María S Avendaño, Cecilia Perdices-Lopez, Yolanda Guerrero-Ruiz, Francisco Ruiz-Pino, Ana B Rodriguez-Sanchez, María J Sanchez-Tapia, Verónica Sobrino, Rafael Pineda, Alexia Barroso, Alejandro Correa-Sáez, Maribel Lara-Chica, José C Fernandez-Garcia, Ana B García-Redondo, Raquel Hernanz, Miguel Ruiz-Cruz, David Garcia-Galiano, Nelly Pitteloud, Marco A Calzado, Ana M Briones, María J Vázquez, Manuel Tena-Sempere
BACKGROUND: Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected condition in men, which aggravates the metabolic complications of overweight. While hypothalamic suppression of Kiss1-encoded kisspeptin has been suggested to contribute to OIH, the molecular mechanisms for such repression in obesity, and the therapeutic implications thereof, remain unknown. METHODS: A combination of bioinformatic, expression and functional analyses was implemented, assessing the role of the evolutionary-conserved miRNAs, miR-137 and miR-325, in mediating obesity-induced suppression of hypothalamic kisspeptin, as putative mechanism of central hypogonadism and metabolic comorbidities...
May 8, 2024: Metabolism: Clinical and Experimental