The relationship between obesity, glycemia and leptin level of type 2 diabetes mellitus patients with metabolic syndrome.

OBJECTIVE: The aim of the study was to establish the relationship between obesity, glucose and leptin level of 2 type diabetes mellitus patients with metabolic syndrome.

PATIENTS AND METHODS: Materials and methods: 79 male patients were examined. They were divided into 2 groups. The first group included 48 patients who took Metformin and the second one - 31 persons taking Metformin, Glimepiride of one-day functioning and Thiazolidinediones. The patients were examined to determine their waistline, body mass index (BMI), level of glucose, glycohemoglobin, and leptin. The investigation was conducted at the hospitalization runtime, in 14 days, in 6 months and in 12 months.

RESULTS: Results: It was determined that after 12 months of therapy glycemia levels went significantly down, so the number of patients with glycemia level up to 7.0 mole per litre increased to 69.44% in the first group and to 55.56% in the second groupю It is also shown that positive dynamics in reducing glycohemoglobin levels has been achieved. These indices correlated clearly with the triglycerides level which decreased significantly from 1,53±0,17 mole per litre to 1,06±0,56 mole per litre in the first group of patients, but TG levels increased from 1,29±0,19 mole per litre to 1,49±0,30 mole per litre in the second group of patients.

CONCLUSION: Conclusions: The survey examined leptin level and showed that leptin level increases alongside with the disease duration. Consequently, insulin resistance index HOMA is associated with leptin resistance and there is a direct correlation between them.