Journals Metabolism: Clinical and Exper...

Metabolism: Clinical and Experimental
Xuemei Luo, Zixuan Li, Lingling Chen, Xinhui Zhang, Xinyu Zhu, Zinan Wang, Yan Chen
BACKGROUND: The monocarboxylate transporter 1 (MCT1) is a member of the MCT family and is implicated in the transport of lactate and a few other monocarboxylates across the cell membrane. How hepatic MCT1 regulates the metabolic functions of the body is currently unknown. METHODS: The functions of hepatic MCT1 on metabolism were analyzed using a mouse model with liver-specific deletion of Slc16a1 that encodes MCT1. Obesity and hepatosteatosis of the mice were induced by high fat diet (HFD)...
March 16, 2023: Metabolism: Clinical and Experimental
Jun Seok Kim, Hye-Sook Han, Je Kyung Sung, Young-Gyu Ko, Seung-Hoi Koo
BACKGROUND: Exposure to cold temperature stimulates the sympathetic nervous system that activates β-adrenergic receptor signals in brown and beige adipocytes, leading to the induction of adaptive thermogenesis in mammals. Prominin-1 (PROM1) is a pentaspan transmembrane protein that is widely identified as a marker for stem cells, although the role of this protein as a regulator of many intracellular signaling cascades has been recently delineated. The main focus of the current study is to identify the previously unknown role of PROM1 in beige adipogenesis and adaptive thermogenesis...
March 16, 2023: Metabolism: Clinical and Experimental
Annemette Overgaard Brethvad, Hannah Louise Zakariassen, Joachim Holt, Julie Rehné Lundgren, Alexander Jakobsen, Bolette Hartmann, Eva Winning Lehmann, Hannelouise Kissow, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov, Birgitte Holst
BACKGROUND: The gut derived anorexigenic hormone neurotensin (NT) is upregulated after bariatric surgery which may contribute to the sustained weight loss. In contrast, diet-induced weight loss is most often followed by weight regain. We therefore investigated whether diet-induced weight loss impacts levels of circulating NT in mice and humans and whether NT levels predicts body weight change after weight loss in humans. METHODS: In vivo mice study: Obese mice were fed ad-libitum or a restricted diet (40-60 % of average food intake) for 9 days to obtain similar weight loss as observed in the human study...
March 16, 2023: Metabolism: Clinical and Experimental
William Tucker, Robyn L McClelland, Matthew A Allison, Moyses Szklo, Kerry-Anne Rye, Kwok Leung Ong
BACKGROUND: Fibroblast growth factor 21 (FGF21) levels are often elevated in heart failure (HF), although this has not been assessed using a longitudinal study design. Therefore, we investigated the association between baseline plasma FGF21 levels and incident HF in the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS: A total of 5408 participants, free of clinically apparent cardiovascular disease, were included in the analysis, of which 342 developed HF over a median follow-up period of 16...
March 15, 2023: Metabolism: Clinical and Experimental
Shuai Yuan, Susanna C Larsson
Sarcopenia is a geriatric condition featured by a progressive loss of muscle mass and function and associated with various adverse health outcomes. In this review, we aimed to summarize the epidemiological features of sarcopenia as well as consequences and risk factors of the disease. We performed a systematic review of meta-analysis on sarcopenia to collect data. The prevalence of sarcopenia varied between studies and depending on definition used. Sarcopenia was estimated to influence 10 %-16 % of the elderly worldwide...
March 10, 2023: Metabolism: Clinical and Experimental
Qingwen Yu, Guangyuan Zhao, Jingjing Liu, Yajie Peng, Xueli Xu, Fei Zhao, Yangyang Shi, Chengyun Jin, Ji Zhang, Bo Wei
Heart diseases are associated with substantial morbidity and mortality worldwide. The underlying mechanisms and pathological changes associated with cardiac diseases are exceptionally complex. Highly active cardiomyocytes require sufficient energy metabolism to maintain their function. Under physiological conditions, the choice of fuel is a delicate process that depends on the whole body and organs to support the normal function of heart tissues. However, disordered cardiac metabolism has been discovered to play a key role in many forms of heart diseases, including ischemic heart disease, cardiac hypertrophy, heart failure, and cardiac injury induced by diabetes or sepsis...
March 6, 2023: Metabolism: Clinical and Experimental
Hafiz Muhammad Ahmad Javaid, Eun Ko, Esther Jin Joo, Soon Hyo Kwon, Jong-Hwan Park, Sooim Shin, Kae Won Cho, Joo Young Huh
BACKGROUND AND AIMS: Obesity is a state of chronic low-grade systemic inflammation. Recent studies showed that NLRP3 inflammasome initiates metabolic dysregulation in adipose tissues, primarily through activation of adipose tissue infiltrated macrophages. However, the mechanism of NLRP3 activation and its role in adipocytes remains elusive. Therefore, we aimed to examine the activation of TNFα-induced NLRP3 inflammasome in adipocytes and its role on adipocyte metabolism and crosstalk with macrophages...
March 2, 2023: Metabolism: Clinical and Experimental
Chakhtoura Marlene, Mantzoros S Christos
No abstract text is available yet for this article.
March 2, 2023: Metabolism: Clinical and Experimental
Sha-Sha Li, Ming-Jie Sheng, Zhuo-Yi Sun, Yang Liang, Li-Xia Yu, Qi-Feng Liu
Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and progression of CKD. Conversely, an increase in Klotho levels results in improved kidney function and delays CKD progression, supporting the notion that modulating Klotho levels could represent a possible therapeutic strategy for CKD treatment. Nevertheless, the regulatory mechanisms responsible for the loss of Klotho remain elusive...
March 1, 2023: Metabolism: Clinical and Experimental
Jian Lv, Yimeng Hu, Lili Li, Yuan He, Jingjing Wang, Ningning Guo, Yu Fang, Qin Chen, Cheguo Cai, Jingjing Tong, Lixu Tang, Zhihua Wang
INTRODUCTION: Aging is characterized by progressive metabolic dyshomeostasis that increases morbidity and mortality. Solutions for optimizing healthy aging are challenged by lacking appropriate biomarkers. Moreover, druggable targets to rejuvenate the aging-associated metabolic phenotypes remain unavailable. METHODS: Proteomics analysis was performed in a cohort of young and elderly adults. Circulating levels of insulin-like growth factor 1 (IGF-1) and fatty acid binding protein 4 (FABP4) were evaluated by ELISA...
February 25, 2023: Metabolism: Clinical and Experimental
Jing Wu, Qiao You, Ruining Lyu, Yajie Qian, Hongji Tao, Fang Zhang, Yurong Cai, Na Jiang, Nan Zheng, Deyan Chen, Zhiwei Wu
BACKGROUND: Folate (FA) is an essential cofactor in the one-carbon (1C) metabolic pathway and participates in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. FA metabolism has been reported to play an important role in viral replications; however, the roles of FA metabolism in the antiviral innate immune response are unclear. OBJECTIVE: To evaluate the potential regulatory role of FA metabolism in antiviral innate immune response, we establish the model of FA deficiency (FAD) in vitro and in vivo...
February 21, 2023: Metabolism: Clinical and Experimental
You-Cheol Hwang, Hong-Yup Ahn, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
BACKGROUND: Little is known about the subtypes of type 2 diabetes (T2D) and their association with clinical outcomes in Asians. METHODS: We performed data-driven cluster analysis in patients with newly diagnosed drug-naive T2D (n = 756) from the Korean Genome and Epidemiology Study. Clusters were based on five variables (age at diagnosis, BMI, HbA1c, and HOMA2 β-cell function, and insulin resistance). RESULTS: We identified four clusters of patients with T2D according to k-means clustering: cluster 1 (22...
February 4, 2023: Metabolism: Clinical and Experimental
Xi Chen, Aurora Merovci, Ralph A DeFronzo, Devjit Tripathy
BACKGROUND AND AIMS: Hyperglucagonemia is a characteristic feature of type 2 diabetes mellitus (T2DM). We examined the effect of chronic (48-72 h) physiologic increase (+50 mg/dl) in plasma glucose concentration on suppression of plasma glucagon concentration by insulin and by hyperglycemia in normal glucose tolerance (NGT) individuals. MATERIALS AND METHODS: Study One: 16 NGT subjects received OGTT and 3-step hyperinsulinemic (10, 20, 40 mU/m2 ·min) euglycemic clamp before and after 48 hour glucose infusion to increase plasma glucose by ~50 mg/dl...
February 4, 2023: Metabolism: Clinical and Experimental
Gaborit Bénédicte, Fernandes Sara, Loubet Paul, Ninove Laetitia, Dutour Anne, Cariou Bertrand, Coupaye Muriel, Clement Karine, Czernichow Sébastien, Carette Claire, Resseguier Noémie, Esterle Laure, Sabrina Kali, Marie Houssays, de Lamballerie Xavier, Wittkop Linda, Launay Odile, Laville Martine
BACKGROUND: Patients with diabetes and obesity are populations at high-risk for severe COVID-19 outcomes and have shown blunted immune responses when administered different vaccines. Here we used the 'ANRS0001S COV-POPART' French nationwide multicenter prospective cohort to investigate early humoral response to COVID-19 vaccination in the sub-cohort ('COVPOP OBEDIAB') of patients with obesity and diabetes. METHODS: Patients with diabetes (n = 390, type 1 or 2) or obesity (n = 357) who had received two vaccine doses and had no history of previous COVID-19 infection and negative anti-nucleocapsid (NCP) antibodies were included and compared against healthy subjects (n = 573)...
January 30, 2023: Metabolism: Clinical and Experimental
Bryan Chong, Gwyneth Kong, Kannan Shankar, H S Jocelyn Chew, Chaoxing Lin, Rachel Goh, Yip Han Chin, Darren Jun Hao Tan, Kai En Chan, Wen Hui Lim, Nicholas Syn, Siew Pang Chan, Jiong-Wei Wang, Chin Meng Khoo, Georgios K Dimitriadis, Karn Wijarnpreecha, Arun Sanyal, Mazen Noureddin, Mohammad Shadab Siddiqui, Roger Foo, Anurag Mehta, Gemma A Figtree, Derek J Hausenloy, Mark Y Chan, Cheng Han Ng, Mark Muthiah, Mamas A Mamas, Nicholas W S Chew
BACKGROUND: A significant proportion of premature deaths globally are related to metabolic diseases in young adults. We examined the global trends and mortality of metabolic diseases in individuals aged below 40 years using data from the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019. METHODS: From 2000 to 2019, global estimates of deaths and disability-adjusted life years (DALYs) were described for metabolic diseases (type 2 diabetes mellitus [T2DM], hyperlipidemia, hypertension, obesity, non-alcoholic fatty liver disease [NAFLD])...
January 28, 2023: Metabolism: Clinical and Experimental
Nicolaas E P Deutz, Pierre Singer, Raven A Wierzchowska-McNew, Marina V Viana, Itai A Ben-David, Olivier Pantet, John J Thaden, Gabriella A M Ten Have, Mariëlle P K J Engelen, Mette M Berger
BACKGROUND: The trajectory from healthy to critical illness is influenced by numerous factors, including metabolism, which differs substantially between males and females. Whole body protein breakdown is substantially increased in critically ill patients, but it remains unclear whether there are sex differences that could explain the different health outcomes. Hence, we performed a secondary analysis of a study, where we used a novel pulse isotope method in critically ill and matched healthy males and females...
January 27, 2023: Metabolism: Clinical and Experimental
Shunming Zhang, Anna Stubbendorff, Kjell Olsson, Ulrika Ericson, Kaijun Niu, Lu Qi, Yan Borné, Emily Sonestedt
BACKGROUND AND AIMS: In 2019, the EAT-Lancet Commission proposed a mainly plant-based diet that nurtures human health and supports environmental sustainability. However, its association with type 2 diabetes (T2D) has not been widely studied, and it remains unclear whether genetic susceptibility for T2D can modify this association. The aim was therefore to investigate the association between the EAT-Lancet diet and risk of T2D and assess whether the association differs by the genetic predisposition to T2D...
January 19, 2023: Metabolism: Clinical and Experimental
Sarah K Kirschner, Parisa Ghane, Jaekwan K Park, Sunday Y Simbo, Ivan Ivanov, Ulisses M Braga-Neto, Gabriëlla A M Ten Have, John J Thaden, Mariëlle P K J Engelen, Nicolaas E P Deutz
BACKGROUND: Production rates of the short-chain fatty acids (SCFA) acetate, propionate, and butyrate, which are beneficial metabolites of the intestinal microbiota, are difficult to measure in humans due to inaccessibility of the intestine to perform measurements, and the high first-pass metabolism of SCFAs in colonocytes and liver. We developed a stable tracer pulse approach to estimate SCFA whole-body production (WBP) in the accessible pool representing the systemic circulation and interstitial fluid...
January 12, 2023: Metabolism: Clinical and Experimental
Fangzhou Du, Mengmeng Liu, Jingwen Wang, Lvzhong Hu, Dongao Zeng, Shaocong Zhou, Lixing Zhang, Meijia Wang, Xi Xu, Chenglong Li, Jingzhong Zhang, Shuang Yu
INTRODUCTION: Cell therapy with mesenchymal stem cells (MSCs) and biomaterials holds great potential for the treatment of diabetic ulceration; however, the underlying mechanism as well as its compatibility with the first-line anti-diabetic drug, metformin (MTF), has not been well elucidated. METHODS: MSCs derived from the umbilical cord were labeled with fluorescent proteins, followed by transplantation in a fibrin scaffold (MSCs/FG) onto the STZ-induced diabetic wound in a C57BL6/J mouse model...
January 7, 2023: Metabolism: Clinical and Experimental
Hao Zhou, Zhe Dai, Jialei Li, Jin Wang, Hang Zhu, Xing Chang, Yijin Wang
BACKGROUND: The regulatory mechanisms involved in mitochondrial quality control (MQC) dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized. Transmembrane BAX inhibitor motif containing 6 (TMBIM6) is an endoplasmic reticulum protein with Ca2+ leak activity that modulates cellular responses to various cellular stressors. METHODS: In this study, we evaluated the role of TMBIM6 in SCM using cardiomyocyte-specific TMBIM6 knockout (TMBIM6CKO ) and TMBIM6 transgenic (TMBIM6TG ) mice...
January 2, 2023: Metabolism: Clinical and Experimental
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.