Synthesis and carbonic anhydrase inhibitory properties of novel chalcone substituted benzenesulfonamides.

Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial metalloenzymes involved in many bioprocesses, through catalysis of the reversible hydration/dehydration process of CO2 /HCO3 - . The inhibition of human CA isoforms I and II with a new series of sulfonamide derivatives incorporating substituted chalcone moieties were studied in this study. All these newly synthesized sulfonamides demonstrated important inhibitory profiles to these CA isoforms with KI s in the range of 9.88 to 55.43nM, making these compounds interesting leads, with potential applications in medicinal chemistry.