LLFS families and whether it was heritable and associated with other metrics of healthy aging...
January 30, 2019: Metabolism: Clinical and Experimental
Jørgen Sikkeland, Torstein Lindstad, Hatice Zeynep Nenseth, Xavier Dezitter, Su Qu, Ridhwan M Muhumed, Meric Erikci Ertunc, Margaret F Gregor, Fahri Saatcioglu
BACKGROUND: Chronic ER stress and dysfunction is a hallmark of obesity and a critical contributor to metaflammation, abnormal hormone action and altered substrate metabolism in metabolic tissues, such as liver and adipocytes. Lack of STAMP2 in lean mice induces inflammation and insulin resistance on a regular diet, and it is dysregulated in the adipose tissue of obese mice and humans. We hypothesized that the regulation of STAMP2 is disrupted by ER stress. METHODS: 3 T3-L1 and MEF adipocytes were treated with ER stress inducers thapsigargin and tunicamycin, and inflammation inducer TNFα...
January 30, 2019: Metabolism: Clinical and Experimental
Karyne L Vinales, Brittany Begaye, Marie S Thearle, Jonathan Krakoff, Paolo Piaggi
BACKGROUND: In homeothermic animals, approximately 50% of daily energy expenditure (EE) is spent to maintain a consistent core body temperature (CBT). In humans, little is known about CBT responses to feeding and overfeeding and their relationship to diet-related changes in EE. OBJECTIVE: To study the effects of feeding and overfeeding on CBT and its association with diet-induced thermogenesis (DIT). DESIGN: Fifty-three healthy men with normal glucose regulation and a wide range of body composition (mean ± SD, body fat: 25 ± 8%, range: 7-43%) had 24-h EE assessed during fasting in a whole-room indirect calorimeter with concomitant CBT measurement by ingestible capsules and 24-h urinary collection for catecholamine measurements...
January 30, 2019: Metabolism: Clinical and Experimental
A E Ortiz-Flores, M Luque-Ramírez, E Fernández-Durán, F Alvarez-Blasco, H F Escobar-Morreale
BACKGROUND: The risk of developing prediabetes and type 2 diabetes (dysglycemia) may be increased in women with PCOS. Whether an oral glucose tolerance test (OGTT) should be performed routinely in all PCOS women at presentation or should be recommended only to a selected subset of patients is still controversial. BASIC PROCEDURES: At a tertiary care center, we conducted a retrospective, observational study including 400 women with PCOS submitted to an OGTT. Our primary objective was to assess the diagnostic agreement between two algorithms commonly used for the screening of dysglycemia in these women: i) relying only on fasting plasma glucose (FPG) or ii) considering both fasting and/or 120-min plasma glucose concentrations during an OGTT...
January 30, 2019: Metabolism: Clinical and Experimental
Hongmei Wu, Mingyue Liu, Vu Thi Quynh Chi, Jing Wang, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Xue Bao, Yeqing Gu, Shunming Zhang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu
BACKGROUND: Muscle weakness is followed by insulin resistance which is associated with metabolic disorders leading to metabolic syndrome (MetS). Therefore, muscle strength decline may be associated with MetS. The aim of this study was to investigate the relationships between muscle strength and MetS and its separate components. METHODS: A cross-sectional study was performed in 17,703 participants aged 40 years and older living in Tianjin, China. Handgrip strength was measured using a handheld digital dynamometer...
January 25, 2019: Metabolism: Clinical and Experimental
Athanasios D Anastasilakis, Stergios A Polyzos, Polyzois Makras, Eleni Douni, Christos S Mantzoros
No abstract text is available yet for this article.
January 25, 2019: Metabolism: Clinical and Experimental
Yin Hu, Ran Xu, Chun-Yuan Chen, Shan-Shan Rao, Kun Xia, Jie Huang, Hao Yin, Zhen-Xing Wang, Jia Cao, Zheng-Zhao Liu, Yi-Juan Tan, Juan Luo, Hui Xie
OBJECTIVE: Senile osteoporosis is one of the most common age-related diseases worldwide. Accumulating evidences have indicated that young blood can reverse age-related impairments. Extracellular vesicles (EVs) exert therapeutic effects in a variety of diseases by delivering bioactive molecules such as microRNAs (miRNAs). The aim of the study is to evaluate the therapeutic potential of EVs from human umbilical cord blood plasma (UCB-EVs) on senile osteoporosis and to preliminarily clarify the underlying mechanism...
January 19, 2019: Metabolism: Clinical and Experimental
Justine Bacchetta, Claire Bardet, Dominique Prié
Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling. The kidneys have a key role in phosphate homeostasis with three hormones having important functions in renal phosphate handling or intestinal absorption: parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1-25-dihydroxyvitamin D (1,25(OH)2D). FGF23 is mainly synthesized by osteocytes; it is a direct phosphaturic factor that also inhibits 1,25(OH)2D and PTH...
January 18, 2019: Metabolism: Clinical and Experimental
Hilda E Ghadieh, Lucia Russo, Harrison T Muturi, Simona S Ghanem, Iyad H Manaserh, Hye Lim Noh, Sujin Suk, Jason K Kim, Jennifer W Hill, Sonia M Najjar
BACKGROUND: CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J.Cc1-/- null mice display hyperinsulinemia due to impaired insulin clearance at 2 months of age, followed by insulin resistance, steatohepatitis, visceral obesity and leptin resistance at 6 months. The study aimed at investigating the primary role of hepatic CEACAM1 in insulin and lipid homeostasis independently of its metabolic effect in extra-hepatic tissues. METHODS: Liver-specific C57BL/6J...
January 18, 2019: Metabolism: Clinical and Experimental
Niki Katsiki, Christos Mantzoros
No abstract text is available yet for this article.
January 16, 2019: Metabolism: Clinical and Experimental
F Samuel van Nierop, C de Jonge, W Kulik, Nicole Bouvy, Frank G Schaap, Steven W Olde Damink, Sander Rensen, Johannes A Romijn, Jan Willem M Greve, Maarten R Soeters
BACKGROUND AND AIMS: Placement of the duodenal-jejunal bypass liner (DJBL) leads to rapid weight loss and restoration of insulin sensitivity in a similar fashion to bariatric surgery. Increased systemic bile acid levels are candidate effectors for these effects through postprandial activation of their receptors TGR5 and FXR. We aimed to quantify postprandial bile acid, GLP-1 and FGF19 responses and assess their temporal relation to the weight loss and metabolic and hormonal changes seen after DJBL placement...
January 15, 2019: Metabolism: Clinical and Experimental
Tasuku Terada, Normand G Boulé
AIMS: Metformin and lifestyle intervention are frequently prescribed together as first-line treatments for type 2 diabetes. However, little is known about their interplay. We investigated if the effects of a lifestyle intervention on glycemia, body mass and cardiorespiratory fitness (CRF) were influenced by metformin therapy. METHODS: Participants randomized to intensive lifestyle intervention (ILI) or diabetes support and education (DSE) from the Look AHEAD trial were categorized into metformin therapy vs...
January 14, 2019: Metabolism: Clinical and Experimental
Matina Kouvari, Demosthenes B Panagiotakos, Mary Yannakoulia, Ekavi Georgousopoulou, Elena Critselis, Christina Chrysohoou, Dimitrios Tousoulis, Christos Pitsavos
BACKGROUND/OBJECTIVES: Metabolically benign obesity remains a scientific field of considerable debate.The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset. METHODS: A prospective longitudinal study was conducted during 2001-2012, the ATTICA study studying 1514 (49.8%) men and 1528 (50.2%) women (aged >18 years old) free of CVD and residing in the greater Athens area, Greece...
January 10, 2019: Metabolism: Clinical and Experimental
Maximilian G Hohenadel, Tim Hollstein, Marie Thearle, Martin Reinhardt, Paolo Piaggi, Arline D Salbe, Jonathan Krakoff
BACKGROUND AND OBJECTIVES: Lower total energy expenditure (TEE) and resting metabolic rate (RMR) are associated with greater weight gain in Native American adults. Whether these effects exist in childhood is unclear. We hypothesized that lower energy expenditure measured in childhood would predict greater relative change in body mass index (BMI) during adolescence. METHODS: Measurements of height, weight, body composition, RMR and TEE were completed in 181 Native American children at exams done at age 5 and 10 years, with 126 children having biennial follow-up assessments of weight and height after age 10 years until age 20 years...
January 9, 2019: Metabolism: Clinical and Experimental
Sabrina M Oussaada, Katy A van Galen, Mellody I Cooiman, Lotte Kleinendorst, Eric J Hazebroek, Mieke M van Haelst, Kasper W Ter Horst, Mireille J Serlie
Body fat mass increases when energy intake exceeds energy expenditure. In the long term, a positive energy balance will result in obesity. The worldwide prevalence of obesity has increased dramatically, posing a serious threat to human health. Therefore, insight in the pathogenesis of obesity is important to identify novel prevention and treatment strategies. This review describes the physiology of energy expenditure and energy intake in the context of body weight gain in humans. We focus on the components of energy expenditure and the regulation of energy intake...
January 9, 2019: Metabolism: Clinical and Experimental
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