Elias Baedorf-Kassis, Michael Murn, Amy L Dzierba, Alexis L Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M Goodspeed, Michael A Matthay, Michelle N Gong, Deborah Cook, Stephen H Loring, Daniel Talmor, Jeremy R Beitler
BACKGROUND: In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid-base state, oxygenation, mechanics, and sedation depth do not fully explain drive heterogeneity. This study evaluated the relationship of systemic inflammation and vascular permeability markers with respiratory drive and clinical outcomes in ARDS. METHODS: ARDS patients enrolled in the multicenter EPVent-2 trial with requisite data and plasma biomarkers were included...
April 23, 2024: Critical Care: the Official Journal of the Critical Care Forum