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Journal Article
Research Support, Non-U.S. Gov't
Review
Conformational changes and disease--serpins, prions and Alzheimer's.
Current Opinion in Structural Biology 1998 December
Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.
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