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Journal Article
Review
Preoperative Pregabalin Prevents Succinylcholine-induced Fasciculation and Myalgia: A Meta-Analysis of Randomized Trials.
Revista española de anestesiología y reanimación. 2023 September 5
Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction; however, its use is associated with fasciculation and myalgia. We performed a systematic review and meta-analysis of randomized controlled clinical trials comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included with a total of 481 patients - 241 in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR = 0.69, 95% CI 0.56-0.84, P < 0.001), which remained statistically significant for pregabalin (RR = 0.71, 95% CI 0.54-0.93, P = 0.013) and gabapentin (RR = 0.61, 95% CI 0.45-0.82, P = 0.001) separately. There was no difference in fasciculations between the groups (RR = 0.92, 95% CI 0.82-1.03, P = 0.148). Preoperative use of gabapentinoids is associated with lower incidence of succinylcholine-induced myalgias within the first 24 hours of surgery.
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