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Efficient A·T-to-C·G Base Editing via Adenine Transversion Editors.
Cellular Reprogramming 2023 September 20
Generating A-to-C transversions to correct defective alleles or introduce novel alleles has posed significant challenges. However, two recent studies focusing on adenine transversions have achieved successful A-to-C transversions in mouse embryos and plant cell. These remarkable accomplishments notably broaden the range of base editing and their applications both in fundamental research and in therapeutics.
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