Trivial aortic valve regurgitation in children and adolescents with structurally normal hearts: physiologic or pathologic?

BACKGROUND: Trivial regurgitation from a normal aortic valve is rarely seen in healthy children and adolescents. The aim of this study was to evaluate timing of presentation, associated conditions, and medium-term prognosis of this incidental finding.

METHODS: Paediatric patients observed to have trivial aortic valve regurgitation with otherwise normal echocardiograms were retrospectively analysed. Clinical and echocardiographic parameters were measured and categorised on presentation and follow-up.

RESULTS: Sixty patients (39 males) were identified over a 13-year period. Age at presentation was 14.8 years (IQR 12.9-16.0), height z-score was + 0.71 (95% CI + 0.48- + 0.94), and body mass index z-score was + 0.66 (95% CI + 0.40- + 0.92). Median aortic regurgitation vena contracta diameter was 1.0 mm (IQR 0.8-1.3). Aortic valve strands were visualised in 28% and physiologic mitral regurgitation in 32%. Aortic annulus, sinotubular junction, and mid-ascending aorta diameters were normal, and mean aortic sinus diameter was only slightly increased (z-score + 0.23, 95% CI + 0.02- + 0.44). Follow-up data were obtained in 36 patients from 1 to 6.7 years later (median 2.1). Aortic regurgitation was no longer detectable in 28%, and none exhibited worsening. Mitral regurgitation prevalence was lower in those with aortic regurgitation resolution versus persistence (10% versus 50%, p = 0.03).

CONCLUSIONS: Trivial aortic regurgitation in paediatric patients with normal hearts is more common in adolescents and is associated with an increased prevalence of aortic valve strands and physiologic mitral regurgitation. These findings do not worsen during growth and may resolve consistent with being physiologic rather than pathologic.