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EDITORIAL
Joy Li, Stephen P Winter, Rishabh Gattu, Kyle D Perry, Kara Gaetke-Udager, Eman Abdulfatah, Jonathan B McHugh, Kristine E Konopka, Mohamed Abdelmohsen Bedewi, Steven B Soliman
No abstract text is available yet for this article.
April 29, 2024: Skeletal Radiology
#2
JOURNAL ARTICLE
Aaron B Simon, Jeffrey Quezada, Ahmed Mohyeldin, Jeremy Harris, Mengying Shi, Steven Seyedin, Varun Sehgal, Allen M Chen
PURPOSE: Stereotactic radiosurgery (SRS) for brain metastases is frequently prescribed to the maximum tolerated dose to minimize the probability of local progression. However, many patients die from extracranial disease prior to local progression and may not require maximally aggressive treatment. Recently, improvements in models of SRS tumor control probability (TCP) and overall survival (OS) have been made. We predicted that by combining models of OS and TCP, we could better predict the true risk of local progression after SRS than by using TCP modeling alone...
June 2024: Advances in Radiation Oncology
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JOURNAL ARTICLE
Iben Møller-Hansen, Javier Sáez-Sáez, Steven A van der Hoek, Jane D Dyekjær, Hanne B Christensen, Marina Wright Muelas, Steve O'Hagan, Douglas B Kell, Irina Borodina
The exchange of small molecules between the cell and the environment happens through transporter proteins. Besides nutrients and native metabolic products, xenobiotic molecules are also transported, however it is not well understood which transporters are involved. In this study, by combining exo-metabolome screening in yeast with transporter characterization in Xenopus oocytes, we mapped the activity of 30 yeast transporters toward six small non-toxic substrates. Firstly, using LC-MS, we determined 385 compounds from a chemical library that were imported and exported by S...
2024: Frontiers in Microbiology
#4
JOURNAL ARTICLE
Donna M Edwards, Laila A Gharzai, Weilin Wang, Charles Mayo, Krithika Suresh, Matthew Schipper, Joseph R Evans, Kelly Malloy, Steven B Chinn, Mark Prince, Matthew Spector, Andrew Shuman, Chaz Stucken, Paul L Swiecicki, Francis Worden, Jennifer Jarema, Caitlin Henderson, Amanda Kovach, Chad Brenner, Jennifer L Shah, Michelle L Mierzwa, Keith Casper
BACKGROUND: Post-treatment surveillance recommendations for oropharyngeal cancer do not vary with p16 status despite the differences in outcomes. The optimal algorithm personalizing follow-up for these patients remains undefined. Here, we evaluate the feasibility and utility of incorporating electronic patient-reported outcomes (ePROs) and circulating tumor DNA (ctDNA) into routine surveillance for patients treated for p16+ oropharynx cancer. METHODS: A prospective registry was developed in which ePROs and ctDNA were incorporated into routine surveillance among patients with oropharynx cancer...
April 29, 2024: Head & Neck
#5
JOURNAL ARTICLE
Takezawa Yuki, Masayoshi Kamon, Keiko Hiraki-Kamon, Arisa Mitani, Atsushi Shiraishi, Hidemasa Kato
The conjunctiva is a non-keratinized, stratified columnar epithelium with characteristics different from the cornea and eyelid epidermis. From development to adulthood, a distinguishing feature of ocular versus epidermal epithelia is the expression of the master regulator PAX6. A conditionally immortalized conjunctival epithelial cell line (iHCjEC) devoid of stromal or immune cells established in our laboratory spontaneously manifested epidermal metaplasia and upregulated expression of the keratinization-related genes SPRR1A/B and the epidermal cytokeratins KRT1 and KRT10 at the expense of the conjunctival trait...
April 26, 2024: Experimental Eye Research
#6
JOURNAL ARTICLE
Amida H Kuah, Lara H Sattgast, Kathleen A Grant, Steven W Gonzales, Rupak Khadka, John G Damrath, Matthew R Allen, David B Burr, Joseph M Wallace, Gianni F Maddalozzo, Mary Lauren Benton, Laura M Beaver, Adam J Branscum, Russell T Turner, Urszula T Iwaniec
Chronic heavy alcohol consumption is a risk factor for low trauma bone fracture. Using a non-human primate model of voluntary alcohol consumption, we investigated the effects of 6 months of ethanol intake on cortical bone in cynomolgus macaques (Macaca fascicularis). Young adult (6.4 ± 0.1 years old, mean ± SE) male cynomolgus macaques (n = 17) were subjected to a 4-month graded ethanol induction period, followed by voluntary self-administration of water or ethanol (4 % w/v) for 22 h/d, 7 d/wk...
April 26, 2024: Bone
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JOURNAL ARTICLE
Jordyn A Lopes, Nicole E Garnier, Yanlong Pei, Jacob G E Yates, Elena S B Campbell, Melanie M Goens, Madison E Hughes, Amira D Rghei, Brenna A Y Stevens, Matthew M Guilleman, Brad Thompson, Cezar M Khursigara, Leonardo Susta, Sarah K Wootton
Pseudomonas aeruginosa poses a significant threat to immunocompromised individuals and those with cystic fibrosis. Treatment relies on antibiotics, but persistent infections occur due to intrinsic and acquired resistance of P. aeruginosa towards multiple classes of antibiotics. To date, there are no licensed vaccines for this pathogen, prompting the urgent need for novel treatment approaches to combat P. aeruginosa infection and persistence. Here we validated AAV vectored immunoprophylaxis as a strategy to generate long-term plasma and mucosal expression of highly protective monoclonal antibodies (mAbs) targeting the exopolysaccharide Psl (Cam-003) and the PcrV (V2L2MD) component of the type-III secretion system injectosome either as single mAbs or together as a bispecific mAb (MEDI3902) in a mouse model...
April 27, 2024: Gene Therapy
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JOURNAL ARTICLE
Mac Giollabhui Naoise, A Lowry Christopher, Nyer Maren, L Foster Simmie, T Liu Richard, G Smith David, P Cole Steven, E Mason Ashley, Mischoulon David, L Raison Charles
There is urgent need for novel antidepressant treatments that confer therapeutic benefits via engagement with identified mechanistic targets. The objective of the study was to determine whether activation of the classical anti-inflammatory interleukin-6 signaling pathways is associated with the antidepressant effects of whole-body hyperthermia. A 6-week, randomized, double-blind study compared whole-body hyperthermia with a sham condition in a university-based medical center. Medically healthy participants aged 18-65 years who met criteria for major depressive disorder, were free of psychotropic medication use, and had a baseline 17-item Hamilton Depression Rating Scale score ≥ 16 were randomized with 1-to-1 allocation in blocks of 6 to receive whole-body hyperthermia or sham...
April 25, 2024: Brain, Behavior, and Immunity
#9
JOURNAL ARTICLE
Kate R Oppegaard, Samantha J Mayo, Terri S Armstrong, Vasuda Dokiparthi, Michelle Melisko, Jon D Levine, Adam B Olshen, Joaquin A Anguera, Ritu Roy, Steven Paul, Bruce Cooper, Yvette P Conley, Marilyn J Hammer, Christine Miaskowski, Kord M Kober
BACKGROUND: Cancer-related cognitive impairment (CRCI) and anxiety co-occur in patients with cancer. Little is known about mechanisms for the co-occurrence of these two symptoms. The purposes of this secondary analysis were to evaluate for perturbed pathways associated with the co-occurrence of self-reported CRCI and anxiety in patients with low versus high levels of these two symptoms and to identify potential mechanisms for the co-occurrence of CRCI and anxiety using biological processes common across any perturbed neurodegenerative disease pathways...
April 27, 2024: Cancer
#10
JOURNAL ARTICLE
Hadley Stevens Smith, Caryn Kseniya Rubanovich, Jill Oliver Robinson, Ariel N Levchenko, Sarah A Classen, Janet Malek, Barbara Biesecker, Kyle B Brothers, Benjamin S Wilfond, Christine Rini, Sara J Knight, Amy L McGuire, Cinnamon S Bloss
INTRODUCTION: Measuring effects of genomic sequencing (GS) on patients and families is critical for translational research. We aimed to develop and validate an instrument to assess parents' perceived utility of pediatric diagnostic GS. METHODS: Informed by a five-domain conceptual model, the study comprised five steps: (1) item writing, (2) cognitive testing, (3) pilot testing and item reduction, (4) psychometric testing, and (5) evaluation of construct validity...
April 24, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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JOURNAL ARTICLE
Anneke D van Dijk, Fieke W Hoff, Yihua Qiu, Stefan E Hubner, Robin L Go, Vivian R Ruvolo, Amanda R Leonti, Robert B Gerbing, Alan S Gamis, Richard Aplenc, Edward A Kolb, Todd A Alonzo, Soheil Meshinchi, Eveline S J M de Bont, Terzah M Horton, Steven M Kornblau
The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children's Oncology Group phase 3 trial AAML1031 (NCT01371981). Proteasome inhibition influences the chromatin landscape and proteostasis, and we hypothesized that baseline proteomic analysis of histone- and chromatin-modifying enzymes (HMEs) would identify AML subgroups that benefitted from bortezomib addition. A proteomic profile of 483 patients treated with AAML1031 chemotherapy was generated using a reverse-phase protein array...
April 9, 2024: Cancers
#12
JOURNAL ARTICLE
Matthew J Lee, Ellen Lee, Mike Bradburn, Daniel Hind, Emily B Strong, Farhat Din, Arkadiusz P Wysocki, Jon Lund, Christine Moffatt, Jonathan Morton, Asha Senapati, Helen Jones, Steven R Brown
AIM: Pilonidal sinus disease is a common condition treated by colorectal surgeons. There is a lack of literature in the field to guide optimal management of this condition. As part of the PITSTOP study, we aimed to identify policy and research priorities to provide direction to the field. METHOD: Patients and surgeons were invited to participate. A 'So what, now what' exercise was conducted, informed by data from PITSTOP. This generated statements for research and practice priorities...
April 26, 2024: Colorectal Disease
#13
JOURNAL ARTICLE
Rachel P Ogilvie, J Bradley Layton, Patricia C Lloyd, Yixin Jiao, Djeneba Audrey Djibo, Hui Lee Wong, Joann F Gruber, Ron Parambi, Jie Deng, Michael Miller, Jennifer Song, Lisa B Weatherby, Lauren Peetluk, An-Chi Lo, Kathryn Matuska, Michael Wernecke, Christine L Bui, Tainya C Clarke, Sylvia Cho, Elizabeth J Bell, Grace Yang, Kandace L Amend, Richard A Forshee, Steven A Anderson, Cheryl N McMahill-Walraven, Yoganand Chillarige, Mary S Anthony, John D Seeger, Azadeh Shoaibi
BACKGROUND: COVID-19 vaccines are authorized for use in children in the United States; real-world assessment of vaccine effectiveness in children is needed. This study's objective was to estimate the effectiveness of receiving a complete primary series of monovalent BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine in US children. METHODS: This cohort study identified children aged 5-17 years vaccinated with BNT162b2 matched with unvaccinated children. Participants and BNT162b2 vaccinations were identified in Optum and CVS Health insurance administrative claims databases linked with Immunization Information System (IIS) COVID-19 vaccination records from 16 US jurisdictions between December 11, 2020, and May 31, 2022 (end date varied by database and IIS)...
April 26, 2024: BMC Pediatrics
#14
JOURNAL ARTICLE
Eric J Shumski, Shawn R Eagle, Anthony P Kontos, Jeffrey J Bazarian, Jaclyn B Caccese, Sara P D Chrisman, James R Clugston, Thomas W McAllister, Michael McCrea, Steven P Broglio, Robert C Lynall, Julianne D Schmidt
INTRODUCTION: The purpose of this study was to determine if the time interval between two concussive events influences the number of days to asymptomatic status, days to return to play, or performance on common post-concussion assessments following the second concussion. METHODS: Data from 448 collegiate athletes and service academy cadets with two concussions (time between concussions: median 295.0 days [interquartile range: 125.0-438.2]), 40.0% female) were analyzed from Concussion Assessment Research and Education (CARE) Consortium institutions between 2014 and 2020...
April 26, 2024: Sports Medicine
#15
JOURNAL ARTICLE
Zhishan Chen, Xingyi Guo, Ran Tao, Jeroen R Huyghe, Philip J Law, Ceres Fernandez-Rozadilla, Jie Ping, Guochong Jia, Jirong Long, Chao Li, Quanhu Shen, Yuhan Xie, Maria N Timofeeva, Minta Thomas, Stephanie L Schmit, Virginia Díez-Obrero, Matthew Devall, Ferran Moratalla-Navarro, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah E W Briggs, Victoria Svinti, Kevin Donnelly, Susan M Farrington, James Blackmur, Peter G Vaughan-Shaw, Xiao-Ou Shu, Yingchang Lu, Peter Broderick, James Studd, Tabitha A Harrison, David V Conti, Fredrick R Schumacher, Marilena Melas, Gad Rennert, Mireia Obón-Santacana, Vicente Martín-Sánchez, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John L Hopper, Mark A Jenkins, Aung Ko Win, Rish K Pai, Jane C Figueiredo, Robert W Haile, Steven Gallinger, Michael O Woods, Polly A Newcomb, David Duggan, Jeremy P Cheadle, Richard Kaplan, Rachel Kerr, David Kerr, Iva Kirac, Jan Böhm, Jukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri A Aaltonen, Harri Rissanen, Eero Pukkala, Johan G Eriksson, Tatiana Cajuso, Ulrika Hänninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Satu Männistö, Demetrius Albanes, Stephanie J Weinstein, Edward Ruiz-Narvaez, Julie R Palmer, Daniel D Buchanan, Elizabeth A Platz, Kala Visvanathan, Cornelia M Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter T Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha L Slattery, John D Potter, Kostas K Tsilidis, Matthias B Schulze, Marc J Gunter, Neil Murphy, Antoni Castells, Sergi Castellví-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, D Timothy Bishop, Graham G Giles, Melissa C Southey, Gregory E Idos, Kevin J McDonnell, Zomoroda Abu-Ful, Joel K Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope O Keku, Bethany van Guelpen, Thomas J Hudson, Heather Hampel, Rachel Pearlman, Sonja I Berndt, Richard B Hayes, Marie Elena Martinez, Sushma S Thomas, Paul D P Pharoah, Susanna C Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly F Doheny, Elizabeth Pugh, Tameka Shelford, Andrew T Chan, Marcia Cruz-Correa, Annika Lindblom, David J Hunter, Amit D Joshi, Clemens Schafmayer, Peter C Scacheri, Anshul Kundaje, Robert E Schoen, Jochen Hampe, Zsofia K Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Christopher K Edlund, W James Gauderman, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen J Chanock, Franzel van Duijnhoven, Edith J M Feskens, Lori C Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Barbara Pardini, Liesel M FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie A Bien, Charles Kooperberg, Christopher I Li, Yi Lin, Ross Prentice, Conghui Qu, Stéphane Bézieau, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Loic Le Marchand, Anna H Wu, Chenxu Qu, Caroline E McNeil, Gerhard Coetzee, Caroline Hayward, Ian J Deary, Sarah E Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Ken S Lau, Hongyu Zhao, Li Hsu, Qiuyin Cai, Malcolm G Dunlop, Stephen B Gruber, Richard S Houlston, Victor Moreno, Graham Casey, Ulrike Peters, Ian Tomlinson, Wei Zheng
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV...
April 26, 2024: Nature Communications
#16
JOURNAL ARTICLE
Jeremy Josef Heit, Neeraj Chaudhary, Justin R Mascitelli, Mais Al-Kawaz, Amanda Baker, Ketan R Bulsara, Jan Karl Burkhardt, Franklin A Marden, Daniel Raper, Stavropoula I Tjoumakaris, Clemens M Schirmer, Steven W Hetts
BACKGROUND: Endovascular therapy (EVT) dramatically improves clinical outcomes for patients with anterior circulation emergent large vessel occlusion (ELVO) strokes. With recent publication of two randomized controlled trials in favor of EVT for basilar artery occlusions, the Society of NeuroInterventional Surgery (SNIS) Standards and Guidelines Committee provides this focused update for the existing SNIS guideline, 'Current endovascular strategies for posterior circulation large vessel occlusion stroke...
April 26, 2024: Journal of Neurointerventional Surgery
#17
JOURNAL ARTICLE
Noa G Holtzman, Lauren M Curtis, Rachel B Salit, Brian C Shaffer, Filip Pirsl, Alen Ostojic, Seth M Steinberg, Eduard Schulz, Jennifer S Wilder, Thomas E Hughes, Jeremy Rose, Sarfraz Memon, Robert Korngold, Juan Gea-Banacloche, Daniel H Fowler, Frances T Hakim, Ronald E Gress, Michael R Bishop, Steven Z Pavletic
Chronic graft-versus-host disease (cGVHD) remains a significant problem for patients after allogeneic hematopoietic stem cell transplants (allo-HSCT). While in vivo lymphodepletion by antibodies for cGVHD prophylaxis has been explored in the myeloablative setting, its effects after reduced intensity conditioning (RIC) are not well described. Patients (n=83) with hematologic malignancies underwent targeted lymphodepletion chemotherapy followed by a RIC allo-HSCT using peripheral blood stem cells from unrelated donors...
April 26, 2024: Blood Advances
#18
JOURNAL ARTICLE
Dylan Duchen, Steven J Clipman, Candelaria Vergara, Chloe L Thio, David L Thomas, Priya Duggal, Genevieve L Wojcik
Nearly 300 million individuals live with chronic hepatitis B virus (HBV) infection (CHB), for which no curative therapy is available. As viral diversity is associated with pathogenesis and immunological control of infection, improved methods to characterize this diversity could aid drug development efforts. Conventionally, viral sequencing data are mapped/aligned to a reference genome, and only the aligned sequences are retained for analysis. Thus, reference selection is critical, yet selecting the most representative reference a priori remains difficult...
2024: PloS One
#19
JOURNAL ARTICLE
Steven B Soliman
No abstract text is available yet for this article.
2024: Journal of Medical Ultrasound
#20
JOURNAL ARTICLE
Paul Okunieff, Steven G Swarts, Bruce Fenton, Stephen B Zhang, Zhenhuan Zhang, Lori Rice, Daohong Zhou, France Carrier, Lurong Zhang
Optimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed monkey plasma using a branched DNA (bDNA) technique with a laboratory developed test...
April 25, 2024: Radiation Research
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