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DNA tetrahedron-based nanogels for siRNA delivery and gene silencing.
Chemical Communications : Chem Comm 2019 March 22
DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With a compact architecture that embeds functional siRNA inside, the self-assembled nanogel can efficiently enter cells and knock down the target gene expression, making them potential noncationic vectors for functional nucleic acid delivery.
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